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Search Results: 1 - 10 of 402868 matches for " Julian M Lipscombe "
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BRCA1 and BRCA2 mutations in a population-based study of male breast cancer
Victoria M Basham, Julian M Lipscombe, Joanna M Ward, Simon A Gayther, Bruce AJ Ponder, Douglas F Easton, Paul DP Pharoah
Breast Cancer Research , 2001, DOI: 10.1186/bcr419
Abstract: We have carried out a population-based study of 94 MBC cases collected in the UK. We screened genomic DNA for mutations in BRCA1 and BRCA2 and used family history data from these cases to calculate the risk of breast cancer to female relatives of MBC cases. We also estimated the contribution of BRCA1 and BRCA2 to this risk.Nineteen cases (20%) reported a first-degree relative with breast cancer, of whom seven also had an affected second-degree relative. The breast cancer risk in female first-degree relatives was 2.4 times (95% confidence interval [CI] = 1.4–4.0) the risk in the general population. No BRCA1 mutation carriers were identified and five cases were found to carry a mutation in BRCA2. Allowing for a mutation detection sensitivity frequency of 70%, the carrier frequency for BRCA2 mutations was 8% (95% CI = 3–19). All the mutation carriers had a family history of breast, ovarian, prostate or pancreatic cancer. However, BRCA2 accounted for only 15% of the excess familial risk of breast cancer in female first-degree relatives.These data suggest that other genes that confer an increased risk for both female and male breast cancer have yet to be found.Male breast cancer (MBC) is a rare disease and little is known about its aetiology. However, female first-degree relatives of MBC cases are at increased risk of breast cancer [1,2,3,4,5,6], which suggests that there is an inherited component to the disease. Several genes that are associated with a high lifetime risk of breast cancer in women have been identified during the past decade. One of these, BRCA2, has also been shown to confer a significant risk of breast cancer in men, and a recent study found the risk of breast cancer in male BRCA2 mutation carriers from multiple case breast/ovarian cancer families to be 80-fold higher than in the general population [7]. This equates to a 7% risk of breast cancer by age 80. The prevalence of BRCA2 mutations in MBC cases unselected for family history has been estimated in
Spatial Uncertainty Handling in Lake Extent Trend Analysis Using Remote Sensing and GIS Tools: The Case of Lake Naivasha  [PDF]
Julian Ijumulana, Preksedis M. Ndomba
Journal of Geographic Information System (JGIS) , 2012, DOI: 10.4236/jgis.2012.43033
Abstract: The following article has been retracted due to the investigation of complaints received against it. The Editorial Board found that substantial portions of the text came from other published papers. The scientific community takes a very strong view on this matter, and the Journal of Geographic Information System treats all unethical behavior such as plagiarism seriously. This paper published in Vol.4 No.3 273-278, 2012, has been removed from this site.
Thermal and Photochemical Effects on the Fluorescence Properties of Type I Calf Skin Collagen Solutions at Physiological pH  [PDF]
Julian M. Menter, Latoya Freeman, Otega Edukuye
Open Journal of Physical Chemistry (OJPC) , 2015, DOI: 10.4236/ojpc.2015.52003
Abstract: Mammalian collagens exhibit weak intrinsic UV fluorescence that depends on the age and previous history of the sample. Post-translational modifications result in additional fluorescent products (e.g. DOPA, dityrosine, and advanced glycation end products (AGE)). UV radiation can cause longer wavelength fluorescent oxidative bands. These alterations can assess the extent of photolysis. We describe the ground- and excited-state oxidative transformations of newly-purchased type I calf skin collagens (samples #092014 and #072012) and a 7-year-old sample (#072005). We compare the effects of UV radiation (mainly 254 nm) and age on the photochemical reaction kinetics and fluorescence spectral distribution of type I calf skin collagen at pH 7.4. The fluorescence spectra of samples #072012 and #092014 were similar but not identical to pure tyrosine, whereas #072005 indicated significant “dark” oxidation at the expense of tyrosine. Fading of oxidized product(s) at 270/360 nm is second-order. Build-up of 325/400 nm (dityrosine) fluorescence is linear with time. Rate parameters r2 and r1 were respectively proportional to second order disappearance of ground state oxidation products and the quasi–first-order photochemical formation of dityrosine. There is a reciprocal relationship between the rates of decrease in the 270/360 nm fluorescence and concomitant increase in 325/400 nm fluorescence. Their relative rates depend on the age of the collagen sample. There is a reciprocal relationship between r1 and r2. This relationship results because both ground state autoxidation and excited state photo-dimerization proceed via a common tyrosyl radical intermediate. Water of hydration appears to play a role in generating tyrosyl radical.
The emergence of coherent magnetic excitations in the pseudogap phase of La2-xSrxCuO4
O. J. Lipscombe,B. Vignolle,T. G. Perring,C. D. Frost,S. M. Hayden
Physics , 2008, DOI: 10.1103/PhysRevLett.102.167002
Abstract: We use inelastic neutron scattering to measure the magnetic excitations in the underdoped superconductor La2-xSrxCuO4 (x=0.085, Tc=22 K) over energy and temperatures ranges 5 < E < 200 meV and 5 < T < 300 K respectively. At high temperature (T = 300 K), we observe strongly damped excitations with a characteristic energy scale of approximately 50 meV. As the temperature is lowered to T = 30 K, and we move into the pseudogap state, the magnetic excitations become highly structured in energy and momentum below about 60 meV. This change appears to be associated with the development of the pseudogap in the electronic excitations.
The Persistence of High-Frequency Spin Fluctuations in Overdoped La$_{2-x}$Sr$_{x}$CuO$_{4}$ ($x$=0.22)
O. J. Lipscombe,S. M. Hayden,B. Vignolle,D. F. McMorrow,T. G. Perring
Physics , 2007, DOI: 10.1103/PhysRevLett.99.067002
Abstract: We report a detailed inelastic neutron scattering study of the collective magnetic excitations of overdoped superconducting La1.78Sr0.22CuO4 for the energy range 0-160 meV. Our measurements show that overdoping suppresses the strong response present for optimally doped La2-xSrxCuO4 which is peaked near 50 meV. The remaining response is peaked at incommensurate wavevectors for all energies investigated. We observe a strong high-frequency magnetic response for E >= 80 meV suggesting that significant antiferromagnetic exchange couplings persist well into the overdoped part of the cuprate phase diagram.
Self-gravitating clouds of generalized Chaplygin and modified anti-Chaplygin Gases
T. C. Lipscombe
Physics , 2008, DOI: 10.1088/0031-8949/83/03/035901
Abstract: The Chaplygin gas has been proposed as a possible dark energy, dark matter candidate. As a working fluid in a Friedmann-Robertson-Walker universe, it exhibits early behavior reminiscent of dark matter, but at later times is more akin to a cosmological constant. In any such universe, however, one can expect local perturbations to form. Here we obtain the general equations for a self-gravitating relativistic Chaplygin gas. We solve these equations and obtain the mass-radius relationship for such structures, showing that only in the phantom regime is the mass-radius relationship large enough to be a serious candidate for highly compact massive objects at the galaxy core. In addition, we study the cosmology of a modified anti-Chaplygin gas. A self-gravitating cloud of this matter is an exact solution to Einstein's equations.
(Outo)biografie as teologie
Julian C. Müller
HTS Theological Studies/Teologiese Studies , 2011, DOI: 10.4102/hts.v67i3.1113
Abstract: (Auto)biography as theology This article provides a reflection on the relationship between (auto)biography and theology. This reflection is done with reference to, and in honour of the story of Theuns Dreyer. The author positions himself on the theory that the theology develops on a narrative basis and therefore also by way of (auto)biography. The life of a person, in this case a theologian, is regarded as a ‘piece of art’ and becomes both a reflection of one’s theology and a way of constructing a theology. The richness of walking the inbetween land (ecotone) and to combine two contexts (church and academia) in one story is also explored. How to cite this article: Müller, J.C., 2011, ‘(Outo)biografie as teologie’, HTS Teologiese Studies/Theological Studies 67(3), Art. #1113, 5 pages. http://dx.doi.org/10.4102/hts.v67i3.1113
Practical Theology as part of the landscape of Social Sciences and Humanities – A transversal perspective
Julian C. Müller
HTS Theological Studies/Teologiese Studies , 2013,
Abstract: At the University of Pretoria the author, a practical theologian, experiences a fruitful soil for the development of an interdisciplinary process. He referred to concrete examples of cooperation, but used the article to reflect on best practices for the interdisciplinary dialogue. He came to the conclusion that it probably made more sense to talk of Practical-theological alternatives rather than to describe the subject in a single fixed manner of understanding and action. Our goal should rather be to open up the boundaries between Practical Theology, Human, Social and Natural Sciences.
Postfoundational practical theology for a time of transition
Julian C. Müller
HTS Theological Studies/Teologiese Studies , 2011, DOI: 10.4102/hts.v67i1.837
Abstract: In reflection on the question as to in what sense is our time a time of transition, the article explores the various transitions in epistemology, advocated by the scholars mentioned in brackets: modern to postmodern secular dualism to post-secular holism (Cornel du Toit) structural to poststructural positivistic to relativistic rational-argumentative to narrative proposisionalistic to cultural-linguistic (Lindbeck) fundamentalist to postfoundationalist (Schrag and Van Huyssteen) maintenance to missional. How to cite this article: Müller, J.C., 2011, ‘Postfoundational practical theology for a time of transition’, HTS Teologiese Studies/Theological Studies 67(1), Art. #837, 5 pages. DOI: 10.4102/hts.v67i1.837
HIV/AIDS, narrative practical theology, and postfoundationalism: The emergence of a new story
Julian Müller
HTS Theological Studies/Teologiese Studies , 2009, DOI: 10.4102/hts.v60i1/2.516
Abstract: The practical theology that emerges from this article is one that develops out of a very specific context – in this case, HIV/AIDS. The philosophical framework is found in an integration of two paradigms, namely social-constructionism and postfoundation-alism. The article concludes with a research case study from the HIV/AIDS context. Practical theological research is not only about description and interpretation of experiences, but it is also about deconstruction and emancipation. The bold move should be made to allow all the different stories of the research to develop into a new story of understanding that transcends the local community. According to the narrative approach, this will not happen on the basis of structured and rigid methods, through which stories are analysed and interpreted. It rather happens on the basis of a holistic understanding and as a social-constructionist process to which all the co-researchers are invited and in which they are engaged in the creation of new meaning.
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