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Search Results: 1 - 10 of 232963 matches for " Jose Ma Bellón "
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Effects of highly active antiretroviral therapy with nelfinavir in vertically HIV-1 infected children: 3 years of follow-up. Long-term response to nelfinavir in children
Salvador Resino, Beatriz Larrú, Jose Ma Bellón, Rosa Resino, Ma Isabel de José, Marisa Navarro, Juan Léon, José Ramos, Ma José Mellado, Ma ángeles Mu?oz-Fernández
BMC Infectious Diseases , 2006, DOI: 10.1186/1471-2334-6-107
Abstract: Forty-two vertically HIV-infected children on HAART with NFV were involved in a multicentre prospective study. The children were monitored at least every 3 months with physical examinations, and blood sample collection to measure viral load (VL) and CD4+ cell count. We performed a logistic regression analysis to determinate the odds ratio of baseline characteristics on therapeutic failure.Very important increase in CD4+ was observed and VL decreased quickly and it remained low during the follow-up study. Children with CD4+ <25% at baseline achieved CD4+ >25% at 9 months of follow-up. HIV-infected children who achieved undetectable viral load (uVL) were less than 40% in each visit during follow-up. Nevertheless, HIV-infected children with VL >5000 copies/ml were less than 50% during the follow-up study. Only baseline VL was an important factor to predict VL control during follow-up. Virological failure at defined end-point was confirmed in 30/42 patients. Along the whole of follow-up, 16/42 children stopped HAART with NFV. Baseline characteristics were not associated with therapeutic change.NFV is a safe drug with a good profile and able to achieve an adequate response in children.The introduction of highly active antiretroviral therapy (HAART) has lead to a significant decrease in mortality and disease progression in HIV-1 infected children and adolescents [1,2]. Antirretroviral treatment (ART) in children has special features and consequently, results obtained from clinical trials in adults may not be representative of children and more studies about ART effectiveness in the paediatric age are needed.Nelfinavir (NFV) is an HIV-1 Protease Inhibitor (PI). When combined with other antiretroviral drugs, it has been associated with immunologic and virologic responses in antiretroviral therapy-na?ve and experienced adults and children with a good tolerance profile [3,4]. The challenge to give it weigh twice daily instead of the previous schedule of three times per day [5
Hacia un modelo de cooperación y armonización en el campo de la Salud Pública en Espa a
Martín Moreno Jose Ma
Revista Espa?ola de Salud Pública , 2002,
Predictive factors of virological success to salvage regimens containing protease inhibitors in HIV-1 infected children
Beatriz Larru, Carmen de Mendoza, José Bellón, Ma Isabel de José, Ma José Mellado, Vincent Soriano, Ma Angeles Mu?oz-Fernandez, José T Ramos
BMC Infectious Diseases , 2007, DOI: 10.1186/1471-2334-7-55
Abstract: A multicenter, retrospective, observational study was conducted in children who received rescue salvage antiretroviral therapy after virologic failure. CD4 counts and viral load were determined at baseline and 6 months after rescue intervention. Genotypic HIV-1 resistance test and virtual phenotype were assessed at baseline.A total of 33 children met the inclusion criteria and were included in the analysis. The median viral load (VL) and median percentage of CD4+ at baseline was 4.0 HIV-RNA log copies/ml and 23.0% respectively. The median duration that children were taking the new rescue regimen was 24.3 weeks (23.8–30.6). Overall, 47% of the 33 children achieved virological response at 24 weeks. When we compared the group of children who achieved virological response with those who did not, we found out that mean number of PI related mutations among the group of responders was 3.8 vs. 5.4 (p = 0.115). Moreover, the mean number of susceptible drugs according to virtual phenotype clinical cut-off for maximal virologic response was 1.7 vs. 0.8 and mean number of susceptible drugs according to virtual phenotype cut-off for minimal virlologic response was 2.7 vs. 1.3 (p < 0.01 in all cases). Eighteen children were rescued with a regimen containing a boosted-PI and virological response was significantly higher in those subjects compared with the others (61.1% vs. 28.6%, p < 0.01).Salvage treatment containing ritonavir boosted-PIs in children with virological failure was very efficient. The use of new tools as virtual phenotype could help to improve virologic success in pediatric population.Treatment with highly active antiretroviral therapy (HAART) has resulted in great reductions in mortality and progression of HIV-1 disease in both adults and children. Increasingly, these children are surviving through to adolescent into adult life [1]. However, children taking antiretroviral therapy tend to present with higher plasma viral load (VL) and lower virologic response rates
Complications of continuous renal replacement therapy in critically ill children: a prospective observational evaluation study
Maria J Santiago, Jesús López-Herce, Javier Urbano, María Solana, Jimena del Castillo, Yolanda Ballestero, Marta Botrán, Jose Bellón
Critical Care , 2009, DOI: 10.1186/cc8172
Abstract: A prospective, single-centre, observational study was performed in all critically ill children treated using CRRT in order to determine the incidence of complications related to the technique (problems of catheterization, hypotension at the time of connection to the CRRT, hemorrhage, electrolyte disturbances) and their relationship with patient characteristics, clinical severity, need for vasoactive drugs and mechanical ventilation, and the characteristics of the filtration techniques.Of 174 children treated with CRRT, 13 (7.4%) presented problems of venous catheterization; this complication was significantly more common in children under 12 months of age and in those weighing less than 10 kg. Hypotension on connection to CRRT was detected in 53 patients (30.4%). Hypotension was not associated with any patient or CRRT characteristics. Clinically significant hemorrhage occurred in 18 patients (10.3%); this complication was not related to any of the variables studied. The sodium, chloride, and phosphate levels fell during the first 72 hours of CRRT; the changes in electrolyte levels during the course of treatment were not found to be related to any of the variables analyzed, nor were they associated with mortality.CRRT-related complications are common in children and some are potentially serious. The most common are hypotension at the time of connection and electrolyte disturbances. Strict control and continuous monitoring of the technique are therefore necessary in children on CRRT.Continuous renal replacement therapy (CRRT) is currently the most widely used technique for extrarenal filtration in critically ill children, because it allows continuous and programmed fluid removal [1-5].Although a number of studies have demonstrated that these techniques are useful and safe in critically ill children of any age [4-7], complications do occur [8]. Children are at a higher risk than adults for developing complications associated with CRRT due to the difficulty of venous ca
Circuit life span in critically ill children on continuous renal replacement treatment: a prospective observational evaluation study
Jimena del Castillo, Jesús López-Herce, Elena Cidoncha, Javier Urbano, Santiago Mencía, Maria J Santiago, Jose M Bellón
Critical Care , 2008, DOI: 10.1186/cc6965
Abstract: A prospective observational study was performed in 122 children treated with CRRT in a pediatric intensive care unit from 1996 to 2006. Patient and filter characteristics were analyzed to determine their influence on circuit life. Data were collected on 540 filters in 122 patients and an analysis was performed of the 365 filters (67.6%) that were changed due to circuit coagulation.The median circuit life was 31 hours (range 1 to 293 hours). A univariate and multivariate logistic regression study was performed to assess the influence of each one of the factors on circuit life span. No significant differences in filter life were found according to age, weight, diagnoses, pump, site of venous access, blood flow rate, ultrafiltration rate, inotropic drug support, or patient outcome. The mean circuit life span was longer when the heparin dose was greater than 20 U/kg per hour (39 versus 29.1 hours; P = 0.008), with hemodiafiltration compared with hemofiltration (34 versus 22.7 hours; P = 0.001), with filters with surface areas of 0.4 to 0.9 m2 (38.2 versus 26.1 hours; P = 0.01), and with a catheter size of 6.5 French or greater (33.0 versus 25.0 hours; P = 0.04). In the multivariate analysis, hemodiafiltration, heparin dose of greater than 20 U/kg per hour, filter surface area of 0.4 m2 or greater, and initial creatinine of less than 2 mg/dL were associated with a filter life of more than 24 and 48 hours. Total effluent rate of greater than 35 mL/kg per hour was associated only with a filter life of more than 24 hours.Circuit life span in CRRT in children is short but may be increased by the use of hemodiafiltration, higher heparin doses, and filters with a high surface area.Continuous renal replacement therapy (CRRT) is currently the treatment of choice in critically ill adults and children with acute renal failure, fluid overload, or multiorgan dysfunction as it allows a steady removal of fluid, creatinine, urea, and other substances and produces with less hemodynamic
Medication adherence and utilization in patients with schizophrenia or bipolar disorder receiving aripiprazole, quetiapine, or ziprasidone at hospital discharge: A retrospective cohort study
Ariel Berger, John Edelsberg, Kafi N Sanders, Jose Ma J Alvir, Marko A Mychaskiw, Gerry Oster
BMC Psychiatry , 2012, DOI: 10.1186/1471-244x-12-99
Abstract: Using a database linking hospital admission records to health insurance claims, we identified all patients hospitalized for schizophrenia (ICD-9-CM diagnosis code 295.XX) or bipolar disorder (296.0, 296.1, 296.4-296.89) between January 1, 2001 and September 30, 2008 who received aripiprazole, quetiapine, or ziprasidone at discharge. Patients not continuously enrolled for 6?months before and after hospitalization (“pre-admission” and “follow-up”, respectively) were excluded. We examined patterns of use of these agents during follow-up, including adherence with treatment (using medication possession ratios [MPRs] and cumulative medication gaps [CMGs]) and therapy switching. Analyses were undertaken separately for patients with schizophrenia and bipolar disorder, respectively.We identified a total of 43 patients with schizophrenia, and 84 patients with bipolar disorder. During the 6-month period following hospitalization, patients with schizophrenia received an average of 101 therapy-days with the second-generation antipsychotic agent prescribed at discharge; for patients with bipolar disorder, the corresponding value was 68 therapy-days. Mean MPR at 6?months was 55.1% for schizophrenia patients, and 37.3% for those with bipolar disorder; approximately one-quarter of patients switched to another agent over this period.Medication compliance is poor in patients with schizophrenia or bipolar disorder who initiate treatment with aripiprazole, quetiapine, or ziprasidone at hospital discharge.Schizophrenia is a chronic, debilitating mental disorder that affects approximately 1% of all persons in the US [1]. Symptoms include -- but are not limited to--hallucinations, delusions, movement disorders, cognitive impairment, and lack of pleasure in everyday life. Onset of schizophrenia typically occurs before the age of 45?years; it is equally likely to affect men and women as well as members of all ethnic groups [2]. Antipsychotic drugs are the mainstay of treatment. Older medicat
Pediatric defibrillation after cardiac arrest: initial response and outcome
Antonio Rodríguez-Nú?ez, Jesús López-Herce, Cristina García, Pedro Domínguez, Angel Carrillo, Jose Bellón, the Spanish Study Group of Cardiopulmonary Arrest in Children
Critical Care , 2006, DOI: 10.1186/cc5005
Abstract: Forty-four out of 241 children (18.2%) who were resuscitated from inhospital or out-of-hospital cardiac arrest had been treated with manual defibrillation. Data were recorded according to the Utstein style. Outcome variables were a sustained return of spontaneous circulation (ROSC) and one-year survival. Characteristics of patients and of resuscitation were evaluated.Cardiac disease was the major cause of arrest in this group. Ventricular fibrillation (VF) or pulseless ventricular tachycardia (PVT) was the first documented electrocardiogram rhythm in 19 patients (43.2%). A shockable rhythm developed during resuscitation in 25 patients (56.8%). The first shock (dose, 2 J/kg) terminated VF or PVT in eight patients (18.1%). Seventeen children (38.6%) needed more than three shocks to solve VF or PVT. ROSC was achieved in 28 cases (63.6%) and it was sustained in 19 patients (43.2%). Only three patients (6.8%), however, survived at 1-year follow-up. Children with VF or PVT as the first documented rhythm had better ROSC, better initial survival and better final survival than children with subsequent VF or PVT. Children who survived were older than the finally dead patients. No significant differences in response rate were observed when first and second shocks were compared. The survival rate was higher in patients treated with a second shock dose of 2 J/kg than in those who received higher doses. Outcome was not related to the cause or the location of arrest. The survival rate was inversely related to the duration of cardiopulmonary resuscitation.Defibrillation is necessary in 18% of children who suffer cardiac arrest. Termination of VF or PVT after the first defibrillation dose is achieved in a low percentage of cases. Despite a sustained ROSC being obtained in more than one-third of cases, the final survival remains low. The outcome is very poor when a shockable rhythm develops during resuscitation efforts. New studies are needed to ascertain whether the new internationa
Synchronic gastric adenocarcinoma and lymphoma Adenocarcinoma y linfoma gástricos sincrónicos
Carles Olona-Casas,Vicente Vicente-Guillén,Aleidis Caro-Tarragó,Jose Ma Coronas-Riba
Revista Espa?ola de Enfermedades Digestivas , 2011,
Efecto sobre la mejora y retención de la fuerza de un programa de entrenamiento de fuerza con cargas concentradas en sujetos no entrenados. Effect on the strength improvement and retention during a training program with concentrated loads in non trained subjects.
Ace?a Rubio, Rosa Ma,Díaz Ure?a, Germán,González Ravé, Jose Ma,Juárez Santos García, Daniel
RICYDE : Revista Internacional de Ciencias del Deporte , 2007,
Abstract: Resumen En este estudio se ha analizado la mejora y retención de la fuerza en 34 sujetos no entrenados, distribuidos de forma aleatoria en un grupo experimental (GE) (n=17) que efectuó un programa de entrenamiento para la mejora de la misma de 9 semanas de duración, realizando 4 sesiones consecutivas de entrenamiento semanal, y un grupo control (GC) (n=17) que no llevó a cabo ningún entrenamiento. Se tomaron mediciones del peso máximo elevado en 1RM, la fuerza máxima, y la fuerza media total, con el sistema de medición de fuerzas dinámicas Isocontrol 3.6, en el ejercicio de squat (SQ), antes (PRE-), en la mitad (MED-) y al final del tratamiento (POST 1), así como tras 1 (POST 2) y 2 meses (POST 3) de la finalización mismo. En el GE, las ganancias de fuerza fueron altamente significativas (p<0.01) tanto en la mitad (19%), como al final del programa de entrenamiento (35%), e incluso tras 2 meses de la finalización del mismo (40%). En el GC no se produjeron cambios significativos. En conclusión, tras 9 semanas de entrenamiento de fuerza, se pueden obtener mejoras de la misma altamente significativas utilizando cargas concentradas en sujetos no entrenados, y se pueden seguir alcanzando mayores ganancias durante al menos otras 8 semanas más después de finalizado el entrenamiento.Abstract In this study has analyzed the improvement and retention of strength in 34 nontrained subjects, randomized in an experimental group(GE) (n=17) who realized a strength training program during 9 weeks, making 4 consecutive sessions of weekly training, and a control group (GC) (n=17) who did not realized any training. The 1 repetition maximum (1RM), maximum strength, total mean strength, were measured with ISOCONTROL 3.6. device in squat (SQ). The measured were done before (PRE-), in the middle (MED-), at the end of the treatment (POST 1), as well as after 1 and 2 months of the conclusion of the same one. In the experimental group, the strength gains were highly significant as much in the middle (19%), as at the end of the training program (35%), and even after 2 months of the conclusion of the same one (40%). In the GC significant changes did not take place. In conclusion, after 9 weeks of strength training, can be obtained improvements of same highly significant using concentrated loads in nontrained subjects, and they are possible to be continued reaching greater gains during at least other 8 weeks after more finalized the training.
SPECIAL REPORT: Reaffirm the Communist Manifesto
Jose Ma. Sison
Kasarinlan : Philippine Journal of Third World Studies , 2000,
Abstract: More than 150 years into the foretold struggle between capital and labor, between the bourgeosie and the proletariat, the Communist Manifesto is here reaffirmed. While the communist goal of abolishing private ownership of the means of production remains unrealized due to the comprehensive orchestration of a state aided bourgeosie, the ruling class continues to prosper under the fragmented socialist threat. But as the Manifesto declared, the ruling class will not escape the worsening crisis of its own system. The proletariat can only take so much oppression and exploitation which now exists on a global scale. The next revolution wherein the communist would have relearned lessons of past triumphs and failures and taken into full account the evolving world capitalist order, may finally lead to the realization of the socialist dream and the final reaffirmation of the Manifesto.
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