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Background: This document includes recommendations and guidelines issued by a group of Mexican researchers and specialists gathered in the First National Colloquium for the Diagnosis and Management of Chronic Myeloid Leukaemia (CML) by initiative of Instituto Nacional de Cancerología and with the support of the Leukaemia Department of the MD Anderson Cancer Center. Mexico lacks of updated information taken from its own reality on the diagnosis and treatment of CML and other haematological disorders; besides, there are no national guidelines. Aim: To publish a consensus document with guidelines for the management of CML adjusted to the national environment and overall characteristics. Method: The participants answered a DELPHI questionnaire about the overall aspects of the disease, aiming to target controversial topics, discuss them in the colloquium, and to agree on the best ones. After those meetings, a final document was drawn up. Results: The group presents recommendations for definition, diagnosis, prognosis, monitoring, and treatment of CML in Mexico. Conclusions: Having consensus guidelines for the clinical management of CML in our country will enable the consensual practice of Mexican specialists regarding the clinical approach to CML, as well as optimize the resources which allow the rational planning of the medical care strategies.
In systems in atomic and nano scales such as clusters or
agglomerates constituted of particles from a few to less than one hundred of
atoms, quantum confinement effects are very important. Their optical and
electronic properties are often dependent on the size of the systems and the
way in which the atoms in these clusters are bonded. Generally, these nano-structures
display optical and electronic properties significantly different of those
found in corresponding bulk materials. Silicon agglomerates found in Silicon
Rich Oxide (SRO) films have optical properties, which have reported as depended directly on nano-crystal size. Furthermore, the room temperature
photoluminescence (PL) of Silicon Rich Oxides (SRO) has repeatedly generated a
huge interest due to their possible applications in optoelectronic devices.
However, a plausible emission mechanism has not yet widespread acceptance of
the scientific community. In this research, we employed the Density Functional
Theory with a functional B3LYP and a basis set 6 - 31G* to
calculate the optical and electronic properties of small (six to ten silicon
atoms) and medium size clusters of silicon (constituted of eleven to fourteen
silicon atoms). With the theoretical calculation of the structural and optical
properties of silicon clusters, it is possible to evaluate the contribution of
silicon agglomerates in the luminescent emission mechanism experimentally found
in thin SRO films.