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Search Results: 1 - 10 of 194332 matches for " Kanuprasad D. Patel "
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Synthesis of Cu(II), Ni(II), Co(II), and Mn(II) Complexes with Ciprofloxacin and Their Evaluation of Antimicrobial, Antioxidant and Anti-Tubercular Activity  [PDF]
Ketan S. Patel, Jiten C. Patel, Hitesh R. Dholariya, Vishal K. Patel, Kanuprasad D. Patel
Open Journal of Metal (OJMetal) , 2012, DOI: 10.4236/ojmetal.2012.23008
Abstract: Co(II), Ni(II), Cu(II) and Mn(II) complexes synthesized by reflux of 6-bromo-3-(3-(4-chlorophenyl)acryloyl)-2H- chromen-2-one, Ciprofloxacin and various transition metal. 1H, 13C, IR and ESI Mass confirm the formation of ligand. The metal complexes were characterized on the basis of various spectroscopic techniques like IR studies and elemental analysis while the geometry of complexes was octahedral which is confirmed by electronic spectra and thermogravimetric analysis. The compounds were subjected to antimicrobial, antioxidant and anti-tubercular activity screening using serial broth dilution method and Minimum Inhibitory Concentration (MIC) is determined. Mn(II) complex has shown significant antifungal activity with an MIC of 6.25 μg/ml while Cu(II) complex is noticeable for antibacterial activity at the same concentration. Anti-TB activity of the ligand has enhanced on complexation with Ni(II) and Co(II) ions. While Ni(II) complex shows superior antioxidant activity than other complexes.
Development and Characterization of Novel Interpenetrating Network (IPN) Foams from Epoxy Ester and Aliphatic Epoxy Resin
Kanuprasad Patel,Dhirubhai Desai,Santosh Bhuva
Journal of Chemistry , 2009, DOI: 10.1155/2009/481912
Synthesis, Characterization and Glass - Reinforced Composites of Thiourea - Formaldehyde - Phenol Resin
Kanuprasad Dahyalal Patel,Dhirubhai J. Desai,Manish M. Morekar,Yogesh Shrikant Tilak
Journal of Chemistry , 2004, DOI: 10.1155/2004/569824
Fast dissolving Valdecoxib tablets containing solid dispersion of Valdecoxib
Patel M,Patel D
Indian Journal of Pharmaceutical Sciences , 2006,
Abstract: Valdecoxib is a new non-steroidal antiinflammatory drug, mainly used for osteoarthritis, rheumatoid arthritis, and dysmenorrhea. The major problem with this drug, is its very low solubility in biological fluids, which results in poor bioavailability after oral administration. Therefore, solid dispersions of valdecoxib with mannitol, polyethylene glycol 4000, and polyvinyl pyrrolidone K-12, were prepared with a view to increase its water solubility. Valdecoxib solid dispersion with polyvinyl pyrolidone K-12 showed maximum drug release hence, the tablet formulation containing valdecoxib polyvinyl pyrolidone K-12 solid dispersion, was prepared with a view to improve its water solubility. The dissolution profile of best laboratory developed formulation (F1) was compared with marketed tablet products. The drug release profile was studied in 0.1 N HCL. F1 gave far better dissolution than the conventional marketed tablet, which released only 44.3% drug and valdecoxib in b cyclodextrin, which released 53.4% drug in 20 min, while F1 exhibited almost 100% drug release in 20 min. The dissolution efficiency of F1 was compared with pure drug, conventional market tablet, and valdecoxib in b cyclodextrin. F1 showed maximum dissolution efficiency. F1 was considered better than valdecoxib in b cyclodextrin, as far as the cost of raw materials used in the product is concerned. F1 was subjected to stability studies. The formulation was found to be stable for 4 weeks at 45°, with insignificant change in the hardness, disintegration time, and in vitro drug release pattern.
Optimization of fast dissolving etoricoxib tablets prepared by sublimation technique
Patel D,Patel M
Indian Journal of Pharmaceutical Sciences , 2008,
Abstract: The purpose of this investigation was to develop fast dissolving tablets of etoricoxib. Granules containing etoricoxib, menthol, crospovidone, aspartame and mannitol were prepared by wet granulation technique. Menthol was sublimed from the granules by exposing the granules to vacuum. The porous granules were then compressed in to tablets. Alternatively, tablets were first prepared and later exposed to vacuum. The tablets were evaluated for percentage friability and disintegration time. A 3 2 full factorial design was applied to investigate the combined effect of 2 formulation variables: amount of menthol and crospovidone. The results of multiple regression analysis indicated that for obtaining fast dissolving tablets; optimum amount of menthol and higher percentage of crospovidone should be used. A surface response plots are also presented to graphically represent the effect of the independent variables on the percentage friability and disintegration time. The validity of a generated mathematical model was tested by preparing a checkpoint batch. Sublimation of menthol from tablets resulted in rapid disintegration as compared with the tablets prepared from granules that were exposed to vacuum. The optimized tablet formulation was compared with conventional marketed tablets for percentage drug dissolved in 30 min (Q 30 ) and dissolution efficiency after 30 min (DE 30 ). From the results, it was concluded that fast dissolving tablets with improved etoricoxib dissolution could be prepared by sublimation of tablets containing suitable subliming agent.
Parallel Manipulators Applications—A Survey  [PDF]
Y. D. Patel, P. M. George
Modern Mechanical Engineering (MME) , 2012, DOI: 10.4236/mme.2012.23008
Abstract: This paper presents the comparison between serial and parallel manipulators. Day by day, the applications of the parallel manipulator in various field is become apparent and with a rapid rate utilized in precise manufacturing, medical science and in space exploration equipments. A parallel manipulator can be defined as a closed loop kinematic chain mechanism whose end effector is linked to the base by several independent kinematic chains. The classification of various parallel manipulators is presented herewith. The prime focus of the paper is to realize the parallel manipulators applications for industry, space, medical science or commercial usage by orienting manipulator in the space at the high speed with a desired accuracy.
Seed mucilage from Ocimum americanum linn. as disintegrant in tablets: Separation and evaluation
Patel D,Prajapati D,Patel N
Indian Journal of Pharmaceutical Sciences , 2007,
Abstract: Plant products serve as an alternative to synthetic products because of local accessibility, eco-friendly nature and lower prices compared to imported synthetic products. Natural gums and mucilage have been widely explored as pharmaceutical excipients. The present study was undertaken to separate mucilage from the seeds of Ocimum americanum Linn . and explore its use as a tablet disintegrant. Methods for extraction of mucilage from the seeds were developed and the yield by the method C was found to be 14%. The mucilage was evaluated for various parameters as per Indian Pharmacopoeia. The loss on drying, ash value and microbial load were well within the official limits. The disintegrating efficiency of separated mucilage was compared with that of the starch in tablets prepared using lactose, propranolol hydrochloride and polyvinyl pyrrolidone as model diluent, drug and binder, respectively. The disintegration time for tablet formulations prepared using mucilage (10% w/w) was less (154 s) than that of the tablet formulations prepared using starch as a disintegrant (269 s). The mucilage not interfered with the release of a drug from tablet formulations. Formulated tablets were found stable at 45 o C for 4 weeks without significant change in hardness, disintegration time and in vitro drug release.
Room Temperature Synthesis of Aminocaproic Acid-Capped Lead Sulphide Nanoparticles  [PDF]
Jayesh D. Patel, Frej Mighri, Abdellah Ajji, Sa?d Elkoun
Materials Sciences and Applications (MSA) , 2012, DOI: 10.4236/msa.2012.32020
Abstract: Aminocaproic acid (ACA) mixed methanolic lead acetate-thiourea (PbAc-TU) complex as precursor for fabrication of lead sulphide (PbS) nanoparticles (NPs) has been explained. The size, structure and morphology of as-prepared ACA-capped PbS NPs were systematically characterized by scanning electron microscopy (SEM), Transmission electron mi-croscopy (TEM), X-ray diffraction (XRD), Uv-vis spectroscopy and Brunauer-Emmett-Teller (BET) techniques. The obtained results show that the synthesized PbS NPs are nanocrystalline, size quantized and their agglomeration shows a mesoporous network of 8.7 nm in pore size. The binding nature of ACA molecules on PbS surface was studied by thermo gravimetric analysis (TGA), Fourier transform infrared (FTIR) and X-ray photoelectron (XPS) techniques. Results indicate that ACA acts as a soft template that restricts the growth of PbS NPs through its binding to Pb surface via nitrogen lone pair.
Medicinal plants in G.G.V. Campus, Bilaspur, Chhattisgarh in central India
International Journal of Medicinal and Aromatic Plants , 2012,
Abstract: Herbal medicines used for treatment of various diseases are of significant value throughout the world. Among the plant diversity some of them have great potential to treat many diseases which are referred as medicinal plants. The main aim of the present study is to focus on the diversity of medicinal plants for further utility and conservation. Current research is a useful account on medicinal plants flora in Central University Guru Ghasidas Vishwavidyalaya, Bilaspur Campus. A survey on medicinal plant diversity was made during August 2009 to December 2010 in G. G. V., Campus, Bilaspur (Chhatisgarh). After field survey, observed medicinal plants were listed followed by botanical name, family, habit, part used, uses and propagation with the help of available literature. Total of 157 medicinal plants species belonging to 58 families were recorded, which indicate the heterogeneous floristic composition in the University campus. Maximum species diversity was recorded under the family Fabaceae. Over the recorded medicinal plants 70.06 % plants are propagated by their seeds. Herbaceous medicinal plants showed their maximum presence in the Campus.
An Unusually Broad Behavioral Repertory for a Major Worker in a Dimorphic Ant Species: Pheidole Morrisi (Hymenoptera, Formicidae)
Aniruddh D. Patel
Psyche , 1990, DOI: 10.1155/1990/56747
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