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Search Results: 1 - 10 of 197959 matches for " Juan E. Feliu "
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Rosiglitazone-Induced Mitochondrial Biogenesis in White Adipose Tissue Is Independent of Peroxisome Proliferator-Activated Receptor γ Coactivator-1α
Rosario Pardo, Natàlia Enguix, Jaime Lasheras, Juan E. Feliu, Anastasia Kralli, Josep A. Villena
PLOS ONE , 2011, DOI: 10.1371/journal.pone.0026989
Abstract: Background Thiazolidinediones, a family of insulin-sensitizing drugs commonly used to treat type 2 diabetes, are thought to exert their effects in part by promoting mitochondrial biogenesis in white adipose tissue through the transcriptional coactivator PGC-1α (Peroxisome Proliferator-Activated Receptor γ Coactivator-1α). Methodology/Principal Findings To assess the role of PGC-1α in the control of rosiglitazone-induced mitochondrial biogenesis, we have generated a mouse model that lacks expression of PGC-1α specifically in adipose tissues (PGC-1α-FAT-KO mice). We found that expression of genes encoding for mitochondrial proteins involved in oxidative phosphorylation, tricarboxylic acid cycle or fatty acid oxidation, was similar in white adipose tissue of wild type and PGC-1α-FAT-KO mice. Furthermore, the absence of PGC-1α did not prevent the positive effect of rosiglitazone on mitochondrial gene expression or biogenesis, but it precluded the induction by rosiglitazone of UCP1 and other brown fat-specific genes in white adipose tissue. Consistent with the in vivo findings, basal and rosiglitazone-induced mitochondrial gene expression in 3T3-L1 adipocytes was unaffected by the knockdown of PGC-1α but it was impaired when PGC-1β expression was knockdown by the use of specific siRNA. Conclusions/Significance These results indicate that in white adipose tissue PGC-1α is dispensable for basal and rosiglitazone-induced mitochondrial biogenesis but required for the rosiglitazone-induced expression of UCP1 and other brown adipocyte-specific markers. Our study suggests that PGC-1α is important for the appearance of brown adipocytes in white adipose tissue. Our findings also provide evidence that PGC-1β and not PGC-1α regulates basal and rosiglitazone-induced mitochondrial gene expression in white adipocytes.
Tratamiento laparoscópico del cáncer gástrico Laparoscopic management of gastric cancer
E. M. Targarona,X. Feliu,C. Balagué
Revista Espa?ola de Enfermedades Digestivas , 2006,
Abstract:
Higher arithmetic Chow groups
J. I. Burgos Gil,E. Feliu
Mathematics , 2009,
Abstract: We give a new construction of higher arithmetic Chow groups for quasi-projective arithmetic varieties over a field. Our definition agrees with the higher arithmetic Chow groups defined by Goncharov for projective arithmetic varieties over a field. These groups are the analogue, in the Arakelov context, of the higher algebraic Chow groups defined by Bloch. The degree zero group agrees with the arithmetic Chow groups of Burgos. Our new construction is shown to be a contravariant functor and is endowed with a product structure, which is commutative and associative.
Da?os Neuropsicológicos Asociados a los Tratamientos Quimioterapéuticos: Una Propuesta de Evaluación
López-Santiago,Sonia; Cruzado,Juan Antonio; Feliu,Jaime;
Clínica y Salud , 2012,
Abstract: chemotherapy treatments in cancer patients may cause cognitive impairment in a percentage ranging from 15 to 50%, and cause significant deficits in their quality of life. we present the main methodological problems in this field and the recommendations for overcoming them, in terms of design, sampling, impairment criteria, assessment tools and control groups. we present a proposal to assess chemotherapy-induced cognitive impairment in spanish samples. the guidelines aim to assess three cognitive domains that may be t risk of deterioration: verbal memory, executive function and psychomotor abilities, as well as modulating variables: quality of life, fatigue and emotional state (anxiety and depression). the study design should be longitudinal, with assessment at the baseline, before chemotherapy, posttreatment and follow-up. we present the most suitable instruments to assess each of the variables, and recommendations about impairment criteria, interpretation and analysis.
Perfil lipídico, apolipoproteínas y fibrinógeno en adultos portadores de VIH o con SIDA: Estudio preliminar
Stambullian,Marcela; Feliu,María Susana; Slobodianik,Nora Haydée;
Acta bioqu?-mica cl?-nica latinoamericana , 2006,
Abstract: the aim of this paper was to analyze the lipid profile, plasma levels of apolipoproteins and fibrinogen in a group of hiv+/aids adults. the study was performed on 41 patients (19 hiv+ and 22 aids), between 26 and 44 years old. body weight, w (kg) and height, h (m) were determined, and the body mass index calculated (w/h2). blood samples were collected from fasting patients. plasma cholesterol (tc), hdl and ldl, triglycerides, fibrinogen and apolipoproteins were determined. some patients from both groups showed overweight concomitant with increased levels of fibrinogen and apolipoprotein b levels and decreased hdl values. fibrinogen and apo b measurements seem to be more sensitive than tc and ldl determinations. these findings support previous studies on hiv+/aids-infected infants, and stress the importance of incorporating fibrinogen and apolipoprotein b in the periodic nutritional control of these patients. this would enable an early evaluation of cardiovascular risk and the assessment of the therapeutic guidelines, implemented along with the specific anti retroviral treatment and adequate selection of food with a protector effect on plasma lipids.
Perfil lipídico, apolipoproteínas y fibrinógeno en adultos portadores de VIH o con SIDA: Estudio preliminar Lipid profile, plasma apolipoproteins and fibrinogen levels in HIV+/aids adults: Preliminary study
Marcela Stambullian,María Susana Feliu,Nora Haydée Slobodianik
Acta bioqu?-mica cl?-nica latinoamericana , 2006,
Abstract: El objetivo de este trabajo fue analizar el perfil lipídico y la concentración plasmática de apolipoproteinas (A-I y B) y fibrinógeno en un grupo de adultos portadores de VIH o con SIDA con tratamiento antirretroviral de alta eficacia (HAART). Se estudiaron 41 pacientes (19 VIH+ y 22 con SIDA) entre 26 y 44 a os de edad. Se determinó el peso corporal P (kg) y la talla T (m), calculándose el índice de masa corporal (IMC, P/T2). Las muestras de sangre obtenidas en ayunas fueron recogidas en tubos con EDTA y sobre plasma se determinó la concentración de colesterol total (CT), HDL y triglicéridos (TG) (mg/dL), por método enzimático-colorimétrico; la fracción LDL fue calculada a partir de la ecuación de Friedewald. Las apolipoproteínas A-I, B (ApoA-I y ApoB ) y el fibrinógeno (F), se determinaron por inmunodifusión radial cuantitativa sobre placas (Diffuplate, Biocientífica SA) (mg/dL). Un 20% y 44% de los pacientes VIH+ y con SIDA, respectivamente, presentaron sobrepeso. Los resultados obtenidos en este grupo de pacientes, con tratamiento antirretroviral de alta eficacia, evidencian algunas alteraciones en el perfil lipídico y en los niveles de fibrinógeno y apolipoproteína B. Se enfatiza la necesidad de una terapéutica nutricional adecuada con objeto de realizar una apropiada selección de alimentos que puedan ejercer un efecto favorable sobre los lípidos plasmáticos para, de esta manera, compensar los efectos de la medicación. The aim of this paper was to analyze the lipid profile, plasma levels of apolipoproteins and fibrinogen in a group of HIV+/AIDS adults. The study was performed on 41 patients (19 HIV+ and 22 AIDS), between 26 and 44 years old. Body weight, W (kg) and height, H (m) were determined, and the Body Mass Index calculated (W/H2). Blood samples were collected from fasting patients. Plasma cholesterol (TC), HDL and LDL, triglycerides, fibrinogen and apolipoproteins were determined. Some patients from both groups showed overweight concomitant with increased levels of fibrinogen and apolipoprotein B levels and decreased HDL values. Fibrinogen and Apo B measurements seem to be more sensitive than TC and LDL determinations. These findings support previous studies on HIV+/AIDS-infected infants, and stress the importance of incorporating fibrinogen and apolipoprotein B in the periodic nutritional control of these patients. This would enable an early evaluation of cardiovascular risk and the assessment of the therapeutic guidelines, implemented along with the specific anti retroviral treatment and adequate selection of food with a protector effect o
On Goncharov's regulator and higher arithmetic Chow groups
J. I. Burgos Gil,E. Feliu,Y. Takeda
Mathematics , 2009,
Abstract: In this paper we show that the regulator defined by Goncharov from higher algebraic Chow groups to Deligne-Beilinson cohomology agrees with Beilinson's regulator. We give a direct comparison of Goncharov's regulator to the construction given by Burgos and Feliu. As a consequence, we show that the higher arithmetic Chow groups defined by Goncharov agree, for all projective arithmetic varieties over an arithmetic field, with the ones defined by Burgos and Feliu.
M2DAT-HYMO: una herramienta basada en MDA para la generación automática de aplicaciones Web a partir del modelo del hipertexto
Nicolau,Feliu Trias; Vi?ambres,Iván Santiago; Vara,Juan Manuel; Castro,Valeria de;
RISTI - Revista Ibérica de Sistemas e Tecnologias de Informa??o , 2010,
Abstract: nowadays, any software development methodological proposal must be accompanied by the corresponding technological support. such premise becomes even more relevant when the proposal is based on model driven engineering principles. therefore, this proposal presents the tool support for hm3, the hypertext modelling method of midas. in particular, it presents the specification and coding of the model-to-model transformations that bridge the different models that compose hm3, as well as the model-to-text transformations that support code generation. one of the most outstanding aspects of this proposal is the use of weaving models to personalize the model-to-model transformations proposed by hm3.
Pt(S)[n(100)×(110)]表面Cu欠电位沉积
Rubén Gisbert,Víctor Climent,Enrique Herrero,Juan M. Feliu
电化学 , 2012,
Abstract: 本文研究了Cu在Pt(100)台阶面和(110)单原子台阶的欠电位沉积.发现若不考虑阴离子吸附,初始阶段Cu在台阶面和台阶处的电沉积同时进行.在电沉积满单层的伏安曲线上,可以观察到若干峰.通过对峰电荷与台阶密度关系的分析,可认为这些峰分别对应于不同的沉积位点.较正电位的峰对应于Cu在台阶面上的电沉积,而在台阶处Cu的电沉积则因溶液中的阴离子而具有不同的伏安性质.此外,还发现Pt电极表面的Cu沉积电荷转移数接近2e,且沉积初始阶段阴离子覆盖度不变.
Damien Coulon, Barcelone et le grand commerce d’Orient au Moyen ge. Un siècle de relations avec l’Egypte et la Syrie-Palestine (ca. 1330 - ca. 1430).
Feliu, Gaspar
Anuario de Estudios Medievales , 2006,
Abstract:
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