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Search Results: 1 - 10 of 5075 matches for " Juliana;Bentley "
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Stratum corneum lipids liposomes for the topical delivery of 5-aminolevulinic acid in photodynamic therapy of skin cancer: preparation and in vitro permeation study
Maria Pierre, Ant?nio C Tedesco, Juliana M Marchetti, M Vitória LB Bentley
BMC Dermatology , 2001, DOI: 10.1186/1471-5945-1-5
Abstract: SCLLs were obtained by reverse phase evaporation technique and size distribution of the vesicles was determinated by photon correlation spectroscopy. In vitro permeation profile was characterized using hairless mouse skin mounted in modified Franz diffusion cell.Size exclusion chromatography on gel filtration confirmed vesicle formation. SCLLs obtained by presented a degree of encapsulation of 5-ALA around 5.7%. A distribution of vesicle size centering at around 500 nm and 400 nm respectively for SCLLs and SCLLs containing 5-ALA was found. In vitro 5-ALA permeation study showed that SCLLs preparations presented higher skin retention significantly (p < 0.05) on the epidermis without SC + dermis, with a decreasing of skin permeation compared to aqueous solution.The in vitro delivery performance provided by SCLLs lead to consider this systems adequate for the 5-ALA-PDT of skin cancer, since SCLLs have delivered 5-ALA to the target skin layers (viable epidermis + dermis) to be treated by topical PDT of skin cancer.Photodynamic therapy (PDT) is a modality of experimental cancer treatment using a photosensitizer, which localizes in tumor tissue and can produce tissue destruction upon absorption of light of an appropriate wavelength and dose [1]. The topical application of 5-aminolevulinic acid (5-ALA) followed by light irradiation is a new concept of PDT [2]. 5-ALA is a prodrug that can be converted in situ into a highly fluorescent substance, protoporphyrin IX (PpIX), an effective photosensitizer by the heme biosynthetic pathway. The presence of exogenous 5-ALA bypasses feedback control, and thus may induce intracellular accumulation of photosensitizing concentrations of PpIX [3]. Topical photodynamic therapy using 5 aminolevulinic acid (5-ALA-PDT) has shown to be highly efficient for the topical treatment of a variety of superficial skin malignances [4]; it presents advantages over conventional treatments, like surgery, electrodessication, cryosurgery, topical applicati
HPLC assay of lidocaine in in vitro dissolution test of the Poloxamer 407 gels
Ricci Júnior, Eduardo;Bentley, Maria Vitória Lopes Badra;Marchetti, Juliana Maldonado;
Revista Brasileira de Ciências Farmacêuticas , 2002, DOI: 10.1590/S1516-93322002000100011
Abstract: a simple high performance liquid chromatography method to assay lidocaine hydrochloride in aqueous receiving media, following in vitro release, is presented. lidocaine hydrochloride was analysed using a 5 mm lichrocart? rp-18 column (125 x 4 mm i.d.). the mobile phase was acetonitrile: 0.05 m sodium phosphate buffer, ph 6.0 (35:65) and 0.05% of diethylamine at a flow rate of 1 ml/min. the retention time was 7.9 min. detection was carried out at 210 nm at room temperature (28 oc). the method was found to be linear in the range 1.25 to 25 mg/ml, showing average intraassay and inter-assay coefficients of variation below 3.5%. the proposed method was validated for linearity, specificity, precision and accuracy and was shown to be useful for the analysis of lidocaine hydrochloride in in vitro release studies.
A study of the characteristics and in vitro permeation properties of CMC/ chitosan microparticles as a skin delivery system for vitamin E
Alencastre, Juliana Bucchi;Bentley, Maria Vitoria Lopes Badra;Garcia, Fabiola Silva;Moragas, Maria de;Viladot, Joseph Luis;Marchetti, Juliana Maldonado;
Revista Brasileira de Ciências Farmacêuticas , 2006, DOI: 10.1590/S1516-93322006000100007
Abstract: carboxymethylcellulose (cmc)/chitosan microparticles containing vitamin e were prepared by a complex coacervation method and their potential use as a topical delivery system was evaluated. morphology, particle size distribution, encapsulation yield, physical and chemical stability, in vitro release and permeation through skin were studied. the microparticles appeared to be spherical, with a homogeneous surface and were not aggregated. mean diameters ranged from 2.7 to 7.6 μm and the encapsulation yield was 81%. chemical stability studies indicated a protection of encapsulated vitamin e, of 8.1% for o/w and of 10.83% for w/o emulsions, following storage at 45 °c for 60 days. forty-eight% of vitamin e, determined by hplc, were released within 24 hours. in vitro permeation and retention studies showed a higher penetration rate of vitamin e in the free and encapsulated forms, from the w/o emulsion. the carriers studied seem to be promising systems for topical administration.
When Utility Jumps: The Value of Having Cash in the Hand  [PDF]
Kurt W. Rotthoff, Bentley Coffey
Theoretical Economics Letters (TEL) , 2018, DOI: 10.4236/tel.2018.81004
Abstract: Different theoretical explanations have been developed for seemingly inconsistent actions that deal with varying levels of risk and time. We propose a simple model of utility that unifies these seemingly separate phenomena, while not departing too far from the standard models of utility maximization already in use. Our driving assumption is that preferences over riskier outcomes discontinuously depart from preferences under certainty; a jump from no risk to some risk is fundamentally different from a movement of some risk to more risk.
Europeanization of the World or Globalization of Europe?
Jerry Bentley
Religions , 2012, DOI: 10.3390/rel3020441
Abstract: Building on his long career as a distinguished historian of early modern Europe, John Miles Headley has recently turned his gaze to the influence of Europe in the larger world. In The Europeanization of the World, Headley makes an insistent case for the uniqueness of European values—particularly human rights and democracy—and argues that these values are Europe’s most precious gifts to the larger world. Without seeking to diminish the remarkable intellectual and cultural achievements of European peoples, this presentation will suggest a more nuanced view of relations between Europe and the larger world. Human rights and democracy mean different things to different peoples in different contexts at different times, and there have in fact been numerous expressions of both in societies beyond Europe. Furthermore, European theorists of human rights and democracy drew influence from societies beyond Europe. To the extent that the Europeanization of the world is a persuasive idea, it is possible only because of a prior globalization of Europe.
Karl Barth's definition of church in politics and culture: Growth points for the church in South Africa
W Bentley
HTS Theological Studies/Teologiese Studies , 2007,
Abstract: The article describes briefly Karl Barth's views on church, its role in politics and how it relates to culture. This is done by identifying the way in which the church participates in the social realm through its relationship with the State. The historic religious question asks whether there is a natural mutual-determining relationship between church and State. The church may ask whether faith and politics should mix, while a secular state may question the authority which the church claims to speak from. To a large extent culture determines the bias in this relationship. History has shown that church- State dynamics is not an either/or relationship, whereby either the authority of the church or the authority of the State should function as the ruling norm. Karl Barth describes the dynamics of this relationship very well, within the context of culture, in the way his faith engages with the political status quo. Once the relationship is better understood, Barth's definition of the church will prove to be more effective in its evangelical voice, speaking to those who guide its citizens through political power. HTS Theological Studies Vol. 63 (4) 2007: pp. 1643-1661
The formation of Christian leaders: a Wesleyan approach
W. Bentley
Koers : Bulletin for Christian Scholarship , 2010, DOI: 10.4102/koers.v75i3.96
Abstract: The problem of leadership is that it is defined according to a very narrow understanding. It postulates that all people can be divided into two categories. People are either leaders or followers. This article explores the formation of Christian leaders using the model offered by the Wesleyan revival of eigteenthcentury England. It asks what leaders would look like when we use the Wesleyan definition instead of the leader-follower understanding to which we have grown accustomed.
Karl Barth’s definition of church in politics and culture: Growth points for the church in South Africa
Wessel Bentley
HTS Theological Studies/Teologiese Studies , 2009, DOI: 10.4102/hts.v63i4.263
Abstract: The article describes briefly Karl Barth’s views on church, its role in politics and how it relates to culture. This is done by identifying the way in which the church participates in the social realm through its relationship with the State. The historic religious question asks whether there is a natural mutual-determining relationship between church and State. The church may ask whether faith and politics should mix, while a secular state may question the authority which the church claims to speak from. To a large extent culture determ-ines the bias in this relationship. History has shown that church-State dynamics is not an either/or relationship, whereby either the authority of the church or the authority of the State should function as the ruling norm. Karl Barth describes the dynamics of this relationship very well, within the context of culture, in the way his faith engages with the political status quo. Once the relationship is better understood, Barth’s definition of the church will prove to be more effective in its evangelical voice, speaking to those who guide its citizens through political power. “Fürchtet Gott, ehret den K nig!” (1 Pt 2:17)
Dobi ek in prostor
Ian Bentley
Urbani Izziv , 1997,
Abstract: V razpravi so predstavljeni fizi ni in simbolni vplivi grajenega okolja na lovekove dejavnosti v kapitalisti nih razmerah. Grajeno okolje je integrirano v kapitalisti no gospodarstvo na treh ravneh: kot jedro dobi konosne predelovalne industrije (gradbeni tva), kot prizori e delovanja drugih dejavnosti in kot zagotovilo delovanja sistema v celoti. Grajeno okolje je v razpravi opredeljeno kot izdelek. V nadaljevanju so prikazane napetosti, ki izvirajo iz kapitalisti nega sistema, in ki e posebej pomembno vplivajo na oblikovanje grajenega prostora. Prva napetost izvira iz dejstva, da sistemu, ki je prepu en sam sebi, manjka celostna funkcija planiranja, druga iz sposobnosti sistema porajati dohodek, tretja pa iz dejstva, da ima delo zna aj, ki je druga en od zna aja ostalega blaga uporabljenega v proizvodnem procesu. Razpravo zaklju ujejo razmi ljanja o na inih oblikovanja grajenega prostora, tako da se ohranja dru beni red.
Profit and place
Ian Bentley
Urbani Izziv , 1997,
Abstract: The article deals with the physical and symbolic effects the built environment has on human activities in a capitalist economy. The built environment is integrated in the capitalist economy on three levels: as the focus of a profit-oriented manufacturing industry, as the setting for all sorts of other enterprises and as the built context of the whole economy. The built environment is understood as a commodity. The capitalist system contains inbuilt tensions which have important design implications: the first tension arises because the system, if left to itself, lacks any overall planning functions, the second tension stems from the ability of the system to generate profit and the third arises from the character of labour, which distinguishes it from other commodities used in the production process. In conclusion methods of designing built environments, which perpetuate social order, are discussed.
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