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Search Results: 1 - 10 of 7792 matches for " Karl Heinz Weiss "
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Separate basolateral and apical phosphatidylcholine secretion routes in intestinally differentiated tumor cells
Daniel Gotthardt, Annika Braun, Anke Tietje, Karl Heinz Weiss, Robert Ehehalt, Wolfgang R Stremmel
World Journal of Gastroenterology , 2009,
Abstract: AIM: To investigate whether the secretion of phosphatidylcholine (PC) in intestinal mucus occurs by apical secretion or via basolateral excretion and to determine its subsequent passage across the tight junctions to the apical mucus.METHODS: We addressed this question using the polarized intestinally differentiated tumor cell line CaCo-2 grown on filters to confluence in Transwell culture chambers. The released PC and sphingomyelin (Sph) from apical and basolateral media were analyzed by mass spectrometry.RESULTS: The secreted PC species were identical in both compartments indicating the same intracellular origin of PC. However, PC secretion into the basolateral compartment was more effective, and the PC:Sph ratio in the basolateral compartment was significantly higher than that in the apical compartment (8.18 ± 1.84 vs 4.31 ± 1.22, P = 0.01). Both pathways were temperature sensitive and were unaltered in the presence of cyclosporine.CONCLUSION: The data demonstrate the PC secretion capacity of CaCo-2 cells and indicate two separated apical and basolateral release mechanisms.
Outcome Results of Treatment with Selective Internal Radiation Therapy (SIRT) in Patients with Hepatocellular Carcinoma: A Single Center Experience  [PDF]
Jan Pfeiffenberger, Tatjana Zimmermann, Daniel N. Gotthardt, Christoph Springfeld, Wolfgang Stremmel, Peter Schirmacher, Henning Schulze-Bergkamen, Arianeb Mehrabi, Christoph W. Michalski, Katrin Hoffmann, Nikolas Kortes, Boris Radeleff, Uwe Haberkorn, Clemens Kratochwil, Karl Heinz Weiss, Carsten Grüllich
Journal of Cancer Therapy (JCT) , 2017, DOI: 10.4236/jct.2017.84031
Abstract: Background: Hepatocellular carcinoma (HCC) has a poor prognosis. Selective internal radiation therapy (SIRT) with microspheres is a treatment option for HCC. This study aimed to assess safety and survival (OS) in patients with HCC treated with SIRT, to stratify patients with tumor vascularization and analyze the impact of sequential sorafenib treatment. Methods: Thirty-nine patients who received SIRT for HCC between 2010 and 2013 at our center were included in this retrospective analysis. Tumor vascularization was assessed using a combination of MRI, MAA-scintigraphy and angiography. Tumor vascularization was correlated with survival. Subgroups are treated with two commercially available 90Y-labeled products SIR-Spheres (n = 16) and TheraSpheres (n = 23) and sequential therapy with sorafenib compared to SIRT only was analyzed. Results: Adverse events occurred in 49% of patients with only four grade 3 and no grade 4 event. Median survival for all patients was 12.5 months (95% CI: 8.7 - 16.3). No significant differences were detectable between Thera Spheres or SIR Spheres. Survival was shorter in patients with low tumor vascularization score (OS: 3.8 months (95% CI 0 - 15.0), p = 0.043). Survival was longer with sorafenib upon progression after SIRT (n=16) with an OS of 17.4 months (95% CI: 12.1 – 22.7) compared to no sorafenib (n = 13; 9.1 months; 95% CI: 3.0 - 15.1) or progression upon sorafenib before SIRT (n = 10; 8.6 months; 95% CI: 5.5 - 11.7). Conclusions: SIRT is safe in HCC patients. Tumor vascularization by radiography and scintigraphy may predict survival benefit. Sorafenib is active after SIRT and significantly prolongs survival.
Health care needs need to be focused on health  [PDF]
Johannes Bircher, Karl-Heinz Wehkamp
Health (Health) , 2011, DOI: 10.4236/health.2011.36064
Abstract: In the past decades health care and medicine in most countries got more or less in a state of crisis. This is not surprising because, so far, there is no consensus about the nature of health. This shortcoming inhibits constructive, interdisciplinary dialogues about health values. It renders priority setting controversial and subject to power struggles. A new definition of health, known as the Meikirch Model, could correct this deficiency. It states: “Health is a dynamic state of wellbeing characterized by a physical, mental and social potential, which satisfies the demands of a life commensurate with age, culture, and personal responsibility. If the potential is insufficient to satisfy these de-mands the state is disease.” The potential is composed of a biologically given and a person-ally acquired component. Thus this definition characterizes health with six essential features, which are suitable for an analysis of and priority setting in medical consultations and in health care policy decisions. A wide discussion about this definition of health followed by its imple-mentation is expected to render health care in-dividually and socially more beneficial.
On the Quantum Zeno Effect and Time Series Related to Quantum Measurements  [PDF]
Karl-Heinz Fichtner, Kei Inoue
Applied Mathematics (AM) , 2013, DOI: 10.4236/am.2013.410A3008

Our main aim is to prove a more general version of the quantum Zeno effect. Then we discuss some examples of the quantum Zeno effect. Furthermore, we discuss a possibility that based on the quantum Zeno effect and certain experiments one could check whether, from the statistical point of view, a concrete system behaves like a quantum system. The more general version of quantum Zeno effect can be helpful to prove that the brain acts like in a quantum system. The proof of our main result is based on certain formulas describing probability distributions of time series related to quantum measurements.

An introduction to endoreversible thermodynamics
Hoffmann, Karl Heinz
Atti della Accademia Peloritana dei Pericolanti : Classe di Scienze Fisiche, Matematiche e Naturali , 2008, DOI: 10.1478/c1s0801011
Abstract: Reversible thermodynamic processes are convenient abstractions of real processes, which are always irreversible. Approaching the reversible regime means to become more and more quasistatic, letting behind processes which achieve any kind of finite transformation rate for the quantities studied. On the other hand studying processes with finite transformation rates means to deal with irreversibilities and in many cases these irreversibilities must be included in a realistic description of such processes. Endoreversible thermodynamics is a non-equilibrium approach in this direction by viewing a system as a network of internally reversible (endoreversible) subsystems exchanging energy in an irreversible fashion. This material provides an introduction to the subject.
El principio de investigación de oficio en la praxis del proceso penal alemán
Karl Heinz G?ssel
Derecho Penal y Criminología , 2005,
Ultra-High Energy Cosmic Ray and Neutrino Observations
Karl-Heinz Kampert
Physics , 2009,
Abstract: Recent measurements of ultra-high energy cosmic rays and neutrinos are briefly reviewed. With several new large scale observatories nearing completion or becoming fully operational only very recently, a large body of high quality and high statistics data is growing up now. Already these first data have started to open up a new window to the high energy Universe giving us first direct clues about the origin of the most energetic particles with energies of about 10^{20} eV as well as about their interactions from extragalactic sources to Earth. Also, for the first time full sky views of high energy neutrinos have become available with neutrino telescopes operating on either Hemisphere. While a "smoking gun" is still missing on galactic sources of cosmic rays, constraining upper limits to neutrino fluxes from various source candidates are reported. Thus, future neutrino telescopes, such as KM3NeT in the Mediterranean should aim at volumes significantly larger than one cubic kilometer. Besides seeking the sources of galactic and extragalactic cosmic rays, the new generation of cosmic ray and neutrino observatories touches a wide range of scientific issues and they have already provided important results on tests of fundamental physics.
Experimental Summary: Very High Energy Cosmic Rays and their Interactions
Karl-Heinz Kampert
Physics , 2013, DOI: 10.1051/epjconf/20125213001
Abstract: The XVII International Symposium on Very High Energy Cosmic Ray Interactions, held in August of 2012 in Berlin, was the first one in the history of the Symposium, where a plethora of high precision LHC data with relevance for cosmic ray physics was presented. This report aims at giving a brief summary of those measurements and it discusses their relevance for observations of high energy cosmic rays. Enormous progress has been made also in air shower observations and in direct measurements of cosmic rays, exhibiting many more structure in the cosmic ray energy spectrum than just a simple power law with a knee and an ankle. At the highest energy, the flux suppression may not be dominated by the GZK-effect but by the limiting energy of a nearby source or source population. New projects and application of new technologies promise further advances also in the near future. We shall discuss the experimental and theoretical progress in the field and its prospects for coming years.
Ultra-High Energy Cosmic Rays: Results and Prospects
Karl-Heinz Kampert
Physics , 2013, DOI: 10.1007/s13538-013-0150-1
Abstract: Observations of cosmic rays have been improved at all energies, both in terms of higher statistics and reduced systematics. As a result, the all particle cosmic ray energy spectrum starts to exhibit more structures than could be seen previously. Most importantly, a second knee in the cosmic ray spectrum -- dominated by heavy primaries -- is reported just below 10^{17} eV. The light component, on the other hand, exhibits an ankle like feature above 10^{17} eV and starts to dominate the flux at the ankle. The key question at the highest energies is about the origin of the flux suppression observed at energies above 5 x 10^{19} eV. Is this the long awaited GZK-effect or the exhaustion of sources? The key to answering this question is again given by the still largely unknown mass composition at the highest energies. Data from different observatories don't quite agree and common efforts have been started to settle that question. The high level of isotropy observed even at the highest energies starts to challenge a proton dominated composition if extragalactic (EG) magnetic fields are on the order of a few nG or more. We shall discuss the experimental and theoretical progress in the field and the prospects for the next decade.
Methods of Determination of the Energy and Mass of Primary Cosmic Ray Particles at Extensive Air Shower Energies
Karl-Heinz Kampert
Physics , 2001, DOI: 10.1088/0954-3899/27/7/321
Abstract: Measurements of cosmic ray particles at energies above E = 5 x 10^{14} eV are performed by large area ground based air shower experiments. Only they provide the collection power required for obtaining sufficient statistics at the low flux levels involved. In this review we briefly outline the physics and astrophysics interests of such measurements and discuss in more detail various experimental techniques applied for reconstructing the energy and mass of the primary particles. These include surface arrays of particle detectors as well as observations of Cherenkov- and of fluorescence light. A large variety of air shower observables is then reconstructed from such data and used to infer the properties of the primary particles via comparisons to air shower simulations. Advantages, limitations, and systematic uncertainties of different approaches will be critically discussed.
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