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Search Results: 1 - 10 of 20462 matches for " Juwon Kim "
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The Documentation of Endangered Altaic Languages and the Creation of a Digital Archive to safeguard linguistic diversity
Choi Woonho,You Hyun-Jo,Kim Juwon
International Journal of Intangible Heritage , 2012,
Abstract: Language is a vehicle of intangible heritage and transmits many social and cultural concepts from generation to generation. Half of the world's languages, including most of the Altaic languages, are now in danger of extinction. The loss of a language means the loss of cultural and intellectual diversity. This paper describes a linguistic project which aims to preserve the endangered Altaic languages. The ASK REAL (Altaic Society of Korea, Researches on Endangered Altaic Languages) team has gathered linguistic resources from thirty-eight Altaic languages and plans to build an extensive digital archive of all fifty-five of them. Through field research in minority language communities spread over a vast area of Eurasia, we acquired nearly three thousand lexical items of multimediadata, a few hundred grammatical constructions and another few hundred examples of daily conversation for each language. The data is converted into a standard digital format and managed in a database. A small part of the collection is currently available to the public via an easily accessible web interface with multilingual annotations for international users.
Spectrum of EGFR Gene Copy Number Changes and KRAS Gene Mutation Status in Korean Triple Negative Breast Cancer Patients
Yoonjung Kim, Juwon Kim, Hy-De Lee, Joon Jeong, Woochang Lee, Kyung-A Lee
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0079014
Abstract: Anti-epidermal growth factor receptor (EGFR) therapy has been tried in triple negative breast cancer (TNBC) patients without evaluation of molecular and clinical predictors in several randomized clinical studies. Only fewer than 20% of metastatic TNBCs showed response to anti-EGFR therapy. In order to increase the overall response rate, first step would be to classify TNBC into good or poor responders according to oncogenic mutation profiles. This study provides the molecular characteristics of TNBCs including EGFR gene copy number changes and mutation status of EGFR and KRAS gene in Korean TNBC patients. Mutation analysis for EGFR, KRAS, BRAF and TP53 from a total of 105 TNBC tissue samples was performed by direct sequencing, peptide nucleic acid-mediated PCR clamping method and real-time PCR. Copy number changes of EGFR gene were evaluated using multiplex ligation-dependent probe amplification. Out of all 105 TNBCs, 15.2% (16/105) showed EGFR copy number changes. Among them, increased or decreased EGFR copy number was detected in 13 (5 single copy gain, 2 amplification and 4 high-copy number amplification) and 3 cases (3 hemizygous deletion), respectively. The mutation frequencies of KRAS, EGFR and TP53 gene were 1.9% (G12V and G12D), 1.0% (exon 19 del) and 31.4%, respectively. There was no BRAF V600E mutation found. Future studies are needed to evaluate the clinical outcomes of TNBC patients who undergo anti-EGFR therapy according to the genetic status of EGFR.
Spatial and Temporal Variation in PBL Height over the Korean Peninsula in the KMA Operational Regional Model
Seung-Jae Lee,Juwon Lee,Steven J. Greybush,Minseok Kang,Joon Kim
Advances in Meteorology , 2013, DOI: 10.1155/2013/381630
Abstract: Spatial and temporal variations in planetary boundary layer height (PBLH) over the Korean Peninsula and its surrounding oceans are investigated using a regional grid model operated at the Korea Meteorological Administration (KMA). Special attention is placed on daily maximum mixing height for evaluation against two radiosonde observation datasets. In order to construct a new high-resolution PBLH database with 3-hour time and 10?km spatial resolution, short-term integrations with the regional model are carried out for a one-year period from June 2010 to May 2011. The resulting dataset is then utilized to explore the seasonal patterns of horizontal PBLH distribution over the peninsula for one year. Frequency distributions as well as monthly and diurnal variations of PBLH at two selected locations are examined. This study reveals specific spatiotemporal structure of boundary layer depth over the Korean Peninsula for the first time at a relatively high-resolution scale. The results are expected to provide insights into the direction for operational tuning and future development in the model boundary layer schemes at KMA. 1. Introduction The diurnally evolving structure of the planetary boundary layer (PBL) for a typical synoptic high-pressure system is described by Stull [1]. The depth of the PBL provides important information for numerical weather prediction (NWP) and atmospheric dispersion models. It has been used as a key parameter in the trigger function for convection in cumulus parameterization schemes in many NWP models (e.g., [2, 3]). Accurate prediction of PBL’s vertical extent is crucial in determining whether harmful gases (e.g., those erupted from a volcano) would reach the ground or not [4]. It affects near-surface atmospheric pollutant concentrations (e.g., [5]), low-level moisture availability, and updraft conditions prior to thundershowers (e.g., [6]). In particular, daytime mixed-layer (ML) height has been regarded as the location of a capping temperature inversion atop the convective boundary layer. Raupach et al. [7] and Denmead et al. [8] formularized the relationship between carbon dioxide concentration and ML depth through entrainment processes. To identify the ML top, there have been several methods for which radiosondes, wind profilers, and ceilometer/light detection and ranging (LIDAR) were utilized (e.g., [9–14]). These kinds of techniques to extract PBLH information have been also applied over the Korean Peninsula to surface flux [15–17], radiosonde [18, 19], LIDAR [20], and wind profiler [21] data. Most of the researchers
An Experimental Study of the Physicochemical Properties of a Cement Matrix Containing Dredged Materials  [PDF]
Hongseob Oh, Juwon Lee, N. Banthia, S. Talukdar
Materials Sciences and Applications (MSA) , 2011, DOI: 10.4236/msa.2011.27115
Abstract: Recently, the amount of dredged soil material (DM) has been rapidly increasing in Korea due to four major river maintenance projects and new harbor construction. DM waste is mostly dumped into the ocean, while only a small part of it has been utilized for coastal reclaiming, or as filling and backfilling material. This study carried out physical and chemical tests to map out a specific plan for utilizing DM in a mortar mixture. The compressive strength tests and microstructure analysis using XRD and SEM of cement mortar contained DM were performed as a replacement for fine aggregate or as a filler material of mortar matrix. The study measured the impact of contaminants contained in DM and how silt and clay influenced the compressive strength of the mortar.
Experimental Investigations on the Effects of Carbon and Nitrogen Sources on Concomitant Amylase and Polygalacturonase Production by Trichoderma viride BITRS-1001 in Submerged Fermentation
Arotupin Daniel Juwon,Ogunmolu Funso Emmanuel
Biotechnology Research International , 2012, DOI: 10.1155/2012/904763
Abstract: The paper investigates the effects of different commercial carbon and nitrogen sources on the concomitant synthesis of amylase and polygalacturonase enzymes with the aim of optimizing them for maximal enzyme production. The microorganism used in this work was the fungus Trichoderma viride BITRS-1001, which had been previously identified as a highly active producer of amylase and polygalacturonase enzymes. The results showed that the different commercial carbon and nitrogen substrate significantly affected the concomitant syntheses of amylase and polygalacturonase in culture media supplemented with the different commercial carbon and nitrogen substrates. The result obtained suggested that for optimal and concomitant synthesis of the enzymes by Trichoderma viride BITRS-1001 in submerged fermentation, minimal medium supplemented with maltose and casein were the carbon and nitrogen substrates of choice. 1. Introduction Microbes are rich sources of enzymes [1]. In nature, they have been endowed with vast potentials to produce array of enzymes, which have been exploited commercially over the years. Traditionally, enzymes have been extracted from plants and animals. However, microbial enzymes have formed the basis of commercial enzyme production. In recent years, the potential of using microorganisms as biotechnological sources of industrially relevant enzymes has stimulated interest in the exploration of extracellular enzymatic activity in several microorganisms isolated from different environments owing to several reasons [2–7]. Amylase (EC and polygalacturonase (EC from microbial origin have high biotechnological interest such as in the processing of foods, manufacturing of detergents, textiles, pharmaceutical products, medical therapy, in molecular biology, and in many industrial processes as reviewed in [4, 6, 8–22]. While amylase has been reported to have approximately 25% of the enzyme market of industrial enzymes [17, 23, 24], microbial pectinases have been reported to account for 25% of the global food enzymes sales [4]. The synthesis of these enzymes by microorganisms has been reported to be highly influenced by factors such as carbon sources, temperature, pH, and operating parameter such as incubation time in submerged culture [25, 26]. Factors like carbon, nitrogen sources and their concentrations have always been of great interest to researchers in the industry for the low-cost media design. It is also known that 30–40% of the production cost of industrial enzymes is estimated to be the cost of growth medium. Therefore, it is of
Screening of Fungal Isolates from Nigerian Tar Sand Deposit in Ondo State for Novel Biocatalysts
Arotupin Daniel Juwon,Ogunmolu Funso Emmanuel
Journal of Biological Sciences , 2012,
Abstract: Fungi associated with tar sand samples from Ondo State, Nigeria were isolated and identified using standard microbiological method (serial dilution-spread plate technique). Also the isolates were screened for some enzymes of biotechnological importance. The fungal occurrence and frequency of the fungal isolates from the tar sand samples are Trichoderma viride BITRS-1001 (21%), Aspergillus fumigatus BITRS-1003 (10%), Rhizopus nigricans BITRS-1004 (10%), Penicillum italicum BITRS-1005 (16%), Spondylocladiella botrytioides BITRS-1006 (5.4%), Paecilomyces spp. BITRS-1007 (2.7%), Aspergillus flavus BITRS-1008 (8.1%), Mycotypha microsporium BITRS-1009 (13.5%), Articulospora inflata BITRS-1010 (5.4%) and Candida albicans BITRS-1002 (2.7%). All the isolates elaborated enzymatic activity, which were ranked as follows: Amylase 100% protease 100%, lipase 90%, polygalacturonase 60% and pectin methylesterase (60%). This study revealed the array of fungi associated with tar sand and their ability to elaborate hydrolytic enzymes. Harnessing these enzymes from the isolates would provide a clue to the biotransformation of essential nutrients of tar sand in addition to their application in industries.
Adewale Sogo Olalemi,Daniel Juwon Arotupin
Journal of Microbiology, Biotechnology and Food Sciences , 2012,
Abstract: An investigation into the effect of refined petroleum products contamination on bacterial population and physicochemical characteristics of cultivated agricultural soil was carried out. The soil samples obtained from the Teaching and Research Farm, Obakekere, Federal University of Technology, Akure, Ondo State were contaminated with varying volumes of petrol, diesel and kerosene. The results revealed higher bacterial populations in uncontaminated soils than contaminated soils. The counts of bacteria ranged from 3.0 × 105 to 5.0 × 105 cfu/g in uncontaminated soils and 1.0 × 105 to 3.0 × 105 cfu/g in contaminated soils. The isolated bacteria were identified as Bacillus subtilis, Flavobacterium lutescens, Micrococcus luteus, Corynebacterium variabilis, Pseudomonas fluorescens. The contamination had no significant effect on pH, potassium, sodium, organic carbon and nitrogen content of the soils, while the moisture, calcium, phosphorus and magnesium content of the contaminated soils were significantly different (P < 0.05) compared with the uncontaminated soils. The ability of Bacillus subtilis, Flavobacterium lutescens, Micrococcus luteus, and Pseudomonas fluorescens to utilize the refined petroleum products suggest that these bacteria had potential to bioremediate petroleum contaminated soils.
Solitary Plasmacytoma of the Zygoma in a 70-Year-Old Nigerian: A Case Report and Review of Literature  [PDF]
Obitade S. Obimakinde, Olufemi J. Taiwo, Ahmed O. Lawal, Akinyele O. Adisa, Victoria N. Okoje, Juwon T. Arotiba
International Journal of Otolaryngology and Head & Neck Surgery (IJOHNS) , 2014, DOI: 10.4236/ijohns.2014.34036

Purpose: Solitary bone plasmacytoma [SBP] is a localised variant of plasma cell tumor which commonly affects the axial skeleton but rarely found in the maxillofacial region. We hereby report an unusual case of solitary plasmacytoma of the right zygomatic bone in a 70-year-old Nigerian. Case Report: The patient presented with a painless right zygomatic swelling of 2 years duration. Examination showed that the swelling was of mixed consistency [mostly bony but firm in some areas] and it measured about 8 × 8 cm. Radiographic examination revealed an osteolytic lesion over the right zygoma with involvement of the apex and lateral wall of the antrum. An initial working diagnosis of ossifying fibroma was made and the patient was scheduled for surgery. Histological staining with H & E and immunohistochemistry of the surgical specimen however confirmed a diagnosis of SBP. Serum monoclonal protein and Bence Jones proteinuria was negative throughout the follow up period. Conclusion: SBP of the maxillofacial region is amenable to surgery combined with postoperative radiotherapy. However, prognosis can be worsened with tumor recurrence or dissemination into MM. Thus patients with SBP must be closely followed up after treatment so that immediate therapeutic steps can be taken if recurrence or systemic dissemination is encountered.

Purification, Characterization and Application of Polygalacturonase from Aspergillus niger CSTRF
Arotupin Daniel Juwon,Akinyosoye F. A.,Onifade Anthony Kayode
Malaysian Journal of Microbiology , 2012,
Abstract: Aims: The research was carried out to study the purification, characterization and application of polygalacturonase fromAspergillus niger CSTRF.Methodology and Results: The polygalacturonase (PG) from the fungus was purified by ammonium sulphate precipitation and dialysed. The resulting fraction of the enzyme was further separated by molecular exclusion and ion exchange chromatography. The enzyme was purified 28.19 fold with a yield of approximately 69 % following purificationwith SP C-50. It has a relative molecular weight of 79,430 daltons and markedly influenced by temperature, pH and substrate concentrations of reactions with optimum activity at 35 °C, pH 4.0 and 8 mg/mL respectively. The PG was heat stable over a broad range of temperatures. Line weaver-Burk plot for the apparent hydrolysis of pectin showed approximately Km value of 2.7 mg/mL. The activity of the enzyme was enhanced by Na+, Ca2+, Mg2+ and Zn2+, while EDTA, PbCl2, HgCl2 and IAA were inhibitory. The ability of the purified enzyme to clarify fruit juice was also investigated.Conclusion, significance and impact of the study: This study revealed that polygalacturonase possesses properties for clarification of fruit juice and by extension bioprocessing applications.
Local spectroscopy of moiré-induced electronic structure in gate-tunable twisted bilayer graphene
Dillon Wong,Yang Wang,Jeil Jung,Sergio Pezzini,Ashley M. DaSilva,Hsin-Zon Tsai,Han Sae Jung,Ramin Khajeh,Youngkyou Kim,Juwon Lee,Salman Kahn,Sajjad Tollabimazraehno,Haider Rasool,Kenji Watanabe,Takashi Taniguchi,Alex Zettl,Shaffique Adam,Allan H. MacDonald,Michael F. Crommie
Physics , 2015, DOI: 10.1103/PhysRevB.92.155409
Abstract: Twisted bilayer graphene (tBLG) forms a quasicrystal whose structural and electronic properties depend on the angle of rotation between its layers. Here we present a scanning tunneling microscopy study of gate-tunable tBLG devices supported by atomically-smooth and chemically inert hexagonal boron nitride (BN). The high quality of these tBLG devices allows identification of coexisting moir\'e patterns and moir\'e super-superlattices produced by graphene-graphene and graphene-BN interlayer interactions. Furthermore, we examine additional tBLG spectroscopic features in the local density of states beyond the first van Hove singularity. Our experimental data is explained by a theory of moir\'e bands that incorporates ab initio calculations and confirms the strongly non-perturbative character of tBLG interlayer coupling in the small twist-angle regime.
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