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Search Results: 1 - 10 of 2670 matches for " Justin Ntokamunda Kadima "
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Preliminary Phytochemical Content and Antidiabetic Potential Investigations of Panda oleosa (Pierre) Used in Kisangani Areas  [PDF]
Frédéric Katemo Muhoya, Justin Ntokamunda Kadima, Njakarinala Ranarivelo, Michel Frédérich, Philippe Hubert, Roland Marini Djang’eing’a
American Journal of Analytical Chemistry (AJAC) , 2017, DOI: 10.4236/ajac.2017.89041
Abstract: Panda oleosa Pierre (POP), a tropical plant tree, has been used in traditional medicine in Kisangani city and around to treat various diseases including diabetes and HIV/AIDs. This study aims to evaluate the chemical composition of POP extracts while setting up chromatographic fingerprints for their quality control, and the anti-hyperglycemic potential of trunk bark aqueous extracts of POP. Common chemical reactions were used for identification of main secondary metabolic groups. Thin layer chromatography was used to set up several chromatographic fingerprints of water and alcoholic extracts while evaluating chemical composition. Oral glucose tolerance test served to induce hyperglycemia in a rabbit model. The extracts were given as 25 mg/kg, 50 mg/kg, and 100 mg/kg body weight, 30 minutes before loading animals with glucose 4 g/kg. Blood samples were collected at various times: just before extracts (T-30), before (T0) and after glucose load (T30, T60, T120, and T180). Blood glucose levels were measured with One Touch Glucometer. The identification tests revealed the presence of saponins (3.58%), tannins (5%); alkaloids, quinones, flavonoids, and terpenes sterols could not be formerly detected by the reagents used. Interesting chromatographic spots were observed whose behaviors are of catechic tannin proanthocyanes. The extract significantly reduced glucose levels in dose dependent manner as compared to control and glibenclamide reference groups. The average of mean percentage of reduction in glucose level at T120 with the extract 100 mg/kg was close to that of glibenclamide 0.25 mg/kg (49% and 40.2%). These findings back the traditional use of the plant to treat diabetic patients and constitute a foundation for an extensive study to find a new antidiabetic phythomedicine.
Simple LC Isocratic Methods Development, Validation, and Application in the Analysis of Poor Quality Antimalarial Medicines  [PDF]
Védaste Habyalimana, Jérémie Kindenge Mbinze, Achille Loconon Yemoa, Justin-Léonard Kadima Ntokamunda, Philippe Hubert, Roland Marini Djang’eing’a
American Journal of Analytical Chemistry (AJAC) , 2017, DOI: 10.4236/ajac.2017.89042
Abstract: Liquid chromatographic methods in isocratic mode for the analysis of poor quality medicines are privileged due to their simplicity and facility in methods development. They are generally fast; do not need to be re-equilibrated between sample injections; have larger flexibility with acceptable changes on different column dimensions; and are applicable to LC systems equipped with simple or high developed pumps. In this study, we focused on developing simple isocratic methods using classical mobile phase composed by methanol and ammonium formate buffer for the analysis of most common antimalarial medicines marketed in malaria endemic countries and susceptible of being counterfeit/falsified, substandard and degraded. The selected medicines were quinine and related cinchona alkaloids in tablets and injectable forms; artemether/lumefantrine tablets; and artemisinin compounds (arteether, artemether, and artesunate) in injectable forms. The current methods were developed thanks to simple methodological approach consisting in sequential isocratic runs through adjustment or adaptation of existing methods to obtain optimal analytical conditions without complex design of experiments that might be long and costly. Then, the new methods presented shorter analysis time; allowed increase of sample analysis throughput; and obviously consumed little mobile phase solvents on classical analytical columns: 50 - 250 mm of length (L), 4.6 mm of internal diameter (I.D.), and 3.5 - 5.0 μm of particle size (dp).
Effect of TB Therapy on the Health and Nutritional Status of Infants Aged 6 Months to 5 Years Diagnosed with Latent TB  [PDF]
Kasai Emmanuel Tebandite, Kampunzu Véronique Muyobela, Mukunda Fran?ois Lusamaki, Bukaka Gaspard Mande, Gwendiza Jean Mopepe, Sadiki Dady Falay, Likele Bibi Batoko, Oloma Antoine Tshomba, Dauly Nestor Ngbonda, Opara Jean Pierre Alworong’a, Justin Ntokamunda Kadima
Journal of Tuberculosis Research (JTR) , 2018, DOI: 10.4236/jtr.2018.64022
Abstract: Background: Infants with latent tuberculosis are often subject to high morbidity, nutritional deficiency and mortality. Early treatment can prevent the onset of TB by reducing morbidity and improving nutritional status. This paper assessed whether preventive chemotherapy for TB can improve health and nutritional status of infants diagnosed with latent TB in Kisangani City. Method: Children diagnosed TB+ by tuberculin skin test and other clinical examinations were treated with Rifampicin, Isoniazid, Pyrazinamide and Ethambutol. Clinical symptoms and nutritional status were determined before to start treatment and at the 5th month of treatment. Results: Out of 161 infants treated, 73 (45.3%) were <1 year old, 49 (30.4%) were 1 - 2 years old and 39 (24.2%) were 3 - 5 years old. Both boys and girls were almost equally represented (50.3/49.7%). The proportion of infants with fever (T > 37°C) was 62.7% before treatment and 17.4% at the 5th month of treatment; the difference was statistically significant (p < 0.001). Similarly, the proportion of children with weights below the ideal weight adjusted for each age decreased from 21.7% before treatment to 8.1% after treatment. Infants younger than one year were more likely to have fever than older children, while girls were more likely to be malnourished than boys (p < 0.05) before treatment, but the recovery rates were not different. Conclusion: Treatment of infants diagnosed of latent TB prevents TB disease and improves nutritional status, but not in all cases. Control of fever and weight gain can be an indicator of good outcome in poor health care settings.
Analytical Tools and Strategic Approach to Detect Poor Quality Medicines, Identify Unknown Components, and Timely Alerts for Appropriate Measures: Case Study of Antimalarial Medicines  [PDF]
Védaste Habyalimana, Jérémie Kindenge Mbinze, Nicodème Kalenda Tshilombo, Amandine Dispas, Achille Yemoa Loconon, Pierre-Yves Sacré, Jo?lle Widart, Pascal De Tullio, Stéphane Counerotte, Justin-Léonard Kadima Ntokamunda, Eric Ziemons, Philippe Hubert, Roland Marini Djang’eing’a
American Journal of Analytical Chemistry (AJAC) , 2015, DOI: 10.4236/ajac.2015.613093
Abstract: Nowadays, the circulation of poor quality medicines is becoming an alarming worldwide phenomenon with serious public health and socio-economic concerns. The situation is particularly critical in developing countries where drug quality assurance and regulatory systems for drug manufacturing, importation, distribution and sales are weak. A sustained vigilance on poor quality medicines that regroup counterfeit/falsified, substandard and degraded medicines is therefore required to ensure patient safety and genuine medicines integrity. A case situation is illustrated including a strategic approach and analytical tools that were found useful to detect poor quality medicines, identify unknown components, and timely alerts for appropriate measures against the spread of those harmful products. Several suspected medicines randomly sampled in several strategic Rwandan areas were firstly check-controlled by means of visual inspection and then applying several analytical techniques from simple to more complex ones. The following medicines were studied: quinine sulfate tablets, artemisinin-based combination tablets, and artesunate powders for injection. Taking into account the pharmaceutical forms and the chemical characteristics, the following tests were applied: uniformity of mass, friability, disintegration, fluorescence, identification and assay. They were followed by more complex analytical techniques that allowed more comprehension of abnormal findings among which the presence of a wrong active pharmaceutical ingredient in quinine sulfate tablets which is mainly discussed in this paper to illustrate a strategic approach and various analytical tools that can be used in detecting and identifying unknown component in poor quality medicines.
Animals in Medical Research
K. B. Kadima, I. Hamman
Nigerian Journal of Surgical Research , 2000,
Abstract: (Nig J Surg Res 2000; 2: 43 - 47)
Stepsize Selection in Explicit Runge-Kutta Methods for Moderately Stiff Problems  [PDF]
Justin Steven Calder Prentice
Applied Mathematics (AM) , 2011, DOI: 10.4236/am.2011.26094
Abstract: We present an algorithm for determining the stepsize in an explicit Runge-Kutta method that is suitable when solving moderately stiff differential equations. The algorithm has a geometric character, and is based on a pair of semicircles that enclose the boundary of the stability region in the left half of the complex plane. The algorithm includes an error control device. We describe a vectorized form of the algorithm, and present a corresponding MATLAB code. Numerical examples for Runge-Kutta methods of third and fourth order demonstrate the properties and capabilities of the algorithm.
A Case Study of Gut Fermentation Syndrome (Auto-Brewery) with Saccharomyces cerevisiae as the Causative Organism  [PDF]
Barbara Cordell, Justin McCarthy
International Journal of Clinical Medicine (IJCM) , 2013, DOI: 10.4236/ijcm.2013.47054

Gut Fermentation Syndrome also known as Auto-Brewery Syndrome is a relatively unknown phenomenon in modern medicine. Very few articles have been written on the syndrome and most of them are anecdotal. This article presents a case study of a 61 years old male with a well documented case of Gut Fermentation Syndrome verified with glucose and carbohydrate challenges. Stool cultures demonstrated the causative organism as Saccharomyces cerevisiae. The patient was treated with antifungals and a low carbohydrate diet and the syndrome resolved. Helicobacter pylori was also found and could have been a possible confounding variable although the symptoms resolved post-treatment of the S. cerevisiae.

Strategizing the Development of Alzheimer’s Therapeutics  [PDF]
Justin Davis, Robin Couch
Advances in Alzheimer's Disease (AAD) , 2014, DOI: 10.4236/aad.2014.33011
Abstract: Alzheimer’s Disease is a complex, progressive condition with symptoms that do not reveal themselves until significant changes to neuronal morphology have already occurred. The delayed manifestation of cognitive decline makes determination of the true etiological origins difficult. As a result, identification of ideal drug targets becomes seemingly impossible. The existing treatments for Alzheimer’s Disease may temporarily suppress the rate of cognitive decline, but do little to slow or halt neuronal decay. While many believe that the current approaches to identifying a cure for the disease are too narrow-minded, focusing heavily on the physical manifestations of the diseased brain such as amyloid plaques and neurofibrillary tangles, this review asserts the status of Alzheimer’s research as rational and multi-faceted.
Cohesive Chains in the Transfiguration Narrative of Matthew 17:1-13  [PDF]
Justin R. Woods
Open Journal of Modern Linguistics (OJML) , 2015, DOI: 10.4236/ojml.2015.53027
Abstract: While much work in biblical studies has been offered in the form of theological exposition and historical critical speculation of literary origins of the gospels, few modern biblical studies scrutinize the language of these gospels from rigorous linguistic criteria. This paper takes a discourse analytic approach from the field of Systemic Functional Linguistics (SFL) founded by M. A. K. Halliday. The notion of cohesive chaining is taken in order to evaluate the level of literary unity in the original Greek of the episode of the transfiguration narrative found within the Gospel of Matthew. Cohesive chaining will be defined; its function within the greater sociolinguistic theory of SFL will be examined, and then the concept will be directly applied. The study concludes with a unique contribution demonstrating how these cohesive chains are then unified via choices in verbal aspect as the grammar that not only solidifies semantic continuity among those chains, but contours the discourse using a scheme of markedness that signals the prioritization of its message. The hope of this study is to reinforce the recent paradigm shift of biblical research utilizing modern linguistic paradigms as tools to transform biblical interpretation and exegesis into a rigorously discourse-centered linguistic methodology.
Beyond Values and Interests: The Anglo-America Special Relationship during the Syrian Conflict  [PDF]
Justin Gibbins, Shaghayegh Rostampour
Open Journal of Political Science (OJPS) , 2019, DOI: 10.4236/ojps.2019.91005
Abstract: This paper attempts to reveal how intervention in international conflicts (re) constructs the Anglo-American Special Relationship (AASR). To do this, this article uses Syria as a case study. Analyzing parliamentary debates, presidential/prime ministerial speeches and formal official addresses, it offers a discursive constructivist analysis of key British and US political spokespeople. We argue that historically embedded values and interests stemming from unity forged by World War Two have taken on new meanings: the AASR being constructed by both normative and strategic cultures. The former, we argue, continues to forge a common alliance between the US and Britain, while the latter produces notable tensions between the two states.
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