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Search Results: 1 - 10 of 226835 matches for " Joshua R Shak "
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The effect of H. pylori eradication on meal-associated changes in plasma ghrelin and leptin
Fritz Francois, Jatin Roper, Neal Joseph, Zhiheng Pei, Aditi Chhada, Joshua R Shak, Asalia de Perez, Guillermo I Perez-Perez, Martin J Blaser
BMC Gastroenterology , 2011, DOI: 10.1186/1471-230x-11-37
Abstract: Veterans referred for upper GI endoscopy were evaluated at baseline and ≥8 weeks after endoscopy, and H. pylori status and body weight were ascertained. During the first visit in all subjects, and during subsequent visits in the initially H. pylori-positive subjects and controls, blood was collected after an overnight fast and 1 h after a standard high protein meal, and levels of eight hormones determined.Of 92 enrolled subjects, 38 were H. pylori-negative, 44 H. pylori-positive, and 10 were indeterminate. Among 23 H. pylori-positive subjects who completed evaluation after treatment, 21 were eradicated, and 2 failed eradication. After a median of seven months following eradication, six hormones related to energy homeostasis showed no significant differences, but post-prandial acylated ghrelin levels were nearly six-fold higher than pre-eradication (p = 0.005), and median integrated leptin levels also increased (20%) significantly (p < 0.001). BMI significantly increased (5 ± 2%; p = 0.008) over 18 months in the initially H. pylori-positive individuals, but was not significantly changed in those who were H. pylori-negative or indeterminant at baseline.Circulating meal-associated leptin and ghrelin levels and BMI changed significantly after H. pylori eradication, providing direct evidence that H. pylori colonization is involved in ghrelin and leptin regulation, with consequent effects on body morphometry.The healthful regulation of energy homeostasis in humans, depends on centrally-acting hormones such as ghrelin and leptin [1,2]. Serum ghrelin concentrations increase during fasting, and decrease after eating [3]; ghrelin decreases energy expenditure and promotes weight gain [4]. In contrast, leptin produced primarily by adipocytes, reduces appetite and increases energy utilization [5]. The gastric epithelium expresses both ghrelin and leptin (and their receptors) [6,7]; inflammation can modify their production [8,9].Helicobacter pylori, which colonizes the human stom
Impact of Experimental Human Pneumococcal Carriage on Nasopharyngeal Bacterial Densities in Healthy Adults
Joshua R. Shak, Amelieke J. H. Cremers, Jenna F. Gritzfeld, Marien I. de Jonge, Peter W. M. Hermans, Jorge E. Vidal, Keith P. Klugman, Stephen B. Gordon
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0098829
Abstract: Colonization of the nasopharynx by Streptococcus pneumoniae is a necessary precursor to pneumococcal diseases that result in morbidity and mortality worldwide. The nasopharynx is also host to other bacterial species, including the common pathogens Staphylococcus aureus, Haemophilus influenzae, and Moraxella catarrhalis. To better understand how these bacteria change in relation to pneumococcal colonization, we used species-specific quantitative PCR to examine bacterial densities in 52 subjects 7 days before, and 2, 7, and 14 days after controlled inoculation of healthy human adults with S. pneumoniae serotype 6B. Overall, 33 (63%) of subjects carried S. pneumoniae post-inoculation. The baseline presence and density of S. aureus, H. influenzae, and M. catarrhalis were not statistically associated with likelihood of successful pneumococcal colonization at this study’s sample size, although a lower rate of pneumococcal colonization in the presence of S. aureus (7/14) was seen compared to that in the presence of H. influenzae (12/16). Among subjects colonized with pneumococci, the number also carrying either H. influenzae or S. aureus fell during the study and at 14 days post-inoculation, the proportion carrying S. aureus was significantly lower among those who were colonized with S. pneumoniae (p = 0.008) compared to non-colonized subjects. These data on bacterial associations are the first to be reported surrounding experimental human pneumococcal colonization and show that co-colonizing effects are likely subtle rather than absolute.
Assesments of Patient Rights Applications at the Hospitals of Ministry of Health
shak AYDEM?R,Vedat I?IKHAN
Eski?ehir Osmangazi üniversitesi Sosyal Bilimler Dergisi , 2012,
Abstract: This research has been performed for the purpose of assessing the conformity of the applications conducted in hospitals under Ministry of Health in Turkey to accreditation standards for rights of patients and their relatives, created by JCI. The research implemented n the patient's rights unit of hospitals under the Ministry of Health. Survey form consisted of three parts that are some socio - demographic features of patient rights unit officers, application status of JCI standards and problems that patient rights unit officers have faced, methods they found to solve those problems and their suggestions about the subject aimed at improving the quality of patient rights applications. According to the results of the study patients' rights practices in hospitals under the Ministry of Health are in conformity with JCI standards.
ISSUES IN THE APPLICATION OF RESEARCH TO PRACTICE
Ketefian, Shaké;
Revista Latino-Americana de Enfermagem , 2001, DOI: 10.1590/S0104-11692001000500002
Abstract: in recent years calls for evidence-based practice are being made emphatically in the nursing literature worldwide. yet, the underlying construct, which relates to use of scientifically-based knowledge and research to practice, has been with us for a long time. this analytic paper provides an overview of research utilization models developed and used in nursing and other fields, highlighting some of their features. the paper then reviews research utilization and application issues at the institutional level, highlighting the importance of organizational mechanisms for enabling optimum research use and application, rather than relying on individual nurses. it then describes ways in which research can be used at the societal level in the formation of healthy public policies, using the united states as a case study. a number of recommendations are then presented for organizations and the profession at large in a global context.
Leadership in Health Services Management
Shaké Ketefian
Health SA Gesondheid , 2004, DOI: 10.4102/hsag.v9i2.159
Abstract: Dr. Karien Jooste, Assistant Professor, Department of Nursing, Rand Afrikaans University, has edited this outstanding book, published in 2003. She is listed as the editor, although she has also written a number of its chapters. In addition to herself, ten other individuals have authored various chapters. They are authorities in their fields and represent several institutions from three countries in the region. *Please note: This is a reduced version of the abstract. Please refer to PDF for full text.
Quality assessment of doctoral programmes
Shaké Ketefian
Health SA Gesondheid , 2001, DOI: 10.4102/hsag.v6i2.66
Abstract: The purpose of this article is to focus attention on the different ways in which doctoral education can be evaluated. *Please note: This is a reduced version of the abstract. Please refer to PDF for full text.
On The Theoretical Bases of the Ottoman Archival Science Osmanl Ar ivcili inin Teorik Dayanaklar Hakk nda
shak Keskin
Türk Kütüphanecili?i , 2007,
Abstract: The archival practices of the Ottoman State can be learnt by analysing the devices that inspired the administrative practices of this state. And this requires knowing the Turkish-Islamic-Persian State tradition. By doing so, on the one hand the way that bureaucratic and archival processes pass from one state to another can be observed and, on the other hand, an answer to the problem of originality of the Otoman archival practices can be found. Osmanl Devleti'nin ar ivsel uygulamalar bu devletin idari uygulamalar na ilham kayna olan ara lar g zden ge irilerek renilebilir. Bu da, Osmanl idari yap lanmas nda etkili olan Türk- slam-Sasani devlet gelene inin bilinmesine ba l d r. B ylelikle, bir yandan bürokratik ve ar ivsel i leyi in bir devletten di erine nas l intikal etti i g zlemlenebilirken, di er yandan da Osmanl ar iv prati inin zgünlü ü sorununa bir cevap bulunabilir.
ISSUES IN THE APPLICATION OF RESEARCH TO PRACTICE
Ketefian Shaké
Revista Latino-Americana de Enfermagem , 2001,
Abstract: In recent years calls for evidence-based practice are being made emphatically in the nursing literature worldwide. Yet, the underlying construct, which relates to use of scientifically-based knowledge and research to practice, has been with us for a long time. This analytic paper provides an overview of research utilization models developed and used in nursing and other fields, highlighting some of their features. The paper then reviews research utilization and application issues at the institutional level, highlighting the importance of organizational mechanisms for enabling optimum research use and application, rather than relying on individual nurses. It then describes ways in which research can be used at the societal level in the formation of healthy public policies, using the United States as a case study. A number of recommendations are then presented for organizations and the profession at large in a global context.
Current situation of renal stone treatment: a cross-sectional survey from stanbul
Cenk Gürbüz,Metin ?shak ?ztürk,Orhan Koca,As?f Y?ld?r?m
Turkish Journal of Urology , 2011,
Abstract: Objective: In this study, the adequacy of technical equipment used in the treatment of renal stone along with treatment approaches was evaluated.Materials and methods: Between January 2010 and June 2010, 106 urology residents and specialists practicing in 10 different urology departments of training hospitals in stanbul were asked to fill a questionnaire to evaluate the adequacy of necessary equipment and the treatment approaches for the treatment of renal stone.Results: Eighty percent of the physicians who participated in the study treated at least 8 patients with renal stone per month. While all participating clinics had rigid nephroscope, flexible ureterorenoscopy and electroshock wave lithotriptor were available in 41% and 49% of the clinics, respectively. The preferred radiologic evaluation before percutaneous nephrolithotomy (PNL) was intravenous pyelography, and abdominopelvic computed tomography in 72% and 69%, respectively. Tubeless PNL was not preferred by 71% of the participants. The first choice of treatment for coraliform stone was PNL and open surgery in 71% and 26% of participants, respectively. Fifty-four percent of the participants stated that PNL was applied for patients older than 12 years old. Retrograde intrarenal surgery was suggested by 26% of the participants for the treatment of symptomatic lower calix stone.Conclusion: It is encouraging that PNL application is performed in all clinics involved in this study, however, training hospitals should be more equipped.
Intraspecific Variation in a Scorpionfly Newly Recorded from Texas and the State of Taxonomy of North American Panorpidae (Mecoptera)
Joshua R. Jones
Psyche , 2010, DOI: 10.1155/2010/152981
Abstract: Panorpa vernalis Byers is recorded for the first time from Texas, and represents only the second species of Panorpa documented from the state. Intraspecific variations between the Texas specimens and Byers' original description are discussed. A synopsis of the principal modern keys for identification of North American Panorpa is provided, and an argument for a modern taxonomic review of the Panorpidae of North America is presented. 1. Introduction Texasis the largest state within the continental United States. Its expanse, an area 773 miles (1244 kilometers) wide and 790 miles (1270 kilometers) long and covering 261,797 square miles (678,050 square kilometers), includes mountains, deserts, medium-elevation hill country, high- and low-elevation plains, extensive drainages, and a long coastline, all products of a complex geologic history [1]. The diversity of these regions comprises a vast array of habitats with highly varied floras and faunas. In the east, pine forests predominate. Mixed oak grasslands occupy much of the central portions of the state, while sage and mesquite blend with a host of woody shrubs and grasses in the panhandle, west and south. Ranches and farmland dot this landscape, and riverine forests course throughout [2]. While some of Texas’ geologic regions are contained completely within the political boundaries of the state, several, with their respective floras and faunas, extend into Texas from adjacent states and regions [3, 4]. The latter distribution pattern ought to hold true for the scorpionfly genus Panorpa (Mecoptera: Panorpidae), a speciose taxon (84 North American species) [5] distributed broadly throughout the deciduous forests of eastern North America, from Quebec to Mexico and from the East Coast westward to at least Kansas and Oklahoma. However, despite the presence of abundant habitat ideal for scorpionflies in the eastern portions of Texas, prior to this paper only a single species of Panorpa had been recorded from the state, Panorpa nuptialis Gerstaecker [5]. This large and conspicuous species, sometimes referred to as “the Texas scorpionfly,” is fairly widespread in the midwestern and southeast US, having been recorded in the fall in Alabama, Arkansas, Kansas, Louisiana, Mississippi, Missouri, Oklahoma, Texas, and northeastern Mexico [5]. Numerous species of Panorpa have been recorded from the three states that form the northern and eastern borders of Texas: Oklahoma, Arkansas, and Louisiana. No species of Panorpa have been recorded from New Mexico, which abuts the entire western U.S. border of Texas. From Oklahoma
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