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Search Results: 1 - 10 of 48137 matches for " Jui-Yun Lu "
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Gene expression profiling in a mouse model of infantile neuronal ceroid lipofuscinosis reveals upregulation of immediate early genes and mediators of the inflammatory response
Xingwen Qiao, Jui-Yun Lu, Sandra L Hofmann
BMC Neuroscience , 2007, DOI: 10.1186/1471-2202-8-95
Abstract: A total of 267 genes were significantly (approximately 2-fold) up- or downregulated over the course of the disease. Immediate early genes (Arc, Cyr61, c-fos, jun-b, btg2, NR4A1) were among the first genes upregulated during the presymptomatic period whereas immune response genes dominated at later time points. Chemokine ligands and protease inhibitors were among the most transcriptionally responsive genes. Neuronal survival factors (IGF-1 and CNTF) and a negative regulator of neuronal apoptosis (DAP kinase-1) were upregulated late in the course of the disease. Few genes were downregulated; these included the α2 subunit of the GABA-A receptor, a component of cortical and hippocampal neurons, and Hes5, a transcription factor important in neuronal differentiation.A molecular description of gene expression changes occurring in the brain throughout the course of neuronal ceroid lipofuscinosis suggests distinct phases of disease progression, provides clues to potential markers of disease activity, and points to new targets for therapy.An unusual group of lysosomal storage disorders, the neuronal ceroid lipofuscinoses, are characterized by retinal and cortical neurodegeneration with scant autofluorescent storage material that accumulates in the brain and peripheral tissues (reviewed in [1]). Distinct subsets of NCL are recognized based on characteristic appearance by electron microscopy that include granular osmiophilic deposits and/or various membrane profiles (curvilinear, fingerprint, and rectilinear) [2]. Autosomal recessive mutations in at least seven different genes are responsible for these disorders [3], and while the function of only a few is known, each appears to participate in some aspect of endo/lysosomal function [4]. The CLN1 (ceroid lipofuscinosis, neuronal-1) gene encodes a soluble lysosomal palmitoyl-protein thioesterase (PPT1) that functions to remove fatty acids (usually palmitate) from modified cysteine residues in proteins [5,6]. A growing number of s
Two New Cembrane-Based Diterpenoids from the Marine Soft Coral Sinularia crassa
Yun-Sheng Lin,Nai-Lun Lee,Mei-Chin Lu,Jui-Hsin Su
Molecules , 2012, DOI: 10.3390/molecules17055422
Abstract: Two new cembrane diterpenes, sicrassarines A and B (compounds 1 and 2), were isolated from the Taiwanese soft coral Sinularia crassa. The structures of the new metabolites were determined on the basis of extensive spectroscopic analysis, particularly mass spectroscopy and 2D NMR (1H–1H COSY, HMQC, HMBC, and NOESY) spectroscopy.
Simple Patchy-Based Simulators Used to Explore Pondscape Systematic Dynamics
Wei-Ta Fang, Jui-Yu Chou, Shiau-Yun Lu
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0086888
Abstract: Thousands of farm ponds disappeared on the tableland in Taoyuan County, Taiwan since 1920s. The number of farm ponds that have disappeared is 1,895 (37%), 2,667 ponds remain (52%), and only 537 (11%) new ponds were created within a 757 km2 area in Taoyuan, Taiwan between 1926 and 1960. In this study, a geographic information system (GIS) and logistic stepwise regression model were used to detect pond-loss rates and to understand the driving forces behind pondscape changes. The logistic stepwise regression model was used to develop a series of relationships between pondscapes affected by intrinsic driving forces (patch size, perimeter, and patch shape) and external driving forces (distance from the edge of the ponds to the edges of roads, rivers, and canals). The authors concluded that the loss of ponds was caused by pond intrinsic factors, such as pond perimeter; a large perimeter increases the chances of pond loss, but also increases the possibility of creating new ponds. However, a large perimeter is closely associated with circular shapes (lower value of the mean pond-patch fractal dimension [MPFD]), which characterize the majority of newly created ponds. The method used in this study might be helpful to those seeking to protect this unique landscape by enabling the monitoring of patch-loss problems by using simple patchy-based simulators.
Strategic Capabilities, Innovation Intensity, and Performance of Service Firms  [PDF]
Lu-Jui Chen, Chun-Chung Chen, Wen-Ruey Lee
Journal of Service Science and Management (JSSM) , 2008, DOI: 10.4236/jssm.2008.12011
Abstract: This study developed and empirically tested a model examining the relationships among strategic capabilities, innova-tion intensity, and firm performance. Strategic capabilities include internal venturing capability and social relation-ship capability. Analyzing a sample of service firms from Taiwan, the study indicates that social relationships with other firms are important to facilitate innovative activities of service firms. Innovation intensity further helps service firms to improve a firm’s expected performance. However, internal resources capability does not show the expected effect on innovation intensity. And innovation intensity is also not related to a firm’s growth.
Reducts of the random bipartite graph
Yun Lu
Mathematics , 2011,
Abstract: Let $\Gamma$ be the random bipartite graph, a countable graph with two infinite sides, edges randomly distributed between the sides, but no edges within a side. In this paper, we investigate the reducts of $\Gamma$ that preserve sides. We classify the closed permutation subgroups containing the group $Aut(\Gamma)^*$, where $Aut(\Gamma)^*$ is the group of all isomorphisms and anti-isomorphisms of $\Gamma$ preserving the two sides. Our results rely on a combinatorial theorem of Ne\v{s}et\v{r}il-R\"{o}dl and a strong finite submodel property for $\Gamma$.
Reducts of the Generalized Random Bipartite Graph
Yun Lu
Mathematics , 2011,
Abstract: Let \Gamma be the generalized random bipartite graph that has two sides Rl and Rr with edges for every pair of vertices between R1 and Rr but no edges within each side, where all the edges are randomly colored by three colors P1; P2; P3. In this paper, we investigate the reducts of \Gamma that preserve Rl and Rr, and classify the closed permutation subgroups in Sym(Rl)\timesSym(Rr) containing the group Aut(\Gamma). Our results rely on a combinatorial theorem of Nesetril-Rodl and the strong finite submodel property of the random bipartite graph.
Novel Dual-Band Design of Planar Dipole Array for 4G LTE/WiMAX Access Points
Jui-Han Lu,Shi-Wei You
International Journal of Antennas and Propagation , 2011, DOI: 10.1155/2011/638034
Abstract: A novel planar dipole array with dual-band operation for LTE/WiMAX access points is proposed. The impedance bandwidths, determined from , can reach about 525/747?MHz (20.2/21.3%) for the 2.6/3.5?GHz operating bands, respectively, which are covering the required bandwidth for LTE (2.5 ~ 2.7?GHz) and WiMAX (3.3 ~ 3.7?GHz) system. This proposed dual-band dipole array also provides maximum peak antenna gains and efficiencies of 7.3/7.5?dBi and 89/75% across 2.6/3.5?GHz bands, respectively, with good omnidirectional radiation pattern in XY-plane. 1. Introduction Recently, LTE (Long-Term Evolution) and WiMAX (Worldwide Interoperability for Microwave Access) systems for the Fourth-Generation (4G) mobile communication has attracted high attention for broadband access in wireless metropolitan area network (WMAN) environment. For the LTE/WiMAX base stations or access points, the high-gain array antenna with omnidirectional radiation in the azimuthal plane is usually required for long-distance communication. The related array designs had been presented by using two dipole arrays [1], collinear array antenna with three in-phase half-wavelength radiating elements [2], and four-element collinear array antenna [3]. However, these above array antennas were focused on the single-band operation. For dual-band operation, only the array design [4] had been proposed by using one dipole antenna for 2.4?GHz and array antenna for 5.2?GHz WLAN communication. And, there was a disadvantage of lower antenna gain (less than 4?dBi), which was unsuitably in the practical applications for LTE/WiMAX access points. Meanwhile, dual-band dipole array for LTE/WiMAX applications is very scant in the open literature. Therefore, in this paper, we propose a novel planar dual-band dipole array mainly comprises two dipole arrays arranged back to back, and can be easily constructed by printing on both sides of a dielectric substrate (see the geometry shown in Figure 1). By properly adjusting the arms’ lengths of each unsymmetrical dipole element, the operating bandwidths (VSWR ≦ 2.0) can reach about 525/747?MHz (20.2/21.3%), which are enough for LTE and WiMAX system. Also, the proposed dipole array provides maximum peak antenna gains and efficiencies of 7.3/7.5?dBi and 89/75% across 2.6/3.5?GHz bands, respectively, with good omnidirectional radiation pattern in the azimuthal plane and narrow-beamwidth pattern in the elevation plane. Details of the proposed dual-band dipole array designs are described, and experimental results for the obtained high-gain performance are presented and discussed.
Cultural Issues in Using the SF-36 Health Survey in Asia: Results from Taiwan
Hsu-Min Tseng, Jui-fen Lu, Barbara Gandek
Health and Quality of Life Outcomes , 2003, DOI: 10.1186/1477-7525-1-72
Abstract: A total of 1191 volunteered subjects from the general population answered the translated SF-36 Taiwan version, which was developed following IQOLA project protocols.Results from tests of scaling assumptions and reliability generally were satisfactory. Convergent validity, as assessed by comparing the SF-36 to a mental health oriented inventory, was acceptable. Results of principal components analysis were similar to US results for many scales. However, differences were seen for the Vitality scale which was a stronger measure of mental health than physical health in Taiwan. Results are compared to those from other Asian studies and the U.S.The results raise important questions regarding cultural influences in international studies of health status assessment. Further research into the conceptualization and components of mental health in Asian countries is warranted.The health outcomes of a population can be measured in terms of etiology and pathogenesis. Nevertheless, well-developed health outcome measurement systems have expanded the measurement of health beyond the classical endpoints of mortality and morbidity in clinical practice [1,2]. Health-related quality of life has emerged as the new reflection of modern medicine as viewed from biopsychosocial perspectives. With the fast growth in health care expenditures, this concept has been increasingly used as an important attribute in patient care and clinical studies as well as health economic evaluations [3].Over the past 20 years, health status measures have been widely applied in different medical fields such as oncology, cardiology, arthritis, and psychiatry [4]. Health researchers have begun to evaluate whether common standardized health status measures are technically and conceptually equivalent for various socio-cultural groups. Hence, there is an increasing need for international standards to measure health status in a manner that allows comparisons across countries, but which also are relevant within individ
Planar Compact Multi-Band C-Shape Monopole Antenna with Inverted L-Shape Parasitic Strip for Wimax Applications
Jui-Han Lu;You-Shiang Cai
PIER C , 2011, DOI: 10.2528/PIERC11011404
Abstract: A novel compact multi-band design of planar C-shaped monopole antenna with inverted L-shaped parasitic strip is proposed for IEEE 802.16m WiMAX system. The obtained impedance bandwidth across the 2.6/3.5/5.5 GHz operating bands can reach about 240/570/4470 MHz, respectively. Only with the antenna size of 15×30×0.8 mm, the proposed monopole antenna has the compact operation with more than 50% antenna size reduction. The measured peak gains and radiation efficiencies are about 2.1/2.2/2.9 dBi and 91/96/94% for the 2.6/3.5/5.5 GHz operating band, respectively, with nearly omni-directional pattern in the XY-plane.
Planar Multi-Band T-Shaped Monopole Antenna with a Pair of Mirrored L-Shaped Strips for WLAN/Wimax Operation
Jui-Han Lu;Ying-Hwei Li
PIER C , 2011, DOI: 10.2528/PIERC11021406
Abstract: A novel compact design of planar T-shaped monopole antenna with multi-band operation for WLAN/WiMAX system is proposed. By insetting a pair of mirrored L-shaped monopole strips, multi resonant modes close to 2.45/3.5/5.5 GHz band are excited to meet the specifications of WLAN/WiMAX system. And, the obtained impedance bandwidth across the operating bands can reach about 160/1100/2690 MHz for the 2.45/3.5/5.5 GHz bands, respectively. Only with the antenna size of 30×42×0.8 mm, the proposed monopole antenna has the compact operation with more than 20% antenna size reduction. The measured peak gains and radiation efficiencies are about 3.2/3.5/5.4 dBi and 72/98/96% for the 2.45/3.5/5.5 GHz band, respectively, with nearly omni-directional pattern in the XY-plane.
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