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Search Results: 1 - 10 of 287583 matches for " José R. Sanches; "
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Genomic instability in human actinic keratosis and squamous cell carcinoma
Cabral, Luciana Sanches;Festa Neto, Cyro;Sanches Jr, José A.;Ruiz, Itamar R. G.;
Clinics , 2011, DOI: 10.1590/S1807-59322011000400001
Abstract: objective: to compare the repetitive dna patterns of human actinic keratoses and squamous cell carcinomas to determine the genetic alterations that are associated with malignant transformation. introduction: cancer cells are prone to genomic instability, which is often due to dna polymerase slippage during the replication of repetitive dna and to mutations in the dna repair genes. the progression of benign actinic keratoses to malignant squamous cell carcinomas has been proposed by several authors. material and methods: eight actinic keratoses and 24 squamous cell carcinomas (scc), which were pair-matched to adjacent skin tissues and/or leucocytes, were studied. the presence of microsatellite instability (msi) and the loss of heterozygosity (loh) in chromosomes 6 and 9 were investigated using nine pcr primer pairs. random amplified polymorphic dna patterns were also evaluated using eight primers. results: msi was detected in two (d6s251, d9s50) of the eight actinic keratosis patients. among the 8 patients who had squamous cell carcinoma-i and provided informative results, a single patient exhibited two loh (d6s251, d9s287) and two instances of msi (d9s180, d9s280). two loh and one example of msi (d6s251) were detected in three out of the 10 patients with squamous cell carcinoma-ii. among the four patients with squamous cell carcinoma-iii, one patient displayed three msis (d6s251, d6s252, and d9s180) and another patient exhibited an msi (d9s280). the altered random amplified polymorphic dna ranged from 70% actinic keratoses, 76% squamous cell carcinoma-i, and 90% squamous cell carcinoma-ii, to 100% squamous cell carcinoma-iii. discussion: the increased levels of alterations in the microsatellites, particularly in d6s251, and the random amplified polymorphic dna fingerprints were statistically significant in squamous cell carcinomas, compared with actinic keratoses. conclusion: the overall alterations that were observed in the repetitive dna of actinic keratoses and s
Fluxo de potência AC para opera??o independente de áreas interligadas
Echeverri, Mauricio Granada;Rider, Marcos J.;Mantovani, José R. Sanches;
Sba: Controle & Automa??o Sociedade Brasileira de Automatica , 2011, DOI: 10.1590/S0103-17592011000400001
Abstract: this paper adjusts a mathematical decomposition approach to the ac power flow problem in power systems with interconnected areas operated by diferent transmission system operators (tso). the proposed strategy allows finding the operation point of a particular area without explicit knowledge of network data of the other interconnected areas, being only necessary to exchange border information related to the tie-lines between areas. the methodology is based on the decomposition of the first-order optimality conditions of the ac power flow, which is formulated as a nonlinear programming problem. to allow better visualization of the concept of independent operation of each tso, an artificial neural network have been used to simulate the border information calculation of the interconnected tsos. a multi-area power flow tool can be seen as a basic building block able to address a large number of problems under a multi-tso competitive market philosophy. the ieee rts-96 power system is used in order to show the operation and effectiveness of the decentralized ac power flow.
Modelo de programa??o matemática para controle do crescimento da vegeta??o sob redes de distribui??o de energia elétrica
Apolinário, Liliani A. V.;Mantovani, José R. Sanches;
Sba: Controle & Automa??o Sociedade Brasileira de Automatica , 2011, DOI: 10.1590/S0103-17592011000300006
Abstract: in this paper the problem of scheduling execution of tree pruning under the distribution network is formulated as a binary programming model. this model seeks reducing the fault rates due to the vegetation and the optimized allocation of the annual financial and human resources available by the utilities to maintain the trees under the feeders without violating the financial resources constraints and the reliability index. the reliability index due to the vegetation causes are obtained by regression techniques of historical data from the faults occurred in each feeder. to solve the optimization model it is proposed a dedicated chu-beasley genetic algorithm. the proposed methodology is tested for an aerial distribution system of a medium size city.
Aloca??o otimizada de dispositivos de controle e prote??o em redes de distribui??o
Silva, Luis Gustavo W. da;Pereira, Rodrigo A. F.;Mantovani, José R. Sanches;
Sba: Controle & Automa??o Sociedade Brasileira de Automatica , 2010, DOI: 10.1590/S0103-17592010000300007
Abstract: optimized allocation and/or re-allocation of control and protective devices in distribution networks allows for a better operation and improvement of the reliability indices of the system. control devices (used to reconfigure the feeders) are allocated in distribution networks to obtain an optimal operation strategy to facilitate power supply restoration in the case of a contingency. protective devices (used to isolate faults) are allocated in distribution systems to improve the reliability and continuity of the power supply. it significantly reduces the impacts of faults in terms of customers' outages, and the time needed for fault location and system restoration. in this work, a binary non-linear programming model (bnlp) for the sectionalizing switches and protection devices allocation and/or re-allocation problem is presented. constraints considered for the problem reflect technical and economical limitations, such as in-series protective devices coordination, number of available equipments, importance of the analyzed feeder, circuit topology, quality of power supply and physical limitations of the system. a dedicated reactive tabu search algorithm (rts) is proposed for solving this problem. results and optimized strategies for allocating or re-allocating protection devices and switches considering a real-life network restoration are presented.
Comparative Study of Conventional, Fuzzy Logic and Neural PID Speed Controllers with Torque Ripple Minimization for an Axial Magnetic Flux Switched Reluctance Motor  [PDF]
Eric S. Sanches, José A. Santisteban
Engineering (ENG) , 2014, DOI: 10.4236/eng.2014.611065
Abstract: Three speed controllers for an axial magnetic flux switched reluctance motor with only one stator, are described and experimentally tested. As it is known, when current pulses are imposed in their windings, high ripple torque is obtained. In order to reduce this ripple, a control strategy with modified current shapes is proposed. A workbench consisting of a machine prototype and the control system based on a microcontroller was built. These controllers were: a conventional PID, a fuzzy logic PID and a neural PID type. From experimental results, the effective reduction of the torque ripple was confirmed and the performance of the controllers was compared.
Freqüência da muta??o 844ins68 do gene da cistationina beta-sintetase em pacientes com trombose venosa profunda
Bonini-Domingos, Claudia R.;Zamaro, Paula J. A.;Mendiburu, Carlos F.;Sanches, Fábio E.;Cintra, Juliana R.;Godoy, José M. P. de;Mattos, Luiz C. de;
Revista Brasileira de Hematologia e Hemoterapia , 2005, DOI: 10.1590/S1516-84842005000100005
Abstract: hyperhomocysteinemia, resulting from a deficiency in the conversion of homocysteine to cystathionine, constitutes an independent risk factor for vascular diseases. the 844ins68 mutation of the cystathionine-b-synthetase gene is an additional risk factor for deep venous thrombosis. the aim of this study was to evaluate the frequency of the 844ins68 mutation of the cystathionine-b-synthetase gene in deep venous thrombosis. in a case control study, 95 patients with deep venous thrombosis were evaluated in respect to the presence of the 844ins68 mutation on exon 8 of the cystathionine-b-synthetase gene. the inclusion criterion included the presence of deep venous thrombosis confirmed by duplex or phlebography. a control group was formed consisting of 95 blood donors, without previous history of venous thrombosis with data such as gender, age and race similar to the study group. five milliliters of venous blood were collected in edta anticoagulant from all the members of both groups. the dna was extracted from the leukocytes by te dtab and ctab methods. detection of the gene mutation was made by amplification by pcr, using primers for the insertion region and observed by 2% agarose gel electrophoresis using ethidium bromide stain. the fragment corresponding to the normal allele contains 184 base pairs and the mutant allele 252 base pairs. the fisher exact test was utilized in the analysis of the results. heterozygote individuals for the mutation were evidenced in 14.73% of the patients and in 3.1% of the control group (p-value = 0.009). the frequency of the mutant allele demonstrated a significant difference (0.074 for the patients versus 0.016 for the control group) (p-value = 0.01). no homozygotic individuals were found.
Interannual Variability of Energy Flux in Atmospheric Instability Conditions at Pantanal of Mato Grosso-Brazil  [PDF]
Leone Francisco Amorim Curado, José de Souza Nogueira, Luciana Sanches, Marcelo Sacardis Biudes, Thiago Rangel Rodrigues
Atmospheric and Climate Sciences (ACS) , 2012, DOI: 10.4236/acs.2012.24046
Abstract: The energy balance partitions in wetlands have gained notoriety due to the dynamics and importance of these areas for regional and local climate. Thus, the study was conducted about seasonal and interannual behavior energy fluxes, as well as the influences of the conditions of atmospheric stability and instability. The results showed highest fluxes happened in instability atmospheric conditions. The fluxes of latent and sensible heat showed seasonal variation, indicating that the water availability in the atmosphere has influence on the site energy partition, but the interannual patterns remained similar during the two years of study.
Effects of Sky Conditions Measured by the Clearness Index on the Estimation of Solar Radiation Using a Digital Elevation Model  [PDF]
Marcelo de Carvalho Alves, Luciana Sanches, José de Souza Nogueira, Vanessa Augusto Mattos Silva
Atmospheric and Climate Sciences (ACS) , 2013, DOI: 10.4236/acs.2013.34064

This study evaluated the effects of sky conditions (measured by the clearness index, KT) on the estimation of solar radiation and its components. Solar radiation was calculated by a digital elevation model derived from the Shuttle Radar Topography Mission (SRTM). The calculated radiation was parameterized and validated with measured solar radiation from two stations inside the urban perimeter of the city of Cuiabá, Brazil, during 2006 to 2008. The measured solar radiation varied seasonally, with the highest values in December-March and the lowest in June-September. Comparisons between calculated and measured values for two sites in Cuiabá demonstrate that the model is accurate for daily Rg estimates under clear sky conditions based on Root Mean Square Error, Mean Bias Error and Willmott’s index. However, under partially cloudy and cloudy sky conditions the model was not able to provide robust estimates. Spatially, the highest values of incident Rg occurred on strands with North, Northeast and Northwest orientations and were lowest on those oriented to the South, Southeast and Southwest.

Contribui??es das técnicas projetivas gráficas para a compreens?o da personalidade de andarilhos de estrada
Peres, Rodrigo Sanches;Justo, José Sterza;
Estudos de Psicologia (Natal) , 2005, DOI: 10.1590/S1413-294X2005000200018
Abstract: research results indicate that the highway wanderers' desertion involves socioeconomic and psychological factors. the objective of the present study was the investigation of the highway wanderers' personality. for so much, the hammers' graphic battery was applied to a group of 23 highway wanderers sheltered in an caring institution. the collected data was evaluated and interpreted by the utilization of meanings attribution's criteria supplied by the scientific literature. data analysis indicate that the participants possess a corporal image committed by inferiority feelings and inadequacy and an affective organization marked by sexual conflicts, primary defense mechanisms and a vehement tendency to isolation in interpersonal relationships. such results supply subsidies for the understanding of some personality characteristics of the researched individuals. however, the corroboration of these hypotheses depends on the accomplishment of new empirical studies.
Amostragem domiciliar contínua em estudos epidemiológicos e no ensino
Carvalheiro,José da Rocha; Sanches,Odécio;
Revista de Saúde Pública , 1979, DOI: 10.1590/S0034-89101979000300004
Abstract: the use of adequate populational-base survey is frequently impossible in epidemiological studies. special studies are made among particular groups of individuals to investigate simultaneously the presence of both the factor and the disease. in these studies it is obviously important to use adequate sampling techniques. a system of continuous household sampling is described, designed to perform, simultaneously, epidemiological research, health system monitoring and to serve as a basis for courses on sampling techniques and epidemiological methods. in the municipality of ribeir?o preto, s. paulo, brazil a household sampling system has been in operation since 1974, using a master sample of 8500 households. every two weeks, 380 households are visited and information is gathered about diseases, accidents, and the use of health services. special epidemiological research is introduced when necessary. future development includes the use of standardized questionnaires and physical and laboratory examinations of the people interviewed.
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