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Search Results: 1 - 10 of 22691 matches for " Jong Yeol Kim "
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Understanding Oriental Medicine Using a Systems Approach
Jong Yeol Kim,Duong Duc Pham
Evidence-Based Complementary and Alternative Medicine , 2011, DOI: 10.1093/ecam/nep037
Abstract: Two international meetings, the International Physiome Symposium 2008 and the Workshop on Systems Biology (SB) and Oriental Medicine (OM), were held to discuss the most appropriate scientific tools to research OM. Participants agreed that since OM is holistic medicine it needs a systems approach such as SB. However, SB itself is still a long way from identifying the high-level organization processes in the biological system that might correlate with concepts in OM. As such, a modest goal of launching a project to examine the problems of translation and interpretation of OM concepts would be the first step. 1. Introduction Oriental medicine (OM), which is defined by World Health Organization as East Asian medicine, is a theory-based medicine that originated from ancient China and it was speedily absorbed, modified and practiced within several China's traditional cultural influenced countries (Korea, Japan and Vietnam) [1]. Unlike Western medicine (WM) constituted from various outcomes of experimental research designs coming along with the development of a great number of disciplines, OM is based on systematic observations and knowledge inherited from generation to generation. The concepts and theories of OM were postulated to give convincible explanations to physio-pathological phenomena. Concepts such as Qi (), Yin (), Yang () and so on are unfamiliar to WM doctors whose background is scientific trust. During several last decades, OM is transplanted and developed rapidly in the West that may be due to its real effective curativeness, despite its insufficient scientific evidence and vague concepts. Scientists have been fascinated to evaluating OM; however, most current researchers simply assess OM in biomedical terms by reductionistic approach. This trend could only draw separate pieces of a picture, but it is unable to understand OM as the whole [2]. Along with the development of science, researchers think that they may need more appropriate tools to tap into the deeper secrets of OM. Two international meetings were recently held to discuss the most appropriate scientific tools to research OM. The International Physiome Symposium 2008 was held in Seoul, Korea, on April 10-11, 2008, organized by Korea Institute of Oriental Medicine and the Korean Physiome Society. The Workshop on Systems Biology (SB) and Oriental Medicine was held at Oxford University, UK, on July 9, 2008, organized by Prof. Denis Noble and Dr Jong Yeol Kim. This article aims to highlight and discuss on the main themes of these meetings. 2. Toward Holistic Medicine: A Need of System
Sasang Constitutional Medicine as a Holistic Tailored Medicine
Jong Yeol Kim,Duong Duc Pham
Evidence-Based Complementary and Alternative Medicine , 2009, DOI: 10.1093/ecam/nep100
Abstract: Sasang constitutional medicine (SCM) is a unique traditional Korean therapeutic alternative form of medicine. Based on the Yin and Yang theory and on Confucianism, humans are classified into four constitutions. These differ in terms of (i) sensitivity to certain groups of herbs and medicines, (ii) equilibrium among internal organic functions, (iii) physical features and (iv) psychological characteristics. We propose that two main axes in the physiopathology of SCM (food intake/waste discharge and consuming/storing Qi and body fluids) are equivalent to the process of internal–external exchange and catabolism/anabolism in modern physiology, respectively. We then used this hypothesis to discuss the physiological and pathological principles of SCM. Constitution-based medicine is based on the theory that some medicinal herbs and remedies are only appropriate for certain constitutions and can cause adverse effects in others. The constitutional approach of SCM share the same vision as tailored medicine; an individualized therapy that can minimize the risk of adverse reaction while increasing the efficacy and an individualized self-regulation that can help prevent specific susceptible chronic disease and live healthily. There is still a long way to this goal for both SCM and tailored medicine, but we may benefit from systems approaches such as systems biology. We suggest that constitutional perspective of SCM and our hypothesis of two main processes may provide a novel insight for further studies.
Selected Papers from the 10th International Conference 2009 on Nonlinear Functional Analysis and Applications
Yeol Je Cho,Jong Kyu Kim
Journal of Inequalities and Applications , 2010, DOI: 10.1155/2010/747463
A Comparison of the Predictive Power of Anthropometric Indices for Hypertension and Hypotension Risk
Bum Ju Lee, Jong Yeol Kim
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0084897
Abstract: Background and Aims It is commonly accepted that body fat distribution is associated with hypertension, but the strongest anthropometric indicator of the risk of hypertension is still controversial. Furthermore, no studies on the association of hypotension with anthropometric indices have been reported. The objectives of the present study were to determine the best predictors of hypertension and hypotension among various anthropometric indices and to assess the use of combined indices as a method of improving the predictive power in adult Korean women and men. Methods For 12789 subjects 21–85 years of age, we assessed 41 anthropometric indices using statistical analyses and data mining techniques to determine their ability to discriminate between hypertension and normotension as well as between hypotension and normotension. We evaluated the predictive power of combined indices using two machine learning algorithms and two variable subset selection techniques. Results The best indicator for predicting hypertension was rib circumference in both women (p = <0.0001; OR = 1.813; AUC = 0.669) and men (p = <0.0001; OR = 1.601; AUC = 0.627); for hypotension, the strongest predictor was chest circumference in women (p = <0.0001; OR = 0.541; AUC = 0.657) and neck circumference in men (p = <0.0001; OR = 0.522; AUC = 0.672). In experiments using combined indices, the areas under the receiver operating characteristic curves (AUC) for the prediction of hypertension risk in women and men were 0.721 and 0.652, respectively, according to the logistic regression with wrapper-based variable selection; for hypotension, the corresponding values were 0.675 in women and 0.737 in men, according to the na?ve Bayes with wrapper-based variable selection. Conclusions The best indicators of the risk of hypertension and the risk of hypotension may differ. The use of combined indices seems to slightly improve the predictive power for both hypertension and hypotension.
Bone Mineral Density-Associated Polymorphisms Are Associated with Obesity-Related Traits in Korean Adults in a Sex-Dependent Manner
Seongwon Cha, Hyunjoo Yu, Jong Yeol Kim
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0053013
Abstract: Obesity and osteoporosis share common physiological factors, including the presence of atherosclerosis, a risk factor for cardiometabolic disease, as well as a common progenitor that differentiates into both adipocytes and osteoblasts. Among the 23 polymorphisms associated with bone mineral density (BMD) in recent genome-wide association studies (GWASs), an Osterix polymorphism has been identified and associated with childhood obesity in girls. Therefore, we focused on elucidating polymorphisms associated with adulthood obesity in a sex-dependent manner among the previously published BMD-associated polymorphisms from GWASs. We performed 2 screenings of 18 BMD-associated polymorphisms for obesity-related traits in 2,362 adults aged >20 years. We excluded 13 polymorphisms showing deviations from Hardy–Weinberg equilibrium or no association with obesity-related traits (body mass index, waist circumference (WC), and waist-to-hip ratio). Among 5 selected polymorphisms (rs9594738 of RANKL, rs17066364 of NUFIP1, rs7227401 of OSBPL1A, and rs1856057 and rs2982573 of ESR1) analyzed, 2 polymorphisms (rs9594738 and rs17066364) were associated with obesity-related traits. We found sex-dependent associations such that the 4 polymorphisms (excluding rs9594738 of RANKL) were associated with abdominal traits such as WC and waist-to-hip ratio only in men. In addition, when the combined genetic risk score (GRS) for WC increase was calculated with 4 SNPs (rs9594738, rs17066364, rs7227401, and rs1856057) exhibiting similar trends for both sexes, the magnitude of the GRS effect for the WC increase was larger in men than in women (effect size = 0.856 cm, P = 0.0000452 for men; effect size = 0.598 cm, P = 0.00228 for women). In summary, we found 4 polymorphisms, previously related to osteoporosis, to be associated to obesity-related traits in a sex-dependent manner in Korean adults, particularly in men.
Prevalence of Metabolic Syndrome according to Sasang Constitutional Medicine in Korean Subjects
Kwang Hoon Song,Sung-Gon Yu,Jong Yeol Kim
Evidence-Based Complementary and Alternative Medicine , 2012, DOI: 10.1155/2012/646794
Abstract: Metabolic syndrome (MS) is a complex disorder defined by a cluster of abdominal obesity, atherogenic dyslipidemia, hyperglycemia, and hypertension; the condition is recognized as a risk factor for diabetes and cardiovascular disease. This study assessed the effects of the Sasang constitution group (SCG) on the risk of MS in Korean subjects. We have analyzed 1,617 outpatients of Korean oriental medicine hospitals who were classified into three SCGs, So-Yang, So-Eum, and Tae-Eum. Significant differences were noted in the prevalence of MS and the frequencies of all MS risk factors among the three SCGs. The odds ratios for MS as determined via multiple logistic regression analysis were 2.004 for So-Yang and 4.521 for Tae-Eum compared with So-Eum. These results indicate that SCG may function as a significant risk factor of MS; comprehensive knowledge of Sasang constitutional medicine may prove helpful in predicting susceptibility and developing preventive care techniques for MS.
Comparison of Sasang Constitutional Medicine, Traditional Chinese Medicine and Ayurveda
Jong Yeol Kim,Duong Duc Pham,Byung Hee Koh
Evidence-Based Complementary and Alternative Medicine , 2011, DOI: 10.1093/ecam/neq052
Abstract: Sasang constitutional medicine (SCM), traditional Chinese medicine (TCM) and Ayurveda are three different forms of Asian traditional medicine. Although these traditions share a lot in common as holistic medicines, the different philosophical foundations found in each confer distinguishing attributes and unique qualities. SCM is based on a constitution-based approach, and is in this way relatively more similar to the Ayurvedic tradition than to the TCM, although many of the basic SCM theories were originally derived from TCM, a syndrome-based medicine. SCM and TCM use the same botanical materials that are distributed mainly in the East Asian region, but the basic principles of usage and the underlying rationale are completely different from each other. Meanwhile, the principles of the Ayurvedic use of botanical resources are very similar to those seen in SCM, but the medicinal herbs used in Ayurveda generally originate from the West Asian region which displays a different spectrum of flora.
A Classification Method of Normal and Overweight Females Based on Facial Features for Automated Medical Applications
Bum Ju Lee,Jun-Hyeong Do,Jong Yeol Kim
Journal of Biomedicine and Biotechnology , 2012, DOI: 10.1155/2012/834578
Abstract: Obesity and overweight have become serious public health problems worldwide. Obesity and abdominal obesity are associated with type 2 diabetes, cardiovascular diseases, and metabolic syndrome. In this paper, we first suggest a method of predicting normal and overweight females according to body mass index (BMI) based on facial features. A total of 688 subjects participated in this study. We obtained the area under the ROC curve (AUC) value of 0.861 and kappa value of 0.521 in Female: 21–40 (females aged 21–40 years) group, and AUC value of 0.76 and kappa value of 0.401 in Female: 41–60 (females aged 41–60 years) group. In two groups, we found many features showing statistical differences between normal and overweight subjects by using an independent two-sample t-test. We demonstrated that it is possible to predict BMI status using facial characteristics. Our results provide useful information for studies of obesity and facial characteristics, and may provide useful clues in the development of applications for alternative diagnosis of obesity in remote healthcare.
Novel Diagnostic Algorithm for the Floating and Sunken Pulse Qualities and Its Clinical Test
Jaeuk U. Kim,Young Ju Jeon,Yu Jung Lee,Keun Ho Kim,Jong Yeol Kim
Evidence-Based Complementary and Alternative Medicine , 2011, DOI: 10.1155/2011/813427
Abstract: We propose a novel classification algorithm for the floating pulse and the sunken pulse using a newly defined coefficient (fs). To examine the validity of the proposed algorithm, we carried out a clinical test in which 12 oriental medical doctors made pairwise diagnoses on the pulses of volunteering subjects. 169 subjects were simultaneously diagnosed by paired doctors, and the diagnoses in 121 subjects were concordant, yielding an accuracy of 72% and a Matthews correlation coefficient of 0.42, which indicates reasonable agreement between doctors. Two sample T-tests showed that subjects in the sunken pulse group had significantly higher BMI and fs (<.05) than those in the floating pulse group. The pulse classification by the algorithm converged with the diagnoses of paired doctors with an accuracy up to 69%. With these results, we confirm the validity of the novel classification algorithm for the floating and sunken pulses.
Novel Diagnostic Model for the Deficient and Excess Pulse Qualities
Jaeuk U. Kim,Young Ju Jeon,Young-Min Kim,Hae Jung Lee,Jong Yeol Kim
Evidence-Based Complementary and Alternative Medicine , 2012, DOI: 10.1155/2012/563958
Abstract: The deficient and excess pulse qualities (DEPs) are the two representatives of the deficiency and excess syndromes, respectively. Despite its importance in the objectification of pulse diagnosis, a reliable classification model for the DEPs has not been reported to date. In this work, we propose a classification method for the DEPs based on a clinical study. First, through factor analysis and Fisher's discriminant analysis, we show that all the pulse amplitudes obtained at various applied pressures at Chon, Gwan, and Cheok contribute on equal orders of magnitude in the determination of the DEPs. Then, we discuss that the pulse pressure or the average pulse amplitude is appropriate for describing the collective behaviors of the pulse amplitudes and a simple and reliable classification can be constructed from either quantity. Finally, we propose an enhanced classification model that combines the two complementary variables sequentially.
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