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Search Results: 1 - 10 of 5626 matches for " Karen Kelley "
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Canadian university students’ perceptions of future personal infertility  [PDF]
Amanda N. Whitten, Olivia Remes, Kelley-Anne Sabarre, Zainab Khan, Karen P. Phillips
Open Journal of Obstetrics and Gynecology (OJOG) , 2013, DOI: 10.4236/ojog.2013.37101

Objective: University is a time for self-discovery, development of independence and transition to adulthood. It is not well examined whether childless university students also consider the potential of future personal infertility. The objective of this study was to document expectations and perceptions related to personal infertility in a sample of young adults. Methods: Using a qualitative approach, interviews were conducted with 39 male and female university students in Ottawa, Canada. Interview topics included contemplation of personal infertility, anticipated gendered experience of infertility and cultural perceptions of infertility. Results: The possibility of future infertility was not contemplated by most participants (74%). Although students generally expected infertility to be an emotional experience, women especially anticipated that infertility would be associated with negative gender identity and reduced self-esteem. Ethnic-minority participants from pro-natalist countries perceived infertility to be stigmatized by their communities, particularly against women. Conclusions: This sample of childless young adults anticipated many gendered and cultural dimensions of the experience of infertility, suggesting that these perceptions are shaped well in advance of contemplation of family planning.

Involvement of Root Hair during Rhizobial Invasion in Cultivated Peanut (Arachis hypogaea L.)  [PDF]
James Maku, Liping Wang, Fengxia Liu, Lixia Liu, Karen Kelley, Ze Peng, Jianping Wang
American Journal of Plant Sciences (AJPS) , 2018, DOI: 10.4236/ajps.2018.98119
Abstract: Peanut root invasion by Bradyrhizobia is through a crack entry, which is different from many other legumes applying an infection thread entry in root hair. Understanding the role of root hair in the crack entry of Bradyrhizobia invasion of peanut root and subsequent peanut nodulation would facilitate improvement of biological nitrogen fixation in cultivated peanut. The objective of this study was to investigate the involvement of root hair in Bradyrhizobial invasion of peanut. Seedling roots of a nodulating peanut
Bridging health and foreign policy: the role of health impact assessments
Lee,Kelley; Ingram,Alan; Lock,Karen; McInnes,Colin;
Bulletin of the World Health Organization , 2007, DOI: 10.1590/S0042-96862007000300014
Abstract: health impact assessment (hia) is an important tool for exploring the intersection between health and foreign policy, offering a useful analytical approach to increase positive health impacts and minimize negative impacts. numerous subject areas have brought health and foreign policy together. yet further opportunities exist for hia to address a broader range of health impacts that otherwise may not be seen as relevant to foreign policy. hia may also improve the quality of scientific evidence available to policy-makers. the framework convention on tobacco control offers lessons for the strategic use of hia. however, hia alone is limited in influencing these decision-making processes, notably when issues diverge from other core concerns such as economics and security. in such cases, hia is an important tool to be used alongside the mobilization of key constituencies and public support.
Opportunities for nurses in the era of electronic health records  [PDF]
Tiffany Kelley
Open Journal of Nursing (OJN) , 2014, DOI: 10.4236/ojn.2014.41003

Nursing leaders are currently faced with opportunities to advance nursing’s role in the use of electronic health records (EHRs). Nurse leaders can advance the design of EHRs with nurse informaticists to improve health outcomes of individual and populations of patients.

Cortactin Phosphorylated by ERK1/2 Localizes to Sites of Dynamic Actin Regulation and Is Required for Carcinoma Lamellipodia Persistence
Laura C. Kelley,Karen E. Hayes,Amanda Gatesman Ammer,Karen H. Martin,Scott A. Weed
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0013847
Abstract: Tumor cell motility and invasion is governed by dynamic regulation of the cortical actin cytoskeleton. The actin-binding protein cortactin is commonly upregulated in multiple cancer types and is associated with increased cell migration. Cortactin regulates actin nucleation through the actin related protein (Arp)2/3 complex and stabilizes the cortical actin cytoskeleton. Cortactin is regulated by multiple phosphorylation events, including phosphorylation of S405 and S418 by extracellular regulated kinases (ERK)1/2. ERK1/2 phosphorylation of cortactin has emerged as an important positive regulatory modification, enabling cortactin to bind and activate the Arp2/3 regulator neuronal Wiskott-Aldrich syndrome protein (N-WASp), promoting actin polymerization and enhancing tumor cell movement.
Mechanism of Repeat-Associated MicroRNAs in Fragile X Syndrome
Karen Kelley,Shin-Ju E. Chang,Shi-Lung Lin
Neural Plasticity , 2012, DOI: 10.1155/2012/104796
Abstract: The majority of the human genome is comprised of non-coding DNA, which frequently contains redundant microsatellite-like trinucleotide repeats. Many of these trinucleotide repeats are involved in triplet repeat expansion diseases (TREDs) such as fragile X syndrome (FXS). After transcription, the trinucleotide repeats can fold into RNA hairpins and are further processed by Dicer endoribonuclases to form microRNA (miRNA)-like molecules that are capable of triggering targeted gene-silencing effects in the TREDs. However, the function of these repeat-associated miRNAs (ramRNAs) is unclear. To solve this question, we identified the first native ramRNA in FXS and successfully developed a transgenic zebrafish model for studying its function. Our studies showed that ramRNA-induced DNA methylation of the FMR1 5′-UTR CGG trinucleotide repeat expansion is responsible for both pathological and neurocognitive characteristics linked to the transcriptional FMR1 gene inactivation and the deficiency of its protein product FMRP. FMRP deficiency often causes synapse deformity in the neurons essential for cognition and memory activities, while FMR1 inactivation augments metabotropic glutamate receptor (mGluR)-activated long-term depression (LTD), leading to abnormal neuronal responses in FXS. Using this novel animal model, we may further dissect the etiological mechanisms of TREDs, with the hope of providing insights into new means for therapeutic intervention. 1. Introduction More than 97% of a human genome consists of noncoding DNA, the function of which was unknown until recent years. Variations between individuals’ noncoding DNA can sometimes manifest into biological and clinical dysfunction. MicroRNA (miRNA) is a subclass of noncoding RNA that is involved in a wide variety of physiological and developmental events, including developmental timing, embryonic patterning, cell fate determination, cell lineage differentiation, cell proliferation, apoptosis, organogenesis, growth control, and metabolism [1, 2]. MiRNAs are single-stranded molecules consisting of about 18 to 27 ribonucleotides in length and regulate the expression of other protein-coding genes through an intracellular gene silencing mechanism named RNA interference (RNAi). MiRNAs can be located within the noncoding DNA or protein-coding region of DNA [2, 3]. After transcription, instead of being translated the primary miRNA transcript (pri-miRNA) is processed by Drosha-like endoribonucleases to a hairpin-like stem-loop precursor, termed “pre-miRNA.” Further processing of the precursor by Dicer-like
Class II Transactivator (CIITA) Enhances Cytoplasmic Processing of HIV-1 Pr55Gag
Kristen A. Porter,Lauren N. Kelley,Annette George,Jonathan A. Harton,Karen M. Duus
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0011304
Abstract: The Pr55gag (Gag) polyprotein of HIV serves as a scaffold for virion assembly and is thus essential for progeny virion budding and maturation. Gag localizes to the plasma membrane (PM) and membranes of late endosomes, allowing for release of infectious virus directly from the cell membrane and/or upon exocytosis. The host factors involved in Gag trafficking to these sites are largely unknown. Upon activation, CD4+ T cells, the primary target of HIV infection, express the class II transcriptional activator (CIITA) and therefore the MHC class II isotype, HLA-DR. Similar to Gag, HLA-DR localizes to the PM and at the membranes of endosomes and specialized vesicular MHC class II compartments (MIICs). In HIV producer cells, transient HLA-DR expression induces intracellular Gag accumulation and impairs virus release.
Investigation of the Relationship between Myopia and Intelligence in a Sample of Undergraduate Students  [PDF]
Michael P. Kelley
Neuroscience & Medicine (NM) , 2011, DOI: 10.4236/nm.2011.24041
Abstract: In a sample of undergraduate students, myopia was associated with higher Math and Total SAT score, and males had higher Math and Total SAT scores than females. The association between myopia and higher Math and Total SAT scores was significant only among males, and the gender differences in Math and Total SAT scores were significant only among allergic participants. There were also significant associations between ethnicity and both myopia and SAT scores, but regression analyses revealed that ethnicity, gender, and myopia each made significant independent contributions to Math SAT scores. The findings provide support for Storfer’s theory of myopia and brain growth.
Kaplansky's ternary quadratic form
James Kelley
International Journal of Mathematics and Mathematical Sciences , 2001, DOI: 10.1155/s0161171201005294
Abstract: This paper proves that if N is a nonnegative eligible integer, coprime to 7, which is not of the form x2
Tobacco Control Yields Clear Dividends for Health and Wealth
Kelley Lee
PLOS Medicine , 2008, DOI: 10.1371/journal.pmed.0050189
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