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Search Results: 1 - 10 of 62422 matches for " Jun-Yong Choi "
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Moxibustion for hypertension: a systematic review
Jong-In Kim, Jun-Yong Choi, Hyangsook Lee, Myeong Soo Lee, Edzard Ernst
BMC Cardiovascular Disorders , 2010, DOI: 10.1186/1471-2261-10-33
Abstract: We searched 15 databases without language restrictions from their respective dates of inception until March 2010. We included randomized controlled trials (RCTs) comparing moxibustion to either antihypertensive drugs or no treatment. The risk of bias was assessed for each RCT.During the course of our search, we identified 519 relevant articles. A total of 4 RCTs met all the inclusion criteria, two of which failed to report favorable effects of moxibustion on blood pressure (BP) compared to the control (antihypertensive drug treatment alone). However, a third RCT showed significant effects of moxibustion as an adjunct treatment to antihypertensive drug therapy for lowering BP compared to antihypertensive drug therapy alone. The fourth RCT included in this review addressed the immediate BP-lowering effects of moxibustion compared to no treatment. None of the included RCTs reported the sequence generation, allocation concealment and evaluator blinding.There is insufficient evidence to suggest that moxibustion is an effective treatment for hypertension. Rigorously designed trials are warranted to answer the many remaining questions.By 2025, the number of adults with hypertension is predicted to be 1.56 billion worldwide [1]. Despite the efforts of conventional healthcare, more than 50% of the patients with high blood pressure (BP) fail to satisfactorily control this condition [2]. One reason is the adverse effects of many antihypertensive drugs, which result in patient noncompliance [3]. Therefore, a substantial proportion of hypertensive patients resort to complementary and alternative medicines to reduce their BP [4,5].Moxibustion is a traditional East Asian medical intervention that involves the burning of moxa (i.e., Artemisia vulgaris or mugwort) directly or indirectly at the acupuncture points. The indications of moxibustion include breech presentation, dysmenorrhea, knee osteoarthritis, diarrhea, asthma, stroke, cancer and hypertension, and so on [6,7]. Unlike th
Unique fiber sum decomposability of genus 2 Lefschetz fibrations
Jun-Yong Park
Mathematics , 2015,
Abstract: By applying the lantern relation substitutions to the positive relation of the genus two Lefschetz fibration over $\mathbb{S}^{2}$. We show that $K3\#2 \overline{\mathbb{CP}}{}^{2}$ can be rationally blown down along seven disjoint copies of the configuration $C_2$. We compute the Seiberg-Witten invariant of the resulting symplectic 4-manifolds, and show that they are symplectically minimal. We also investigate how these exotic smooth 4-manifolds constructed via lantern relation substitution method are fiber sum decomposable. Furthermore by considering all the possible decompositions for each of our decomposable exotic examples, we will find out that there is a uniquely decomposing genus 2 Lefschetz fibration which is not a self sum of the same fibration up to diffeomorphism on the indecomposable summands.
Acupuncture Treatment of a Patient with Persistent Allergic Rhinitis Complicated by Rhinosinusitis and Asthma
Ae-Ran Kim,Jun-Yong Choi,Jong-In Kim,So-Young Jung,Sun-Mi Choi
Evidence-Based Complementary and Alternative Medicine , 2011, DOI: 10.1093/ecam/nep240
Abstract: A pathophysiologic relationship between allergic rhinitis and rhinosinusitis and asthma has long been suggested. However, few clinical studies of acupuncture have been conducted on these comorbid conditions. A 48-year-old male suffering from persistent allergic rhinitis with comorbid chronic rhinosinusitis and asthma since the age of 18 years was studied. He complained of nasal obstruction, sneezing, cough, rhinorrhea and moderate dyspnea. He occasionally visited local ear-nose-throat clinics for his nasal symptoms, but gained only periodic symptom relief. The patient was treated with acupuncture, infrared radiation to the face and electro-acupuncture. Needles were inserted at bilateral LI20, GV23, LI4 and EX-1 sites with De-qi. Electro-acupuncture was performed simultaneously at both LI20 sites and additional traditional Korean acupuncture treatments were performed. Each session lasted for 10 min and the sessions were carried out twice a week for 5 weeks. The patient’s Mini-Rhinoconjunctivitis Quality-of-Life Questionnaire score decreased from 38, at the beginning of treatment, to 23, 3 weeks after the last treatment. The Total Nasal Symptom Score was reduced from six (baseline) to five, 3 weeks after the last treatment. There was significant clinical improvement in the forced expiratory volume in 1 s—from 3.01 to 3.50 l—with discontinuation of the inhaled corticosteroid, and no asthma-related complaints were reported. Further clinical studies investigating the effectiveness of acupuncture for the patients suffering from allergic rhinitis and/or rhinosinusitis with comorbid asthma are needed.
Acupuncture for the treatment of tinnitus: a systematic review of randomized clinical trials
Jong-In Kim, Jun-Yong Choi, Dong-Hyo Lee, Tae-Young Choi, Myeong Soo Lee, Edzard Ernst
BMC Complementary and Alternative Medicine , 2012, DOI: 10.1186/1472-6882-12-97
Abstract: Fourteen databases were searched from the dates of their creation to July 4th, 2012. Randomized clinical trials (RCTs) were included if acupuncture was used as the sole treatment. The Cochrane risk of bias tool was used to assess the risk of bias.A total of 9 RCTs met all the inclusion criteria. Their methodological quality was mostly poor. Five RCTs compared the effectiveness of acupuncture or electroacupuncture with sham acupuncture for treating tinnitus. The results failed to show statistically significant improvements. Two RCTs compared a short one-time scalp acupuncture treatment with the use of penetrating sham acupuncture at non-acupoints in achieving subjective symptom relief on a visual analog scale; these RCTs demonstrated significant positive effects with scalp acupuncture. Two RCTs compared acupuncture with conventional drug treatments. One of these RCTs demonstrated that acupuncture had statistically significant effects on the response rate in patients with nervous tinnitus, but the other RCT did not demonstrate significant effects in patients with senile tinnitus.The number, size and quality of the RCTs on the effectiveness of acupuncture for the treatment of tinnitus are not sufficient for drawing definitive conclusions. Further rigorous RCTs that overcome the many limitations of the current evidence are warranted.
Impact of Including Korean Randomized Controlled Trials in Cochrane Reviews of Acupuncture
Kun Hyung Kim,Jae Cheol Kong,Jun-Yong Choi,Tae-Young Choi,Byung-Cheul Shin,Steve McDonald,Myeong Soo Lee
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0047619
Abstract: Acupuncture is commonly practiced in Korea and is regularly evaluated in clinical trials. Although many Cochrane reviews of acupuncture include searches of both English and Chinese databases, there is no information on the value of searching Korean databases. This study aimed to investigate the impact of searching Korean databasesand journals for trials eligible for inclusion in existing Cochrane acupuncture reviews.
Study Protocol: effects of acupuncture on hot flushes in perimenopausal and postmenopausal women – a multicenter randomized clinical trial
Kun-Hyung Kim, Kyung-Won Kang, Hee-Jung Jung, Ji-Eun Park, So-Young Jung, Jun-Yong Choi, Sun-Mi Choi
Trials , 2008, DOI: 10.1186/1745-6215-9-70
Abstract: We aim to evaluate the effectiveness of Traditional Korean Acupuncture (TKA) in conjunction with usual care, compared to usual care alone, on hot flushes in perimenopausal and postmenopausal women in Korea.This study consists of a multi-center randomized controlled trial with 2 parallel arms. Participants included in the study will meet the following criteria: 1) a documented daily average hot flush score ≥ 10 for one week prior to the screening visit 2) not taking HRT and other pharmaceutical therapies which might affect hot flushes or other vasomotor symptoms.While maintaining usual care, the treatment group will receive acupuncture 3 times a week, for a total of 12 sessions over 4 weeks. The control group will receive usual care alone during the same period. Post-treatment follow-up will be performed one month after completing 12 sessions of acupuncture.This trial will provide evidence for the effectiveness of acupuncture as a treatment for hot flushes. The primary endpoint in both groups is a change in hot flush score from baseline to week 4 and/or week 8. As the secondary endpoint, we will employ the Menopause Rating Scale (MRS), a health-related quality of life questionnaire. Further analysis will examine the frequency, severity and difference in symptoms for daytime vs. nighttime hot flushes, sub-domain analysis of MRS, and participants' expectations of acupuncture treatment.Current Controlled Trials ISRCTN49335612Hot flushes are the most frequent climacteric symptom and a major cause of suffering in menopausal women [1,2]. Diminished overall quality of life, social distress and emotional embarrassment are also frequent complaints due to menopause-associated hot flushes [3].The prevalence of hot flushes varies according to ethnicity, region and cultural characteristics [4,5]. Most women experience hot flushes for 6 months to 2 years [4]. For many women, most menopause-related vasomotor symptoms including hot flushes tend to resolve spontaneously within a few
Lantern substitution and new symplectic 4-manifolds with ${b_{2}}^{+} = 3$
Anar Akhmedov,Jun-Yong Park
Mathematics , 2012,
Abstract: Motivated by the construction of H. Endo and Y. Gurtas, changing a positive relator in Dehn twist generators of the mapping class group by using lantern substitutions, we show that 4-manifold $K3#2\CPb$ equipped with the genus two Lefschetz fibration can be rationally blown down along six disjoint copies of the configuration $C_2$. We compute the Seiberg-Witten invariants of the resulting symplectic 4-manifold, and show that it is symplectically minimal. Using our example, we also construct an infinite family of pairwise non-diffeomorphic irreducible symplectic and non-symplectic 4-manifolds homeomorphic to $M = 3\CP# (19-k)\CPb$ for $1 \leq k \leq 4$.
Acupuncture for dry eye: a randomised controlled trial protocol
Tae-Hun Kim, Jong-In Kim, Mi-Suk Shin, Myeong Lee, Jun-Yong Choi, So-Yong Jung, Ae-Ran Kim, Jae-Uk Seol, Sun-Mi Choi
Trials , 2009, DOI: 10.1186/1745-6215-10-112
Abstract: A randomised, patient-assessor blinded, sham (non-acupuncture point, shallow acupuncture) controlled study was established. Participants allocated to verum acupuncture and sham acupuncture groups will be treated three times weekly for three weeks for a total of nine sessions per participant. Seventeen points (GV23; bilateral BL2, GB4, TE23, Ex1 (Taiyang), ST1 and GB20; and left SP3, LU9, LU10 and HT8 for men, right for women) have been selected for the verum acupuncture; for the sham acupuncture, points have been selected that do not coincide with a classical acupuncture point and that are located close to the verum points, except in the case of the rim of the eye. Ocular surface disease index, tear film breakup time, the Schirmer I test, medication quantification scale and general assessment of improvement will be used as outcome variables for evaluating the effectiveness of acupuncture. Safety will also be assessed at every visit. Primary and secondary outcomes will be assessed four weeks after screening. All statistical analyses will be performed using analysis of covariance.The results of this trial will be used as a basis for clarifying the efficacy of acupuncture for dry eye.ClinicalTrials.gov NCT00969280.Dry eye is one of the most frequently occurring opthalmological health problems worldwide. The prevalence of dry eye is estimated to be in the range of 5% to 35% and its incidence has recently been increasing [1]. According to a recent survey, over 20% of outpatients in ophthalmologic clinics in Korea were diagnosed with dry eye [2]. The burden of dry eye involves not only problems with common activities such as reading, carrying out professional work, using the computer, watching television, and driving [3], but also widespread limitations in the activities of daily life, bodily pain, discomfort and lower energy and vitality [4].Currently, the use of artificial tears and lifestyle modifications are the most common choices in management of patients with mild
Evaluation of wet-cupping therapy for persistent non-specific low back pain: a randomised, waiting-list controlled, open-label, parallel-group pilot trial
Jong-In Kim, Tae-Hun Kim, Myeong Lee, Jung Kang, Kun Kim, Jun-Yong Choi, Kyung-Won Kang, Ae-Ran Kim, Mi-Suk Shin, So-Young Jung, Sun-mi Choi
Trials , 2011, DOI: 10.1186/1745-6215-12-146
Abstract: We recruited 32 participants (21 in the wet-cupping group and 11 in the waiting-list group) who had been having PNSLBP for at least 3 months. The participants were recruited at the clinical research centre of the Korea Institute of Oriental Medicine, Korea. Eligible participants were randomly allocated to wet-cupping and waiting-list groups. Following the practice of traditional Korean medicine, the treatment group was provided with wet-cupping treatment at two acupuncture points among the BL23, BL24 and BL25 6 times within 2 weeks. Usual care, including providing brochures for exercise, general advice for PNSLBP and acetaminophen, was allowed in both groups. Separate assessors participated in the outcome assessment. We used the 0 to100 numerical rating scale (NRS) for pain, the McGill Pain Questionnaire for pain intensity (PPI) and the Oswestry Disability Questionnaire (ODQ), and we assessed acetaminophen use and safety issues.The results showed that the NRS score for pain decreased (-16.0 [95% CI: -24.4 to -7.7] in the wet-cupping group and -9.1 [-18.1 to -0.1] in the waiting-list group), but there was no statistical difference between the groups (p = 0.52). However, the PPI scores showed significant differences between the two groups (-1.2 [-1.6 to -0.8] for the wet-cupping group and -0.2 [-0.8 to 0.4] for the waiting-list group, p < 0.01). In addition, less acetaminophen was used in the wet-cupping group during 4 weeks (p = 0.09). The ODQ score did not show significant differences between the two groups (-5.60 [-8.90 to -2.30] in the wet-cupping group and -1.8 [-5.8 to 2.2] in the waiting-list group, p = 0.14). There was no report of adverse events due to wet-cupping.This pilot study may provide preliminary data on the effectiveness and safety of wet-cupping treatments for PNSLBP. Future full-scale randomised controlled trials will be needed to provide firm evidence of the effectiveness of this intervention.ClinicalTrials.gov: (Identifier: NCT00925951)Date of tr
An Angiotensin I Converting Enzyme Polymorphism Is Associated with Clinical Phenotype When Using Differentiation-Syndrome to Categorize Korean Bronchial Asthma Patients
Sung-ki Jung,Jehyeon Ra,Jungchul Seo,Hee-Jae Jung,Jun-Yong Choi,Yong-Ju Cho,Mee-Suk Hong,Joo-Ho Chung,Jinju Kim
Evidence-Based Complementary and Alternative Medicine , 2011, DOI: 10.1093/ecam/nep053
Abstract: In this study, genetic analysis was conducted to investigate the association of angiotensin I converting enzyme (ACE) gene polymorphism with clinical phenotype based on differentiation-syndrome of bronchial asthma patients. Differentiation-syndrome is a traditional Korean medicine (TKM) theory in which patients are classified into a Deficiency Syndrome Group (DSG) and an Excess Syndrome Group (ESG) according to their symptomatic classification. For this study, 110 participants were evaluated by pulmonary function test. Among them, 39 patients were excluded because they refused genotyping. Of the remaining patients, 52 with DSG of asthma (DSGA) and 29 with ESG of asthma (ESGA), as determined by the differentiation-syndrome techniques were assessed by genetic analysis. ACE insertion/deletion (I/D) polymorphism analysis was conducted using polymerase chain reaction (PCR). Student's t, chi-square, Fisher and Hardy-Weinberg equilibrium tests were used to compare groups. No significant differences in pulmonary function were observed between DSGA and ESGA. The genotypic frequency of ACE I/D polymorphism was found to differ slightly between DSGA and ESGA (P = .0495). However, there were no significant differences in allelic frequency observed between DSGA and ESGA (P = .7006, OR = 1.1223). Interestingly, the allelic (P = .0043, OR = 3.4545) and genotypic (P = .0126) frequencies of the ACE I/D polymorphism in female patients differed significantly between DSGA and ESGA. Taken together, the results presented here indicate that the symptomatic classification of DSGA and ESGA by differentiation-syndrome in Korean asthma patients could be useful in evaluation of the pathogenesis of bronchial asthma.
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