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Search Results: 1 - 10 of 80167 matches for " Juan-Carlos Gomez "
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A randomized, double-blind, placebo-controlled study of rapid-acting intramuscular olanzapine in Japanese patients for schizophrenia with acute agitation
Hideaki Katagiri, Shinji Fujikoshi, Takuya Suzuki, Kiyoshi Fujita, Naoya Sugiyama, Michihiro Takahashi, Juan-Carlos Gomez
BMC Psychiatry , 2013, DOI: 10.1186/1471-244x-13-20
Abstract: We conducted a placebo-controlled, randomized, double-blind, parallel-group study in Japanese patients diagnosed with schizophrenia according to the diagnostic criteria specified in the DSM-IV-TR. Patients were randomized to 2 treatment groups: IM olanzapine (10 mg) or IM placebo. The primary efficacy outcome was the change in PANSS-EC from baseline to 2 hours after the first IM injection. Treatment groups were compared with an analysis of variance model which included treatment and site as factors. During the 24-hour treatment period, safety was assessed by clinical examination and laboratory investigations, electrocardiograms, extrapyramidal symptoms scales, and recording spontaneously reported adverse events.Of the 91 randomized patients, 90 patients (45 IM olanzapine-group; 45 IM placebo-group) were in the full analysis set. The mean change of PANSS-EC total score from baseline to 2 hours after the first IM injection (mean±standard deviation) was ?9.2±4.5 for the IM olanzapine group and ?2.8±5.6 for the IM placebo group. The difference between treatment groups was statistically significant (p<.001). There were no deaths, serious adverse events, treatment-emergent adverse events (TEAEs) leading to discontinuation, severe TEAEs, or instances of oversedation in this study. There were no statistically significant differences between treatment groups in the proportion of patients with potentially clinically significant changes in laboratory tests, vital signs (blood pressure and pulse rate), electrocardiograms, and treatment-emergent extrapyramidal symptoms.The efficacy of IM olanzapine 10 mg in patients with exacerbation of schizophrenia with acute psychotic agitation was greater than IM placebo in the primary efficacy measure, PANSS-EC. Intramuscular olanzapine 10 mg was shown to be generally safe and tolerable, and could be a new option for treatment of schizophrenia in Japan.NCT00970281Schizophrenia is a chronic disease, but in the acute phase agitation is common
Pomaglumetad Methionil (LY2140023 Monohydrate) and Aripiprazole in Patients with Schizophrenia: A Phase 3, Multicenter, Double-Blind Comparison
David H. Adams,Lu Zhang,Brian A. Millen,Bruce J. Kinon,Juan-Carlos Gomez
Schizophrenia Research and Treatment , 2014, DOI: 10.1155/2014/758212
Abstract: We tested the hypothesis that long-term treatment with pomaglumetad methionil would demonstrate significantly less weight gain than aripiprazole in patients with schizophrenia. In this 24-week, multicenter, randomized, double-blind, Phase 3 study, 678 schizophrenia patients were randomized to either pomaglumetad methionil ( ) or aripiprazole ( ). Treatment groups were also compared on efficacy and various safety measures, including serious adverse events (SAEs), discontinuation due to adverse events (AEs), treatment-emergent adverse events (TEAEs), extrapyramidal symptoms (EPS), and suicide-related thoughts and behaviors. The pomaglumetad methionil group showed significantly greater weight loss at Week 24 (Visit 12) compared with the aripiprazole group (?2.8?±?0.4 versus 0.4?±?0.6; ). However, change in Positive and Negative Syndrome Scale (PANSS) total scores for aripiprazole was significantly greater than for pomaglumetad methionil (?15.58?±?1.58 versus ?12.03?±?0.99; ). The incidences of SAEs (8.2% versus 3.1%; ) and discontinuation due to AEs (16.2% versus 8.7%; ) were significantly higher for pomaglumetad methionil compared with aripiprazole. No statistically significant differences in the incidence of TEAEs, EPS, or suicidal ideation or behavior were noted between treatment groups. In conclusion, long-term treatment with pomaglumetad methionil resulted in significantly less weight gain than aripiprazole. This trial is registered with ClinicalTrials.gov NCT01328093. 1. Introduction All of the current antipsychotics target dopamine receptors as their common mechanism of action [1, 2]. Due to differences in the affinities to the dopamine receptors and interactions with other biogenic monoamine receptors, therapeutic profiles and limitations of individual drugs vary [1]. The conventional/typical antipsychotic drugs are effective in treating positive symptoms of schizophrenia [3, 4]. However, they are associated with extrapyramidal symptoms (EPS) and hyperprolactinemia [3, 4]. The newer generation atypical antipsychotics not only improve positive and, to some extent, negative symptoms of schizophrenia [5, 6] but also have a lower propensity to cause EPS [3, 4, 7, 8] and hyperprolactinemia [3, 4]. However, these agents may still be associated with other adverse events (AEs), such as body weight gain, lipid abnormalities [9, 10], and glucose dysregulation [3, 4] in some patients. Furthermore, drug-induced weight gain may affect long-term compliance, which directly influences the likelihood of successfully managing the course of disease [11, 12]. Hence, a
Comparing the Surgical Outcomes of Modified Quad and Triangle Tilt Surgeries to other Procedures Performed in Obstetric Brachial Plexus Injury  [PDF]
Rahul K. Nath, Juan-Carlos Pretto, Chandra Somasundaram
Surgical Science (SS) , 2013, DOI: 10.4236/ss.2013.49A003
Abstract:

Purpose: To compare results from our surgical treatment experiences in children with obstetric brachial plexus injuries (OBPI), to those who have had other surgical treatments. Methods: We conducted a retrospective study in our medical records consisting of two groups of OBPI patients. Group 1: 26 OBPI children (16 girls and 10 boys), age range between 2.0 and 12.0 (mean age 6.9), who have undergone surgical treatments at other institutions between 2005 and 2010. Group 2: 45 OBPI children (20 boys and 25 girls), age between 0.7 and 12.9 (mean age 3.7), who have had modified Quad and triangle tilt surgical treatment between 2005 and 2010 at our institution. In both groups Mean modified Mallet scores and radiological scores were measured and compared. All measurements were made at least one year post surgery in both groups. Results: Post-operative mean modified Mallet score was 11.8 ± 2.4 in group 1 patients, whereas post-mean modified Mallet score was 20 ± 2.7 (P < 0.0001) following modified Quad and triangle tilt surgeries in group 2 patients. Further, their radiological scores such as posterior subluxation, and glenoid version were 13.4 ± 21.3 and 30.2 ± 19.1 in group 1, whereas 32.1 ±13.5 (P < 0.0004), and 16.3 ± 11.5 (P < 0.008) in group 2 patients, when compared to normal values of 50, and 0 respectively. Conclusion: Patients who have had mod Quad and triangle tilt for OBPI obtained significantly better functional outcomes in modified total Mallet score as well as in radiological scores, when compared to those OBPI children, who underwent other procedures such as posterior glenohumeral capsulorrhaphy, biceps tendon lengthening, humeral osteotomy, anterior capsule release, nerve transfer/graft, botox and muscle/tendon transfer and release.

Asymmetry in Hilbert's fourth problem
Juan-Carlos Alvarez Paiva
Mathematics , 2013,
Abstract: In the asymmetric setting, Hilbert's fourth problem asks to construct and study all (non-reversible) projective Finsler metrics: Finsler metrics defined on open, convex subsets of real projective $n$-space for which geodesics lie on projective lines. While asymmetric norms and Funk metrics provide many examples of essentially non-reversible projective metrics defined on proper convex subsets of projective $n$-space, it is shown that any projective Finsler metric defined on the whole projective $n$-space is the sum of a reversible projective metric and an exact 1-form.
Clave fotográfica para hembras de Haemagogus Williston 1896 (Diptera: Culicidae) de Venezuela, con nuevo registro para el país
Liria,Jonathan; Navarro,Juan-Carlos;
Boletín de Malariología y Salud Ambiental , 2009,
Abstract: the neotropical genus heamagogus williston includes mosquitoes with diurnal activity and immature breeding on phytotelmata (tree-holes and cut bamboo internodes). haemagogus species have been involved in sylvatic yellow fever transmission, a virus circulating in forest areas in latin america among arboreal primates and marsupials by means of mosquito bite. the genus comprises 28 species, nine of them occurring in venezuela. one of these, haemagogus (comopostegus) clarki, is a new record for this country. we show here an update of the taxonomic status and the geographical distribution of the genus in venezuela and the first photographical key using simple terms for non-expert personnel.
Wyeomyia trujilloi Pulido y Sutil, 1981, nuevo sinónimo de Wyeomyia bicornis (Root, 1928) (Culicidae: Sabethini), con redescripción de la pupa parte de la larva
Navarro,Juan-Carlos; Liria,Jonathan;
Boletín de Malariología y Salud Ambiental , 2007,
Abstract: wyeomyia (wyeomyia) trujilloi pulido & sutil, 1981, is recognized as the synonym of wyeomyia (nunezia) bicornis (root 1928), based on larval chaeototaxy and mouthparts morphology, pupae and male genitals in comparison and analysis with wy. bicornis holotype, topotypes and wy. trujilloi holotype. discussion and characteristics illustration about subgeneric level are provided. the larval mouthparts morphology and pupae chaetotaxy are described and illustrated by first time, and head of larvae chaetotaxy are re-described.
Mayaro: a re-emerging arbovirus in Venezuela and Latin America Mayaro: un arbovirus re-emergente en Venezuela y Latinoamerica
Manuel Mu?oz,Juan-Carlos Navarro
Biomédica , 2011,
Abstract: Mayaro virus produces nonspecific, sublethal disease symptoms, often confused with dengue, but symptoms of arthalgias that can cause incapacitating disability. Outbreaks have been localized and sporadic in the Pan-Amazonia forest since its first isolation in 1954 (Trinidad and Tobago). The literature available is scarce, diverse and dispersed. Mayaro virus is an alphavirus, phylogenetically related to the Semliki forest antigenic complex. UNA and Mayaro viruses are the only viruses of this complex that have been isolated in the New World. Mayaro consists of single-stranded RNA of positive charge, length of 12kb, subdivided into genomic and subgenomic regions, which encode nonstructural and structural proteins respectively. Mayaro shows a great plasticity in vertebrate host infection, whereas high specificity in the family Culicidae (mosquitoes). Risk factors of infection are associated with forest areas of northern South America and the rainy season. Two genotypes of MAYV have been identified, L (Belterra, Brazil) and D (widely distributed in the Pan-Amazonia). The enzootic cycle is similar to the jungle cycle of yellow fever, which involves Haemagogus mosquitoes and monkeys as reservoirs. However the involvement of other secondary vectors and other hosts that may be important in spread of the virus cannot be ruled out. Humans may have high levels of viremia, and efficient experimental transmission has been demonstrated in Aedes aegypti, Aedes albopictus and Aedes scapularis, suggesting a significant risk to public health in urban, rural and peridomestic locations close to enzootic foci of Mayaro virus. El virus Mayaro produce una enfermedad de síntomas inespecíficos y sub-letales, frecuentemente confundida con dengue, con síntomas de artralgias que pueden generar incapacidad laboral. Los brotes han sido esporádicos y localizados en la región selvática de la Panamazonia posterior a su primer aislamiento en 1954 (Trinidad y Tobago). La información en la literatura es escaza, diversa y dispersa. Mayaro es un alphavirus filogenéticamente relacionado al complejo del virus del bosque de Semliki, siendo junto a UNA, los únicos virus de dicho complejo aislados en el nuevo mundo. Está conformado por ARN de cadena simple de carga positiva, longitud de 12kb con la región 42S y 26S, que codifican para proteínas no estructurales y estructurales. El virus Mayaro presenta gran plasticidad de infección en vertebrados y especificidad hacia la familia Culicidae (mosquitos) como vectores/hospedadores invertebrados. Los factores de riesgo están asociados a zonas boscosas
High Tc Superconductors: New Insights from Angle-Resolved Photoemission
Mohit Randeria,Juan-Carlos Campuzano
Physics , 1997,
Abstract: Recent angle-resolved photoemission (ARPES) studies of the high Tc superconductors are reviewed. Amongst the topics discussed are: the spectral function interpretation of ARPES data and sum rules; studies of the momentum distribution and the Fermi surface (FS); dispersion of electronic states, flat bands and superlattice effects; unusual lineshapes and their temperature dependence; the question of bilayer splitting; detailed studies of the superconducting gap and its anisotropy; and, finally, studies of the pseudogap and evolution of the FS with doping in the underdoped materials.
The lower envelope of positive self-similar Markov processes
Lo?c Chaumont,Juan-Carlos Pardo
Mathematics , 2006,
Abstract: We establish integral tests and laws of the iterated logarithm for the lower envelope of positive self-similar Markov processes at 0 and $+\infty$. Our proofs are based on the Lamperti representation and time reversal arguments. These results extend laws of the iterated logarithm for Bessel processes due to Dvoretsky and Erd\"{o}s, Motoo and Rivero.
Optimalité systolique infinitésimale de l'oscillateur harmonique
Juan-Carlos álvarez Paiva,Florent Balacheff
Mathematics , 2010,
Abstract: We study the infinitesimal aspects of the following problem. Let H be a Hamiltonian of \R^{2n} whose energy surface {H=1} encloses a compact starshaped domain of volume equal to that of the unit ball in \R^{2n}. Does the energy surface {H=1} carry a periodic orbit of the Hamiltonian system associated to H with action less than or equal to \pi ?
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