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Search Results: 1 - 10 of 2784 matches for " Judith Sewing "
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In silico Study on Sulfated and Non-Sulfated Carbohydrate Chains from Proteoglycans in Cnidaria and Interaction with Collagen  [PDF]
Thomas Eckert, Sabine St?tzel, Monika Burg-Roderfeld, Judith Sewing, Thomas Lütteke, Nikolay E. Nifantiev, Johannes F. G. Vliegenthart, Hans-Christian Siebert
Open Journal of Physical Chemistry (OJPC) , 2012, DOI: 10.4236/ojpc.2012.22017
Abstract: Proteoglycans and collagen molecules are interacting with each other thereby forming various connective tissues. The sulfation pattern of proteoglycans differs depending on the kind of tissue and/or the degree of maturation. Tissues from Cnidaria are suitable examples for exploration of the effects in relation to the presence and the absence of sulfate groups, when studying characteristic fragments of the long proteoglycan carbohydrate chains in silico. It has been described that a non-sulfated chondroitin appears as a scaffold in early morphogenesis of all nematocyst types in Hydra. On the other hand, sulfated glucosaminoglycans play an important role in various developmental processes of Cnidaria. In order to understand this biological phenomenon on a sub-molecular level we have analysed the structures of sulfated and non-sulfated proteoglycan carbohydrate chains as well as the structure of diverse collagen molecules with computational methods including quantum chemical calculations. The strong interactions between the sulfate groups of the carbohydrates moieties in proteoglycans and positively charged regions of collagen are essential in stabilizing various Cnidaria tissues but could hinder the nematocyst formation and its proper function. The results of our quantum chemical calculations show that the sulfation pattern has a significant effect on the conformation of chondroitin structures under study.
Retrospective Study of the Use of a Fractional Radio Frequency Ablative Device in the Treatment of Acne Vulgaris and Related Acne Scars  [PDF]
Judith Hellman
Journal of Cosmetics, Dermatological Sciences and Applications (JCDSA) , 2015, DOI: 10.4236/jcdsa.2015.54038
Abstract: Background: Acne vulgaris (AV) is a common disease that often results in disfiguring facial scarring that carries into adulthood. Here we report our experience with fractional radiofrequency (FRF) device in treatment of patients with acne and acne related scarring. Materials & Methods: We retrospectively reviewed the charts of all patients with acne scarring who completed a four treatment regimen in our clinic. Results: We identified eight patients who completed four treatments with median age of 20.5 years (range 17 - 41). All patients demonstrated significant improvement of acne lesions and acne scarring. Skin biopsies demonstrated reduction of scar depth and increased new collagen production, and repopulation of the scar tissue by elastic fibers and adnexal structures after the fourth treatment. Conclusion: FRF emerges as a safe and effective treatment modality for AV and acne related scars. Further randomized controlled studies are required to fully evaluate the magnitude of this positive effect and more basic science studies are needed in order to better characterize its mechanism of action on acne lesions.
Long Term Follow-Up Results of a Fractional Radio Frequency Ablative Treatment of Acne Vulgaris and Related Acne Scars  [PDF]
Judith Hellman
Journal of Cosmetics, Dermatological Sciences and Applications (JCDSA) , 2016, DOI: 10.4236/jcdsa.2016.63013
Abstract: Introduction: Acne vulgaris and acne scarring are prevalent conditions that can have a negative effect on a patient’s quality of life. Fractional radiofrequency technologies have been shown to be clinically safe and effective in managing acne scars through dermal remodeling without causing direct damage to the epidermis. In a recently published study, we presented our clinical and histological results in the treatment of patients with active acne and acne related scarring using a Fractional RF (FRF) device. In the current article we demonstrate long term follow-up results, up to two years post last fractional treatment. Methods: Four out of the eight patients who completed a four treatment regimen were invited for long term follow-up visit to document treatment results. In some cases, touch-up treatments were conducted to optimize clinical results. Results: Patients demonstrated significant improvement of acne lesions, acne scarring, pores and skin texture. Long term photos demonstrated that clinical improvement progressed with time. Conclusion: The current study further supports the previous findings that FRF is a safe and effective treatment modality for active acne and acne related scars. Treatment protocol can be customized according to patient needs and clinical results last for long term.
The Post-Modern Mind. A Reconsideration of John Ashbery’s “Self-Portrait in a Convex Mirror” (1975) from the Viewpoint of an Interdisciplinary History of Ideas  [PDF]
Roland Benedikter, Judith Hilber
Open Journal of Philosophy (OJPP) , 2012, DOI: 10.4236/ojpp.2012.21010
Abstract: This paper gives a short description of basic features of the dominating mindset in the Western world between the 1970s and today, often called “post-modern”, through a re-reading of John Ashbery’s poem “Self-Portrait in a Convex Mirror” (1975). In doing so, it applies the viewpoint of an interdisciplinary history of ideas. Since collective mindsets have become the most important contextual political factors, the implications are multiple.
Gender Differences and Leadership Styles in a Non Secular Setting  [PDF]
Judith Corbett Carter
Open Journal of Leadership (OJL) , 2012, DOI: 10.4236/ojl.2012.11001
Abstract: Women are increasingly taking on the role of religious leaders despite some institutional barriers. Do ef- fective female clergy lead differently than effective male clergy? The focus of this study was to examine gender differences in the context of non secular leadership. The Multifactor Leadership Questionnaire (MLQ) styles and NEO-Five Factor Inventory (FFI) was used to measure leadership and personal charac- teristics of female and male pastors. Limited findings indicate that female pastors were higher in Open- ness and Charisma than male pastors.
“I’ve Got the Pilot”: An Interpretation of Flight, a Film by John Gatins, Writer, and Robert Zemeckis, Director  [PDF]
Judith Ferster, Paul Weiser
Advances in Literary Study (ALS) , 2014, DOI: 10.4236/als.2014.23013

Robert Zemeckis’s recent film Flight, about a talented but flawed commercial airline pilot (played by Denzel Washington) is discussed on both the realistic and allegorical levels, showing the relationship between the contemporary plot and the fifteenth-century morality play, The Summoning of Everyman. Evidence for and against the different kinds of interpretation is identified and discussed. The film forces the main character to make a series of progressively more difficult and significant ethical decisions about drugs, alcohol, friends (true and false), lovers, and personal atonement that challenge him. The audience must make an interpretive decision between the possible levels of meaning.

Teachers Creating Effective Learning Experiences for Indigenous Learners  [PDF]
Lindsey Conner, Judith Bennetts
Creative Education (CE) , 2018, DOI: 10.4236/ce.2018.96074
Abstract: “Recently professional learning and development has turned a corner. Teachers as leaders of learning have realized that they can be agents of change within their classrooms by focusing on quite specific teaching changes to improve outcomes for their learners” (Conner, 2015: p. 7). This paper provides examples of how teachers were challenged to link changes in their practice to include good principles of indigenous pedagogies (through participating in cycles of teaching and inquiry), to changes in students’ outcomes, which has rarely been reported previously. Vignettes of changes teachers made to their teaching were gathered as they responded to reflections and support from mentors and used student achievement data as tools for inquiry. Teachers were provoked to be more aware of the importance of evidence-informed critical reflection on pedagogical development that was appropriate for indigenous students. We provide an overall analysis and vignette examples to illustrate the emerging themes which were: the development of positive professional relationships (mentor-teacher, teacher-teacher and teacher-student), developing pedagogical knowledge that was appropriate for indigenous students that was also informed by seeking student and whānau (family) voice or feedback to inform changes to teaching.
Illness and Medication Appraisals In People with HIVDeciding to Begin Antiretroviral Treatment  [PDF]
Judith Wrubel, Judith T. Moskowitz, Eunice Stephens, Mallory O. Johnson
Psychology (PSYCH) , 2011, DOI: 10.4236/psych.2011.22019
Abstract: Deciding to initiate antiretroviral treatment (ART) for HIV involves a number of factors, including how one thinks about disease (illness appraisals) and how one thinks about treatment (medication appraisals). We conducted semi-structured interviews with 20 adults who were deciding whether to begin ART, in which participants were asked to relate their experience of testing positive, their experience with medications other than ART, and their thoughts about ART. Digital recordings were transcribed for team-based narrative analysis. In response to HIV+ diagnosis, participants described the following appraisals: 1) HIV is a threat to mortality; 2) nonacceptance of the HIV diagnosis; 3) HIV is associated with stigma and rejection; and, 4) the HIV diagnosis meant betrayal by a cared for other. Medication appraisals included: 1) negative feelings about medications in general, 2) taking HIV medication would create a personal crisis; 3) the benefits of taking HIV medication would not outweigh the costs; 4) doubts whether they could adhere, and 5) taking medications would be stigmatizing. Illness and medication appraisals may represent barriers to initiating and adhering to treatment and should be taken into account in helping clients to cope with their diagnosis and manage their healthcare.
Evaluation of Self-Treatment of Acne Using Silk’n Blue Phototherapy System  [PDF]
Judith Hellman, Cielo A. Ramirez
Journal of Cosmetics, Dermatological Sciences and Applications (JCDSA) , 2014, DOI: 10.4236/jcdsa.2014.43025

Background: At-home phototherapy devices for the treatment of acne have emerged as an appealing treatment option and as an effective adjunct treatment to existing modalities. The principal goal of the study was to determine the changes in the number of inflammatory lesions in acne patients. Methods: Patients received instruction for daily at-home use of Silk’n Blue device for 12 weeks. Follow-up visits were conducted at 1 and 3 months to collect data. Results: Fifteen subjects with mild to severe cases experienced improvement over the course of the trial. The decrease in mean inflammatory acne counts (from 41.26 to 24.46) and mean percent reduction (41.8%) were statistically significant (p < 0.001). Some participants experienced percent reductions as great as 67%. No adverse events were recorded. Conclusions: The Silk’n Blue device is a safe and effective modality for at-home treatment of mild, moderate, and severe inflammatory acne vulgaris with proper use.

Evaluation of Tobacco Use and Her-2 Receptor Expression in Breast Cancer in an Ethnically Diverse Inner-City Population  [PDF]
Damien M. Hansra, Judith Hurley
Open Journal of Epidemiology (OJEpi) , 2014, DOI: 10.4236/ojepi.2014.42014
Abstract: Background: Tobacco is linked to most cancers however despite overwhelming biological plausibility and decades of epidemiological studies, no association has been established between tobacco and breast cancer. Although estrogen receptor status has been looked at as a variable there has been no evaluation of the role of Her-2 and smoking in breast cancer. Methods: Review of records from patients treated at the University of Miami/Jackson Memorial Hospital from 1998-2012. The incidence of smoking and Her-2 expression in1255 women was evaluated. Data was analyzed by age, race, ethnic group, menopausal status, tumor stage, and ER/PR/Her-2 receptor status. Results: 1255 charts were analyzed with 1094 having full information. Overall rate of Her-2 expression 18.1%. The rate of Her-2 expression was 21.4% in smokers and 17.0% in non-smokers (p = 0.10). The rate of Her-2 expression was 10.8% in Caucasian smokers and 9.8% in Caucasian non-smokers (p = 0.88); 24.5% in smokers of African descent and 17.3% in non-smokers of African descent (p = 0.24); 22.9% in Latino smokers and 17.4% in Latino non-smokers (p = 0.10). The rate of Her-2/ER expression was 9.4% in smokers and 7.9% in non-smokers (p = 0.42); 5.4% in Caucasian smokers and 4.9% in Caucasian non-smokers (p = 0.916); 12.2% in smokers of African descent and 5.9% in non-smokers of African descent (p = 0.11); 9.5% in Latin smokers and 8.8% in Latin non-smokers (p = 0.77). Conclusions: We found non-statistically significant positive associations in all analyses between Her-2 expression with or without ER expression and tobacco exposure when analyzed by ethnicity.
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