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Search Results: 1 - 10 of 145143 matches for " Kang-Sheng Li "
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Research of Suppressing the Co-channel Interference in STC-OFDM with Robust Algorithm Based on Extended Bayesian Filter

Li Yu,Gu Yu-jie,Chen Kang-sheng,
李 钰

电子与信息学报 , 2008,
Abstract: It is well known that Space-Time Coded Orthogonal Frequency Division Multiplexing (STC-OFDM) is easy to be affected by the Co-Channel Interference (CCI) and it is effective to mitigate CCI by beamforming. However, the existing methods are based on the accurate estimation of source Direction-Of-Arrival (DOA). In fact, the performance of system will degrade significantly when there is error in the estimation of DOA. In this paper, a robust algorithm based on Extended Bayesian(E-Bayesian)filter is proposed to improve the performance of the beamformers with uncertainty or error in desired DOA. In this algorithm, each DOA of desired signal is regarded as a random variable composed by several discrete samples. The posterior probability of these samples will be estimated by Bayesian formula and the samples will be resampled when some posterior probability is under certain threshold. Then, the optimized weights are determined by the posterior probability of these samples. Simulation results show that the proposed algorithm can significantly improve the robustness of the beamformers to combat the co-channel interference over Rayleigh multipath fading channel.
The Application of CBS in the Teaching of Medical Microbiology

QU Wei,LI Kang-Sheng,YANG Mian-Hua,ZHUANG Jian,

微生物学通报 , 2005,
Abstract: CBS(Case Based Study)is a new teaching method,which is based on the case given.It requires students to answer questions according to the case. In the teaching,the students who are divided into groups,seek for resolvent by themselves. They should combine the information provided in the case,find the key answer and the relationship.The students gain the knowledge by reviewing and studying in the textbook,then analyse and solve questions with them. The application of CBS could make knowledge more relatively and systematic, moreover,it also make study more actively and initiatively.


系统科学与数学 , 1992,
Abstract: 设 X 是一个 Banach 空间,假设(Ⅰ)—A 生成 X 上解析半群 e~(-At),‖e~(-At)‖≤Me~(μt),t≥0.令 λ_0>μ,则可定义(参看1])
A Drug Screening Method Based on the Autophagy Pathway and Studies of the Mechanism of Evodiamine against Influenza A Virus
Jian-Ping Dai, Wei-Zhong Li, Xiang-Feng Zhao, Ge-Fei Wang, Jia-Cai Yang, Lin Zhang, Xiao-Xuan Chen, Yan-Xuan Xu, Kang-Sheng Li
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0042706
Abstract: In this research, we have established a drug screening method based on the autophagy signal pathway using the bimolecular fluorescence complementation - fluorescence resonance energy transfer (BiFC-FRET) technique to develop novel anti-influenza A virus (IAV) drugs. We selected Evodia rutaecarpa Benth out of 83 examples of traditional Chinese medicine and explored the mechanisms of evodiamine, the major active component of Evodia rutaecarpa Benth, on anti-IAV activity. Our results showed that evodiamine could significantly inhibit IAV replication, as determined by a plaque inhibition assay, an IAV vRNA promoter luciferase reporter assay and the Sulforhodamine B method using cytopathic effect (CPE) reduction. Additionally, evodiamine could significantly inhibit the accumulation of LC3-II and p62, and the dot-like aggregation of EGFP-LC3. This compound also inhibited the formation of the Atg5-Atg12/Atg16 heterotrimer, the expressions of Atg5, Atg7 and Atg12, and the cytokine release of TNF-α, IL-1β, IL-6 and IL-8 after IAV infection. Evodiamine inhibited IAV-induced autophagy was also dependent on its action on the AMPK/TSC2/mTOR signal pathway. In conclusion, we have established a new drug screening method, and selected evodiamine as a promising anti-IAV compound.
Heterologous SH3-p85β inhibits influenza A virus replication
Dan-gui Zhang, Wei-zhong Li, Ge-fei Wang, Yun Su, Jun Zeng, Chi Zhang, Xiang-xing Zeng, Xiao-xuan Chen, Yan-xuan Xu, Kang-sheng Li
Virology Journal , 2010, DOI: 10.1186/1743-422x-7-170
Abstract: Influenza A viruses are globally important human and animal respiratory pathogens, and viral infections cause highly contagious respiratory diseases. Influenza A virus can be divided into numerous subtypes (H1~H16 and N1~N9) according to the antigenicity of hemagglutinin (HA) and neuraminidase (NA). Among them, H1N1 and H3N2 subtypes are the most common subtype in human influenza infections [1]. However, in some situations, several avian influenza virus subtypes (such as H5N1, H7N7, or H9N2) can break through the species barrier and be transmitted to humans [2]. These avian influenza viruses have posed serious threat to public health.One of the main research emphases in the influenza A virus is its NS1 protein. NS1 can modulate virus infection and host cell signalling pathway [3-6], such as phosphatidylinositol 3-kinase(PI3K)/Akt pathway [7]. The PI3K/Akt pathway plays a central role in modulating diverse downstream signalling pathways associated with cell survival, proliferation, migration, and differentiation [8-10].PI3K is a dimeric enzyme consisting of a p110 catalytic subunit (α, β, or δ) tethered to a smaller, non-catalytic, regulatory subunit p85 (usually p85α, p85β, p55γ, p55α, or p50α) [11-13]. NS1 can interact with p85β of PI3K via direct binding to SH3 domain of p85β and hence promote the activation of PI3K [14], whereas mutation within the SH3 binding motif 1 of NS1 is able to deprive NS1-p85β interaction and result in the reduction of virulence of influenza A virus [15]. Apart from SH3, iSH2 domain (inter-SH2) and cSH2 domain (C-terminal SH2) domain of p85β are responsible for NS1-p85β interaction and the subsequent activation of PI3K [14,16,17]. NS1-mediated PI3K activation is obviously essential for influenza A virus replication because viral titers are significantly decreased when PI3K is inhibited [18,19].We hypothesized that viral replication could be repressed by blocking NS1-p85β interaction (competitively) with heterologously expressed SH3. Sinc
Drug Screening for Autophagy Inhibitors Based on the Dissociation of Beclin1-Bcl2 Complex Using BiFC Technique and Mechanism of Eugenol on Anti-Influenza A Virus Activity
Jian-Ping Dai, Xiang-Feng Zhao, Jun Zeng, Qian-Ying Wan, Jia-Cai Yang, Wei-Zhong Li, Xiao-Xuan Chen, Ge-Fei Wang, Kang-Sheng Li
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0061026
Abstract: Autophagy is involved in many human diseases, such as cancer, cardiovascular disease and virus infection, including human immunodeficiency virus (HIV), hepatitis C virus (HCV), influenza A virus (IAV) and coxsackievirus B3/B4 (CVB3/B4), so a drug screening model targeting autophagy may be very useful for the therapy of these diseases. In our study, we established a drug screening model based on the inhibition of the dissociation of Beclin1-Bcl2 heterodimer, an important negative regulator of autophagy, using bimolecular fluorescence complementation (BiFC) technique for developing novel autophagy inhibitors and anti-IAV agents. From 86 examples of traditional Chinese medicines, we found Syzygium aromaticum L. had the best activity. We then determined the anti-autophagy and anti-IAV activity of eugenol, the major active compound of Syzygium aromaticum L., and explored its mechanism of action. Eugenol could inhibit autophagy and IAV replication, inhibited the activation of ERK, p38MAPK and IKK/NF-κB signal pathways and antagonized the effects of the activators of these pathways. Eugenol also ameliorated the oxidative stress and inhibited the expressions of autophagic genes. We speculated that the mechanism underlying might be that eugenol inhibited the oxidative stress and the activation of ERK1/2, p38MAPK and IKK/NF-κB pathways, subsequently inhibited the dissociation of Beclin1-Bcl2 heterodimer and autophagy, and finally impaired IAV replication. These results might conversely display the reasonableness of the design of our screening model. In conclusion, we have established a drug screening model for developing novel autophagy inhibitor, and find eugenol as a promising inhibitor for autophagy and IAV infection.
Problems and Their Solutions of PBL Teaching in Medical Microbiology

WANG Ge-Fei,LI Kang-Sheng,XIN Gang,SU Yun,SHEN Yan-Qin,YANG Mian-Hua,
,李康生,辛 岗,苏 芸,申延琴,杨棉华

微生物学通报 , 2009,
Abstract: PBL(Problem-Based Learning, PBL) is a problem-oriented and effective supplementary teaching method. PBL is giving a great help to improve self-learning, communication and cooperation, thinking and problems solving abilities for the students. In the process of PBL teaching, attention should be paid to two important items. One item is the role transfer for the teacher. Teacher is only a guider in PBL teaching, teacher should avoid excessive interfere of the process for keeping the passion and enthusiasm of the students. Meanwhile, students should always be realized that they are the main part in PBL teaching, they should not depend on their teacher too much. Another important item is how to find and solve the frequently encountered problems, in order to avoid students wandering from the subject, and lead them toward the main goal to get effective teaching and learning.
Modified EXIT Chart Method for Performance Analysis of Turbo Equalization in Non-Gaussian Impulsive Noise Environments

Luo Kang-sheng,Zhao Ming-sheng,

电子与信息学报 , 2009,
Abstract: A modified EXtrinsic Information Transfer chart (EXIT chart) method is proposed. This EXIT chart is adopted as a tool to analyze the convergence behavior and to predict the performance of turbo equalization in additive non-Gaussian impulsive noise channel. The probability distribution of the extrinsic information is estimated to improve the traditional EXIT chart under symmetric α stable noise environment. Together with the Bit Error Rate (BER) analysis, the performances of turbo equalization, such as iterative trajectory, iterative convergence and the BER value at each iteration, are predicted. The experiments on the truncated turbo equalizer show that the predicted performances are consistent with the simulated results. Thus the validity of the proposed method is verified.
Simplified Algorithm and Hardware Implementation for Particle Filter Applied to Bearings-only Tracking

Hong Shao-hua,Shi Zhi-guo,Chen Kang-sheng,

电子与信息学报 , 2009,
Abstract: A simplified particle filter algorithm, which introduces a compact threshold-based resampling algorithm and features lower computing power and hardware complexity, is proposed for the bearings-only tracking problem. Based on the proposed algorithm, this paper lays emphasis on the efficient hardware implementation of particle filters on FPGA platform, and presents the hardware architecture of the resample/sample unit and the whole system. Simulation results show that the simplified algorithm outperforms the extended Kalman filter. Experimental study indicates that the implemented particle filter can be used to solve the bearings-only tracking problem and has rather fast processing rate.
Influence of process parameters on the microstructural evolution of a rear axle tube during cross wedge rolling
Jia-wei Ma,Cui-ping Yang,Zhen-hua Zheng,Kang-sheng Zhang,Wen-yu Ma
- , 2016, DOI: https://doi.org/10.1007/s12613-016-1352-7
Abstract: In the shaping process of cross wedge rolling (CWR), metal undergoes a complex microstructural evolution, which affects the quality and mechanical properties of the product. Through secondary development of the DEFORM-3D software, we developed a rigid plastic finite element model for a CWR-processed rear axle tube, coupled with thermomechanical and microstructural aspects of workpieces. Using the developed model, we investigated the microstructural evolution of the CWR process. Also, the influence of numerous parameters, including the initial temperature of workpieces, the roll speed, the forming angle, and the spreading angle, on the grain size and the grain-size uniformity of the rolled workpieces was analyzed. The numerical simulation was verified through rolling and metallographic experiments. Good agreement was obtained between the calculated and experimental results, which demonstrated the reliability of the model constructed in this work.
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