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Search Results: 1 - 10 of 367855 matches for " Juliane S. Silva "
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Computational Analysis of Physicochemical, Pharmacokinetic and Toxicological Properties of Deoxyhypusine Synthase Inhibitors with Antimalarial Activity  [PDF]
Nayara S. R. Silva, Luana K. S. Gon?alves, Jonatas L. Duarte, Juliane S. Silva, César F. Santos, Francinaldo S. Braga, Raí C. Silva, Josivan S. Costa, Lorane I. S. Hage-Melim, Cleydson B. R. dos Santos
Computational Molecular Bioscience (CMB) , 2014, DOI: 10.4236/cmb.2014.44006
Abstract: Malaria is a parasitic disease which has as etiological agents protozoa of the genus Plasmodium prevalent in tropical countries. The appearance of Plasmodium strains resistant to artemisinin has become necessary the development of new drugs using computational tools to combat this epidemic. Diverse transporter proteins can act as antimalarials targets, thereby being the enzyme deoxyhypusine synthase a promising antimalarial target. The present study aimed to investigate 15 most active inhibitors of deoxyhypusine synthase target, deposited in databases Binding DB, in order to trace a pattern of physicochemical, pharmacokinetic and toxicological properties of the inhibitors for this enzyme and propose new inhibitors of deoxyhypusine synthase target. The physicochemical properties were obtained according to the Lipinski parameters to evaluate oral absorption. Based on the certain properties were proposed three new inhibitors (A, B and C). The ADME/Tox properties were calculated for new inhibitors compared with results of the selected compounds. The fifteen inhibitors for oral administration showed satisfactory results, because they have adapted to the Lipinski parameters. In relation to the penetration of the blood-brain barrier the inhibitors analyzed showed penetration values less than 1, and ranged from 0.0411815 to 0.481764, being that the compound 1 showed value of CBrain/CBlood = 0.135467. Compound B showed a higher strength in plasma protein binding in relation to the compound 1, having a variation be-tween them of ±1.489344. Therefore, the compound B would present a longer halflife compared with compound 1. The proposed compounds showed positive and satisfactory results, being able to reach less adverse effects related to the central nervous system depending of administered dose.
Agente Comunitário de Saúde no controle da tuberculose na Aten o Primária à Saúde Agente Comunitario de Salud en el control de la tuberculosis en la Atención Primaria a la Salud The Community Health Agent in the control of tuberculosis in Primary Health Care
Juliane de Almeida Crispim,Beatriz Estuque Scatolin,Laís Mara Caetano da Silva,Ione Carvalho Pinto
Acta Paulista de Enfermagem , 2012,
Abstract: OBJETIVO: Avaliar o desempenho do Agente Comunitário de Saúde (ACS) no controle da tuberculose (TB) em áreas assistidas pela Estratégia Saúde da Família (ESF), sendo estabelecida uma análise comparativa com os ACSs inscritos nas Unidades Básicas de Saúde (UBS) tradicionais. MéTODOS: Estudo transversal, realizado em um município prioritário para o controle da TB no Estado de S o Paulo, com uma amostra mínima de 108 ACSs das ESFs e das UBSs. Para a coleta de dados, utilizou-se um instrumento elaborado para a Aten o Primária à Saúde (APS), adaptado para aten o à TB. RESULTADOS: No que concerne às a es de controle da TB, observou-se que n o houve diferen as com significancia estatística entre o desempenho dos ACSs das unidades da ESF e os inscritos nas UBSs. CONCLUS O: O estudo evidenciou a fragilidade dos ACSs em incorporar na sua prática as a es de controle da TB nas distintas modalidades de APS, apesar do destaque dado à ESF. OBJETIVO: Evaluar el desempe o del Agente Comunitario de Salud (ACS) en el control de la tuberculosis (TB) en áreas asistidas por la Estrategia Salud de la Familia (ESF), siendo establecido un análisis comparativo con los ACSs inscritos en las Unidades Básicas de Salud (UBS) tradicionales. MéTODOS: Estudio transversal, realizado en un municipio prioritario para el control de la TB en el Estado de Sao Paulo, con una muestra mínima de 108 ACSs de las ESFs y de las UBSs. Para la recolección de los datos se utilizó un instrumento elaborado para la Atención Primaria a la Salud (APS), adaptado para la atención a la TB. RESULTADOS: En lo que concierne a las acciones de control de la TB, se observó que no hubo diferencias con significancia estadística entre el desempe o de los ACSs de las unidades de la ESF y los inscritos en las UBSs. CONCLUSIóN: En el estudio se evidenció la fragilidad de los ACSs para incorporar en su práctica acciones de control de la TB en las distintas modalidades de APS, a pesar de la importancia dada a la ESF. OBJECTIVE: To evaluate the performance of the Community Health Agent (CHA) in the control of tuberculosis (TB) in areas served by the Family Health Strategy (FHS), which established a comparative analysis with the CHAs enrolled in the traditional Basic Health Units (BHU) . METHODS: A cross-sectional study in a priority municipality for TB control in the state of S o Paulo, with a minimum sample of 108 CHAs of FHSs and the BHUs. For the collection of data, we used an instrument developed for Primary Health Care (PHC), adapted for TB care. RESULTS: With regard to the actions of TB control, it was observed th
Análise retrospectiva dos pacientes infectados por RSV na unidade de transplante de medula óssea
Piazera, Flavia Z.;Fortier, Sergio C.;Morando, Juliane;Bonfim, Carmem M. S.;Silva, Rodney F.;Cunha, Clovis A.;Zanis Neto, José;
Revista Brasileira de Hematologia e Hemoterapia , 2009, DOI: 10.1590/S1516-84842009005000083
Abstract: respiratory syncytial virus (rsv) causes significant mortality in patients submitted to sct. despite the use of ribavirin aerosols (ra), mortality rates are still between 30 and 40% in many centers. the objective of this study was to analyze the clinical course and outcome of 59 patients who developed rsv infections after sct in a single institution. in this retrospective analysis, the diagnosis of rsv infection was confirmed in 59 patients submitted to hsct. ra was administrated during 12 hours at a dose of 5g diluted in 200 ml of distillated water, for 5 days. fifteen patients presented with upper respiratory tract (urt) infection and 44 patients presented with lower respiratory tract (lrt) infection. in the group of patients who received ra (n=50), 40 had urt infections and 10 had lrt infections. in patients who did not receive ra, 3 had urt infections and 6 had lrt infections. twenty patients died (33.8%) with the main cause of death of 13 patients being rsv infection (all these patients required mechanical ventilation). nine patients died before ra therapy became standard treatment for rsv (before 1992). the overall survival of patients treated with ra was 66%. however, the overall survival was lower in patients who had lrt infections (37.5%) compared with those who had urt infections (67.5% - p=0.007). in the multivariate analysis, only the use of ra affected overall survival (p=0.001).
Detection of free circulating Epstein-Barr virus DNA in plasma of patients with Hodgkin?s disease
Musacchio, Juliane Garcez;Carvalho, Maria da Glória da Costa;Morais, José Carlos Oliveira de;Silva, Nathalie Henriques;Scheliga, Adriana;Romano, Sérgio;Spector, Nelson;
Sao Paulo Medical Journal , 2006, DOI: 10.1590/S1516-31802006000300009
Abstract: context and objective: free circulating epstein-barr virus (ebv) dna is often present in the plasma of hodgkin?s disease patients. the aim here was to evaluate the prevalence of this finding, its correlation with the immunohistochemical expression of lmp-1 (latent membrane protein 1) and the influence of other clinical factors. design and setting: prospective study in two public tertiary institutions: hematology service, universidade federal do rio de janeiro, and oncology service, instituto nacional do cancer, rio de janeiro. methods: a cohort of 30 patients with newly diagnosed hodgkin?s disease was studied. the control group consisted of 13 healthy adult volunteers. ebv dna was determined by conventional polymerase chain reaction (pcr). results: the median age was 28 years, and 16 patients were women. advanced disease was present in 19 patients, and six were hiv-positive. ebv dna was present in the plasma of 13 patients and one control (43% versus 8%, p = 0.03). ebv dna prevalence was higher in hiv-positive patients (100% versus 29%, p = 0.0007) and those with advanced disease (63% versus 9%, p = 0.006). among hiv-negative patients alone, ebv dna prevalence remained higher in those with advanced disease. ebv dna was found in 10/11 patients with lmp-1 expression in the lymph nodes, and in 3/19 without lmp-1 expression (kappa coefficient = 0.72). conclusion: ebv dna was present in 91% of patients with ebv-associated hodgkin?s disease, and in all patients with hiv-associated hodgkin?s disease. ebv dna prevalence was higher in patients with advanced disease, irrespective of hiv status.
Evaluation of an Experimental Gel Containing Euclea natalensis: An In Vitro Study
Sílvia Helena de Carvalho Sales-Peres,Letícia Ferreira de Freitas Brianezzi,Juliane Avansini Marsicano,Moacir Rossi Forim,Maria Fatima das Gra as Fernandes da Silva,Arsenio Sales-Peres
Evidence-Based Complementary and Alternative Medicine , 2012, DOI: 10.1155/2012/184346
Abstract: Objective. To evaluate the effect of an experimental gel containing Euclea natalensis extract on dentin permeability. Methods. Thirty-six dentin discs, 1-mm-thick. The discs were prepared from the coronal dentin of extracted human third molars that were divided into 3 groups (). The dentin discs in each group were treated with the groups following experimental materials: (FG): 1.23% fluoride gel, pH 4.1; (EG): Euclea natalensis extract gel, pH 4.1; (CG): control gel, pH 4.1. The gels were applied to the occlusal slide of the dentin under the following conditions: after 37% phosphoric acid and before 6% citric acid. The hydraulic conductance (HC) of each condition was determined four times using a fluid flow apparatus (Flodec). The data were analyzed using Two-way ANOVA and Tukey's test (). Results. The greatest mean reduction in HC was produced in group EG dentin discs (61.2%; ). Even after acid challenge with 6% citric acid the great reduction occurred in group EG (66.0%; ) than other groups (CG-77.1%, FG-90.8%). Conclusion. E. natalensis gel not only reduced dentin permeability, but also resisted posttreatment citric acid challenge without changing its permeability. Further research has to confirm this promising result in the clinical situation.
Biocompatibility of Intracanal Medications Based on Calcium Hydroxide
Carolina Andolfatto,Guilherme Ferreira da Silva,Ana Livia Gomes Cornélio,Juliane Maria Guerreiro-Tanomaru,Mario Tanomaru-Filho,Gisele Faria,Idomeo Bonetti-Filho,Paulo Sérgio Cerri
ISRN Dentistry , 2012, DOI: 10.5402/2012/904963
Abstract: Objective. The aim of this study was to evaluate the rat subcutaneous tissue reaction to calcium hydroxide-based intracanal medicaments, UltraCal XS (calcium hydroxide, barium sulphate, aqueous matrix), Hydropast (calcium hydroxide, barium sulphate, and propyleneglycol), and Calen (Calcium hydroxide, zinc oxide, colophony, and polyethyleneglycol), used as a control. Methods. Forty-eight rats (Rattus Norvegicus Holtzman) were distributed in three groups: Calen, UltraCal XS, and Hydropast. Polyethylene tubes filled with one of the medicaments were implanted in the dorsal subcutaneous. After 7 and 30 days, the implants were removed and the specimens were fixed and embedded in paraffin. Morphological and quantitative analyses were carried out in the HE-stained sections. The numerical density of inflammatory cells in the capsule was evaluated and statistical analyses were performed ( ). Results. At 7 days, all materials induced an inflammatory reaction in the subcutaneous tissue adjacent to the implants. In all groups, a significant reduction in the number of inflammatory cells and giant cells was verified in the period of 30 days. Conclusion. These results indicate that the calcium hydroxide-based medicaments evaluated present biocompatibility similar to Calen. 1. Introduction The success of endodontic treatment of teeth with periapical lesion depends on the reduction or elimination of the intraradicular infection [1, 2]. The root canal mechanical preparation is not enough to eliminate this infection because many microorganisms are not only in the main root canal, but also disseminated throughout the root canal system. Therefore, the use of an intracanal dressing to eliminate the microorganisms is indicated [3–6]. Antimicrobial activity and biocompatibility are characteristics that an ideal intracanal dressing has to show [7]. Calcium hydroxide [Ca(OH)2] has been widely used for its biological and antimicrobial activity [4, 8], ability to dissolve organic tissue [9], and capacity to inactivate bacterial endotoxin [10, 11]. Despite these properties, the Ca(OH)2 has no satisfactory physical properties such as radiopacity to visualize on dental radiographs and flow capacity to facilitate its insertion in the root canal [12, 13]. For this reason, it needs the incorporation of a radiopacifying agent and a vehicle to improve these characteristics [8, 14]. Although the Ca(OH)2 shows an excellent biocompatibility, the addition of other substances can affect its biological properties [8, 12]. In the last years, it has been marketed the calcium hydroxide-based
A rela??o entre o processamento fonológico e a habilidade de leitura: evidência da síndrome de Down e da síndrome de Williams
Cardoso-Martins, Cláudia;Silva, Juliane Ribeiro da;
Psicologia: Reflex?o e Crítica , 2008, DOI: 10.1590/S0102-79722008000100019
Abstract: the present article presents a review of studies which investigated the relationship between phonological processing skills and the ability to read words in two developmental disorders: down syndrome (ds) and williams syndrome (ws). results suggest that, like children without developmental disorders, individuals with ds and individuals with ws learn to read by processing and remembering letter-sound relations in words. it is nonetheless possible that non-phonological processes play a more important role in reading skills among individuals with ds and ws than among typically developed children. as discussed in the text, there is evidence that variations in non-verbal abilities are more strongly correlated with reading ability in ds and ws than among children with typical reading development.
ácidos graxos ?mega 3 e tratamento da esquizofrenia
Zemdegs, Juliane Costa Silva;Pimentel, Gustavo Duarte;Priel, Margareth Rose;
Revista de Psiquiatria Clínica , 2010, DOI: 10.1590/S0101-60832010000500007
Abstract: background: schizophrenia is a complex and debilitating psychiatric disorder, whose primary pharmacological intervention is the use of antipsychotics. there is, however, growing evidence that dietary supplementation with omega 3 fatty acids (n-3) may be beneficial in several psychiatric conditions. objective: to review the efficacy of n-3 as a treatment for schizophrenia. methods: electronic searches of the following databases were performed: medline, lilacs e scielo. the search strategy also included cited reference searching. all relevant randomized controlled trials were included in the review. results: to date, five out of six randomized, double-blind, and placebo controlled studies obtained improvement in the symptoms of the psychosis. besides, an advantage in the intake of eicosapentaenoic fatty acid (epa) in relation to docosahexaenoic fatty acid was designated. essentially, the intake of 2 g/day of epa in addition to the standard medication was effective in decreasing the symptoms of schizophrenia. discussion: the nutritional therapy with epa revealed to be useful as coadjutant in the treatment of schizophrenia. therefore, we suggest that the schizophrenic patients should be encouraged to consume balanced and healthy meals rich in epa and, if the ideal amount is not reached by the diet, the supplementation is likely to be beneficial.
Presenteeism in hospital nurses
Umann, Juliane;Guido, Laura de Azevedo;Grazziano, Eliane da Silva;
Revista Latino-Americana de Enfermagem , 2012, DOI: 10.1590/S0104-11692012000100021
Abstract: this quantitative, descriptive, cross-sectional research aimed to determine the estimated productivity of health-related limitations at work in 129 nurses working in direct care delivery to critical and potentially critical patients. instruments were applied for socio-demographic and functional characterization and for the evaluation of presenteeism (work limitations questionnaire). statistical package for the social sciences software was used for data analysis. in this study, 75% of nurses obtained a lost productivity index of up to 4.84%. the physical demand domain represented the major limitation for these professionals (25%). presenteeism was directly correlated to health care, occurrence and number of absences, and indirectly related to work time at the unit. it was concluded that organizational or individual factors influence individuals' productivity, in view of the circumstances involving care delivery to critical and potentially critical patients.
The relationship between phonological processing and reading ability: evidence from Down syndrome and Williams syndrome / A rela o entre o processamento fonológico e a habilidade de leitura: evidência da síndrome de Down e da síndrome de Williams
Cláudia Cardoso-Martins,Juliane Ribeiro da Silva
Psicologia: Reflex?o e Crítica , 2008,
Abstract: The present article presents a review of studies which investigated the relationship between phonological processing skills and the ability to read words in two developmental disorders: Down syndrome (DS) and Williams syndrome (WS). Results suggest that, like children without developmental disorders, individuals with DS and individuals with WS learn to read by processing and remembering letter-sound relations in words. It is nonetheless possible that non-phonological processes play a more important role in reading skills among individuals with DS and WS than among typically developed children. As discussed in the text, there is evidence that variations in non-verbal abilities are more strongly correlated with reading ability in DS and WS than among children with typical reading development.
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