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Search Results: 1 - 10 of 3506 matches for " Justin Bishop "
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A Large Nonmetastatic Anaplastic Thyroid Cancer with Complete Thyroidal Confinement
Jeffrey C. Xing,Justin A. Bishop,Nestoras Mathioudakis,Nishant Agrawal,Ralph P. Tufano
Case Reports in Medicine , 2011, DOI: 10.1155/2011/583978
Abstract: Anaplastic thyroid cancer (ATC) is rare but extremely aggressive, which accounts for about 2% of all thyroid cancers yet nearly 50% of thyroid-cancer-associated deaths in the United States. The median survival time from diagnosis is 5 months, with a 1-year survival rate of only 20%. We report here a case of ATC in a 56-year-old man who survived a large ATC. Preoperative fine-needle aspiration biopsy study to a large right thyroid mass suggested ATC. Total thyroidectomy with radical lateral neck and central neck dissection removed a well-circumscribed 9.5 cm tumor without extrathyroidal extension or lymphovascular invasion. All 73 lymph nodes removed were negative for metastasis. The tumor consisted of highly pleomorphic, undifferentiated cells with large zones of necrosis and loss of thyroid transcription factor-1 and thyroglobulin expression. A focal well-differentiated component and PAX8 expression confirmed its thyroid follicular cell origin. Nine months after postsurgical adjuvant concurrent radiation therapy and chemotherapy, the patient remained well without clinical, biochemical, and radiographical evidence for cancer recurrence. This is an unusual case of ATC in that it is one of the largest ATC tumors reported to display mild pathologic behavior and relatively long-term patient survival.
Piloting the Global Subsidy: The Impact of Subsidized Artemisinin-Based Combination Therapies Distributed through Private Drug Shops in Rural Tanzania
Oliver J. Sabot, Alex Mwita, Justin M. Cohen, Yahya Ipuge, Megumi Gordon, David Bishop, Moses Odhiambo, Lorrayne Ward, Catherine Goodman
PLOS ONE , 2009, DOI: 10.1371/journal.pone.0006857
Abstract: Background WHO estimates that only 3% of fever patients use recommended artemisinin-based combination therapies (ACTs), partly reflecting their high prices in the retail sector from where many patients seek treatment. To overcome this challenge, a global ACT subsidy has been proposed. We tested this proposal through a pilot program in rural Tanzania. Methods/Principal Findings Three districts were assigned to serve either as a control or to receive the subsidy plus a package of supporting interventions. From October 2007, ACTs were sold at a 90% subsidy through the normal private supply chain to intervention district drug shops. Data were collected at baseline and during intervention using interviews with drug shop customers, retail audits, mystery shoppers, and audits of public and NGO facilities. The proportion of consumers in the intervention districts purchasing ACTs rose from 1% at baseline to 44.2% one year later (p<0.001), and was significantly higher among consumers purchasing for children under 5 than for adults (p = 0.005). No change in ACT usage was observed in the control district. Consumers paid a mean price of $0.58 for ACTs, which did not differ significantly from the price paid for sulphadoxine-pyrimethamine, the most common alternative. Drug shops in population centers were significantly more likely to stock ACTs than those in more remote areas (p<0.001). Conclusions A subsidy introduced at the top of the private sector supply chain can significantly increase usage of ACTs and reduce their retail price to the level of common monotherapies. Additional interventions may be needed to ensure access to ACTs in remote areas and for poorer individuals who appear to seek treatment at drug shops less frequently. Trial Registration Controlled-Trials.com ISRCTN39125414.
Hypofractionated Prostate Radiotherapy with or without Conventionally Fractionated Nodal Irradiation: Clinical Toxicity Observations and Retrospective Daily Dosimetry
Andrew M. McDonald,Justin M. Bishop,Rojymon Jacob,Michael C. Dobelbower,Robert Y. Kim,Eddy S. Yang,Heather Smith,Xingen Wu,John B. Fiveash
Prostate Cancer , 2012, DOI: 10.1155/2012/546794
Abstract: Purpose. To evaluate toxicity associated with the addition of elective nodal irradiation (ENI) to a hypofractionated regimen for the treatment of prostate cancer. Methods and Materials. Fifty-seven patients received pelvic image-guided IMRT to 50.4?Gy in 28 fractions with a hypofractionated simultaneous boost to the prostate to 70?Gy. Thirty-one patients received prostate-only treatment to 70?Gy in 28 fractions. Results. Median followup was 41.1 months. Early grade ≥2 urinary toxicity rates were 49% (28 of 57) for patients receiving ENI and 58% (18 of 31) for those not ( ). Early grade ≥2 rectal toxicity rates were 40% (23 of 57) and 23% (7 of 31), respectively ( ). The addition of ENI resulted in a 21% actuarial rate of late grade ≥2 rectal toxicity at 4 years, compared to 0% for patients treated to the prostate only ( ). Retrospective daily dosimetry of patients experiencing late rectal toxicity revealed an average increase of 2.67% of the rectal volume receiving 70?Gy compared to the original plan. Conclusions. The addition of ENI resulted in an increased risk of late rectal toxicity. Grade ≥2 late rectal toxicity was associated with worse daily rectal dosimetry compared to the treatment plan. 1. Introduction Hypofractionated treatment regimens for clinically localized prostate cancer remain a topic of debate as large prospective trials such as RTOG 0415 continue to mature. The large retrospective series from Cleveland Clinic as well as recently published phase III data by Arcangeli et al. indicate that hypofractionated RT is well-tolerated and offers high rates of biochemical control [1, 2]. However, most published series focus primarily on patients with a relatively low risk of lymph node involvement and have, therefore, restricted treatment to the prostate and seminal vesicles only. Traditionally, patients with high-risk prostate cancer receive whole-pelvic radiotherapy (WPRT), and such regimens have formed the backbone of large-scale clinical trials such as RTOG 8531, RTOG 9202, and EORTC 22863 [3–6]. Though conventionally fractionated WPRT has been safely delivered on a number of clinical trials, little data exists concerning treatment of the pelvic lymph nodes as part of a hypofractionated regimen. To date, there has only been one phase III trial which utilized hypofractionated WPRT for patients with high-risk disease [7]. While the short-term toxicity results of this study are promising, a detailed report of the long-term toxicities is pending. Advances in radiation delivery such as intensity-modulated radiotherapy (IMRT) and image-guided
Plant-to-plant horizontal gene transfer
CL Bishop
Genome Biology , 2003, DOI: 10.1186/gb-spotlight-20030710-01
Abstract: Bergthorsson et al. surveyed the mitochondrial gene content of a number of angiosperms and found distribution anomalies. Phylogenetic analysis of two mitochondrial ribosomal protein genes - rps2 and rps11 - resulted in the identification of four cases of plant-to-plant HGT, suggesting that the frequency of HGT is significant. The authors also suggest that previous placements of the atp1 gene should be reclassed as an HGT event. Expression analysis of Sanguinaria indicated that the rps11 RNA is probably functional and that the atp1 gene of Amborella is transcribed and edited. Using molecular-clock - based divergence times, the age of each transfer was also estimated."These results establish for the first time that conventional genes are subject to evolutionarily frequent HGT during plant evolution and provide the first unambiguous evidence that plants can donate DNA horizontally to other plants. This is also the best evidence that eukaryotic genomes regularly acquire genes by means of horizontal events that are relatively recent, datable and definable as to donor and recipient," conclude the authors.
“Modern Supramolecular Gold Chemistry”, edited Antonio Laguna
Peter Bishop
Gold Bulletin , 2009, DOI: 10.1007/BF03214912
Publications of B.J. van der Walt 1960-2010
S. Bishop
Koers : Bulletin for Christian Scholarship , 2010, DOI: 10.4102/koers.v75i1.82
Abstract: At the Ferdinand Postma Library of the Potchefstroom Campus of the North-West University an electronic list (both chronological and alphabetical according to titles) of B.J. van der Walt’s publications from 1960 to 2000 is available. (To access the list, go to http://www4-win2.p.nwu.ac.za/dbtw-wpd/textbases/puk-eeu.htm and type in the author’s name: Van der Walt BJ) The website of Mr. Steve Bishop (www.allofliferedeemed.co.uk/ vanderwalt.htm) provides an annotated bibliography of all Van der Walt’s publications in English, as well as a list of the publications of the Institute for Reformational Studies. (E-mail: stevebishop.uk@gmail.com)
Pre-service teacher discourses: Authoring selves through multimodal compositions
John Bishop
Digital Culture & Education , 2009,
Abstract: This article explores the use of digital and multimodal compositions among preservice elementary education students in a university language and literacy methods course. Furthermore, this piece argues for the inclusion of multimodal representation in our literacy courses given the changes in our digital landscape and the ever-increasing multimodality of our representational and communicational means online. This research aligns with a burgeoning collection of literature, namely New Literacies (Knobel & Lankshear, 2007) and multimodality (Kress & van Leeuwen, 2001). In addition, this research merges with ‘traditional’ print-based literacy pedagogies that argue for models of teacher learning that foreground opportunities to ‘do’ digital composition in order to more effectively prepare students for 21st century literacy skills in epistemologically diverse digital environments. A combination of discourse and multimodal analysis provides a means to couple both linguistic and semiotic data to examine how multimodal design functions in the construction of teacher identities and how the flexibility of these identities in turn work to prepare new teachers for successful transitions into public school cultures. In other words, how might the practice of multimedia production, and reflection on those processes, foster a deeper self-awareness during a time when students are moving from university settings into public schools? This article argues that multimodal text design is dialogic and purposeful with regards to constructions of teacher identities and highlights two ‘Digital Literacy Projects,’ multimodal video compositions designed and produced by preservice teachers with video editing software. The two DLPs contrast the potential for authors to stabilize and/or improvise formations of identity, both which create opportunities to engage in praxis that merge university experiences with public school responsibilities.
Graines souterraines ? Le sexo-générique dans une oeuvre (auto)-censurée d’Anne Hébert : Les Songes en équilibre
Neil Bishop
Voix Plurielles , 2010,
Abstract: Les songes en équilibre d'Anne Hébert
Reading Backwards: Constructing God the Impossible in Psychoanalysis and the Challenge of Islam
Benjamin Bishop
S : Journal of the Jan van Eyck Circle for Lacanian Ideology Critique , 2009,
The Dread of sameness
Bishop , Rebecca
Cultural Studies Review , 2011,
Abstract: A review of Jackie Stacey, 'The Cinematic Life of the Gene'.
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