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Search Results: 1 - 10 of 231613 matches for " José Lamartine de Andrade;Castro "
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Resposta terapêutica e inflamatória de ratos com peritonite secundária submetidos ao uso tópico de ampicilina/sulbactam
Kreimer, Flávio;Aguiar, José Lamartine de Andrade;Castro, Célia M M B;Lacerda, Cláudio Moura;Reis, Tarcisio;Lisboa Júnior, Fernando;
Acta Cirurgica Brasileira , 2005, DOI: 10.1590/S0102-86502005000700007
Abstract: objectives: the acute peritonitis is an important cause of sepsis and death on intensive care units and surgery. the treatment must include: systemical use of antibiotics, drainage of abscess and restauration of gastrointestinal integrity. the topical use of antibiotics in the peritoneal cavity is controversial. the aim of this study was to evaluate the use of topical use of ampicilin/sulbactam in the treatment of peritonitis. methods: we measured the plasmatic levels of nitric oxide, count of eosinophils, lymphocytes, monocytes, and neutrophils in blood and peritoneal cavity, using a model of peritonitis in rats (transfixation and ligature of cecum). twenty four wistar rats were divided in 4 groups (n=6 each). group a: induction of peritonitis with ligature of cecum and topical treatment with saline; group b: induction of peritonitis with ligature of cecum and topical treatment with ampicilin/sulbactam; group c: transfixation of cecum; group d: laparotomy and peritoneal exsudate + blood sample. the transfixation-ligture of cecum remained for 24 hs before treatment. a relaparotomy was performed in 18 rats and peritoneal exsudate/blood were collected. dosage of nitric oxide, count of eosinophil, lynphocytes, monocytes, and neutrophils in blood and peritoneal exsudte were done. results: the difference was not significant in the levels of nitric oxide, eosinophil, lynphocytes, monocytes, and neutrophils in blood and peritoneal exsudate (p > 0,05) among the studied groups. concluson: the use of ampicilin associated to sulbactam via intraperitoneal in rats with fecal peritonitis did not change survival.; the levels of plama nitric oxide, count of eosinophil, lynphocytes, monocytes, and neutrophils in blood and peritoneal exsudate were not affected.
A New Biomaterial for Urinary Catheters  [PDF]
Roberto Santos Lima, Salvador Vilar Correia Lima, José Lamartine De Andrade Aguiar, Eziel Cavalcanti Vasconcelos Rocha, Flávia Cristina Morone Pinto
Journal of Biomaterials and Nanobiotechnology (JBNB) , 2018, DOI: 10.4236/jbnb.2018.91001
Abstract: Several studies argue that an ideal biomaterial for urinary catheters is utopian. Based in literature review it seems to be true. However, research advances: the biomaterial itself, new designs, new coatings, associated drugs, etc. Once implanted and interacting with urine, two old problems persist: encrustation and bacterial colonization. In this context, an extracellular product from bacterial synthesis on sugarcane molasses biomaterial has been studied in several experimental and clinical studies. Based on its high biocompatibility, the aim of this study is to evaluate its performance in an in vivo model as an endourologic prosthesis implanted in the bladder of Wistar rats. We evaluate physical, chemical and biological phenomena in comparison to an already established biomaterial, polyurethane. Even though it is not a finished product, the sugarcane biopolymer presented similar performance compared to polyurethane in several analyzed parameters and has an important characteristic: low cost.
área viável e vasculariza o, pós autonomiza o cirúrgica, de retalho pré-fabricado por implante vascular em ratos
Sá Jairo Zacchê de,Aguiar José Lamartine de Andrade,Morais Júlio,Coelho Antonio Roberto Barros
Acta Cirurgica Brasileira , 2002,
Abstract: Os objetivos do presente estudo foram avaliar os efeitos da autonomiza o cirúrgica sobre a extens o da área viável e da vasculariza o de retalhos cutaneos pré-fabricados com área média de 48,2cm2 na parede abdominal de ratos. Os retalhos de pele eram pré-fabricados por implante de um pedículo femoral ligado distalmente e implantado diretamente na camada subdérmica. A pele da parede abdominal de 25 ratos Wistar foi comparada em três grupos de retalhos: grupo A, implante vascular sem autonomiza o e grupos B e C, implante vascular com autonomiza o no mesmo tempo cirúrgico. Três semanas após, os retalhos dos grupos A e B foram elevados como retalhos em ilha, nutridos pelo pedículo implantado. No grupo C, o pedículo implantado foi seccionado no momento da eleva o do retalho. Sete dias após, a extens o das áreas viáveis nos grupos A, B e C foi delimitada e o percentual da área viável, em rela o à área total do retalho, calculado por meio do Auto Cad R 14. A densidade vascular em torno do pedículo implantado, nos grupos A e B, foi avaliada por estudo histológico. O valor médio do percentual de área viável dos retalhos de pele foi de 9,6% no grupo onde os retalhos n o foram autonomizados, 44,8% no grupo onde os retalhos foram autonomizados e 0,3% no grupo onde o pedículo implantado foi seccionado. Os resultados mostraram que o procedimento de autonomiza o aumentou significativamente (p< 0,01, teste bicaudal de Mann - Whitney) os percentuais de área viável e n o alterou estatisticamente (p = 0,307, teste bicaudal de Mann - Whitney) a densidade vascular em torno do pedículo, três semanas após o mesmo ter sido implantado.
Influência do corticóide na cicatriza o da anastomose traqueal sob tens o em c es
Araújo Carlos Alberto Almeida de,Aguiar José Lamartine de Andrade,Lima Francisco Pignataro,Azevêdo ítalo Medeiros de
Acta Cirurgica Brasileira , 2003,
Abstract:
Cardiocirculatory changes in hemorrhagic shock induced in pigs submitted to three distinct therapeutic methods
Abreu, Gilberto Fernandes Silva de;Coelho, Ant?nio Roberto Barros;Aguiar, José Lamartine de Andrade;Moura Filho, Sílvio Amorim;
Acta Cirurgica Brasileira , 2010, DOI: 10.1590/S0102-86502010000100025
Abstract: purpose: to evaluate and compare the response of pigs submitted to hemorrhagic shock and treated using three different strategies. methods: thirty-five dalland pigs were divided into four groups: control; bleeding; saline and saline + red cell concentrate. parameters evaluated: heart rate (hr), mean arterial blood pressure (map) and central vein pressure (cvp).hemorrhagic shock was induced by removing (624.25±64.55), (619.30±44.94) and (664.23±39.96) ml of blood respectively, with the following treatment: bleeding group - zero volume replacement; saline group - replacement with 676 ml of 0.9% saline solution; saline + red cell concentrate group - replacement with 440 ml of 0.9% saline solution + 291 ml of red cell concentrate. the treatment was evaluated after 10 (t3), 30 (t4), 45 (t5) and 60 (t6) minutes. results: hr: no statistically significant difference was found between the bleeding and saline [p=1.000], bleeding and saline + red cell concentrate [p=1.000], and saline and saline + red cell concentrate [p=0.721] groups. map; significant differences were found between all the groups studied. cvp: no significant difference was found between the groups. conclusion: non-replacement and euvolemic resuscitation maintained a satisfactory hemodynamic pattern in controlled severe hemorrhagic shock in swine. the euvolemic replacement strategies exceeded the limit values of map for rebleeding.
Transloca o de bactérias marcadas com Tc99 na icterícia obstrutiva em ratos
Alencar Suelene Suassuna Silvestre de,Medeiros Aldo da Cunha,Brandt Carlos Teixeira,Aguiar José Lamartine de Andrade
Acta Cirurgica Brasileira , 2002,
Abstract: Estudo realizado com o objetivo de avaliar a transloca o bacteriana (TB) do tubo gastrointestinal para órg os viscerais na icterícia obstrutiva. Quatro grupos de ratos foram estudados: grupo I (n=10) ligadura do colédoco, grupo II (n=10) controle ou "sham operation", grupo III (n=12) ligadura do colédoco e gavagem com 99mTc-Escherichia coli e grupo IV (n=5) controle ou "sham operation" e gavagem com 99mTc-E.coli. Usando técnica asséptica e sob anestesia com pentobarbital sódico (20mg/kg), os animais foram submetidos à laparotomia e nos ratos dos grupos I e III foi realizada ligadura do colédoco com fio de seda no 000. Nos ratos dos grupos II e IV foi feita apenas a manipula o do colédoco com pin a de Adison. Após sete dias, os animais dos grupos I e II foram mortos e ressecados fígado, ba o, linfonodos mesentéricos e pulm es para exame microbiológico (meios Agar-sangue e Agar Mac Conkey) e exame histopatológico (colora o H.E. e Tricr mico de Masson) por análise morfométrica. Nos animais dos grupos III e IV, após sete dias, foi administrada por via oral (gavagem) 99mTc-E.coli e após 24h, os ratos de ambos os grupos foram mortos e seus órg os retirados para contagem da radioatividade em cintilador automático Gama, modelo ANSR (ABBOT). O nível médio de bilirrubina, nos grupos ictéricos, foi significantemente maior do que o do grupo controle. O estudo microbiológico revelou maior incidência de bactérias translocadas no grupo I, comparada ao controle (p< 0,05). Os resultados n o mostraram diferen a significante na capta o da 99mTc-E.coli entre os dois grupos. Porém, a análise das intera es grupo x órg o mostrou diferen a entre os grupos ictérico e controle para os órg os: fígado e pulm o. Os dados permitem concluir que em ratos ictéricos por ligadura do colédoco ocorreu TB detectável por exame microbiológico. N o ocorreu TB com 99mTc-E. coli no modelo proposto.
Surgarcane biopolymer patch in femoral artery angioplasty on dogs
Aguiar, José Lamartine de Andrade;Lins, Esdras Marques;Marques, Silvio Romero de Barros;Coelho, Ant?nio Roberto de Barros;Rossiter, Renata de Oliveira;Melo, Roberto José Vieira de;
Acta Cirurgica Brasileira , 2007, DOI: 10.1590/S0102-86502007000700015
Abstract: purpose: the objective of this study was to evaluate the use of the sugarcane biopolymer membrane in femoral artery patch angioplasty on dogs. methods: eight dogs were submitted to bilateral femoral artery patch angioplasty with a sugarcane biopolymer membrane patch on one side and e-ptfe patch on the contralateral side. this research was performed at experimental surgical research laboratory of the centro de ciências da saúde at universidade federal de pernambuco. the dogs were submitted to a new surgery at 180 days after the patch angioplasty in order to harvest the femoral artery. all the animals were evaluated by: clinical examination, measure of femoral artery diameter, arteriogram and doppler fluxometry. yet the material harvested was sent to histological study. each animal served as its own control. results: in all vessels of both groups there were no cases of infection, aneurysm formation, rupture or pseudoaneurysm formation and thrombosis. in both groups it was observed a chronic inflammatory reaction with lymphocytes, neutrophils and fibrosis in the outer surface of the patches. it was observed fibrosis in the inner surfaces of all the patches. in e-ptfe patches occurred invasion by fibroblasts. conclusion: the sugarcane biopolymer membrane can be used as a patch in femoral artery angioplasty on dogs.
Um novo substituto vascular: arterioplastia femoral em c?es com remendo de membrana de biopolímero de cana-de-a?úcar - avalia??o hemodinamica e histopatológica
Marques, Silvio Romero de Barros;Lins, Esdras Marques;Aguiar, José Lamartine de Andrade;Albuquerque, Maria Claudia Sodré;Rossiter, Renata de Oliveira;Montenegro, Luciano Tavares;Vieira, Roberto José;
Jornal Vascular Brasileiro , 2007, DOI: 10.1590/S1677-54492007000400003
Abstract: background: achievement of an ideal arterial substitute to be used in the reconstruction of small- and medium-caliber arteries is still the main objective of most scientific research studies developed in the area of vascular substitutes. sugarcane biopolymer membrane could be extremely useful to perform vascular reconstruction in arteries with diameter smaller than 4 mm, allowing treatment of diseases that affect millions of people in brazil and worldwide. objective: to evaluate the hemodynamic and histopathologic behavior of sugarcane biopolymer membrane when used as a patch in femoral artery angioplasty in dogs. method: eight adult mongrel dogs, under general anesthesia, underwent percutaneous doppler velocimetry of the left and right femoral arteries for preoperative control at the health sciences center experimental research laboratory of universidade federal de pernambuco. after being disinfected, the dogs underwent femoral artery patch angioplasty using a sugarcane membrane biopolymer patch on the left side and an expanded ptfe (e-ptfe) patch on the right side. the dogs underwent daily clinical evaluation for the first week and weekly thereafter. clinical evaluation consisted of an examination of femoral artery pulses, gait assessment and verification as to whether there was any pulsatile tumor, bruising, hemorrhage or surgical wound infection. one hundred and eighty days after the angioplasties, percutaneous doppler velocimetry of the femoral arteries was performed under general anesthesia. next, the dogs underwent dissection of the femoral arteries, measurement of the arterial diameter and perioperative doppler velocimetry proximally and distally to the artery angioplasty. laparotomy was then performed to expose the abdominal aorta for angiographic access. the femoral artery segments with patches were harvested for histopathologic analysis, and the animals were sacrificed under a toxic dosage of anesthetic. results: at 180 days, no cases of surgical wound in
Miastenia grave: evolu??o das pesquisas na clínica neurológica do hospital das clínicas da Faculdade de Medicina da USP
Assis, José Lamartine de;
Arquivos de Neuro-Psiquiatria , 1986, DOI: 10.1590/S0004-282X1986000400013
Abstract: the evolution of investigations in myasthenia gravis in the division of neurology, university of s?o paulo medical school, during the period from 1956 to 1986 is reported. the most important findings in the therapeutical, clinical and immunological researches are showed.
História do estudo da miastenia grave na clínica neurológica do Hospital das Clínicas da Faculdade de Medicina da Universidade de S?o Paulo
Assis, José Lamartine de;
Arquivos de Neuro-Psiquiatria , 1994, DOI: 10.1590/S0004-282X1994000300015
Abstract: it is synthetized the evolution of the researches on myasthenia gravis at the department of neurology of the hospital das clínicas of the faculty of medicine, medical school of the university of s?o paulo (brazil) between 1950 and 1992. the most important results observed about therapeutical, clinical and pathophysiological researches are reviewed. immunologic studies and advances on molecular biology are emphasized.
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