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Search Results: 1 - 10 of 225498 matches for " José Lamartine De Andrade Aguiar "
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A New Biomaterial for Urinary Catheters  [PDF]
Roberto Santos Lima, Salvador Vilar Correia Lima, José Lamartine De Andrade Aguiar, Eziel Cavalcanti Vasconcelos Rocha, Flávia Cristina Morone Pinto
Journal of Biomaterials and Nanobiotechnology (JBNB) , 2018, DOI: 10.4236/jbnb.2018.91001
Abstract: Several studies argue that an ideal biomaterial for urinary catheters is utopian. Based in literature review it seems to be true. However, research advances: the biomaterial itself, new designs, new coatings, associated drugs, etc. Once implanted and interacting with urine, two old problems persist: encrustation and bacterial colonization. In this context, an extracellular product from bacterial synthesis on sugarcane molasses biomaterial has been studied in several experimental and clinical studies. Based on its high biocompatibility, the aim of this study is to evaluate its performance in an in vivo model as an endourologic prosthesis implanted in the bladder of Wistar rats. We evaluate physical, chemical and biological phenomena in comparison to an already established biomaterial, polyurethane. Even though it is not a finished product, the sugarcane biopolymer presented similar performance compared to polyurethane in several analyzed parameters and has an important characteristic: low cost.
área viável e vasculariza o, pós autonomiza o cirúrgica, de retalho pré-fabricado por implante vascular em ratos
Sá Jairo Zacchê de,Aguiar José Lamartine de Andrade,Morais Júlio,Coelho Antonio Roberto Barros
Acta Cirurgica Brasileira , 2002,
Abstract: Os objetivos do presente estudo foram avaliar os efeitos da autonomiza o cirúrgica sobre a extens o da área viável e da vasculariza o de retalhos cutaneos pré-fabricados com área média de 48,2cm2 na parede abdominal de ratos. Os retalhos de pele eram pré-fabricados por implante de um pedículo femoral ligado distalmente e implantado diretamente na camada subdérmica. A pele da parede abdominal de 25 ratos Wistar foi comparada em três grupos de retalhos: grupo A, implante vascular sem autonomiza o e grupos B e C, implante vascular com autonomiza o no mesmo tempo cirúrgico. Três semanas após, os retalhos dos grupos A e B foram elevados como retalhos em ilha, nutridos pelo pedículo implantado. No grupo C, o pedículo implantado foi seccionado no momento da eleva o do retalho. Sete dias após, a extens o das áreas viáveis nos grupos A, B e C foi delimitada e o percentual da área viável, em rela o à área total do retalho, calculado por meio do Auto Cad R 14. A densidade vascular em torno do pedículo implantado, nos grupos A e B, foi avaliada por estudo histológico. O valor médio do percentual de área viável dos retalhos de pele foi de 9,6% no grupo onde os retalhos n o foram autonomizados, 44,8% no grupo onde os retalhos foram autonomizados e 0,3% no grupo onde o pedículo implantado foi seccionado. Os resultados mostraram que o procedimento de autonomiza o aumentou significativamente (p< 0,01, teste bicaudal de Mann - Whitney) os percentuais de área viável e n o alterou estatisticamente (p = 0,307, teste bicaudal de Mann - Whitney) a densidade vascular em torno do pedículo, três semanas após o mesmo ter sido implantado.
Influência do corticóide na cicatriza o da anastomose traqueal sob tens o em c es
Araújo Carlos Alberto Almeida de,Aguiar José Lamartine de Andrade,Lima Francisco Pignataro,Azevêdo ítalo Medeiros de
Acta Cirurgica Brasileira , 2003,
Abstract:
Cardiocirculatory changes in hemorrhagic shock induced in pigs submitted to three distinct therapeutic methods
Abreu, Gilberto Fernandes Silva de;Coelho, Ant?nio Roberto Barros;Aguiar, José Lamartine de Andrade;Moura Filho, Sílvio Amorim;
Acta Cirurgica Brasileira , 2010, DOI: 10.1590/S0102-86502010000100025
Abstract: purpose: to evaluate and compare the response of pigs submitted to hemorrhagic shock and treated using three different strategies. methods: thirty-five dalland pigs were divided into four groups: control; bleeding; saline and saline + red cell concentrate. parameters evaluated: heart rate (hr), mean arterial blood pressure (map) and central vein pressure (cvp).hemorrhagic shock was induced by removing (624.25±64.55), (619.30±44.94) and (664.23±39.96) ml of blood respectively, with the following treatment: bleeding group - zero volume replacement; saline group - replacement with 676 ml of 0.9% saline solution; saline + red cell concentrate group - replacement with 440 ml of 0.9% saline solution + 291 ml of red cell concentrate. the treatment was evaluated after 10 (t3), 30 (t4), 45 (t5) and 60 (t6) minutes. results: hr: no statistically significant difference was found between the bleeding and saline [p=1.000], bleeding and saline + red cell concentrate [p=1.000], and saline and saline + red cell concentrate [p=0.721] groups. map; significant differences were found between all the groups studied. cvp: no significant difference was found between the groups. conclusion: non-replacement and euvolemic resuscitation maintained a satisfactory hemodynamic pattern in controlled severe hemorrhagic shock in swine. the euvolemic replacement strategies exceeded the limit values of map for rebleeding.
Transloca o de bactérias marcadas com Tc99 na icterícia obstrutiva em ratos
Alencar Suelene Suassuna Silvestre de,Medeiros Aldo da Cunha,Brandt Carlos Teixeira,Aguiar José Lamartine de Andrade
Acta Cirurgica Brasileira , 2002,
Abstract: Estudo realizado com o objetivo de avaliar a transloca o bacteriana (TB) do tubo gastrointestinal para órg os viscerais na icterícia obstrutiva. Quatro grupos de ratos foram estudados: grupo I (n=10) ligadura do colédoco, grupo II (n=10) controle ou "sham operation", grupo III (n=12) ligadura do colédoco e gavagem com 99mTc-Escherichia coli e grupo IV (n=5) controle ou "sham operation" e gavagem com 99mTc-E.coli. Usando técnica asséptica e sob anestesia com pentobarbital sódico (20mg/kg), os animais foram submetidos à laparotomia e nos ratos dos grupos I e III foi realizada ligadura do colédoco com fio de seda no 000. Nos ratos dos grupos II e IV foi feita apenas a manipula o do colédoco com pin a de Adison. Após sete dias, os animais dos grupos I e II foram mortos e ressecados fígado, ba o, linfonodos mesentéricos e pulm es para exame microbiológico (meios Agar-sangue e Agar Mac Conkey) e exame histopatológico (colora o H.E. e Tricr mico de Masson) por análise morfométrica. Nos animais dos grupos III e IV, após sete dias, foi administrada por via oral (gavagem) 99mTc-E.coli e após 24h, os ratos de ambos os grupos foram mortos e seus órg os retirados para contagem da radioatividade em cintilador automático Gama, modelo ANSR (ABBOT). O nível médio de bilirrubina, nos grupos ictéricos, foi significantemente maior do que o do grupo controle. O estudo microbiológico revelou maior incidência de bactérias translocadas no grupo I, comparada ao controle (p< 0,05). Os resultados n o mostraram diferen a significante na capta o da 99mTc-E.coli entre os dois grupos. Porém, a análise das intera es grupo x órg o mostrou diferen a entre os grupos ictérico e controle para os órg os: fígado e pulm o. Os dados permitem concluir que em ratos ictéricos por ligadura do colédoco ocorreu TB detectável por exame microbiológico. N o ocorreu TB com 99mTc-E. coli no modelo proposto.
Surgarcane biopolymer patch in femoral artery angioplasty on dogs
Aguiar, José Lamartine de Andrade;Lins, Esdras Marques;Marques, Silvio Romero de Barros;Coelho, Ant?nio Roberto de Barros;Rossiter, Renata de Oliveira;Melo, Roberto José Vieira de;
Acta Cirurgica Brasileira , 2007, DOI: 10.1590/S0102-86502007000700015
Abstract: purpose: the objective of this study was to evaluate the use of the sugarcane biopolymer membrane in femoral artery patch angioplasty on dogs. methods: eight dogs were submitted to bilateral femoral artery patch angioplasty with a sugarcane biopolymer membrane patch on one side and e-ptfe patch on the contralateral side. this research was performed at experimental surgical research laboratory of the centro de ciências da saúde at universidade federal de pernambuco. the dogs were submitted to a new surgery at 180 days after the patch angioplasty in order to harvest the femoral artery. all the animals were evaluated by: clinical examination, measure of femoral artery diameter, arteriogram and doppler fluxometry. yet the material harvested was sent to histological study. each animal served as its own control. results: in all vessels of both groups there were no cases of infection, aneurysm formation, rupture or pseudoaneurysm formation and thrombosis. in both groups it was observed a chronic inflammatory reaction with lymphocytes, neutrophils and fibrosis in the outer surface of the patches. it was observed fibrosis in the inner surfaces of all the patches. in e-ptfe patches occurred invasion by fibroblasts. conclusion: the sugarcane biopolymer membrane can be used as a patch in femoral artery angioplasty on dogs.
Um novo substituto vascular: arterioplastia femoral em c?es com remendo de membrana de biopolímero de cana-de-a?úcar - avalia??o hemodinamica e histopatológica
Marques, Silvio Romero de Barros;Lins, Esdras Marques;Aguiar, José Lamartine de Andrade;Albuquerque, Maria Claudia Sodré;Rossiter, Renata de Oliveira;Montenegro, Luciano Tavares;Vieira, Roberto José;
Jornal Vascular Brasileiro , 2007, DOI: 10.1590/S1677-54492007000400003
Abstract: background: achievement of an ideal arterial substitute to be used in the reconstruction of small- and medium-caliber arteries is still the main objective of most scientific research studies developed in the area of vascular substitutes. sugarcane biopolymer membrane could be extremely useful to perform vascular reconstruction in arteries with diameter smaller than 4 mm, allowing treatment of diseases that affect millions of people in brazil and worldwide. objective: to evaluate the hemodynamic and histopathologic behavior of sugarcane biopolymer membrane when used as a patch in femoral artery angioplasty in dogs. method: eight adult mongrel dogs, under general anesthesia, underwent percutaneous doppler velocimetry of the left and right femoral arteries for preoperative control at the health sciences center experimental research laboratory of universidade federal de pernambuco. after being disinfected, the dogs underwent femoral artery patch angioplasty using a sugarcane membrane biopolymer patch on the left side and an expanded ptfe (e-ptfe) patch on the right side. the dogs underwent daily clinical evaluation for the first week and weekly thereafter. clinical evaluation consisted of an examination of femoral artery pulses, gait assessment and verification as to whether there was any pulsatile tumor, bruising, hemorrhage or surgical wound infection. one hundred and eighty days after the angioplasties, percutaneous doppler velocimetry of the femoral arteries was performed under general anesthesia. next, the dogs underwent dissection of the femoral arteries, measurement of the arterial diameter and perioperative doppler velocimetry proximally and distally to the artery angioplasty. laparotomy was then performed to expose the abdominal aorta for angiographic access. the femoral artery segments with patches were harvested for histopathologic analysis, and the animals were sacrificed under a toxic dosage of anesthetic. results: at 180 days, no cases of surgical wound in
Influência do corticóide na cicatriza??o da anastomose traqueal sob tens?o em c?es
Araújo, Carlos Alberto Almeida de;Aguiar, José Lamartine de Andrade;Lima, Francisco Pignataro;Azevêdo, ítalo Medeiros de;Medeiros, Aldo da Cunha;
Acta Cirurgica Brasileira , 2003, DOI: 10.1590/S0102-86502003000700007
Abstract: objective: the aim of this study is to analyze the incidence and intensity of stenosis in the anastomotic area, after tracheal resection and under tension anastomosis, with the use of methyl-prednisolone as a prophylactic agent of the tracheal stenosis. the wound healing with and without the use of corticoid was analyzed as well. methods: the experimental study was done in 20 mongrel dogs weighing 13± 5 kg randomly separated into two groups. in group a (n=10) corticoid was not used and in the group b (n=10) it was used methyl-prednisolone im 10mg/kg. under general anesthesia with orotracheal intubation, three tracheal rings were ressected from each animal. the force for approach the trachea extremities was 300 gf. the animals were killed with a letal dosis of anesthetic and kcl after 30 days, when the trachea was ressected in order to measure the internal diameter of the anastomosis using a digital pachymeter. the histological study of the anastomotic zone was done by the he and masson trichromic coloration and by a digital system to the quantitative analysis of the histologic data. results: in the group a (control) it was detected a greater stenosis index than in the b (corticosteroid) one and the difference was significant (p<0,01). the same group b revealed inflammatory reaction significantly less intense than the control (p<0,01). conclusion: the data allow to conclude that the use of methyl-prednisolone in dogs submmited to tracheal resection and under tension anastomosis, contributed to decrease the intensity and frequence of stenosis of the anastomosis and reduced the inflammatory reaction in the healing tissue.
Esquistossomose hepatoesplênica cirúrgica: histopatologia hepatica e endoscopia digestiva alta em crian?as comparadas a adultos
Brandt, Carlos Teixeira;Domingues, Ana Lúcia Coutinho;Figueredo-Silva, José;Jucá, Norma;Aguiar, José Lamartine de Andrade;Domingues, Luiz Ant?nio W.;
Revista do Colégio Brasileiro de Cirurgi?es , 2000, DOI: 10.1590/S0100-69912000000100004
Abstract: aiming to get a better understanding on the pathogenesis of severe schistosomiasis mansoni in adults and children, the differences on the liver histopathology and the pattern of upper digestive endoscopy among these patients were studied, twenty-one adults and equal number of children were included in this investigation. all patients underwent splenectomy and ligature of the left gastric vein. the pathological findings were assessed on the sections of wedge liver biopsy. the pathological findings in adults were symmer’s fibrosis grades - i, in one; ii, in seven; and iii, in thirteen. minimal inflammatory activity was observed in five, fair in seven, moderate in six and severe in one. two patients showed no inflammatory activity. minimal granuloma reaction was observed in four patients and moderare in two; fifteen had no such reaction. minimal schistosomotic pigmentation was observed in four patients and moderare in one, howeve1; in sixteen patients, such pigmentation was not observed. in children, symmer's fibrosis grade i was observed in one patient, grade ii in four and grade iii in sixteen. minimal inflammatory reaction was observed in seven patients; and fair reaction in fourteen. minimal granuloma reaction in six patients, fair in five, and moderate in two; in eight patients such reaction was not observed. minimal schistosomotic pigmentation was observed in six patients, fair in three, moderare in six, and not observed in six patients. upper digestive endoscopy showed the following results. adults: medium size esophageal varices in eight (38%) patients, and large size in thirteen (62%). varices in the pyloric part of the stomach were found in eight patients (38%), and five (24%) in the body. portal hypertension gastropathy was seen in sixteen patients (76%). children: four (19%) showed thin esophageal varices, eight (38%) medium size varices, and nine (43%) large size varices. three (14%) patients showed gastric varices, two in the pyloric region and one in the
Effects of the basic fibroblast growth factor and its anti-factor in the healing and collagen maturation of infected skin wound
Dantas Filho, Antonio Medeiros;Aguiar, José Lamartine de Andrade;Rocha, Luís Reginaldo de Menezes;Azevedo, ítalo Medeiros;Ramalho, Esdras;Medeiros, Aldo Cunha;
Acta Cirurgica Brasileira , 2007, DOI: 10.1590/S0102-86502007000700013
Abstract: purpose: the infection is one of the main factors that affect the physiological evolution of the surgical wounds. the aim of this work is to evaluate the effects of fibroblast growth factor (fgfa) and anti-fgfa in the healing, synthesis and maturation of collagen when topically used on infected skin wounds of rats. methods: an experimental study was perfomed in 60 male wistar rats. all animals were divided in two groups (a and b). each group was divided in three subgroups a1, b1; a2, b2 and a3, b3. after anesthesia with pentobarbital, two open squared wounds (1cm2), 4cm distant to each other, were done in the dorsal skin of all the rats. in group a (n=30) the wounds were contaminated with multibacterial standard solution, and in group b(n=30) the wounds were maintained sterile. these wounds were named f1 (for inflammation analysis) and f2 (for collagen study). the open wounds of a1 and b1 rats were topically treated with saline solution, a2 and b2 were treated with fgfa and subgroups a3 and b3 were treated with fgfa and anti-fgfa. the rats were observed until complete epitelization of f2 wounds for determination of healing time and the expression of types i and iii collagen, using picro sirius red staining. inflammatory reaction in f1 wounds was studied using hematoxilineosin staining. the three variable was measured by the image pro-plus média cybernetics software. the statistical analysis was performed by anova and tukey test, considering p<0.05 as significant. results: it was observed that infection retarded significantly (p<0.05) the time of wound scarring and the topical application of fcfb reverted the inhibition of healing caused by bacteria. the inflammatory reaction was greater in the subgroup b2 than in b1 and a3, and the difference was significant (p<0.05). it was observed greater expression of type i collagen in all the subgroups treated with fcfb, when compared with the untreated subgroups. type iii collagen was significantly decreased in wounds of b3 r
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