oalib

Publish in OALib Journal

ISSN: 2333-9721

APC: Only $99

Submit

Any time

2020 ( 3 )

2019 ( 41 )

2018 ( 76 )

2017 ( 65 )

Custom range...

Search Results: 1 - 10 of 41165 matches for " Jose Luis;Delgado "
All listed articles are free for downloading (OA Articles)
Page 1 /41165
Display every page Item
Key Performance Indicators for QOS Assessment in TETRA Networks
Jose Dario Luis Delgado,Jesus Maximo Ramirez Santiago
Computer Science , 2014, DOI: 10.5121/ijmnct.2013.3601
Abstract: Key Performance Indicators (KPIs) are widely used by GSM and UMTS carriers with the aim of evaluating the network performance and the Quality of Service (QoS) delivered to users. TETRA networks are basically designed to provide telecommunication services to Public Safety & Security (PSS) organizations, thus the compliance of the QoS levels required by these clients is usually critical. Despite that, the use of KPIs to assess the network performance and the QoS achieved in TETRA systems is not very common. This paper not only states the need of monitoring and evaluating these parameters, but also introduces a set of KPIs which is considered necessary and sufficient in order to allow TETRA operators to be aware of whether provided services meet the QoS requirements established by end users.
An Illustrative Case of Subcutaneous Panniculitis-Like T-Cell Lymphoma
Farshad Bagheri,Kelly L. Cervellione,Belkis Delgado,Luis Abrante,Jose Cervantes,Jitendra Patel,Alan Roth
Journal of Skin Cancer , 2011, DOI: 10.1155/2011/824528
Abstract: Subcutaneous panniculitis-like T-cell lymphoma (SPTCL) is a very rare form of skin lymphoma that is localized primarily to the subcutaneous adipose tissue without palpable involvement of the lymph nodes. Diagnosis of SPTCL is a challenge, especially during its early phases when symptoms mimic other, more common conditions, such as benign panniculitis, eczema, dermatitis, psoriasis and cellulitis. Clinical and systemic features are nonspecific and can include fever, chills, and weight loss. Further complicating diagnosis is the high number of false negatives provided by biopsy. Here we present a case of SPTCL that illustrates the full course of the disease, from presentation and multiple misdiagnoses to correct disease recognition and successful treatment. A review of the challenges of diagnosis is provided with recommendations for more accurate and timely recognition of SPTCL. 1. Introduction Subcutaneous panniculitis-like T-cell lymphoma (SPTCL) is a very rare form of skin lymphoma that is localized primarily to the subcutaneous adipose tissue without palpable involvement of the lymph nodes. It was first described in 1991 in an 8-case series [1] but was not recognized as a distinct entity by the World Health Organization until 2001 [2]. It is estimated that SPTCL accounts for less than 1% of all non-Hodgkins lymphomas [2]. Most often it presents as multiple, painless, subcutaneous nodules on the extremities and trunk. In its early phases, the nodules may resolve without treatment and subsequently new nodules may develop on the same or different skin locations. Diagnosis of SPTCL is a challenge, especially during initial contact with physicians when symptoms mimic other, more common conditions, such as benign panniculitis, eczema, dermatitis, psoriasis, cellulites, and other skin and soft tissue infections. Clinical and systemic symptoms are nonspecific and can include fever, chills, and weight loss; approximately half of patients develop mild cytopenias. More serious conditions associated with SPTCL include hepatosplenomegaly, mucosal ulcers, serosal effusions, hemophagocytosis syndrome (HPS), and pancytopenia, though these are less common [3, 4]. Here we describe a case of a middle-aged woman who presented with recurring fevers of unknown origin and an 8-month history of thigh and leg swelling and rash. After several in-patient and out-patient visits, she was diagnosed with SPTCL based on clinical history and results of surgical pathology. Challenges of diagnosis are discussed. 2. Case Report 2.1. First Admission A 44-year-old morbidly obese female
Toxicity of Spathodea campanulata P Beauvois (Scrophulariales: Bignoniaceae) aqueous extracts against immature stages of Anopheles albimanus (Diptera: Culicidae) under laboratory conditions
Jose Luis Torres-Estrada, Julio Cesar Velazquez Gonzalez, Silvany M Rios Delgado, et al
Research and Reports in Tropical Medicine , 2010, DOI: http://dx.doi.org/10.2147/RRTM.S14130
Abstract: xicity of Spathodea campanulata P Beauvois (Scrophulariales: Bignoniaceae) aqueous extracts against immature stages of Anopheles albimanus (Diptera: Culicidae) under laboratory conditions Original Research (3966) Total Article Views Authors: Jose Luis Torres-Estrada, Julio Cesar Velazquez Gonzalez, Silvany M Rios Delgado, et al Published Date December 2010 Volume 2010:1 Pages 83 - 87 DOI: http://dx.doi.org/10.2147/RRTM.S14130 Jose Luis Torres-Estrada1, Julio Cesar Velazquez Gonzalez1, Silvany M Rios Delgado1, María Guadalupe Vazquez-Martinez1, R Patricia Penilla-Navarro1, Americo D Rodriguez1 1Centro Regional de Investigación en Salud Pública, Instituto Nacional de Salud Pública, Colonia Centro, Tapachula, Chiapas, México Purpose: To determine the effects of African tulip Spathodea campanulata aqueous extracts on every immature stage of Anopheles albimanus under laboratory conditions. Methods: The extract was obtained making an incision on the apical part of prefloral bulbs, and two sets of dilutions with distilled water were prepared. The first set was used at 50%, 20%, 10%, 5%, and 2.5% concentrations in bioassays to test its effect on egg-hatching inhibition. The second set was used at 10%, 5%, 1%, 0.1%, and 0.01% to test toxicity on larvae and pupae. Also, residual efficacy and lethal time (LT) were estimated. Results: The highest inhibition (87.5%) recorded for egg hatching was at a 50% concentration. Third and fourth instar larvae and pupae were the most susceptible to 10% and 5% of S. campanulata aqueous extracts, with 98.3%–100% mortality. The residual activity with 10% concentration persisted 7 days, with 100% mortality, and LT for 99% mortality (LT99) was 2.28 hours on third instar larvae, 1.7 hours on fourth instar larvae, and 2.25 hours on pupae. Conclusion: S. campanulata extracts are promising as biolarvicides. Further toxicological and chromatographic studies are encouraged and needed.
Toxicity of Spathodea campanulata P Beauvois (Scrophulariales: Bignoniaceae) aqueous extracts against immature stages of Anopheles albimanus (Diptera: Culicidae) under laboratory conditions
Jose Luis Torres-Estrada,Julio Cesar Velazquez Gonzalez,Silvany M Rios Delgado,et al
Research and Reports in Tropical Medicine , 2010,
Abstract: Jose Luis Torres-Estrada1, Julio Cesar Velazquez Gonzalez1, Silvany M Rios Delgado1, María Guadalupe Vazquez-Martinez1, R Patricia Penilla-Navarro1, Americo D Rodriguez11Centro Regional de Investigación en Salud Pública, Instituto Nacional de Salud Pública, Colonia Centro, Tapachula, Chiapas, MéxicoPurpose: To determine the effects of African tulip Spathodea campanulata aqueous extracts on every immature stage of Anopheles albimanus under laboratory conditions.Methods: The extract was obtained making an incision on the apical part of prefloral bulbs, and two sets of dilutions with distilled water were prepared. The first set was used at 50%, 20%, 10%, 5%, and 2.5% concentrations in bioassays to test its effect on egg-hatching inhibition. The second set was used at 10%, 5%, 1%, 0.1%, and 0.01% to test toxicity on larvae and pupae. Also, residual efficacy and lethal time (LT) were estimated.Results: The highest inhibition (87.5%) recorded for egg hatching was at a 50% concentration. Third and fourth instar larvae and pupae were the most susceptible to 10% and 5% of S. campanulata aqueous extracts, with 98.3%–100% mortality. The residual activity with 10% concentration persisted 7 days, with 100% mortality, and LT for 99% mortality (LT99) was 2.28 hours on third instar larvae, 1.7 hours on fourth instar larvae, and 2.25 hours on pupae.Conclusion: S. campanulata extracts are promising as biolarvicides. Further toxicological and chromatographic studies are encouraged and needed.Keywords: African tulip, botanical insecticides, malaria, mosquitoes
Estrategias y obstáculos para el desarrollo de la investigación en programas de anestesiología: documento de consenso en Colombia Strategies and obstacles to research development in anesthesiology programs: consensus document in Colombia
Jose Andrés Calvache,Luis Enrique Chaparro,Alexandra Chaves,Martha Beatriz Delgado
Revista Colombiana de Anestesiología , 2012,
Abstract: La práctica clínica perioperatoria en Latinoamérica está influenciada por investigación generada y publicada en países desarrollados. Afortunadamente, las condiciones económicas cada vez más favorables para la ciencia en los países en vías de desarrollo, sumado al incremento en la visibilidad de nuestras publicaciones científicas, han desencadenado un incremento en el interés por mejorar los estándares de la calidad de la investigación local y a su vez en los trabajos de grado que se generan durante los estudios de posgrado en anestesiología. El presente documento es el resultado de la participación y discusión activa de los expositores y asistentes al evento: Simposio de investigaciones en Anestesia: El camino para participar en la sociedad del conocimiento , organizado por la Sociedad Antioque a de Anestesiología y Reanimación (SADEA) y la Sociedad Colombiana de Anestesiología y Reanimación (SCARE) en el a o 2011. El objetivo del documento es plantear estrategias para ajustar, planificar y mejorar los procesos de investigación, así como la creación y la divulgación del conocimiento generado en anestesiología, medicina del dolor y cuidado intensivo para Colombia y países afines. Incluimos recomendaciones para los programas de posgrado, las instituciones prestadoras de salud y sociedades de anestesiología. Perioperative clinical practice in Latin America is influenced by research developed and published in developed countries. Fortunately, the increasingly favorable economic conditions for science in the developing countries, in addition to the heightened visibility of our scientific publications has triggered greater interest in improving the quality standards of local research and of the graduate theses generated in the course of graduate studies in anesthesiology. This document is the result of the active participation and discussion among the speakers attending the Symposium on Research in Anesthesia: the path to participation in the society of knowledge , organized by the Society of Anesthesiology and Resuscitation of Antioquia (SADEA) and the Colombian Society of Anesthesiology and Resuscitation (SCARE) in 2011. The purpose of the document is to discuss the strategies to adjust, plan and improve the research processes, as well as the creation and dissemination of knowledge generated in Anesthesiology, Pain Medicine and Intensive Care in Colombia and other developing countries. Recommendations have been included for graduate programs, health care providers and the societies of anesthesiology.
DNA testing for parentage verification in a conservation nucleus of Pantaneiro horse
Sereno, Fabiana Tavares Pires de Souza;Sereno, José Robson Bezerra;Vega-Pla, Jose Luis;Delgado, Juan Vicente;
Genetics and Molecular Biology , 2008, DOI: 10.1590/S1415-47572008000100013
Abstract: we investigated the genealogy of the in situ conservation nucleus of the pantaneiro horse using dna microsatellites by evaluating 101 horses, the group consisting of 71 adult horses (3 stallions, 40 male and 31 mares) and 27 foals (14 colts and 13 fillies). genomic dna was extracted from hair roots and genotyped using 12 microsatellite markers (aht4, aht5, asb2, asb17, asb23, hms3 hms6, hms7, htg4, htg10, lex33 and vhl20). the number of alleles per locus varied from 6 to 13, with a mean of 7.8 and the expected heterozygosity ranged from 0.544 to 0.734 (mean 0.644). the vlh20, asb2, htg10, asb23 markers had a high (> 0.8) polymorphism information content and the total exclusion probability of the 12 microsatellite loci was 0.99. the genealogical study of the pantaneiro horse using genetic markers was efficient in detecting mistakes during paternity and maternity designation and is an important tool which can be used together with traditional systems of animal identification. the use of genetic markers is recommended in the systematic control of the genealogical registrations and conservation plans to improve genetic aspects of the pantaneiro horse.
The PDZ-Binding Motif of Severe Acute Respiratory Syndrome Coronavirus Envelope Protein Is a Determinant of Viral Pathogenesis
Jose M. Jimenez-Guarde?o,Jose L. Nieto-Torres,Marta L. DeDiego,Jose A. Regla-Nava,Raul Fernandez-Delgado,Carlos Casta?o-Rodriguez,Luis Enjuanes
PLOS Pathogens , 2014, DOI: doi/10.1371/journal.ppat.1004320
Abstract: A recombinant severe acute respiratory syndrome coronavirus (SARS-CoV) lacking the envelope (E) protein is attenuated in vivo. Here we report that E protein PDZ-binding motif (PBM), a domain involved in protein-protein interactions, is a major determinant of virulence. Elimination of SARS-CoV E protein PBM by using reverse genetics caused a reduction in the deleterious exacerbation of the immune response triggered during infection with the parental virus and virus attenuation. Cellular protein syntenin was identified to bind the E protein PBM during SARS-CoV infection by using three complementary strategies, yeast two-hybrid, reciprocal coimmunoprecipitation and confocal microscopy assays. Syntenin redistributed from the nucleus to the cell cytoplasm during infection with viruses containing the E protein PBM, activating p38 MAPK and leading to the overexpression of inflammatory cytokines. Silencing of syntenin using siRNAs led to a decrease in p38 MAPK activation in SARS-CoV infected cells, further reinforcing their functional relationship. Active p38 MAPK was reduced in lungs of mice infected with SARS-CoVs lacking E protein PBM as compared with the parental virus, leading to a decreased expression of inflammatory cytokines and to virus attenuation. Interestingly, administration of a p38 MAPK inhibitor led to an increase in mice survival after infection with SARS-CoV, confirming the relevance of this pathway in SARS-CoV virulence. Therefore, the E protein PBM is a virulence domain that activates immunopathology most likely by using syntenin as a mediator of p38 MAPK induced inflammation.
Identification of the Mechanisms Causing Reversion to Virulence in an Attenuated SARS-CoV for the Design of a Genetically Stable Vaccine
Jose M. Jimenez-Guarde?o?,Jose A. Regla-Nava?,Jose L. Nieto-Torres?,Marta L. DeDiego?,Carlos Casta?o-Rodriguez?,Raul Fernandez-Delgado,Stanley Perlman?,Luis Enjuanes
PLOS Pathogens , 2015, DOI: 10.1371/journal.ppat.1005215
Abstract: A SARS-CoV lacking the full-length E gene (SARS-CoV-?E) was attenuated and an effective vaccine. Here, we show that this mutant virus regained fitness after serial passages in cell culture or in vivo, resulting in the partial duplication of the membrane gene or in the insertion of a new sequence in gene 8a, respectively. The chimeric proteins generated in cell culture increased virus fitness in vitro but remained attenuated in mice. In contrast, during SARS-CoV-?E passage in mice, the virus incorporated a mutated variant of 8a protein, resulting in reversion to a virulent phenotype. When the full-length E protein was deleted or its PDZ-binding motif (PBM) was mutated, the revertant viruses either incorporated a novel chimeric protein with a PBM or restored the sequence of the PBM on the E protein, respectively. Similarly, after passage in mice, SARS-CoV-?E protein 8a mutated, to now encode a PBM, and also regained virulence. These data indicated that the virus requires a PBM on a transmembrane protein to compensate for removal of this motif from the E protein. To increase the genetic stability of the vaccine candidate, we introduced small attenuating deletions in E gene that did not affect the endogenous PBM, preventing the incorporation of novel chimeric proteins in the virus genome. In addition, to increase vaccine biosafety, we introduced additional attenuating mutations into the nsp1 protein. Deletions in the carboxy-terminal region of nsp1 protein led to higher host interferon responses and virus attenuation. Recombinant viruses including attenuating mutations in E and nsp1 genes maintained their attenuation after passage in vitro and in vivo. Further, these viruses fully protected mice against challenge with the lethal parental virus, and are therefore safe and stable vaccine candidates for protection against SARS-CoV.
N-acetyl-L-cysteine combined with mesalamine in the treatment of ulcerative colitis: Randomized, placebo-controlled pilot study
Luis G Guijarro, Jose Mate, Javier P Gisbert, Jose Luis Perez-Calle, Ignacio Marín-Jimenez, Encarna Arriaza, Tomás Olleros, Mario Delgado, Maria S Castillejo, David Prieto-Merino, Venancio Gonzalez Lara, Amado Salvador Pe?a
World Journal of Gastroenterology , 2008,
Abstract: AIM: To evaluate the effectiveness and safety of oral N-acetyl-L-cysteine (NAC) co-administration with mesalamine in ulcerative colitis (UC) patients.METHODS: Thirty seven patients with mild to moderate UC were randomized to receive a four-wk course of oral mesalamine (2.4 g/d) plus N-acetyl-L-cysteine (0.8 g/d) (group A) or mesalamine plus placebo (group B). Patients were monitored using the Modified Truelove-Witts Severity Index (MTWSI). The primary endpoint was clinical remission (MTWSI ≤ 2) at 4 wk. Secondary endpoints were clinical response (defined as a reduction from baseline in the MTWSI of ≥ 2 points) and drug safety. The serum TNF-α, interleukin-6, interleukin-8 and MCP-1 were evaluated at baseline and at 4 wk of treatment.RESULTS: Analysis per-protocol criteria showed clinical remission rates of 63% and 50% after 4 wk treatment with mesalamine plus N-acetyl-L-cysteine (group A) and mesalamine plus placebo (group B) respectively (OR = 1.71; 95% CI: 0.46 to 6.36; P = 0.19; NNT = 7.7). Analysis of variance (ANOVA) of data indicated a significant reduction of MTWSI in group A (P = 0.046) with respect to basal condition without significant changes in the group B (P = 0.735) during treatment. Clinical responses were 66% (group A) vs 44% (group B) after 4 wk of treatment (OR = 2.5; 95% CI: 0.64 to 9.65; P = 0.11; NNT = 4.5). Clinical improvement in group A correlated with a decrease of IL-8 and MCP-1. Rates of adverse events did not differ significantly between both groups.CONCLUSION: In group A (oral NAC combined with mesalamine) contrarily to group B (mesalamine alone), the clinical improvement correlates with a decrease of chemokines such as MCP-1 and IL-8. NAC addition not produced any side effects.
Genetic diversity of Brazilian Pantaneiro horse and relationships among horse breeds
Sereno, Fabiana Tavares Pires de Souza;Sereno, José Robson Bezerra;Vega-Pla, Jose Luis;Kelly, Lucy;Bermejo, Juan Vicente Delgado;
Pesquisa Agropecuária Brasileira , 2008, DOI: 10.1590/S0100-204X2008000500007
Abstract: the objective of this work was to evaluate the genetic diversity of brazilian pantaneiro horse by microsatellite markers, investigate the effect of genetic bottlenecks and estimate genetic differentiation among four horse breeds. genetic variation was estimated through allele frequencies and mean breed heterozygosity. nei's genetic distances among the breeds pantaneiro, thoroughbred, arabian, spanish pure breed (andalusian), and uruguay creole were calculated, and it was used to construct an upgma dendrogram. clustering at different k values was calculated to infer population structure and assign individuals to populations. nei's distances showed a minimum distance between pantaneiro horse and spanish pure breed (0.228), and similar distances from spanish pure breed to thoroughbred and to arabian (0.355 and 0.332). it was observed a great level of diversity, clear distance from pantaneiro horse to other breeds, and genetic uniformity within breed. it was verified a certain level of substructure of pantaneiro horse showing no influences from the other studied breeds.
Page 1 /41165
Display every page Item


Home
Copyright © 2008-2017 Open Access Library. All rights reserved.