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Search Results: 1 - 10 of 110587 matches for " José Carlos;Lehn "
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Rela??o entre o estadiamento, o tratamento e a sobrevida no cancer da faringe
Berto, José Carlos;Rapoport, Abr?o;Lehn, Carlos Neutzling;Cestari Filho, Guilherme Antonio;Javaroni, Afonso do Carmo;
Revista do Colégio Brasileiro de Cirurgi?es , 2006, DOI: 10.1590/S0100-69912006000400002
Abstract: background: our purpose is to establish the relationship between stage, therapy and survival for patients with squamous cell carcinoma (scc) of the pharynx. methods: a retrospective study of 507 files of patients with squamous cell carcinoma (scc) of the phrarynx at department de cirurgia de cabe?a e pesco?o do hospital amaral carvalho, jaú, from 1996 to 2001 was conduced. considering variables such as gender, ethnic, symptons, staging, therapy and survival were evaluated using kaplan meyer method for survival and k square test (p<0,05) for others variables. results: median age was 55,6 years (± 11,9 years), 456 males and 51 females (9:1 relation). about ethnic, 480 patients were white (94.7%) and 27 black, follow by wound (13.6%), neck node (11.8%) and hoaseness (7.9%). stage iv (60.6%), justifyng isolated surgery in 11.0% and irradiation in 5.7%. for hipopharynx cancer with surgery alonemortality was (62.2%) ,for oropharynx (68.0%) and nasopharynx (38.9%) with chemoradiotherapy association. conclusion: the 5 years survival for initial stages for oropharynx and hipopharynx were satisfactory with surgical therapy and for nasopharynx with chemoradiotherapy association.
Efeito do priming na redu??o da latência do pipecur?nio, novo bloqueador neuromuscular n?o-despolarizante
Canga, José Carlos;Lehn, Carlos Neutzling;Tonelli, Deoclécio;Sacco, Paula de Camargo Neves;Beltr?o, Danielle;Kirsch, Marcelo;Serralheiro, Fernando César;Cimerman, Gustavo;
Revista Brasileira de Anestesiologia , 2005, DOI: 10.1590/S0034-70942005000400002
Abstract: background and objectives: one of the most important neuromuscular blockers property is short onset, allowing early tracheal intubation. low nondepolarizing blocker dose before the full dose is known to decrease the onset of most neuromuscular blockers. pipecuronium bromide is a long-lasting aminosteroid with major cardiovascular stability, however, with late onset. this study aimed at evaluating pipecuronium priming effect in adult patients submitted to elective surgeries under general anesthesia. methods: participated in this study 33 adult patients of both genders, aged 20 to 65 years, physical status asa i or ii, to be submitted to elective surgeries under general anesthesia. exclusion criteria were patients with kidney or liver failure, neuromuscular diseases, in concurrent use of drugs influencing pipecuronium pharmacokinetics, and patients with family history of malignant hyperthermia. patients were divided in 2 groups: group 1 = priming with 0.01 mg.kg-1 and 3 minutes later the remaining 0.07 mg.kg-1 (total 0.08 mg.kg-1); group 2 = no priming dose (group control). neuromuscular relaxation was controlled by acceleromyography (tof-guard device) and laryngoscopy was accomplished when t1 < 10%. t test for independent samples was used for statistical analysis and shapiro wilks was used to test normality. results: groups were homogeneous. time for t1 < 10% was 161.4 ± 13.7 seconds for group 1 and 217.8 ± 23.4 seconds for group 2, with p < 0.001 and statistically significant differences between groups. conclusions: our results have shown statistically significant differences between groups with and without priming, indicating that pipecuronium also has its onset decreased, similarly to other known neuromuscular blockers.
Fire resistance in a population of Cyathea atrovirens (Langsd. & Fisch.) Domin (Cyatheaceae) in the state of Rio Grande do Sul, Brazil.
Carlos Rodrigo Lehn,Caroline Leuchtenberger
Biotemas , 2008,
Abstract: Cyathea atrovirens (Langsd. & Fisch.) Domin is a tree fern that occurs in the state of Rio Grande do Sul from sea level to an altitude of 300m. We monitored a population of 10 individuals of C. atrovirens affected by burning in the municipality of Campo Bom, Rio Grande do Sul, Brazil. The objective of this study was to analyze the responses of a Cyathea atrovirens population after the occurrence of a fire, considering the following aspects: frond production, annual rates of relative growth of caudex length, and the production, maturation and release of spores. The sporophytes of larger size produced more fronds than the smaller ones. We observed a significant relationship between caudex length and relative growth (TCR) in individuals of smaller size. In the first year, after the fire, all individuals produced new fronds. The spore production was asynchronic. The species apparently demonstrated its capacity to support the occurrence of quick fires, since the post-fire frond production was gradually reestablished.
The desmoplastic limph node reaction as a prognostic factor of cancer of the tongue and floor of the mouth.
Lehn, Carlos Neutzling;Rapoport, Abr?o;
Sao Paulo Medical Journal , 1994, DOI: 10.1590/S1516-31801994000300004
Abstract: to determine the prognostic significance of desmoplasia in metastatic lymph nodes of squamous cell carcinoma of the oral tongue and floor of mouth, 37 cases of this disease were studied. desmoplasia was present in 59,4% of the cases and associated extracapsular spread in 40,5%. the association of desmoplasia with large lymph node involvement occurred in 59,4%. these relationships were statistically significant (p= 0,002 and 0,0069). the results obtained suggest that desmoplasia is a bad prognosis associated factor.
Complexo nasossinusal: anatomia radiológica
Souza, Ricardo Pires de;Brito Júnior, Joel Pinheiro de;Tornin, Olger de Souza;Paes Junior, Ademar José de Oliveira;Barros, Cristiano Ventorim de;Trevisan, Felipe Amstalden;Lehn, Carlos Neutzling;
Radiologia Brasileira , 2006, DOI: 10.1590/S0100-39842006000500013
Abstract: the aim of this study is to evaluate the sinonasal complex to identify the main findings and to determine the diseases in this area. an accurate analysis of the local extent and tumoral dissemination through computed tomography and magnetic resonance imaging plays a significant role in the therapeutic planning, also affecting the prognosis.
Spinal accessory nerve neuropathy following neck dissection
Lima, Luciana Pereira de;Amar, Ali;Lehn, Carlos Neutzling;
Brazilian Journal of Otorhinolaryngology , 2011, DOI: 10.1590/S1808-86942011000200017
Abstract: tthe most common complication of neck dissection is shoulder dysfunction due to manipulation of spinal accessory nerve, resulting in trapezius muscle atrophy mainly in procedures involving the posterior neck triangle. aim: this study used electromyography to evaluate the injury to the spinal accessory nerve following neck dissection. materials and methods: prospective case series of 51 patients submitted to 60 neck dissections followed by physical therapy evaluation of shoulder dysfunction. nerve integrity was evaluated before and after the surgery by means of surface emg registering the electric activity of the trapezius muscle during voluntary contraction. the patients were grouped according to the type of neck dissection, presence of shoulder pain, impairment during abduction movement and hypotrophy/atrophy of the trapezius muscle. results: action potential had median values of 54.3 microv before surgery and 11.6 microv after it (p<0.001). there was a mean decrease of 70% comparing to preoperative values. the median was 12.5 microv after dissection including level iib, and 8.9 microv after dissection including levels iib and v (p<0.002). conclusion: surface emg is a sensitive and painless method for spinal accessory nerve dysfunction evaluation. the results suggest the usefulness of the trapezius muscle electromyography to confirm diagnosis and early physical therapy intervention in neuropathies of the spinal accessory nerve.
Efeito da clorexidina na mucosite induzida por radioterapia em cancer de cabe?a e pesco?o
Labbate, Rogério;Lehn, Carlos Neutzling;Denardin, Odilon Victor Porto;
Revista Brasileira de Otorrinolaringologia , 2003, DOI: 10.1590/S0034-72992003000300009
Abstract: the radiotherapy in patients with neoplasias of head and neck causes alterations in the oral mucous membrane interfering with the therapeutic execution and the final result. aim: to evaluate the protective effect of the chlorhexidin on the oral mucous membrane, during the radiotherapy and its reflex in the quality of life referred by patients. study design: clinical prospective. material and mathod: 21 patients with cancer of head and neck were selected and allocated in two groups: group placebo (n=11, 9 men and 2 women, mean age 58 years) distilled water - two daily mouthwashes and group medication (n=10, 7 men and 2 women, mean age 52 years) chlorhexidin 0,12% - two daily mouthwashes. the patients were appraised weekly with local exam for detection of the mucous membrane alterations (classification in agreement with who and group of therapy for radiation in oncology - degrees 0 to iv) and completion of questionnaire of life quality emphasizing the pain aspects, appetite, palate and alimentary habits. the statistical analysis accomplished by fisher's exact test. results: the graduation of mucositis was more intense in the group placebo in 6 of the 10 weeks of evaluation. the frequency and intensity of pain were worse in the group placebo in the 4th week of radiotherapy and the palate modification was more intense in the individuals that didn't use the medicine just in the 7th week. they were not found differences in the other parameters of life quality. conclusions: we can conclude that the chlorhexidin didn't eliminate the mucous membrane lesions but decreased, significantly, their harmful effects and intensity without presenting a persistent reflex in the quality of the patients' life.
Efeito da clorexidina na mucosite induzida por radioterapia em cancer de cabe a e pesco o
Labbate Rogério,Lehn Carlos Neutzling,Denardin Odilon Victor Porto
Revista Brasileira de Otorrinolaringologia , 2003,
Abstract: A radioterapia em pacientes com neoplasias de Cabe a e Pesco o causa altera es na mucosa oral comprometendo a execu o terapêutica e o resultado final. OBJETIVO: Avaliar o efeito protetor do gluconato de clorexidina, sobre a mucosa oral, durante o tratamento actínico fracionado e o seu reflexo na qualidade de vida referida pelos pacientes. FORMA DE ESTUDO: Clínico prospectivo. MATERIAL E MéTODO: Foram selecionados 21 portadores de cancer de Cabe a e Pesco o alocados em dois grupos: grupo Placebo (n=11, 9H e 2M, idade média 58 anos) água destilada - dois bochechos diários e grupo Medica o (n=10, 7H e 2M, idade média 52 anos) gluconato de clorexidina a 0,12% - dois bochechos diários. Os pacientes foram avaliados semanalmente com exame local para detec o das altera es de mucosa (classifica o de acordo com a WHO e Grupo de Terapia por Radia o em Oncologia - graus 0 a IV) e preenchimento de questionário de qualidade de vida ressaltando os aspectos de dor, apetite, paladar e hábitos alimentares. A análise estatística realizada pelo teste exato de Fisher. RESULTADOS: A gradua o da mucosite foi mais intensa no grupo Placebo em 6 das 10 semanas de avalia o. A freqüência e intensidade das dores foram piores no grupo Placebo na 4a semana de radioterapia e a modifica o de paladar foi mais intensa nos indivíduos que n o usavam o medicamento apenas na 7a semana. N o foram encontradas diferen as nos outros parametros de qualidade de vida. CONCLUS O: Podemos concluir que o gluconato de clorexidina n o eliminou as les es de mucosa mas diminuiu, significativamente, os seus efeitos deletérios e intensidade sem apresentar um reflexo persistente na qualidade de vida dos pacientes.
Results of surgical treatment versus chemoradiation therapy in oropharyngeal early tumors
Chedid, Helma Maria,Lehn, Carlos Neutzling,Dedivitis, Rogério Aparecido
International Archives of Otorhinolaryngology , 2009,
Abstract: Introduction: The epidermoid carcinoma of the upper aerodigestive tract is diagnosed in approximately 40% of the cases of advanced clinical stages. Objective: To evaluate the disease-free interval in patients with clinical stages I and II epidermoid carcinoma who were submitted to surgery or chemoradiation. Method: Retrospective study of the records of 139 patients treated for oropharyngeal epidermoid carcinoma submitted to treatment with curative intent. Among those patients, 38 were classified with early tumors clinical stages I and II. Twenty-seven (71.1%) underwent surgical treatment whereas eleven (28.9%) were treated with chemoradiation. The mean age was 56.4 years; 31 cases (81.6%) were in men and seven (18.4%) were in women. Results: Among the eleven patients who were submitted to chemoradiation, 72.7% obtained locoregional control of the disease and their disease-free survival was of 42%. Among the 27 patients operated, 19 remained in Clinical Stages I and II in the histological report and six underwent postoperative radiation therapy. The disease-free interval for two years was of 70%. Conclusion: The patients submitted to the surgery had a better disease-free interval as compared to those submitted to chemoradiation treatment.
Resultados do tratamento cirúrgico versus quimioradioterápico em tumores iniciais da orofaringe
Chedid, Helma Maria,Lehn, Carlos Neutzling,Dedivitis, Rogério Aparecido
Arquivos Internacionais de Otorrinolaringologia , 2009,
Abstract: Introdu o: O carcinoma epidermoide na cabe a e pesco o é diagnosticado em aproximadamente 40% dos casos em estádios clínicos avan ados. Objetivo: Avaliar a sobrevida livre de doen a nos pacientes com carcinoma epidermoide de orofaringe de estádio clínico (EC) precoce (I e II), submetidos ao tratamento cirúrgico ou quimioradioterápico. Método: Estudo retrospectivo de 139 prontuários de pacientes portadores de carcinoma epidermoide de orofaringe submetidos a tratamento com inten o curativa, sendo elegíveis 38 casos de tumores de estádios clínicos precoces (I e II). Destes, 27 (71,1%) foram à cirurgia e 11 (28,9%) à quimioradioterapia, com idade média de 56,4 anos. Quanto ao gênero, 31 (81,6%) eram do masculino e sete (18,4%) do feminino. Resultados: Nos 11 pacientes submetidos à quimioradioterapia, 72,7% obtiveram controle loco-regional da doen a e a sobrevida livre de doen a há dois anos foram 42%. Dentre os 27 pacientes operados, 19 mantiveram-se em EC I e II no laudo histológico e seis foram à radioterapia pós-operatória. A sobrevida livre de doen a há dois anos foi 70%. Conclus o: Os pacientes submetidos inicialmente à cirurgia tiveram melhor sobrevida livre de doen a, quando comparados aos pacientes com tratamento quimioradioterápico.
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