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Search Results: 1 - 10 of 297428 matches for " Kaj J?rgensen "
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Plasma neutrophil gelatinase associated lipocalin (NGAL) is associated with kidney function in uraemic patients before and after kidney transplantation
Nils E Magnusson, Mads Hornum, Kaj Jrgensen, Jesper Hansen, Claus Bistrup, Bo Feldt-Rasmussen, Allan Flyvbjerg
BMC Nephrology , 2012, DOI: 10.1186/1471-2369-13-8
Abstract: NGAL was measured using a validated in-house Time-Resolved Immuno-flourometric assay (TRIFMA). Repeated measurements differed by < 10% and mean values were used for statistical analyses. Spearman rank order correlation analysis and the Kruskal-Wallis non-parametric test were used to evaluate the association of NGAL concentrations with clinical parameters.Plasma NGAL levels before transplantation in the Tx and uraemic groups were significantly higher than in the healthy controls (1,251 μg/L, 1,478 μg/L vs. 163 μg/L, p < 0.0001). In the Tx group NGAL concentrations were associated with serum creatinine (R = 0.51, p < 0.0001), duration of end-stage renal failure (R = 0.41, p = 0.002) and leukocyte count (R = 0.29, p < 0.026). At 3 and 12 months plasma NGAL concentrations declined to 223 μg/L and 243 μg/L, respectively and were associated with homocysteine (R = 0.39, p = 0.0051 and R = 0.47, p = 0.0007).Plasma NGAL is a novel marker of kidney function, which correlates to duration of end-stage renal failure (ESRD) and serum creatinine in uraemic patients awaiting kidney transplantation. Plasma NGAL is associated with homocysteine in transplanted patients. The prognostic value of these findings requires further studies.Neutrophil gelatinase associated lipocalin (NGAL) also known as Lipocalin 2 or Lcn2 is a 25 kDa protein identified originally as a protein associated with matrix metalloproteinase 9 (MMP-9) of human neutrophils [1]. Lipocalins are extracellular proteins which share a common tertiary structure that forms a barrel-like hydrophobic ligand binding site [2]. When bound to MMP-9, NGAL protects it from proteolytic degradation sustaining the proteolytic activity of MMP-9. No specific receptor for NGAL has yet been identified. However, the endocytosis low density lipoprotein receptor Megalin has been shown to bind NGAL with high affinity suggesting that NGAL is taken up by host cells [3]. NGAL has been suggested as a bacteriostatic agent indicating involvement of N
Is the tide turning against breast screening?
Karsten Jrgensen
Breast Cancer Research , 2012, DOI: 10.1186/bcr3212
Abstract: The rationale for breast screening with mammography is deceptively simple: catch the cancer early and reduce mortality from the disease and the need for mastectomies. But breast cancer is a complex disease, and complex problems rarely have simple solutions.A key question is if screening can prevent metastasis, as this would reduce breast cancer fatalities. Another is if the screen-detected tumours that previously required a mastectomy are now small enough to allow breast conserving surgery. The fundamental premise for both objectives is that screening must reduce the incidence of advanced breast cancer. Whether such a reduction occurs in a long-running, organized, population-based breast screening programme is what Joost Nederend and colleagues explore in their study from The Netherlands [1].Other researchers have questioned whether breast screening reduce the number of advanced cancers [2,3]. A claimed reduction in breast cancer mortality [4-6] as well as a reduction in the use of mastectomies [7,8] have also been called into doubt in studies of population-based breast screening. In addition, the detection of cancers that would otherwise not have developed into clinical, symptomatic disease (overdiagnosis) is now recognised as an important harm, also for invasive breast cancer [9,10].A recent systematic review of incidence trends in seven countries with at least seven years of screening [2] found that breast screening has not fulfilled its promise of fewer advanced breast cancers. It included The Netherlands, but not data from before organised screening was introduced in the late 1980s. Including data from 1980 to 2008 is a strength of the new study, as it allows reliable estimates of both pre- and post-screening incidence trends of advanced breast cancer. If the background incidence was increasing prior to screening, but stable during the screening period, screening may have prevented a further increase in advanced breast cancer. This seems not to have happened, e
Comment on "Danish auroral science history" by P. Stauning in Hist. Geo Space Sci., 2, 1–28, 2011
T. S. J rgensen
History of Geo- and Space Sciences (HGSS) , 2011, DOI: 10.5194/hgss-2-85-2011
Abstract: No abstract available.
A Blueprint for Destruction: Eco-Activism in Doctor Who during the 1970s
Dolly Jrgensen
Ecozon@ : European Journal of Literature, Culture and Environment , 2012,
Abstract: This article analyzes the television science-fiction show Doctor Who as a cultural forum within the context of British eco-activism of the 1970s. It examines four serials which aired during the 1970s during the first wave of eco-activism in the UK: "The Green Death" (1973), "The Invasion of the Dinosaurs" (1974), "The Seeds of Doom" (1976), and "Nightmare of Eden" (1979). Two environmentalist concerns-pollution and species conservation-put forward by the early British eco-activist movement as underscored in texts such as The Blueprint for Survival from 1972 are evident in these serials. While affirming the validity of some elements of environmentalist concerns, each serial also proposes that the ends do not always justify the means. The Doctor, although a supporter of eco-activism, rejects seemingly utopian approaches to reset the Earth's ecosystems. Rather than presenting viewers with a guide to sustainability, these Doctor Who serials offer dystopian visions of future realities steeped in ecological transgressions – these are the blueprints for destruction.
Folk Narrative and the History of Culture
Lene I. Jrgensen
Folklore : Electronic Journal of Folklore , 2007,
Abstract: The article illustrates that the texts and perceptions of The Old FolkBallads of Denmark reflect traces of different eras. Ballads about the medieval King Valdemar II and his queens Dagmar and Bengerd (Infanta Berengária of Portugal) exemplify this. The formations of the narrated figures are medieval but the formations of the narrated plots are from the Renaissance and concern the arrangement of marriage. Their references concern both the traditional narration of the Middle Ages and the social realities of the Renaissance. The public attention to the ballads increased in the Romantic era. Folk narrative researchers launched the master-narrative about the formation and transmission of the ballads from the medieval time of their figures to the Renaissance telling-time of their plots. However, this master-narrative about the ballads as a phenomenon covers for the recognition of their narratives. Today, the ballads are receiving new attention through a canon for the primary school and in other ways. The master-narrative is reused and renewed in order to respond to the cultural conflict caused by the process of globalisation. The aim is to shape a new unity of the population that now includes both the “old” and “new” Danes. This contradicts with differentiated experiences of one of the two main groups within the population, introducing new alternatives for recognising and identifying with the narrated figures and plots in account.
Pigs and Pollards: Medieval Insights for UK Wood Pasture Restoration
Dolly Jrgensen
Sustainability , 2013, DOI: 10.3390/su5020387
Abstract: English wood pastures have become a target for ecological restoration, including the restoration of pollarded trees and grazing animals, although pigs have not been frequently incorporated into wood pasture restoration schemes. Because wood pastures are cultural landscapes, created through the interaction of natural processes and human practices, a historical perspective on wood pasture management practices has the potential to provide insights for modern restoration projects. Using a wide range of both written and artistic sources form the Middle Ages, this article argues that pigs were fed in wood pastures both during the mast season when acorns were available and at other times as grazing fields. Pollarded pedunculate oak ( Quercus robur) likely dominated these sustainable cultural landscapes during the medieval period.
Scientific results from the deepened Lopra-1 borehole, Faroe Islands: The regional distribution of zeolites in the basalts of the Faroe Islands and the significance of zeolites as palaeotemperature indicators
Jrgensen, Ole
Geological Survey of Denmark and Greenland Bulletin , 2006,
Abstract: The first maps of the regional distribution of zeolites in the Palaeogene basalt plateau of the Faroe Islands are presented. The zeolite zones (thomsonite-chabazite, analcite, mesolite, stilbite-heulandite, laumontite) continue below sea level and reach a depth of 2200 m in the Lopra-1/1A well. Below this level, a high temperature zone occurs characterised by prehnite and pumpellyite. The stilbite-heulandite zone is the dominant mineral zone on the northern island, Vágar, the analcite and mesolite zones are the dominant ones on the southern islands of Sandoy and Sueuroy and the thomsonite-chabazite zone is dominant on the two northeastern islands of Vieoy and Boreoy. It is estimated that zeolitisationof the basalts took place at temperatures between about 40°C and 230°C. Palaeogeothermal gradients are estimated to have been 66 ± 9°C/km in the lower basalt formation of the Lopra area of Sueuroy, the southernmost island, 63 ± 8°C/km in the middle basalt formation on the northernmost island of Vágar and 56 ± 7°C/km in the upper basalt formation on the central island of Sandoy.A linear extrapolation of the gradient from the Lopra area places the palaeosurface of the basalt plateau near to the top of the lower basalt formation. On Vágar, the palaeosurface was somewhere between 1700 m and 2020 m above the lower formation while the palaeosurface on Sandoy was between 1550 m and 1924 m above the base of the upper formation.The overall distribution of zeolites reflects primarily variations in the maximum depth of burial of the basalt rather than differences in heat flow. The inferred thinning of the middle and upper basaltformation from the central to the southern part of the Faroes is in general agreement with a northerly source area for these basalts, centred around the rift between the Faroes and Greenland. The regional zeolite distribution pattern is affected by local perturbations of the mineral zone boundaries that reflect local differences in the temperature, perhaps related to the circulation of water in the underground. The zonal distribution pattern suggests that these temperature anomalies are in part related to NW–SE-trending eruption fissures or zones of weakness separating the present islands and are subparallel to transfer zones in the Faroe–Shetland Basin. Both the regional and the local distribution of zeolite assemblages are probably a reflection of the basic volcanic-tectonic pattern of the Faroe Islands.
A Review of the Hypocalcaemia Contributions given at the 11th ICPD
Jrgensen Rolf
Acta Veterinaria Scandinavica , 2003, DOI: 10.1186/1751-0147-44-s1-s15
A Review of the Hypocalcaemia Contributions given at the 11th ICPD
Jrgensen Rolf
Acta Veterinaria Scandinavica , 2003, DOI: 10.1186/1751-0147-44-s1-s167
Making sense of the German Wikipedia community
Rikke Frank Jrgensen
MedieKultur : Journal of Media and Communication Research , 2012,
Abstract: This article presents the findings from a qualitative study of the German Wikipedia community, focusing on how people engaged with Wikipedia make sense of norms, collaborative practices and means of regulation within the community. The study highlights the strong focus on the quality of the end-product (the encyclopedia) in the German community, stressing that article quality is seen as more important than the wiki-process as such. As the community has grown, an increasing number of rules and mechanisms have been deployed to resolve various issues and conflicts, however the interviewees do not perceive Wikipedia as being bureaucratic, but rather describe it as a “rule-governed anarchy”. The findings suggest that people contribute for a variety of reasons, yet point to reactions from and interactions with fellow Wikipedians as one of the strongest motivational drivers for participation.
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