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Search Results: 1 - 10 of 196 matches for " Kaisa Lehti "
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Membrane-Type-3 Matrix Metalloproteinase (MT3-MMP) Functions as a Matrix Composition-Dependent Effector of Melanoma Cell Invasion
Olga Tatti, Mariliina Arjama, Annamari Ranki, Stephen J. Weiss, Jorma Keski-Oja, Kaisa Lehti
PLOS ONE , 2011, DOI: 10.1371/journal.pone.0028325
Abstract: In primary human melanoma, the membrane-type matrix metalloproteinase, MT3-MMP, is overexpressed in the most aggressive nodular-type tumors. Unlike MT1-MMP and MT2-MMP, which promote cell invasion through basement membranes and collagen type I-rich tissues, the function of MT3-MMP in tumor progression remains unclear. Here, we demonstrate that MT3-MMP inhibits MT1-MMP-driven melanoma cell invasion in three-dimensional collagen, while yielding an altered, yet MT1-MMP-dependent, form of expansive growth behavior that phenocopies the formation of nodular cell colonies. In melanoma cell lines originating from advanced primary or metastatic lesions, endogenous MT3-MMP expression was associated with limited collagen-invasive potential. In the cell lines with highest MT3-MMP expression relative to MT1-MMP, collagen-invasive activity was increased following stable MT3-MMP gene silencing. Consistently, MT3-MMP overexpression in cells derived from less advanced superficially spreading melanoma lesions, or in the MT3-MMP knockdown cells, reduced MT1-MMP-dependent collagen invasion. Rather than altering MT1-MMP transcription, MT3-MMP interacted with MT1-MMP in membrane complexes and reduced its cell surface expression. By contrast, as a potent fibrinolytic enzyme, MT3-MMP induced efficient invasion of the cells in fibrin, a provisional matrix component frequently found at tumor-host tissue interfaces and perivascular spaces of melanoma. Since MT3-MMP was significantly upregulated in biopsies of human melanoma metastases, these results identify MT3-MMP as a matrix-dependent modifier of the invasive tumor cell functions during melanoma progression.
Evaluation as a Tool for Developing the Quality of Academic Libraries. Case Study at a Large and Traditional Research Oriented Scandinavian University
Kaisa Sinikara
Liber Quarterly : The Journal of European Research Libraries , 2006,
Abstract: The leaders of our universities will ask today if we offer those services that a top university requires and whether the proposed resources for the libraries are worth investing. Establishing the European Higher Education Area (EHEA) requires the establishing of quality systems. Quality assurance systems will be introduced throughout the entire European academic sector and will certainly have significant impact on the development of academic organizations. The collaborative effort to evaluate European universities is coordinated by ENQA, the European Association for Quality Assurance in Higher education (Standards, 2005). Most European countries have developed a national quality assurance system. The solutions of different countries can be divided into three different classes: 1) Auditing countries[1] (institutional audit, quality audit, evaluation of quality assurance systems, enhancement-led institutional review): England, Scotland, Ireland, France, Finland, 2) Accreditation[2]: Holland, Germany and 3) Combination or another system: Norway, Switzerland, Denmark, Sweden (Audits, 2006).
Bente Pedersen - en forfatter i marginalitet
Kaisa Lindbach
Nordlit : Tidsskrift i litteratur og kultur , 2000,
Abstract:
Bente Pedersen - en forfatter i marginalitet
Kaisa Lindbach
Nordlit : Tidsskrift i litteratur og kultur , 2000,
Abstract:
Skj nnlitteratur - et etnisk speil? Kvenlitteratur i Nord-Norge
Kaisa Lindbach
Nordlit : Tidsskrift i litteratur og kultur , 1999,
Abstract:
Skj nnlitteratur - et etnisk speil? Kvenlitteratur i Nord-Norge
Kaisa Lindbach
Nordlit : Tidsskrift i litteratur og kultur , 1999,
Abstract:
A Combinatorial Case of the Abelian-Nonabelian Correspondence
Kaisa Taipale
Mathematics , 2011,
Abstract: The abelian-nonabelian correspondence outlined by Bertram, Ciocan-Fontanine, and Kim gives a broad conjectural relationship between (twisted) Gromov-Witten invariants of related GIT quotients. This paper proves a case of the correspondence explicitly relating genus zero m-pointed Gromov-Witten invariants of Grassmannians Gr(2,n) and products of projective space $\PP^{n-1} \times \PP^{n-1}$. Localization is used to compute twisted Gromov-Witten invariants of $\PP^{n-1} \times \PP^{n-1}$, and comparison of the moduli spaces of stable maps completes the proof.
K-theoretic J-functions of type A flag varieties
Kaisa Taipale
Mathematics , 2011,
Abstract: The J-function in Gromov-Witten theory is a generating function for one-point genus zero Gromov-Witten invariants with descendants. Here we give formulas for the quantum K-theoretic J-functions of type A flag manifolds and conjectural formulas for other types. Some K-theoretic tools for computation are also provided. As an application, we prove the quantum K-theoretic J-function version of the abelian-nonabelian correspondence for Grassmannians and products of projective space.
Finding groups in Zariski-like structures
Kaisa Kangas
Mathematics , 2014,
Abstract: We study quasiminimal classes, i.e. abstract elementary classes (AECs) that arise from a quasiminimal pregeometry structure. For these classes, we develop an independence notion, and in particular, a theory of independence in $\M^{eq}$. We then generalize Hrushovski's Group Configuration Theorem to our setting. In an attempt to generalize Zariski geometries to the context of quasiminimal classes, we give the axiomatization for Zariski-like structures, and as an application of our group configuration theorem, show that groups can be found in them assuming that the pregeometry obtained from the bounded closure operator is non-trivial. Finally, we study the cover of the multiplicative group of an algebraically closed field and show that it provides an example of a Zariski-like structure.
Finding a field in a Zariski-like structure
Kaisa Kangas
Mathematics , 2015,
Abstract: We show that if $\M$ is a Zariski-like structure (see \cite{lisuriart}) that does not interpret a non-classical group, and the canonical pregeometry obtained from the bounded closure operator (bcl) is non locally modular, then $\M$ interprets an algebraically closed field.
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