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Search Results: 1 - 10 of 1084 matches for " Kanako Goto "
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Acceleration of Phase Separation in Fe-base Ternary Alloys
Yoshihiro Suwa,Kanako Goto,Kazumi Ochi,Yoshuyuki Saito
Physics , 2001,
Abstract: Mechanism for acceleration of phase separation in Fe-base ternary alloys was investigated with use of a model based on the Cahn-Hilliard equation. Behavior of the minor element in an Fe-base ternary alloy along the trajectory of the peak of the major element is dependent on the sign of the second derivative of the chemical free energy with respect to the concentrations of the major and minor elements. However, the concentration of the major element along the trajectory of its peak top increases with time regardless of the sign of the second derivative of the chemical free energy. The addition of a substitutional element to an Fe-base binary alloy with composition within the spinodal region was found to accelerate phase separation
Chromosome 4q;10q translocations; Comparison with different ethnic populations and FSHD patients
Tsuyoshi Matsumura, Kanako Goto, Gaku Yamanaka, Je Lee, Cheng Zhang, Yukiko K Hayashi, Kiichi Arahata
BMC Neurology , 2002, DOI: 10.1186/1471-2377-2-7
Abstract: To clarify the influence on the deletion of the repeats, we surveyed three different ethnic populations and FSHD patients using the BglII/BlnI dosage test.The frequency of translocation in 153 Japanese, 124 Korean, 114 Chinese healthy individuals and 56 Japanese 4q35-FSHD patients were 27.5%, 29.8%, 19.3%, and 32.1%, respectively. The ratio of '4 on 10' (trisomy and quatrosomy of chromosome 4) was higher than that of '10 on 4' (nullsomy and monosomy of chromosome 4) in all populations.The inter-chromosomal exchange was frequently observed in all four populations we examined, and no significant difference was observed between healthy and diseased groups.Facioscapulohumeral muscular dystrophy (FSHD) is a common form of muscular disorder with an autosomal dominant trait. FSHD is characterized by weakness and atrophy of facial, shoulder-girdle and humeral muscles, with occasional subsequent pelvic-girdle and lower limb involvement. More than 95% of patients with FSHD have a smaller (< 35 kb) EcoRI fragment on chromosome 4q35 detected by probe p13E-11 and are called 4q35-FSHD [1-3]. This EcoRI fragment in normal individuals contains tandem repeated 3.3-kb KpnI units (D4Z4) varying from 11 to 150 in number, while 4q35-FSHD patients showed less than ten units [2,3]. No responsible gene has been isolated within the FSHD gene region.Probe p13E-11 cross-hybridizes with chromosome 10q26, which contains highly homologous 3.3-kb KpnI repeated units. Since the BlnI restriction enzyme site exists exclusively within each unit derived from 10q26, but not in D4Z4 (an unit from 4q35), double enzyme digestion using EcoRI and BlnI can discriminate as 4q35 (BlnI-resistant) and 10q26 (BlnI-sensitive) units [4]. In a Dutch control population, subtelomeric translocations between chromosomes 4 and 10 were seen in about 20% of individuals [5-7]. Furthermore, somatic mosaicism was found in 40% of de novo FSHD families and 46% of these individuals had BlnI-resistant units on chromosome 10 [8].
Association between a C8orf13–BLK Polymorphism and Polymyositis/Dermatomyositis in the Japanese Population: An Additive Effect with STAT4 on Disease Susceptibility
Tomoko Sugiura, Yasushi Kawaguchi, Kanako Goto, Yukiko Hayashi, Takahisa Gono, Takefumi Furuya, Ichizo Nishino, Hisashi Yamanaka
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0090019
Abstract: Background Accumulating evidence has shown that several non-HLA genes are involved in the susceptibility to polymyositis/dermatomyositis. This study aimed to investigate the involvement of C8orf13–BLK, one of the strongest candidate genes for autoimmune diseases, in susceptibility to polymyositis/dermatomyositis in the Japanese population. A possible gene–gene interaction between C8orf13–BLK and STAT4, which we recently showed to be associated with Japanese polymyositis/dermatomyositis, was also analyzed. Methods A single-nucleotide polymorphism in C8orf13–BLK (dbSNP ID: rs13277113) was investigated in the Japanese population using a TaqMan assay in 283 polymyositis patients, 194 dermatomyositis patients, and 656 control subjects. Results The C8orf13–BLK rs13277113A allele was associated with overall polymyositis/dermatomyositis (P<0.001, odds ratio [OR] 1.44, 95% confidence interval [CI] 1.19–1.73), as well as polymyositis (P = 0.011, OR 1.32, 95% CI 1.06–1.64) and dermatomyositis (P<0.001, OR 1.64, 95% CI 1.26–2.12). No association was observed between the C8orf13–BLK rs13277113A allele and either interstitial lung disease or anti-Jo-1 antibody positivity. The C8orf13–BLK rs13277113 A and STAT4 rs7574865 T alleles had an additive effect on polymyositis/dermatomyositis susceptibility. The strongest association was observed in dermatomyositis, with an OR of 3.07 (95% CI; 1.57–6.02) for the carriers of four risk alleles at the two SNP sites, namely, rs1327713 and rs7574865. Conclusions This study established C8orf13–BLK as a new genetic susceptibility factor for polymyositis/dermatomyositis. Both C8orf13–BLK and STAT4 exert additive effects on disease susceptibility. These observations suggested that C8orf13–BLK, in combination with STAT4, plays a pivotal role in creating genetic susceptibility to polymyositis/dermatomyositis in Japanese individuals.
Cut-Off Points of Head, Chest, and Arm Circumferences to Identify Low Birthweight: Meta-Analysis  [PDF]
Eita Goto
Open Journal of Epidemiology (OJEpi) , 2017, DOI: 10.4236/ojepi.2017.72015
Abstract: Background: The cut-off points of newborn anthropometric variables to identify low birthweight (i.e., birthweight < 2500 g) have varied between studies or even within the same study. Methods: Meta-analysis was performed to summarize cut-off points in studies judged as good quality based on the Quality Assessment of Diagnostic Accuracy Studies tool (QUADAS). PubMed (MEDLINE) and nine other databases were searched (January, 2015). PubMed related-citations and references of potentially eligible articles and related reviews were also investigated. The Egger test was used to assess publication bias. Results: With respect to head, chest, and arm circumferences, the cut-off points that involved no publication bias could be summarized based on the data from large numbers of newborns (=21,793, 8917, and 12,912, respectively) in relatively sufficient numbers of studies (=17, 15, and 19, respectively). The optimal cut-off points to identify low birthweight were 33.0 cm (95% confidence interval [CI], 32.8 - 33.2), 30.4 cm (95% CI, 30.3 - 30.6), and 9.3 cm (95% CI, 9.1 - 9.4) for head circumference, chest circumference, and arm circumference, respectively. The summarized cut-off point of birth height, i.e., 47.2 cm (95% CI, 46.7 - 47.7), used to identify low birthweight involved publication bias (n = 13). Conclusion: The cut-off points were determined to identify low birthweight using head, chest, and arm circumferences.
Factors Associated with Social Support Needs of Spouses of Patients with Cancer: Online Survey  [PDF]
Kanako Amano, Kanako Ichikura, Kazuho Hisamura, Yuko Motomatsu, Eisuke Matsushima
International Journal of Clinical Medicine (IJCM) , 2019, DOI: 10.4236/ijcm.2019.104021
Background: A means of assessing the social support needs of spouses of patients with cancer is not available in Japan, yet such individuals are at increased risk of developing psychological difficulties. Objectives: The present study aimed (1) to describe the social support needs of spouses of patients with cancer, and (2) to explore factors associated with social support needs of spouses of patients with cancer. Design: Spouses (n = 559) of patients with cancer were recruited by registered agents of an online survey company and completed a self-reporting, online questionnaire. Measurements: The questionnaires included demographic information and a tool to assess social support needs. Results: Factor analysis of social support needs of the spouses of patients with cancer indicated that (1) “social support needs regarding disease and treatment of patient” (54 items) comprised 3 factors (“medical condition and cure”, “daily life and social support”, “intimacy and employment”), and (2) “social support needs of spouse (19 items)” comprised 2 factors (“family psychological issues and social support” and “intimacy, employment and society”). The ANOVA and T tests showed that “younger age”, “under treatment”, and “cancer not cured: treatment stopped”, “PS1” and “PS 2-4”, the presence of “lung cancer”, and “recurrence/metastasis” were significant factors (all p < 0.05). Conclusions: The age of the spouse, treatment status, performance status, site of cancer, and recurrence/metastasis are important factors related to spousal needs for social support. Clinicians should assess these factors and the social support needs of spouses to provide appropriate support.
An Integrated Contribution Approach Focusing on Technology for Climate Change Mitigation and Promotion of International Technology Cooperation and Transfer  [PDF]
Kanako Tanaka, Ryuji Matsuhashi, Koichi Yamada
Low Carbon Economy (LCE) , 2016, DOI: 10.4236/lce.2016.72008
Abstract: Various technologies exist for climate change mitigation. Technology transfer is important for the efficient use of these technologies globally. Such transfer/cooperation should be implemented, at sector basis, broadly and unlimitedly beyond conventional framework. In this paper, an Integrated Contribution Approach is proposed as a domestic as well as a global strategy. This approach unifies two approaches: seeking ways to reduce greenhouse gas (GHG) emissions, further improve technical capabilities and encourage technical innovation; and implementing technology transfer effectively, clarifying contributions and promoting efforts to achieve substantial global GHG reduction. As an illustration, this paper estimated the technical potential of solar generation in the developing world by the year 2020, considering current and anticipated technology development. The estimate suggests a huge possibility for CO2 reduction as well as business opportunities through worldwide technology cooperation based on recognition of the importance of continual technology development. To achieve such goals, a scheme promoting incentives for private investment is indispensable as it is essential to use economic forces as well as government policy. This paper describes the following considerations: establishing a simple, easy-to-access scheme that can concentrate private resources on technology transfer; clarifying reduction efforts through measuring, reporting, and verification (MRV); applying it to conditionality together with financial and/or economic internal rate of return (FIRR, EIRR); and establishing a database and analysing data on the technical contributions and dissemination
Preparation and Properties of Polyaniline in the Presence of Trehalose  [PDF]
Hirotsugu Kawashima, Hiromasa Goto
Soft Nanoscience Letters (SNL) , 2011, DOI: 10.4236/snl.2011.13013
Abstract: Oxidative polymerization of aniline in aqueous solution in the presence of trehalose was conducted. Fourier transform infrared spectroscopy confirmed successful preparation of polyaniline containing a trace amount of trehalose. Electron spin resonance spectroscopy revealed that electron spin concentration of the polyaniline increases with aniline/trehalose ratio in the polymerization. Scanning electron microscopy revealed that the polyaniline shows granular and porous morphology. Electrical conductivity of these polyanilines was in the order of 10-4 S/cm.
International Factor Mobility and Dynamic Paths  [PDF]
Hiroshi Goto, Yuji Matsuoka
Theoretical Economics Letters (TEL) , 2013, DOI: 10.4236/tel.2013.36051

The aim of this paper is to consider the adjustment process of the spatial structure in a two-country economy where both labor and capital are mobile. For this purpose, we combine the model of New Economic Geography with the phase diagram technique. We show that the agglomeration processes are not always monotonic since the mobile factors interact with each other. More specifically, even when both factors are eventually agglomerated to one country, it is possible that labor and capital move in opposite directions in the adjustment process. Differences in factor endowment ratio and market size play significant roles in this transition path.

Pitfalls and Remedies in DEA Applications: How to Handle an Occurrence of Zero in Multipliers by Strong Complementary Slackness Conditions  [PDF]
Toshiyuki Sueyoshi, Mika Goto
Engineering (ENG) , 2013, DOI: 10.4236/eng.2013.55A005
Abstract: This study discusses a guideline on a proper use of Data Envelopment Analysis (DEA) that has been widely used for performance analysis in public and private sectors. The use of DEA is equipped with Strong Complementary Slackness Conditions (SCSCs) in this study, but an application of DEA/SCSCs depends upon its careful use, as summarized in the guideline. The guideline consists of the five suggestions. First, a data set used in the DEA applications should not have a ratio variable (e.g., financial ratios) in an input(s) and/or an output(s). Second, radial DEA models under variable and constant Returns to Scale (RTS) need a special treatment on zero in a data set. Third, the DEA evaluation needs to drop an outlier. Fourth, an imprecise number (e.g., 1/3) may suffer from a round-off error because DEA needs to specify it in a precise expression to operate a computer code. Finally, when a large input or output variable may dominate other variables in DEA computation, it is necessary to normalize the data set or simply to divide each observation by its average. Such a simple treatment produces more reliable DEA results than the one without any data adjustment. This study also discusses how to handle an occurrence of zero in DEA multipliers by applying SCSCs. The DEA/SCSCs can serve for a multiplier restriction approach without any prior information. Thus, the propesed DEA/SCSCs can provide more reliable results than a straight use of DEA.
Preparation of Polyaniline/ZnO Films by Electrochemical Polymerization  [PDF]
Yuki Kaitsuka, Hiromasa Goto
Open Journal of Polymer Chemistry (OJPChem) , 2016, DOI: 10.4236/ojpchem.2016.61001
Abstract: A series of polyaniline (PANI)/zinc oxide (ZnO) nano-particle (diameter 70 nm) composite films were prepared by electrochemical polymerization in the presence of ZnO nanoparticle. Furthermore, PANI-ZnO/PVA (PVA = polyvinyl alcohol) double-layer system was prepared. We first report preparations of a photocatalyst/conducting polymer light absorber by using ZnO nano-particles.
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