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Antimicrobial Activities of Syzygium aromaticum (L.) Merr. and L.M. Perry (Myrtaceae) Fruit Extracts on Six Standard Microorganisms and Their Clinical Counterpart  [PDF]
Y.-G. Afanyibo, K. Anani, K. Esseh, Y. Sadji, K. Idoh, K. Koudouvo, A. Agbonon, Y. Améyapoh, K. Tozo, M. Gbeassor
Open Access Library Journal (OALib Journal) , 2018, DOI: 10.4236/oalib.1104951
Abstract:
Syzygium aromaticum is used in combination with other plants as an al-coholic infusion by traditional practitioners to treat infections. It has been selected for evaluation for its antimicrobial properties to justify its use in traditional pharmacopoeia. The fruits were used as plant material while the microbial germs consisted of six reference strains: Escherichia coli ATCC 25922, Staphylococcus aureus ATCC 29213, Salmonella typhimurium ATCC 14028, Pseudomonas aeruginosa ATCC 27853, Shigella flexneri ATCC 12022, Candida albicans ATCC 35659 and their clinical counterparts. The extracts were obtained by aqueous decoction, hydroethanolic and ethanolic macerations. The phytochemical screening was performed by chemical staining tests. The antibiotic susceptibility test was performed using the well diffusion method and the MIC and MBC or MFC were determined using the 96-well microplate dilution method. The results showed that 66.67% of the strains tested were sensitive to the aqueous extract with inhibition diameters ranging from 15 to 21 mm and MIC and MCB or MFC between 0.0976 - 0.3906 mg/mL and 0.1953 - 07812 mg/mL respectively, thus determining bacteriostatic activity. 100% of the germs tested were sensitive to hydroethanolic and ethanolic extracts. The inhibition diameters range from 12 - 28 mm for hydroethanolic extract with MIC and MBC or MFC ranging from 0.0488 - 0.3906 mm and 0.0488 - 0.7812 mm respectively. The ethanolic extract gave inhibition diameters of 12 - 26 mm; MIC and MBC or MFC ranging from 0.0976 - 0.7812 mm. Hydroethanolic extract gave three (3) bactericidal/fungicidal activities compared to four (4) as for ethanolic extract. These results prove the use of S. aromaticum among traditional recipes for treating infections in the pharmacopoeia but further studies remain important to produce traditionally improved drugs.
Mandibular ü üncü molarlar n angulus k r olu umu üzerine etkisi
?smail Akka?,Sinan Tozo?lu,Fatih ?zan
Cumhuriyet Dental Journal , 2012, DOI: 10.7126/cdj.2012.1292
Abstract: The purpose of this study was to estimate the relative risk of mandibular angle fractures among people with a lower third molar compared with those without a lower third molar. For this purpose, database research was performed on a whole PUBMED/MEDLINE by using key words “mandibular third molars” and “angle fractures”. The data obtained from 9 articles that had a similar statistical analysis; and that included mandibular angle fractures and other mandibular fractures as a control group were evaluated statistically. In these 9 retrospective cohort studies, the sum of cases was 6466 and the sum of mandibular angle fractures was 1769. The analysis of articles shows a relative risk for a mandibula to fracture, comparing patients with and without third molars, ranging from 1,2 to 3.6. The estimated relative risk across the 9 studies was 2.14 (95% CI 1.92–2.39). The results obtained in this study suggest that the presence of lower third molar may double risk of an angle fracture of the mandible. Keywords: Mandibular angle fractures, mandibular third molars, relative risk. ZET Bu makalenin amac , mandibular 3. molar di e sahip olan ve olmayan bireylerde mandibula angulus k r olu ma riskinin belirlenmesidir. Bu ama la, “mandibular third molars” ve “angle fractures” anahtar kelimeleri kullan larak PUBMED/MEDLINE veri taban nda literatür taramas ger ekle tirildi. Birbirine benzer istatiksel analiz yapm ve mandibula angulus k r klar ile beraber kontrol grubu olarak kabul edilebilecek ekilde di er mandibula k r klar n al malar na dahil etmi 9 adet makaleden elde edilen veriler istatiksel olarak de erlendirildi. Bu makalelerdeki retrospektif kohort al madaki vaka say s 6466 ve mandibula angulus k r say s 1769’idi. al malardaki r latif risk de erleri, 1,2 ile 3,6 aras nda hesapland . Ayr ca r latif risk ortalamas n n 2,14 oldu u belirlendi (%95 güven aral 1,92–2,39). Sonu olarak mandibular 3. molar di e sahip olan bireylerin olmayanlara g re ortalama 2 kat daha fazla mandibula angulus k r olu ma riskine sahip olduklar bulundu.
Antimicrobial Susceptibility of Microorganisms Isolated from Orofacial Infections
Sinan TOZO?LU,Hakan USLU,ümit ERTA?,?mer KAYA
Duzce Universitesi Tip Fakültesi Dergisi , 2010,
Abstract: Objectives: The purpose of this study was to determine an effective antimicrobial therapy ofcausative agents for orofacial abscesses. In order to do that, bacterial strains isolated from patientsamples were identified based on “bacterial fatty acid profiles” and determined the antimicrobialsusceptibilities by using disc diffusion test for aerobic bacteria, and E test for anaerobic bacteria.Materials and Methods: The present study was carried out in 71 patients with a diagnosis oforofacial infections in Oral and Maxillofacial Surgery Clinic of Atatürk University. Aerobic andanaerobic bacteria were isolated from 71 clinical specimens by Microbial Identification Systemand their antibiotic sensitivity was tested. Results: The most frequently isolated species were Streptococcus spp., Staphylococcus spp.and Bacteroides spp. The highest rate of resistance was detected in the aerobic strains againstpenicillin (58.4%), followed by eriythromycin (46.7%), clindamycin (35.1%), tetracycline(32.5%), amoxycillin/clavulonic acid (31.1%) and cefazoline (27.3%), respectively. The highestrate of resistance was detected in the anaerobic strains against to penicillin (60%), clindamycin(53.3%), metronidazole (30%), cefoxitin (20%) piperacillin/tazobactam (11.6%) and imipenem(0.3%), respectively. Conclusions: In order to treat orofacial infections more effectively, and to prevent antimicrobialresistance which has increased recently, antibiotic susceptility tests should be performedroutinely in regions where antibacterial resistance is high like our area.
Alguns aspectos da escolariza??o de crian?as nas últimas décadas
Simionato-Tozo, Stella Maria Poletti;Biasoli-Alves, Zélia Maria Mendes;
Paidéia (Ribeir?o Preto) , 1996, DOI: 10.1590/S0103-863X1996000100003
Abstract: presently it is common to find someone discussing the school, the changes she is undergoing and the difficulties she is facing. the objectives of this study are to analyse data that describe the school process in the last four decades and to make comparisons identifying the possible variables that can be associated with the changes observed.
O cotidiano e as rela??es familiares em duas gera??es
Simionato-Tozo, Stella Maria Poletti;Biasoli-Alves, Zélia Maria Mendes;
Paidéia (Ribeir?o Preto) , 1998, DOI: 10.1590/S0103-863X1998000100011
Abstract: the western society, during the xx century, is in a constant change process, and the transformations can be seen in many aspects, that include family life and children day-to-day routine. so, this study was planned to bring data about some aspects of brazilian family life and infancy during the last decades. to accomplish this objective, urban families from middle class were interwied according to a guide whith questions about the parents and kids' infancy, as well as their adult relationships. these results allow us to discuss the influence of some macro variables - like industrialization, urbanization, consumption society - in brazilian family life and in the determination of day-to-day children routine. what can be discussed is their influence on childhood development.
Avalia o da qualidade da água purificada em farmácias magistrais da regi o de S o José do Rio Preto, SP
Andreia Haro Moreno,Greici Cristiani Gomes Tozo,Hérida Regina Nunes Salgado
Revista de Ciências Farmacêuticas Básica e Aplicada , 2011,
Abstract: A água é a matéria-prima mais utilizada na produ o de várias formas farmacêuticas, sendo um constituinte da própria formula o e exigindo para tal uma série de especifica es físico-químicas e microbiológicas. Além disso, é um insumo de utiliza o imprescindível para testes laboratoriais e procedimentos de limpeza de equipamentos e utensílios. O presente trabalho teve como objetivo verificar o grau de contamina o química e microbiana em água purificada utilizada em farmácias magistrais da regi o de S o José do Rio Preto, SP. As coletas foram realizadas segundo recomenda es da USP Pharmacopeia, com os devidos cuidados de assepsia, e as amostras encaminhadas imediatamente ao laboratório de controle de qualidade. Foram analisados vários parametros físico-químicos, tais como aspecto, pH, condutividade, resíduo por evapora o, am nia, cálcio, cloreto, metais pesados, sulfato e substancias oxidáveis, além de parametros microbiológicos, como contagem total de aeróbios e pesquisa de coliformes totais e termotolerantes e Pseudomonas aeruginosa. Os resultados indicaram alguns parametros de n o conformidade: em 10% das amostras analisadas para o pH e pesquisa de impurezas inorganicas, em 17% para condutividade, em 14% para substancias oxidáveis e em 20% para análise microbiológica, ressaltando a necessidade de maior rigor na produ o e qualidade da água purificada produzida e/ou armazenada nesses estabelecimentos farmacêuticos. Palavras-chave: água purificada. Controle de qualidade. Pesquisa de impurezas. Avalia o microbiológica. Farmácias magistrais. ABSTRACT Quality assessment of purified water used in pharmacies in S o José do Rio Preto, SP Water is the raw material used most in the production of diverse pharmaceutical forms and, being a constituent of the formulation itself, is subject to a number of physico-chemical and microbiological specifications. In addition, it is indispensable for laboratory tests and the cleaning of equipment and apparatus. The aim of this study was to ascertain the degree of physicochemical and microbiological contamination of purified water used in compounding pharmacies in the city of S o José do Rio Preto, SP, Brazil. Samples were taken as recommended in the USP Pharmacopeia, with careful aseptic technique, and sent immediately the to quality control laboratory. Physicochemical properties were analyzed, including appearance, pH, conductivity, residue after evaporation, ammonia, calcium, chloride, heavy metals, sulfate and oxidizable substances, and microbiological tests were performed: total aerobic microbial count and detecti
Praticando o silêncio: interven o educativa para a redu o do ruído em Unidade de Terapia Intensiva Practicando el silencio: intervención educativa en la reducción del ruido en la Unidad de Cuidados Intensivos Practicing silence: educational intervention for reducing noise in the Intensive Care Unit
Silvana Triló Duarte,Maiara Matos,Tatiane Cristina Tozo,Luis Carlos Toso
Revista Brasileira de Enfermagem , 2012, DOI: 10.1590/s0034-71672012000200013
Abstract: O objetivo deste estudo foi avaliar se os níveis de press o sonora dentro da UTI s o diminuídos após interven o educativa com a equipe multiprofissional. Foram mensurados os níveis de ruído no interior da UTI (através de um decibelímetro instalado próximo à cabeceira de um paciente) durante sete dias, sendo repetido o procedimento após uma interven o educativa, a qual consistiu de palestras, cartazes e dramatiza es, entre outros. Houve grande redu o do nível de ruído entre o período pré e pós-interven o, em todos os horários avaliados. As principais fontes de ruídos dentro da UTI foram da própria equipe. Os níveis de ruído encontrados estiveram acima do recomendado. O estudo mostrou que, com uma interven o educacional junto à equipe da UTI e sua conscientiza o sobre os mecanismos e efeitos, é possível haver redu o dos níveis de ruído e consequente eestressee do ambiente. El objetivo de este estudio fue evaluar si los niveles de presión sonora se redujeron en la UCI después de una intervención educativa con el equipo multidisciplinario. Se midieron los niveles de ruido en la UCI (utilizando un decibelímetro instalado cerca de la cabecera de un paciente) durante siete días, y se repite el procedimiento después de una intervención educativa con el equipo, que consistió en conferencias, carteles y dramatizaciones, entre otros. Hubo una gran reducción en el nivel de ruido entre el período pre y post-intervención, en todos los tiempos evaluados. Las principales fuentes de ruido en la UCI fueron del proprio equipo. Los niveles de ruidos encontrados eran más altos que los recomendados. Este estudio mostró que con una intervención educativa y de sensibilización acerca de los mecanismos y los efectos del ruido con el personal de la UCI, es posible lograr la reducción de los niveles de ruido y el estrés ambiental consecuente. The objective of this study was to evaluate whether the sound pressure levels are decreased in the ICU after an educational intervention with the multidisciplinary team. Noise levels were measured inside the ICU (using a decibelimeter installed near the bedside of a patient) for seven days, and repeated the procedure after an educational intervention, which consisted of lectures, posters and dramatizations, among others. There was a large reduction in noise level between the pre and postintervention period, at all times evaluated. The main sources of noise in the ICU were the own team. The noise levels were higher than recommended. The study showed that with an educational intervention with the ICU staff and their awareness of the mec
Huge Peripheral Giant Cell Granuloma Leading to Bone Resorption: A Report of Two Cases
G?ksel ?im?ek Kaya,Ertan Yal??n,ümmühan Tozo?lu,Sare ?ipal
Cumhuriyet Dental Journal , 2011, DOI: 10.7126/cdj.2012.708
Abstract: ABSTRACT Although peripheral giant cell granulomas (PGCG) develop mainly within soft tissue, on rare occasions they may involve underlying bone and become visible radiologically. In such cases, the diameter of the hemorrhagic lesion rarely exceeds 20 mm, and pain is uncommon. This paper describes the successful treatment of two cases of huge PGCGs that led to alveolar bone resorption. Key words: Peripheral giant cell granuloma, bone resorption, surgery.
Avalia??o da sexualidade em mulheres submetidas à histerectomia para tratamento do leiomioma uterino
Tozo, Imacolada Marino;Moraes, José Cássio;Lima, Sonia Maria Rolim;Gon?alves, Nelson;Auge, Antonio Pedro Flores;Rossi, Lia Mara;Aoki, Tsutomu;
Revista Brasileira de Ginecologia e Obstetrícia , 2009, DOI: 10.1590/S0100-72032009001000006
Abstract: purpose: to evaluate the impact of hysterectomy on the sexuality of women with uterine leiomyoma. methods: prospective study including 33 sexually active women, with ages from 35 to 50 years old, with orgasmic experience and with a fit stable partner. all the women were submitted to two instruments for the evaluation or their sexuality: sexual quotient - female version (sqf) and sexual satisfaction inventory - female version (ssif). both instruments were applied by the same examiner, before and six months after the hysterectomy. results: the sqf has shown that 39.4% of the patients presented deterioration in the sexual intercourse, even though there has not been found an association between the sqf results before and after hysterectomy (χ2= 0.6; degree of freedom=12; p=0.05). the mean scores obtained after the application of the ssif have shown significant deterioration in the following parameters: sexual satisfaction (p=0.03); expression of feminine sensuality (p=0.01); vaginismus/dyspareunia (p=0.02) and anorgasmia (p=0.04). conclusions: it seems that hysterectomy has a negative impact on women's sexual life, with reports of decreased libido, arousal and orgasmic capacity.
The Constrained Mean-Semivariance Portfolio Optimization Problem with the Support of a Novel Multiobjective Evolutionary Algorithm  [PDF]
K. Liagkouras, K. Metaxiotis
Journal of Software Engineering and Applications (JSEA) , 2013, DOI: 10.4236/jsea.2013.67B005
Abstract:

The paper addresses the constrained mean-semivariance portfolio optimization problem with the support of a novel multi-objective evolutionary algorithm (n-MOEA). The use of semivariance as the risk quantification measure and the real world constraints imposed to the model make the problem difficult to be solved with exact methods. Thanks to the exploratory mechanism, n-MOEA concentrates the search effort where is needed more and provides a well formed efficient frontier with the solutions spread across the whole frontier. We also provide evidence for the robustness of the produced non-dominated solutions by carrying out, out-of-sample testing during both bull and bear market conditions on FTSE-100.

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