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Search Results: 1 - 10 of 2002 matches for " Jordan Brennan "
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Proinflammatory cytokines differentially influence adult hippocampal cell proliferation depending upon the route and chronicity of administration
Julie Anne Seguin, Jordan Brennan, Emily Mangano, Shawn Hayley
Neuropsychiatric Disease and Treatment , 2009, DOI: http://dx.doi.org/10.2147/NDT.S4476
Abstract: oinflammatory cytokines differentially influence adult hippocampal cell proliferation depending upon the route and chronicity of administration Original Research (4343) Total Article Views Authors: Julie Anne Seguin, Jordan Brennan, Emily Mangano, Shawn Hayley Published Date December 2008 Volume 2009:5 Pages 5 - 14 DOI: http://dx.doi.org/10.2147/NDT.S4476 Julie Anne Seguin, Jordan Brennan, Emily Mangano, Shawn Hayley Institute of Neuroscience, Carleton University, Ottawa, Ontario, Canada Abstract: Disturbances of hippocampal plasticity, including impaired dendritic branching and reductions of neurogenesis, are provoked by stressful insults and may occur in depression. Although corticoids likely contribute to stressor-induced reductions of neurogenesis, other signaling messengers, including pro-inflammatory cytokines might also be involved. Accordingly, the present investigation assessed whether three proinflammatory cytokines, namely interleukin-1β (IL-1β), IL-6, and tumor necrosis factor-α (TNF-α) (associated with depression) influenced cellular proliferation within the hippocampus. In this regard, systemic administration of TNF-α reduced 5-bromo-2-deoxyuridine (BrdU) labeling within the hippocampus, whereas IL-1β and IL-6 had no such effect. However, repeated but not a single intra-hippocampal infusion of IL-6 and IL-1β actually increased cellular proliferation and IL-6 infusion also enhanced microglial staining within the hippocampus. Yet, no changes in doublecortin expression were apparent, suggesting that the cytokine did not influence the birth of cells destined to become neurons. Essentially, the route of administration and chronicity of cytokine administration had a marked influence upon the nature of hippocampal alterations provoked, suggesting that cytokines may differentially regulate hippocampal plasticity in neuropsychiatric conditions.
Proinflammatory cytokines differentially influence adult hippocampal cell proliferation depending upon the route and chronicity of administration
Julie Anne Seguin,Jordan Brennan,Emily Mangano,Shawn Hayley
Neuropsychiatric Disease and Treatment , 2008,
Abstract: Julie Anne Seguin, Jordan Brennan, Emily Mangano, Shawn HayleyInstitute of Neuroscience, Carleton University, Ottawa, Ontario, CanadaAbstract: Disturbances of hippocampal plasticity, including impaired dendritic branching and reductions of neurogenesis, are provoked by stressful insults and may occur in depression. Although corticoids likely contribute to stressor-induced reductions of neurogenesis, other signaling messengers, including pro-inflammatory cytokines might also be involved. Accordingly, the present investigation assessed whether three proinflammatory cytokines, namely interleukin-1β (IL-1β), IL-6, and tumor necrosis factor-α (TNF-α) (associated with depression) influenced cellular proliferation within the hippocampus. In this regard, systemic administration of TNF-α reduced 5-bromo-2-deoxyuridine (BrdU) labeling within the hippocampus, whereas IL-1β and IL-6 had no such effect. However, repeated but not a single intra-hippocampal infusion of IL-6 and IL-1β actually increased cellular proliferation and IL-6 infusion also enhanced microglial staining within the hippocampus. Yet, no changes in doublecortin expression were apparent, suggesting that the cytokine did not influence the birth of cells destined to become neurons. Essentially, the route of administration and chronicity of cytokine administration had a marked influence upon the nature of hippocampal alterations provoked, suggesting that cytokines may differentially regulate hippocampal plasticity in neuropsychiatric conditions.Keywords: cytokine, depression, neuroplasticity, hippocampus, stressor
For the love and respect of the service: Applied aesthetics and palliative care  [PDF]
Marcia Brennan
Journal of Biomedical Science and Engineering (JBiSE) , 2013, DOI: 10.4236/jbise.2013.610A1001
Abstract: In this article, the author discusses her experiences as an artist in residence in the Department of Palliative Care and Rehabilitation Medicine at the University of Texas M. D. Anderson Cancer Center. Emphasis is placed on applied aesthetics in palliative care and their implications for addressing communication, spiritual, and health care issues for military service members. Drawing on six vivid case studies, the author examines the various ways in which end of life narratives can shed valuable light on key issues concerning individuals’ life experiences in the Navy, the Army, and the Air Force. These cherished images strengthened people’s spirits at the end of life, and each of the men told their stories with pride.
Efficient quantum processing of ideals in finite rings
Pawel M. Wocjan,Stephen P. Jordan,Hamed Ahmadi,Joseph P. Brennan
Physics , 2009,
Abstract: Suppose we are given black-box access to a finite ring R, and a list of generators for an ideal I in R. We show how to find an additive basis representation for I in poly(log |R|) time. This generalizes a recent quantum algorithm of Arvind et al. which finds a basis representation for R itself. We then show that our algorithm is a useful primitive allowing quantum computers to rapidly solve a wide variety of problems regarding finite rings. In particular we show how to test whether two ideals are identical, find their intersection, find their quotient, prove whether a given ring element belongs to a given ideal, prove whether a given element is a unit, and if so find its inverse, find the additive and multiplicative identities, compute the order of an ideal, solve linear equations over rings, decide whether an ideal is maximal, find annihilators, and test the injectivity and surjectivity of ring homomorphisms. These problems appear to be hard classically.
Foods: Where Innovation, Agriculture, Molecular Biosciences and Human Nutrition Meet
Charles Brennan
Foods , 2012, DOI: 10.3390/foods1010001
Abstract: There is one commodity the world over that unites mankind—food. In 2011 the United Nations claimed that the world’s population had reached the seven billion mark, a number which is set to increase dramatically in the decades to come. Food security, supply and sustainability are of paramount concern to the future economic and social progress of humanity. It is the responsibility of the food industry, together with food scientists and technologists, to shoulder the burden of ensuring an adequate supply of nutritious, safe and sensorially acceptable foods for a range of demanding consumers. In responding to this challenge, we need to understand the link between agriculture, engineering, food processing, molecular biosciences, human nutrition, commercialisation and innovation. Access to information concerning the composition and quality of foods has never been so easy for consumers and technologists alike. A plethora of research publications are made available each month to scientists and associated interested parties. The outcomes of these research manuscripts are often distilled and disseminated into messages available to everyone through bulletin boards, forums and the popular press. Newspapers and new agencies constantly report on the latest pharma-medical finding, or news regarding food safety and security concerns. We live in an age where information is so readily available to everyone that the task of finding credible and reputable data can be difficult at times. Providing sound evidenced based research is where a peer-reviewed journal can provide clarity. [...]
Nasopharyngeal carcinoma
Bernadette Brennan
Orphanet Journal of Rare Diseases , 2006, DOI: 10.1186/1750-1172-1-23
Abstract: Nasopharyngeal carcinoma (NPC) is a tumor arising from the epithelial cells that cover the surface and line the nasopharynx. NPC was first described as a separate entity by Regaud and Schmincke in 1921 [1,2]. Approximately one third of nasopharyngeal carcinomas of the undifferentiated type are diagnosed in adolescents or young adults. Although rare, NPC accounts for one third of childhood nasopharyngeal neoplasms (data from USA) [3].The annual incidence of NPC in the UK is 0.25 per million (age standardized, age 0–14 years), 0.1 per million at age 0–9 years and 0.8 per million at age 10–14 years. It seems reasonable to assume, on the basis of England and Wales cancer registry data, that at least 80% of nasopharyngeal cancers at age 15–19 years are carcinomas. This suggests an incidence of 1 to 2 per million for NPC at age 15–19 years.In comparison with other countries, the incidence in the UK is low. In particular, in Tunisia the incidence is relatively high [4]. In southern parts of China, Southeast Asia, the Mediterranean basin and Alaska the incidence of NPC is moderately elevated; an incidence of 2 per million of NPC in China has been reported [5]. In other countries, for example in India, the incidence is comparable to that in the UK at 0.9 per million. Furthermore, the younger age peak in the second decade found in India [6], is also found in the UK [7].NPC is the commonest epithelial cancer in adults. The detection of nuclear antigen associated with Epstein-Barr virus (EBNA) and viral DNA in NPC type 2 and 3, has revealed that EBV can infect epithelial cells and is associated with their transformation [8]. The etiology of NPC (particularly the endemic form) seems to follow a multi-step process, in which EBV, ethnic background, and environmental carcinogens all seem to play an important role.Lo et al. showed that EBV DNA was detectable in the plasma samples of 96% of patients with non-keratinizing NPC, compared with only 7% in controls [9]. More importantly, E
Worship in the Early Church
Christopher Brennan
Theological Librarianship , 2010,
Abstract:
Raymond Andrews as Griot: Privileging Southern Black Communities through Oral Storytelling and Cultural History
Brennan Collins
American Studies Journal , 2012,
Abstract: Raymond Andrews’ novels celebrate rural Black life by focusing on the customs and traditions of Southern African American communities. Critical to this celebration are the rhetorical strategies Andrews uses that privilege oral over literary storytelling. Using Geneva Smitherman’s discussion of the griot and Henry Louis Gates, Jr.’s concept of the speakerly text in the context of John Miles Foley’s work on comparative oral traditions, this essay explores the possibility and implications of describing Andrews’ written work as a form of oral storytelling.
“The Religious Dimension of Poland’s Relations with its Eastern Neighbours.”
Desmond Brennan
Nebula , 2010,
Abstract:
Time, Space, and National Belonging in The Namesake: Redrawing South Asian American Citizenship in the Shadow of 9/11
Sue Brennan
Journal of Transnational American Studies , 2011,
Abstract: The terms of national belonging after 9/11 for South Asian Americans have taken shape through a vague and depoliticized discourse around ethnic identity, one in which the clichés of multiculturalism and melting-pot nationalism stand in for the specific socioeconomic and historical conditions that helped form the South Asian diaspora in the US. This paper explores the ways in which Jhumpa Lahiri’s novel The Namesake and its cinematic adaptation by filmmaker Mira Nair challenge the erasure of South Asian American citizenship following 9/11. Recounting the journey of a young Bengali graduate student and his wife migrating to the US in the late 1960s, each text speaks back to the erasure of South Asian American citizenship through the materialization of time in space: while Lahiri foregrounds the state itself in producing the rhythms through which immigrants are assimilated into the nation, Nair creates a narrative world in which filmic space materializes many, and often competing, histories, unifying multiple temporalities and histories through the representations of space. I argue that the cinematic adaptation of The Namesake generates a new spatiotemporal state of affairs, one in which the iconography of 9/11 both challenges post-9/11 racial logics and destabilizes the singular, progressive, and institutionalized temporality through which Lahiri writes South Asian American immigrants back into nation.
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