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Search Results: 1 - 10 of 5925 matches for " Kamran Gulzar1 "
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Antihyperlipidemic and Hepatoprotective Activity of Dodonaea viscosa Leaves Extracts in Alloxan-Induced Diabetic Rabbits (Oryctolagus cuniculus)
Maqsood Ahmad, Qaisar Mahmood, Kamran Gulzar1, Muhammad Shoaib Akhtar1, Mohammad Saleem and Muhammad Imran Qadir*
Pakistan Veterinary Journal , 2012,
Abstract: Hyperlipidemia is associated with diabetes and hepatotoxicity has emerged as a common clinical complication by antidiabetics. The present study was conducted to determine the antihyperlipidemic and hepatoprotective activity of Dodonaea viscosa leaves extracts in the alloxan-induced diabetic rabbits. The rabbits (n = 70) were divided into seven groups including normal and diabetic control, the remaining were aqueous, aqueous:methanol (70:30), aqueous:methanol (50:50), aqueous: methanol (30:70), and methanol extracts given for 30 days. Serum levels of triglycerides, total cholesterol, LDL-cholesterol, HDL-cholesterol, ALT and AST were estimated by using commercially available kits. The oral administration of aqueous:methanol (70:30) extract of the Dodonaea viscosa leaves significantly (P<0.01) decreased the raised parameters (triglyceride, total cholesterol and LDL-cholesterol) to normal values. But the extract has significantly increased HDL-cholesterol, ALT and AST levels. For the aqueous:methanol (70:30) extract given animals, the average serum level of total cholesterol was 60.00±1.30 mg/dL, LDL-cholesterol was 92.80±2.29 mg/dL, HDL-cholesterol was 31.80±1.0 mg/dL and triglyceride was 15.40±0.75 mg/dL while the average serum levels of ALT and AST were 45.60±3.08 and 27.20±1.36 IU/dL, respectively. It is concluded from the study that aqueous:methanolic (70:30) extract of Dodonaea viscosa leaves exerts antihy- perlipidemic and hepatoprotective effects in the alloxan-induced diabetic rabbits.
Kinetic Studies on β-Galactosidase Isolated from Apricots (Prunus armeniaca kaisa)  [PDF]
Sadaf Gulzar, Shajrul Amin
American Journal of Plant Sciences (AJPS) , 2012, DOI: 10.4236/ajps.2012.35077
Abstract: β-galactosidase was extracted from apricots (Prunus armeniaca kaisa) and characterized biochemically. Three isoenzymes (β-gal I, β-gal II and β-gal III) were obtained by salt fractionation and ionexchange and Sephadex G-100 column chromatography. β-galactosidase II showed a high ability to hy-drolyze the substrate p-nitrophenyl β-D-galactopyranoside than that of β-galactosidase I and III. The individual peaks showed charge homogeneity as revealed by single band on polyacrylamide gel. The molecular weight of β-gal I, β-gal II and β-gal III as determined by gel filtration was found to be 44.15, 34.70 and 23.71 KDa respectively. The optimum pH for the activity different isozymes was found between 4 and 6. The isoenzymes were determined to be thermally stable upto 40?C. The Km value for β-gal I was 1.85 mM which was higher than that of β-gal II (Km = 1.7), and β-gal III (Km = 1.19). The Vmax value for β-gal I, β-gal II and β-gal III was found to be 0.52, 0.70 and 0.38 μmole/min respectively.
Effects of Isosorbide Dinitrate on the Urinary Flow Rate in Patients With Benign Prostatic Hyperplasia
Ali Roshani,1,1 ,1 2,Iraj Khosropanah,Mohammad Salehi,Alireza Noshad Kamran
Urology Journal , 2010,
Abstract: PURPOSE: To compare the immediate effects of a systemic nitric oxide (NO) donor with placebo on the uroflowmetric parameters in patients with benign prostatic hyperplasia (BPH). MATERIALS AND METHODS: Eighty patients with the mean age of 61.5 years (range, 49 to 74 years) who suffered from BPH were enrolled in the study. We examined peak flow rate, average flow rate, and residual urine in all the patients. Then, patients were randomized to receive either 20 mg sublingual isosorbide dinitrate (ISDN) (n = 40) or placebo (n = 40) 20 minutes prior to the second uroflowmetry, which was performed one day after the first test. RESULTS: The mean peak flow rate increased from 7.6 ± 0.41 mL/s to 10.2 ±0.54 mL/s (P = .013) in the ISDN group, while it increased +0.40 mL/s in the placebo group (P > .05). Mean residual urine volume decreased significantly from 51 ± 3.1 mL to 29 ± 2.9 mL and from 56 ± 4.1 to 51 ± 2.6 in the ISDN (P = .02) and the placebo groups (P > .05), respectively. At baseline, the mean arterial pressure was 95 ± 2.1 mmHg and under the influence of the NO-donor, it decreased to 83 ± 1.9 mmHg, which was significant (P < .001). No significant changes of micturition parameters were found in the placebo group. CONCLUSION: Organic nitrates influence micturition parameters in patients with BPH. This new approach could offer a potential pharmacological option to treat obstructive lower urinary tract symptoms.
Linear and Non Linear Analysis of Central Crack Propagation in Polyurethane Material - A Comparison
Mubashir Gulzar
Lecture Notes in Engineering and Computer Science , 2012,
Abstract:
CARCINOMA GALL-BLADDER
Gulzar Ahmed
The Professional Medical Journal , 1998,
Abstract: In this randomised study fifty consecutive patients of cholelithiasis admitted in the surgical departmentBahawal Victoria hospital were examined to see the incidence of gallbladder carcinoma associated withcholelithiasis for a period of two years. This was 28%. Carcinoma gallbladder in patients with cholelithiasiswas found in 30% of the female and 20% of the male patients. Male to female ratio of this disease was 1:6.All the patients of carcinoma gallbladder with cholelithiasis belonged to poor socio-economic group,majority living in the rural areas. All the male patients were in the sixth decade and maximum femalepatients in the fifth decade of their lives. Pain right hypochondrium (100%), nausea, vomiting and flatulence(78.57%) and anorexia (71.43%) were most common presenting complaints. Adenocarcinoma was mostprevalent histological type present in all the patients of carcinoma gallbladder with cholelithiasis.Preoperative diagnosis was possible only in 28.57% patients. All patients of carcinoma gallbladder presentedto the department in the advanced stage IV and V, and therefore the outcome of the surgical managementwas not good.
TESTICULAR TUMOUR
Gulzar Ahmed
The Professional Medical Journal , 1998,
Abstract: OBJECTIVES: (1) To study the clinical presentation of testicular tumours. (2) To study the histologicalpattern of testicular tumours in Bahawalpur. DESIGN: A prospective study. SETTING: Bahawal VictoriaHospital Bahawalpur. PATIENTS: Fifteen consecutive patients of testicular tumours. METHODSPresenting symptoms and findings of clinical examination were recorded. Abdominal ultrasonography andchest x-rays were performed in all the patients. Skeletal radiographs were taken in one patient presentingwith back pain and paraplegia. Staging was done. Inguinal orchiectomy was performed and histology wasdone in all cases. RESULTS: 40% patients presented with primary testicular neoplasms.. While 60%presented with clinical picture due to secondary deposits. Histologic pattern was 33.33% Seminoma, 6.67%Lymphoma, 6.67%. Teratoma, 13.34% Embryonal carcinoma, 6.67% Yolk sac tumour and 33.33%Teratocarcinoma. CONCLUSION: Patients with testicular tumours mostly presented with the clinicalpicture of their secondary deposits and were in advanced stage. Seminoma and teratocarcinoma were thecommonest histological types.
INGUINAL HERNIA REPAIR UNDER LOCAL INFILTRATION ANAESTHESIA
Gulzar Ahmed
The Professional Medical Journal , 1995,
Abstract: Inguinal hernia is common. Surgery is the only satisfactory treatment. General/spinal anaesthesia are not freefrom complications and need prolonged hospital stay. PATIENTS AND METHODS : Sixty inguinal herniapatients 10 years to >60 years of age were operated under 0.5% lignocaine with 1:400,000 adrenaline infiltration.RESULTS : Adequate analgesia was obtained during the operation and in early post operative period. Averagehospital stay was 44 hours and average cost was Rs. 360 only. CONCLUSION : Inguinal hernia repair underlocal anaesthesia is safe and economical.
The ETR (End Treatment Response) of Chinese Brand Human recombinant interferon alpha 2a plus Ribavirin in chronic hepatitis C patients selected from Combined Military Hospitals in Pakistan
Saeed-Ur-Rashid Nazir1, Muhammad Shoaib Aslam1, Abdul Malik1, Kamran1, M.Amer1, M.Nadeem1
Asian Journal of Biomedical and Pharmaceutical Sciences , 2013,
Abstract: This Study was carried out to determine the End of Treatment Response (ETR) of a Chinese Source Human Recombinant Interferon Alpha 2a and Ribavirin in chronic hepatitis C affected patients, selected from different combined military hospitals in Pakistan. Methods: In this study hepatitis affected non-cirrhotic patients from different combined military hospitals in Pakistan were selected from September 2010 to April 2011. Sixty seven patients were selected based on the inclusion exclusion criteria. Fifty seven patients completed the 24 weeks therapy for Hepatitis C. The Patients (n=57) had persistently raised serum aminotransferase (ALT), positive HCV antibodies by 3rd generation ELISA, positive HCV RNA by polymerase chain reaction. Study group patients underwent 24 weeks therapy with a Chinese source Interferon and Ribavirin and subsequently followed up for the End of Treatment Response by the assay of HCV RNA by polymerase chain reaction at 24 weeks. Results: Patients of chronic hepatitis C (44 males and 13 females) had age range 20-56 years. After 24 weeks of therapy with a Chinese source Interferon and Ribavirin, 73.7% patients showed a favourable ETR manifested by Negative HCV RNA polymerase chain reaction. Conclusions: Treatment with a Chinese source Interferon and Ribavirin combination therapy for 24 weeks produces a favourable End of Treatment Response in patients of chronic hepatitis C from different military hospitals in Pakistan
EFFECT OF DECREASING DIETARY PROTEIN LEVELS WITH OPTIMAL AMINO ACIDS PROFILE ON THE PERFORMANCE OF BROILERS
Z. Kamran, M. Aslam Mirza, Ahsan-ul-Haq1 and S. Mahmood1
Pakistan Veterinary Journal , 2004,
Abstract: A six-week trial was conducted to study the effect of decreasing dietary crude protein (CP) level on the performance of broilers in hot climatic conditions. Four experimental rations having CP 23 (control group), 22, 21 and 20%, with optimal amino acid balance were prepared. All the four rations were isocaloric having ME 3200 kcal/kg with Energy: Protein (E:P) 139.0, 146.5, 152.4 and 160 in diets A, B, C and D respectively. One hundred and twenty day-old chicks were randomly distributed into 12 experimental units, each having 10 chicks. Rations were randomly allotted to experimental units such that each unit received three replicates. The experimental diets were fed to birds from day 1st to 42nd. Performance of birds was monitored in terms of weight gain, feed consumption and feed conversion ratio (FCR). At the end of experiment, two birds per each replicate were randomly selected and slaughtered to record the data on carcass yield, breast meat yield, abdominal fat and composition of breast meat. Results of the trial suggested that weight gain was significantly (P<0.01) increased in birds on diets with CP 20 and 21%. Feed consumption and FCR remained un-changed for all the treatment groups. Eviscerated carcass yield was significantly (P<0.05) higher for the group fed on diet with 20% CP. Breast meat yield, abdominal fat and composition of breast meat also remained un-changed. Economic evaluation of the trial revealed that decreasing CP levels from 23 to 20% resulted in reduced feed cost per kg of live weight gain, which clearly indicated that this approach was useful especially in severe summer conditions. The overall picture of the study suggests that dietary protein level of broilers could be reduced from 23 to 20%, with beneficial effects on growth performance and carcass characteristics and increased economic returns in hot environmental conditions, provided that levels of essential amino acids are closely looked after.
Geotechnical Investigation of Slopes along the National Highway (NH-1D) from Kargil to Leh, Jammu and Kashmir (India)  [PDF]
Gulzar Hussain, Yudhbir Singh, Ghulam Mohd Bhat
Geomaterials (GM) , 2015, DOI: 10.4236/gm.2015.52006
Abstract: The national highways are always considered as the economic backbone of the country and have often assisted development work all along their routes. The National Highway (NH-1D) is the most strategic and the only all weather surface link between the two districts of Ladakh region (Kargil and Leh). The area under investigation experiences high vehicular traffic, particularly between March and August, as in the remaining months the Kargil and Leh districtsremain cutofffrom each other due to bad weather. In recent years, frequent occurrences of slope failures along the highway primarily affect the smooth functioning of the traffic movement which severely affects the life of the people of the area. Strategically, this road network is very important and plays a significant role in transportation and other activities. In order to ensure the stability of road network in the area, it becomes extremely important to understand the triggering mechanism of these failures. The present study made an attempt in this direction and the Slope Mass Rating (SMR) method has been used for slope stability analysis at different locations. The stability of the slopes was also assessed using kinematic analysis conjointly with SMR to identify the types of failure and its potential failure directions associated with each slope. The result obtained after calculating RMR from the selected facets ranges from 11 to 89 with lower values indicating presence of potentially unstable areas. Results have shown that in a total of 20 facets, 65.28% belong to wedge failure, 22.26%belong to toppling failure and 12.45% belong to plane failure.
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