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Search Results: 1 - 10 of 44516 matches for " Jun Goo Kang "
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Comparison between the Therapeutic Effect of Metformin, Glimepiride and Their Combination as an Add-On Treatment to Insulin Glargine in Uncontrolled Patients with Type 2 Diabetes
Cheol-Young Park, Jun Goo Kang, Suk Chon, Junghyun Noh, Seung Joon Oh, Chang Beom Lee, Sung Woo Park
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0087799
Abstract: Aims To compare the commonly prescribed oral anti-diabetic drug (OAD) combinations to use as an add-on therapy with insulin glargine in patients with uncontrolled type 2 diabetes despite submaximal doses of OADs. Methods People with inadequately controlled type 2 diabetes (n = 99) were randomly assigned on a 1:1:1 basis to receive insulin glargin, with fixed doses of glimepiride, metformin, and glimepiride plus metformin. Outcomes assessed included HbA1c, the changes in fasting glucose levels, body weight, serum lipids values, insulin dose and symptomatic hypoglycemia. Results After 24 weeks, HbA1C levels improved from (mean ± SD) 8.5±0.9% to 7.7±0.8% (69.0±10.0 mmol/mol to 60.8±8.6 mmol/mol) with insulin glargine plus metformin, from 8.4±1.0% to 7.7±1.3% (68.8±10.6 mmol/mol to 61.1±14.4 mmol/mol) with insulin glargine plus glimepiride and from 8.7±0.9% to 7.3±0.6% (71.7±9.8 mmol/mol to 56.2±6.7 mmol/mol) with insulin glargine plus glimepirde plus metformin. The decrease in HbA1c was more pronounced with insulin glargine plus glimepiride plus metformin than with insulin glargine plus metformin (0.49% [CI, 0.16% to 0.82%]; P = 0.005) (5.10 mmol/mol [CI, 1.64 to 8.61]; P = 0.005) and insulin glargine plus glimepiride (0.59% [CI, 0.13% to 1.05%]; P = 0.012) (5.87 mmol/mol [CI, 1.10 to 10.64]; P = 0.012) (overall P = 0.02). Weight gain and the risk of hypoglycemia of any type did not significantly differ among the treatment groups. Conclusion The combination therapy of metformin and glimepiride plus glargine insulin resulted in a significant improvement in overall glycemic control as compared with the other combinations. Trial registration information ClinicalTrials.gov, NCT00708578. The approval number of Kangbuk Samsung hospital's institutional review board (IRB): C0825.
Tumor budding as a risk factor of lymph node metastasis in submucosal invasive T1 colorectal carcinoma: a retrospective study
Bong-Hyeon Kye, Ji-Han Jung, Hyung-Jin Kim, Se-Goo Kang, Hyeon-Min Cho, Jun-Gi Kim
BMC Surgery , 2012, DOI: 10.1186/1471-2482-12-16
Abstract: In total, 55 patients revealing submucosal invasive colorectal carcinoma on pathology who underwent curative radical resection at the Department of Surgery, St. Vincent’s Hospital, The Catholic University of Korea from January 2007 to September 2010 were evaluated retrospectively. Tumor size, depth of submucosal invasion, histologic grade, lymphovascular invasion, tumor budding, and microacinar structure were reviewed by a single pathologist. Student t-test for continuous variables and Chi-square test for categorical variables were used for comparing the clinicopathological features between two groups (whether lymph node involvement existed or not). Continuous variables are expressed as the mean?±?standard error while statistical significance is accepted at P?<?0.05.The mean age of 55 patients (34 males and 21 females) was 61.2?±?9.6?years (range, 43–83). Histologically, eight (14.5%) patients had metastatic lymph node. In the univariate analysis, tumor budding (P?=?0.047) was the only factor that was significantly associated with lymph node metastasis. Also, the tumor budding had a sensitivity of 83.3%, a specificity of 60.5%, and a negative predictive value of 0.958 for lymph node metastasis in submucosal invasive T1 colorectal cancer.The tumor budding seems to have a high sensitivity (83.3%), acceptable specificity (60.5%), and a high negative predictive value (0.958). A close examination of pathologic finding including tumor budding should be performed in order to manage early CRC properly.An increase in colorectal cancer (CRC) screening and progress in techniques has resulted greater frequency of detection of T1 stage CRC. With recent advances in endoscopic techniques and improved endoscopes, T1 stage CRC and adenomatous polyps are often resected by endoscopes, regardless of their size or location [1-3]. Local treatments such as endoscopic resection and local excision are considered adequate management for early stage CRC without lymph node metastasis. A comple
Stability Problems of Quintic Mappings in Quasi-β-Normed Spaces
In Goo Cho,Dongseung Kang,Heejeong Koh
Journal of Inequalities and Applications , 2010, DOI: 10.1155/2010/368981
Abstract: We investigate the generalized Hyers-Ulam-Rassias stability problem in quasi-β-normed spaces and then the stability by using a subadditive function for the quintic function f:X→Y such that 2f(2x+y)+2f(2x y)+f(x+2y)+f(x 2y)=20[f(x+y)+f(x y)]+90f(x), for all x,y∈X.
Impacts of Pig Manure-Based Liquid Fertilizer Agricultural Application on the Water Quality of Agricultural Catchment  [PDF]
Min-Kyeong Kim, Soon-Ik Kwon, Hyen-Cheng Chun, Goo-Bok Jung, Kee-Kyung Kang
Journal of Environmental Protection (JEP) , 2013, DOI: 10.4236/jep.2013.42023
Abstract:

This study was conducted to understand the effect of the livestock liquid fertilizer treatment at field-scale up to catchment-scale on the water quality properties. Cultivated paddy rice and upland plots located in Gyeonggi province, Korea were treated with two different liquid fertilizers, SP (Liquid fertilizer with storage process) and SCB (Liquid fertilizer with slurry composting and bio-filtration process). Plots with no fertilizer (control A) and chemical fertilizer (control B) were also prepared for comparison. Water quantity and quality were monitored at the catchment outlet for assessing the effect on water quality of stream water. As a result, the losses of N and P and the values of EC (Electronic Conductivity) in the surface drainage water from paddy rice plots treated with SP and SCB were higher than those from the control plots (A and B). In addition, the losses of N and P by the runoff water from upland plots with SP and SCB treatment were higher than those from control plots (A and B). The nutrient outflow from paddy rice fields and uplands with application of liquid pig manure was higher than those from the control plots (A and B). Particularly, the outflow from uplands may directly affect the water quality in neighboring streams. This caused the major eutrophication problem in stream water. In conclusion, it is necessary to establish the proper management practices to prevent the nutrient losses from agricultural fields and the pollutants against water environments.

Epigenetic inactivation of the NORE1 gene correlates with malignant progression of colorectal tumors
Chang Lee, Jin-Hee Lee, Min-Goo Lee, Seong-In Jeong, Tae-Kyu Ha, Min-Ju Kang, Byung-Kyu Ryu, Young Hwangbo, Jae-Jun Shim, Jae Jang, Kil Lee, Hyo Kim, Sung-Gil Chi
BMC Cancer , 2010, DOI: 10.1186/1471-2407-10-577
Abstract: Expression, mutation, and methylation status of NORE1A and NORE1B in 10 cancer cell lines and 80 primary tumors were characterized by quantitative PCR, SSCP, and bisulfite DNA sequencing analyses. Effect of NORE1A and NORE1B expression on tumor cell growth was evaluated using cell number counting, flow cytometry, and colony formation assays.Expression of NORE1A and NORE1B transcript was easily detectable in all normal colonic epithelial tissues, but substantially decreased in 7 (70%) and 4 (40%) of 10 cancer cell lines and 31 (38.8%) and 25 (31.3%) of 80 primary carcinoma tissues, respectively. Moreover, 46 (57.6%) and 38 (47.5%) of 80 matched tissue sets exhibited tumor-specific reduction of NORE1A and NORE1B, respectively. Abnormal reduction of NORE1 was more commonly observed in advanced stage and high grade tumors compared to early and low grade tumors. While somatic mutations of the gene were not identified, its expression was re-activated in all low expressor cells after treatment with the demethylating agent 5-aza-dC. Bisulfite DNA sequencing analysis of 31 CpG sites within the promoter region demonstrated that abnormal reduction of NORE1A is tightly associated with promoter CpG sites hypermethylation. Moreover, transient expression and siRNA-mediated knockdown assays revealed that both NORE1A and NORE1B decrease cellular growth and colony forming ability of tumor cells and enhance tumor cell response to apoptotic stress.Our data indicate that epigenetic inactivation of NORE1 due to aberrant promoter hypermethylation is a frequent event in colorectal tumorigenesis and might be implicated in the malignant progression of colorectal tumors.Mutational activation of Ras plays a critical role in the development and malignant progression of many human tumors [1,2]. Ras oncoproteins participate in the regulation of a broad range of biological processes, including cell growth and differentiation, membrane trafficking, transcriptional regulation and apoptosis [2,3]. Ra
First-Principles Calculations on the Half-Metallicity of Rock-Salt Ferromagnetic FeO  [PDF]
Jun Liu, Xiaolan Yang, Wei Kang
Journal of Materials Science and Chemical Engineering (MSCE) , 2015, DOI: 10.4236/msce.2015.39001
Abstract:

The geometrical structure of ferromagnetic FeO is optimized. Its electric and magnetic properties such as the half-metallicity, the conductivity and the magnetic moment distribution are investigated by performing first-principles calculations within the generalized gradient approximation for the exchange-correlation function based on density functional theory. Results show that ferromagnetic FeO has 100% spin-polarization at the Fermi level. Its supercell magnetic moments are 32.00 μB, which arise mainly from 3d-orbits of Fe-ions. The electronic structures of Fe-ions are Fe2+t2g3↑eg2↑t*2g1↓.

Development of Standardization and Management System for the Severity of Unpaved Test Courses
Do-Kyung Kang,Sang-Ho Lee,Sang-Hwa Goo
Sensors , 2007, DOI: 10.3390/s7092004
Abstract: The vibration environment essentially accompanied by vehicle operation on theground is determined by the shape of road surface, which is called as profile. This paperfocuses on the development of profile measurement and severity analysis system forunpaved test courses. In general, the profile and severity of unpaved road is an importantissue in the reliability of endurance test. In order to measure and maintain unpaved roadprofile and severity, it is necessary to develop a profilometer system. The developedprofilometer system is composed of data processing computer, power unit, air compressorand sensors(encoder, vertical gyro and laser displacement). This study presents themeasuring system configuration, measurement principle of road profile and analysismethod of road characteristics used at CPG (Chang-won Proving Ground) for this purpose.In order to standardize and manage the severity of unpaved test courses, neural network isapplied
Microarray data mining using landmark gene-guided clustering
Pankaj Chopra, Jaewoo Kang, Jiong Yang, HyungJun Cho, Heenam Kim, Min-Goo Lee
BMC Bioinformatics , 2008, DOI: 10.1186/1471-2105-9-92
Abstract: By applying our SigCalc algorithm to three yeast Saccharomyces cerevisiae datasets we show two results. First, we show that different sets of clusters can be generated from the same dataset using different sets of landmark genes. Each set of clusters groups genes differently and reveals new biological associations between genes that were not apparent from clustering the original microarray expression data. Second, we show that many of these new found biological associations are common across datasets. These results also provide strong evidence of a link between the choice of landmark genes and the new biological associations found in gene clusters.We have used the SigCalc algorithm to project the microarray data onto a completely new subspace whose co-ordinates are genes (called landmark genes), known to belong to a Biological Process. The projected space is not a true vector space in mathematical terms. However, we use the term subspace to refer to one of virtually infinite numbers of projected spaces that our proposed method can produce. By changing the biological process and thus the landmark genes, we can change this subspace. We have shown how clustering on this subspace reveals new, biologically meaningful clusters which were not evident in the clusters generated by conventional methods. The R scripts (source code) are freely available under the GPL license. The source code is available [see Additional File 1] as additional material, and the latest version can be obtained at http://www4.ncsu.edu/~pchopra/landmarks.html webcite. The code is under active development to incorporate new clustering methods and analysis.Microarrays have enabled scientists to monitor the activities of thousands of genes simultaneously. Clustering methods provide a useful technique for exploratory analysis of microarray data since they group genes with similar expression patterns together. It is believed that genes that display similar expression patterns are often involved in similar
Harmonic Enhancement in Low Bitrate Audio Coding Using an Efficient Long-Term Predictor
Jeongook Song,Chang-Heon Lee,Hyen-O Oh,Hong-Goo Kang
EURASIP Journal on Advances in Signal Processing , 2010, DOI: 10.1155/2010/939542
Abstract:
Harmonic Enhancement in Low Bitrate Audio Coding Using an Efficient Long-Term Predictor
Song Jeongook,Lee Chang-Heon,Oh Hyen-O,Kang Hong-Goo
EURASIP Journal on Advances in Signal Processing , 2010,
Abstract: This paper proposes audio coding using an efficient long-term prediction method to enhance the perceptual quality of audio codecs to speech input signals at low bit-rates. The MPEG-4 AAC-LTP exploited a similar concept, but its improvement was not significant because of small prediction gain due to long prediction lags and aliased components caused by the transformation with a time-domain aliasing cancelation (TDAC) technique. The proposed algorithm increases the prediction gain by employing a deharmonizing predictor and a long-term compensation filter. The look-back memory elements are first constructed by applying the de-harmonizing predictor to the input signal, then the prediction residual is encoded and decoded by transform audio coding. Finally, the long-term compensation filter is applied to the updated look-back memory of the decoded prediction residual to obtain synthesized signals. Experimental results show that the proposed algorithm has much lower spectral distortion and higher perceptual quality than conventional approaches especially for harmonic signals, such as voiced speech.
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