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Search Results: 1 - 10 of 12623 matches for " Jung-Eun Park "
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International Comparative Case Study of High School Students about Empathy  [PDF]
Heesun Yang, Jung-Eun Park, Ji Hye Kim, Seong-Joo Kang
Psychology (PSYCH) , 2019, DOI: 10.4236/psych.2019.102013
Abstract: In this study, we attempted to investigate the empathy ability of Korean adolescents. Davis’ Interpersonal Reactivity Index was applied to 1155 high school students in Korea, and the results were compared with those obtained from the survey of the American and Dutch students with similar ages. As a result, high school students in Korea had higher cognitive empathy than other countries. But, in cognitive empathy, Fantasy (FN) was lower than Perspective Taking (PT), unlike other countries. The mean score of women in all empathy subscales was higher than that of men. And there is significant difference between humanities and natural science high school students in PT, Empathic Concern (EC) and Personal Distress (PD). However, in the comparison of mean score’s effect size and correlation in the subscales of the empathetic scale, it was confirmed as an unstable structure in PD. Therefore, there is a need to educationally discuss how to improve this limitation of measuring empathy in the further research.
Modulation of Glucose Metabolism by Balanced Deep-Sea Water Ameliorates Hyperglycemia and Pancreatic Function in Streptozotocin-Induced Diabetic Mice
Byung Geun Ha, Jung-Eun Park, Eun Ji Shin, Yun Hee Shon
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0102095
Abstract: The aim of this study was to determine the effects of balanced deep-sea water (BDSW) on hyperglycemia and glucose intolerance in streptozotocin (STZ)-induced diabetic mice. BDSW was prepared by mixing DSW mineral extracts and desalinated water to yield a final hardness of 1000–4000 ppm. Male ICR mice were assigned to 6 groups; mice in each group were given tap water (normal and STZ diabetic groups) or STZ with BDSW of varying hardness (0, 1000, 2000, and 4000 ppm) for 4 weeks. The STZ with BDSW group exhibited lowered fasting plasma glucose levels than the STZ-induced diabetic group. Oral glucose tolerance tests showed that BDSW improves impaired glucose tolerance in STZ-induced diabetic mice. Histopathological evaluation of the pancreas showed that BDSW restores the morphology of the pancreatic islets of Langerhans and increases the secretion of insulin in STZ-induced diabetic mice. Quantitative real-time PCR assay revealed that the expression of hepatic genes involved in gluconeogenesis, glucose oxidation, and glycogenolysis was suppressed, while the expression of the genes involved in glucose uptake, β-oxidation, and glucose oxidation in muscle were increased in the STZ with BDSW group. BDSW stimulated PI3-K, AMPK, and mTOR pathway-mediated glucose uptake in C2C12 myotubes. BDSW increased AMPK phosphorylation in C2C12 myotubes and improved impaired AMPK phosphorylation in the muscles of STZ-induced diabetic mice. Taken together, these results suggest that BDSW is a potential anti-diabetic agent, owing to its ability to suppress hyperglycemia and improve glucose intolerance by modulating glucose metabolism, recovering pancreatic islets of Langerhans and increasing glucose uptake.
Anti-Diabetic Effect of Balanced Deep-Sea Water and Its Mode of Action in High-Fat Diet Induced Diabetic Mice
Byung Geun Ha,Eun Ji Shin,Jung-Eun Park,Yun Hee Shon
Marine Drugs , 2013, DOI: 10.3390/md11114193
Abstract: In this study, we investigated the effects of balanced deep-sea water (BDSW) on hyperglycemia and glucose intolerance in high-fat diet (HFD)-induced diabetic C57BL/6J mice. BDSW was prepared by mixing deep-sea water (DSW) mineral extracts and desalinated water to give a final hardness of 500–2000. Mice given an HFD with BDSW showed lowered fasting plasma glucose levels compared to HFD-fed mice. Oral and intraperitoneal glucose tolerance tests showed that BDSW improves impaired glucose tolerance in HFD-fed mice. Histopathological evaluation of the pancreas showed that BDSW recovers the size of the pancreatic islets of Langerhans, and increases the secretion of insulin and glucagon in HFD-fed mice. Quantitative reverse transcription polymerase chain reaction results revealed that the expression of hepatic genes involved in glucogenesis, glycogenolysis and glucose oxidation were suppressed, while those in glucose uptake, β-oxidation, and glucose oxidation in muscle were increased in mice fed HFD with BDSW. BDSW increased AMP-dependent kinase (AMPK) phosphorylation in 3T3-L1 pre- and mature adipocytes and improved impaired AMPK phosphorylation in the muscles and livers of HFD-induced diabetic mice. BDSW stimulated phosphoinositol-3-kinase and AMPK pathway-mediated glucose uptake in 3T3-L1 adipocytes. Taken together, these results suggest that BDSW has potential as an anti-diabetic agent, given its ability to suppress hyperglycemia and improve glucose intolerance by increasing glucose uptake.
Self-regulated mechanism of Plk1 localization to kinetochores: lessons from the Plk1-PBIP1 interaction
Kyung S Lee, Doo-Yi Oh, Young H Kang, Jung-Eun Park
Cell Division , 2008, DOI: 10.1186/1747-1028-3-4
Abstract: Polo-like kinases (collectively, Plks) have been isolated from various species from budding yeast to mammalian cells. In addition to the N-terminal kinase domain, they are characterized by the presence of a highly conserved polo-box domain (PBD) in the C-terminal non-catalytic region that is critical for subcellular localization (Fig. 1A) (see reviews, [1,2]). In mammalian cells, multiple Plks with distinct functions appear to exist. These include Plk1, Plk2/Snk, Plk3/Prk/Fnk, and Plk4/Sak. Plk4/Sak is the most distantly-related member of the Plks subfamily and one of the two isoforms, Sak-a, possesses a significant C-terminal extension with only the PB1 motif. Among these four members, Plk1 drew most of the attention because of its tight association with oncogenesis. Studies in various organisms have shown that Plk1 and its functional homologs in lower eukaryotic organisms (Xenopus Plx1, Drosophila polo, fission yeast Plo1, and budding yeast Cdc5) play critical roles in various mitotic events such as centrosome maturation, bipolar spindle formation, APC (anaphase promoting complex) activation, and cytokinesis. The mitotic functions of Plk1 during M-phase progression and the importance of PBD for Plk1 function have been comprehensively reviewed in recent years (see reviews, [3-6]). This communication will focus on the dynamic temporal and spatial regulation of Plk1 localization to the interphase and mitotic centromeres as cells proceed through the cell cycle. Failure in this regulation results in a chromosome congression defect that ultimately leads to chromosome missegregation and aneuploidy.Studies in cultured mammalian cells revealed that Plk1 localizes to the centrosomes as early as late S and to the centromeres in early G2. These localizations become most prominent during early mitosis and persist until late anaphase ([7-9], and Fig. 1B). In anaphase, likely due to changes in Plk1-binding proteins, Plk1 delocalizes from the centrosomes and kinetochores and relo
Development of a Novel Recombinant Heamagglutinin-Neuramindase Elisa (rHN-ELISA) for Evaluation of Humoral Immunity in Chicken Vaccinated Against Newcastle Disease Virus (NDV)
Ho-Jin Moon,Jung-Eun Park,Hyeon Yoon,Deu John M. Cruz,Chul-Joong Kim,Hyun-Jin Shin
Journal of Animal and Veterinary Advances , 2012, DOI: 10.3923/javaa.2010.2932.2939
Abstract: Best known method to prevent recurrent out breaks of Newcastle Disease (ND) is by vaccination with specific viral antigens along with better managemental practices. Even after many viral strains utilized for vaccine development, sporadic incidence of ND outbreaks are reported every year. In the present study, an attempt was made to develop a modified diagnostic tool i.e., a recombinant ELISA (rELISA) using prokaryotic expressed recombinant NDV HN (Hemagglutinin-Neuraminidase) protein i.e., the recombinant ND viral protein was cloned and expressed in E. coli after confirmation of the expression; purified protein was used as the coating antigen for rHN-ELISA to study the utility of the presently commercially available vaccines and to compare the present diagnostic method with other alternative detection methods such as ELISA and HI which justified its potential use as a novel diagnostic assay for NDV vaccines. Therefore, an attempt was made to utilise the HN glycoproteins which are fundamentally involved in eliciting immune response against NDV, so that evaluation of antibodies against HN proteins would provide further specific assessment of antibody titres when compared to available diagnostic methods which target to detect antibodies against whole virus. Such novel methods are expected in turn in development of more specific vaccines. Though, rHN-ELISA was inconclusive in its results to substantiate by SN (Serum Neutralizing) test for clearness of neutralizing antibody detection, it may envisage a novel approach towards countering ND outbreaks by supporting its diagnosis and prevention.
A trial for the use of qigong in the treatment of pre and mild essential hypertension: a study protocol for a randomized controlled trial
Ji-Eun Park, Yan Liu, Taeseob Park, Sanghoon Hong, Jung-Eun Kim, Tae-Hun Kim, Ae-Ran Kim, So-Young Jung, Hyoju Park, Sun-Mi Choi
Trials , 2011, DOI: 10.1186/1745-6215-12-244
Abstract: Our objectives are the following: 1) To evaluate the effects of qigong on blood pressure, health status and hormone levels for pre- or mild hypertension. 2) To test the methodological appropriateness of this clinical trial and calculate a sample size for future randomized trials.Forty subjects with pre- or mild hypertension will be randomized to either the qigong exercise group or the non-treated group. Participants in the qigong group will conduct qigong exercises 5 times per week for 8 weeks, and participants in the non-treated group will maintain their current lifestyle, including diet and exercise. The use of antihypertensive medication is not permitted. The primary endpoint is a change in patient blood pressure. Secondary endpoints are patient health status (as measured by the SF-36 and the MYMOP2 questionnaires) and changes in hormone levels, including norepinephrine, epinephrine, and cortisol.This study will be the first randomized trial to investigate the effectiveness of qigong exercises for the treatment of pre- and mild hypertension. The results of this study will help to establish the optimal approach for the care of adults with pre- or mild hypertension.Clinical Research Information Service KCT0000140Hypertension is a risk factor for future cardiovascular events, including heart attack, heart failure, and stroke, which are the most frequent causes of death in developed countries [1,2]. Hypertension affects approximately one billion individuals worldwide, and the prevalence of hypertension tends to increase with age [3]. In Korea, hypertension affects more than 30% of people over the age of 30 and up to 65% of people over 65 [4].Current interventions for hypertension include sodium restriction, pharmacological management, and lifestyle modifications, such as stress management and exercise. However, in clinical practice, hypertension can be difficult to control, due to poor adherence to prescribed interventions [5]. Lifestyle interventions are difficult t
Toll-Like Receptor 4 Decoy, TOY, Attenuates Gram-Negative Bacterial Sepsis
Keehoon Jung, Jung-Eun Lee, Hak-Zoo Kim, Ho Min Kim, Beom Seok Park, Seong-Ik Hwang, Jie-Oh Lee, Sun Chang Kim, Gou Young Koh
PLOS ONE , 2009, DOI: 10.1371/journal.pone.0007403
Abstract: Lipopolysaccharide (LPS), the Gram-negative bacterial outer membrane glycolipid, induces sepsis through its interaction with myeloid differentiation protein-2 (MD-2) and Toll-like receptor 4 (TLR4). To block interaction between LPS/MD-2 complex and TLR4, we designed and generated soluble fusion proteins capable of binding MD-2, dubbed TLR4 decoy receptor (TOY) using ‘the Hybrid leucine-rich repeats (LRR) technique’. TOY contains the MD-2 binding ectodomain of TLR4, the LRR motif of hagfish variable lymphocyte receptor (VLR), and the Fc domain of IgG1 to make it soluble, productive, and functional. TOY exhibited strong binding to MD-2, but not to the extracellular matrix (ECM), resulting in a favorable pharmacokinetic profile in vivo. TOY significantly extended the lifespan, when administered in either preventive or therapeutic manners, in both the LPS- and cecal ligation/puncture-induced sepsis models in mice. TOY markedly attenuated LPS-triggered NF-κB activation, secretion of proinflammatory cytokines, and thrombus formation in multiple organs. Taken together, the targeting strategy for sequestration of LPS/MD-2 complex using the decoy receptor TOY is effective in treating LPS- and bacteria-induced sepsis; furthermore, the strategy used in TOY development can be applied to the generation of other novel decoy receptor proteins.
Exploring the Binding Nature of Pyrrolidine Pocket-Dependent Interactions in the Polo-Box Domain of Polo-Like Kinase 1
Ravichandran N. Murugan, Mija Ahn, Woo Cheol Lee, Hye-Yeon Kim, Jung Hyun Song, Chaejoon Cheong, Eunha Hwang, Ji-Hyung Seo, Song Yub Shin, Sun Ho Choi, Jung-Eun Park, Jeong Kyu Bang
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0080043
Abstract: Background Over the years, a great deal of effort has been focused on the design and synthesis of potent, linear peptide inhibitors targeting the polo-like kinase 1 (Plk1), which is critically involved in multiple mitotic processes and has been established as an adverse prognostic marker for tumor patients. Plk1 localizes to its intracellular anchoring sites via its polo-box domain, and inhibiting the Plk1 polo-box domain has been considered as an approach to circumvent the specificity problems associated with inhibiting the conserved adenosine triphosphate-binding pocket. The polo-box domain consists of two different binding regions, such as the unique, broader pyrrolidine-binding pocket and the conserved, narrow, Tyr-rich hydrophobic channel, among the three Plk polo-box domains (Plks 1–3), respectively. Therefore, the studies that provide insights into the binding nature of the unique, broader pyrrolidine-binding pocket might lead to the development of selective Plk1-inhibitory compounds. Methodology/Principal Findings In an attempt to retain the monospecificity by targeting the unique, broader pyrrolidine-binding pocket, here, for the first time, a systematic approach was undertaken to examine the structure-activity relationship of N-terminal-truncated PLHSpTM derivatives, to apply a site-directed ligand approach using bulky aromatic and non-aromatic systems, and to characterize the binding nature of these analogues using X-ray crystallographic studies. We have identified a new mode of binding interactions, having improved binding affinity and retaining the Plk1 polo-box domain specificity, at the pyrrolidine-binding pocket. Furthermore, our data revealed that the pyrrolidine-binding pocket was very specific to recognize a short and bulky hydrophobic ligand like adamantane, whereas the Tyr-rich hydrophobic channel was specific with lengthy and small hydrophobic groups. Conclusion/Significance The progress made using our site-directed ligands validated this approach to specifically direct the ligand into the unique pyrrolidine-binding region, and it extends the applicability of the strategy for discovering selective protein-protein interaction inhibitors.
Persistent Low Level of Osterix Accelerates Interleukin-6 Production and Impairs Regeneration after Tissue Injury
Wook-Young Baek, Seung-Yoon Park, Yeo Hyang Kim, Min-A Lee, Tae-Hwan Kwon, Kwon-Moo Park, Benoit de Crombrugghe, Jung-Eun Kim
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0069859
Abstract: Osterix (Osx) is an essential transcription factor for osteoblast differentiation and bone formation. Osx knockout show a complete absence of bone formation, whereas Osx conditional knockout in osteoblasts produce an osteopenic phenotype after birth. Here, we questioned whether Osx has a potential role in regulating physiological homeostasis. In Osx heterozygotes expressing low levels of Osx in bones, the expression levels of pro-inflammatory cytokines were significantly elevated, indicating that reduced Osx expression may reflect an inflammatory-prone state. In particular, the expression of interleukin-6, a key mediator of chronic inflammation, was increased in Osx heterozygotes and decreased in Osx overexpressing osteoblasts, and transcriptionally down-regulated by Osx. Although no significant differences were revealed in renal morphology and function between Osx heterozygotes and wild-type under normoxic conditions, recovery of kidneys after ischemic damage was remarkably delayed in Osx heterozygotes, as indicated by elevated blood urea nitrogen and creatinine levels, and by morphological alterations consistent with acute tubular necrosis. Eventually, protracted low Osx expression level caused an inflammatory-prone state in the body, resulting in the enhanced susceptibility to renal injury and the delayed renal repair after ischemia/reperfusion. This study suggests that the maintenance of Osx expression in bone is important in terms of preventing the onset of an inflammatory-prone state.
Anti-Inflammatory and Immune-Regulatory Effects of Subcutaneous Perillae fructus Extract Injections on OVA-Induced Asthma in Mice
Yun-Kyoung Yim,Hyun Lee,Kwon-Eui Hong,Young-Il Kim,Seung-Kyoung Ko,Jung-Eun Kim,Seung-Yong Lee,Kwang-Suk Park
Evidence-Based Complementary and Alternative Medicine , 2010, DOI: 10.1093/ecam/nem118
Abstract: Perillae fructus (perilla seed) is a traditional medicinal herb used to treat bronchial asthma in Oriental medical clinics. ST36 is one of the most widely used acupuncture points, particularly for immune system regulation. Injection of an herbal extract into an acupuncture point (herbal acupuncture) is a therapeutic technique combining both acupuncture and herbal treatment. Perillae fructus extract was injected subcutaneously (Perillae fructus herbal acupuncture; PF-HA) at acupoint ST36 of OVA-induced asthmatic mice. The lung weight, bronchoalveolar fluid (BALF) cell count, the number of CCR3+, CD11b+, CD4+ and CD3e+/CD69+ cells in the lung, and the level of IgE, IL-4, IL-5 and IL-13 in BALF and serum were then measured. RT-PCR was used to measure the mRNA expression of IL-4, IL-5, IL-13 and TNF-α in the lung. Lung sections were analyzed histologically. PF-HA significantly reduced lung weight, the number of inflammatory cells in the lung and BALF, the levels of IgE and Th2 cytokines in BALF and serum, mRNA expression of Th2 cytokines in the lung, and pathological changes in lung tissue. Our results suggest that PF-HA may have an anti-inflammatory and immune-regulatory effect on bronchial allergic asthma by restoring the Th1/Th2 imbalance in the immune system and suppressing eosinophilic inflammation in airways.
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