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Search Results: 1 - 10 of 26392 matches for " Jong Tae Song2 "
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Arabidopsis SIZ1 positively regulates alternative respiratory bypass pathways
Bong Soo Park1, Sung-Il Kim1, Jong Tae Song2 & Hak Soo Seo1,3,*
BMB Reports , 2012,
Abstract: Plant mitochondria possess alternative respiratory pathwaysmediated by the type II NAD(P)H dehydrogenases and alternativeoxidases. Here, E3 SUMO ligase was shown to regulatealternative respiratory pathways and to participate in the maintenanceof carbon and nitrogen balance in Arabidopsis. Thetranscript abundance of the type II NAD(P)H dehydrogenasesNDA2 and NDB2 and alternative oxidases AOX1a and AOX1dgenes was low in siz1-2 mutants compared to that in wild-type.The addition of nitrate or ammonium resulted in a decrease oran increase in the expression of the same gene families, respectively,in both wild-type and siz1-2 mutants. The amountof free sugar (glucose, fructose and sucrose) was lower in siz1-2mutants than that in wild-type. These results indicate that lownitrate reductase activity due to the AtSIZ1 mutation is correlatedwith an overall decrease in alternative respiration andwith a low carbohydrate content to maintain the carbon to nitrogenratio in siz1-2 mutants.
The inhibitory effects of Nardostachys jatamansi on alcoholic chronic pancreatitis
Gi-Sang Bae1, Kyoung-Chel Park2, Bon Soon Koo2, Sun Bok Choi2, Il-Joo Jo2, Chang-Min Choi3, Ho-Joon Song2 & Sung-Joo Park1,2,*
BMB Reports , 2012,
Abstract: Nardostachys jatamansi (NJ) belonging to the Valerianaceae familyhas been used as a remedy for gastrointestinal inflammatory diseasesfor decades. However, the potential for NJ to ameliorate alcoholicchronic pancreatitis (ACP) is unknown. The aim of thisstudy was to examine the inhibitory effects of NJ on ACP.C57black/6 mice received ethanol injections intraperitoneally for 3weeks against a background of cerulein-induced acute pancreatitis.During ACP, NJ was ad libitum administrated orally with water.After 3 weeks of treatment, the pancreas was harvested for histologicalexamination. NJ treatment increased the pancreatic acinarcell survival (confirmed by amylase level testing) and reduced collagendeposition and pancreatic stellate cell (PSC) activation. In addition,NJ treatment reduced the activation but not death of PSC. Inconclusion, our results suggest that NJ attenuated ACP through theinhibition of PSC activation.
Designing an Application Specific Instruction Set Processor for FECs in LTE-Advanced
Hojun Kim,Dongjae Song,Soongyu Kwon,Jong Tae Kim
Lecture Notes in Engineering and Computer Science , 2010,
Abstract:
Protein Disulfide Isomerase-Like Protein 1-1 Controls Endosperm Development through Regulation of the Amount and Composition of Seed Proteins in Rice
Yeon Jeong Kim, Song Yion Yeu, Bong Soo Park, Hee-Jong Koh, Jong Tae Song, Hak Soo Seo
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0044493
Abstract: Protein disulfide isomerase (PDI) is a chaperone protein involved in oxidative protein folding by acting as a catalyst and assisting folding in the endoplasmic reticulum (ER). A genome database search showed that rice contains 19 PDI-like genes. However, their functions are not clearly identified. This paper shows possible functions of rice PDI-like protein 1-1 (PDIL1-1) during seed development. Seeds of the T-DNA insertion PDIL1-1 mutant, PDIL1-1Δ, identified by genomic DNA PCR and western blot analysis, display a chalky phenotype and a thick aleurone layer. Protein content per seed was significantly lower and free sugar content higher in PDIL1-1Δ mutant seeds than in the wild type. Proteomic analysis of PDIL1-1Δ mutant seeds showed that PDIL1-1 is post-translationally regulated, and its loss causes accumulation of many types of seed proteins including glucose/starch metabolism- and ROS (reactive oxygen species) scavenging-related proteins. In addition, PDIL1-1 strongly interacts with the cysteine protease OsCP1. Our data indicate that the opaque phenotype of PDIL1-1Δ mutant seeds results from production of irregular starch granules and protein body through loss of regulatory activity for various proteins involved in the synthesis of seed components.
Identification of a Novel Jasmonate-Responsive Element in the AtJMT Promoter and Its Binding Protein for AtJMT Repression
Jun Sung Seo, Yeon Jong Koo, Choonkyun Jung, Song Yion Yeu, Jong Tae Song, Ju-Kon Kim, Yeonhee Choi, Jong Seob Lee, Yang Do Choi
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0055482
Abstract: Jasmonates (JAs) are important regulators of plant biotic and abiotic stress responses and development. AtJMT in Arabidopsis thaliana and BcNTR1 in Brassica campestris encode jasmonic acid carboxyl methyltransferases, which catalyze methyl jasmonate (MeJA) biosynthesis and are involved in JA signaling. Their expression is induced by MeJA application. To understand its regulatory mechanism, here we define a novel JA-responsive cis-element (JARE), G(C)TCCTGA, in the AtJMT and BcNTR1 promoters, by promoter deletion analysis and Yeast 1-Hybrid (Y1H) assays; the JARE is distinct from other JA-responsive cis-elements previously reported. We also used Y1H screening to identify a trans-acting factor, AtBBD1, which binds to the JARE and interacts with AtJAZ1 and AtJAZ4. Knockout and overexpression analyses showed that AtBBD1 and its close homologue AtBBD2 are functionally redundant and act as negative regulators of AtJMT expression. However, AtBBD1 positively regulated the JA-responsive expression of JR2. Chromatin immunoprecipitation from knockout and overexpression plants revealed that repression of AtJMT is associated with reduced histone acetylation in the promoter region containing the JARE. These results show that AtBBD1 interacts with JAZ proteins, binds to the JARE and represses AtJMT expression.
Snake venom toxin from Vipera lebetina turanica induces apoptosis in colon cancer cells via upregulation of ROS- and JNK-mediated death receptor expression
Mi Hee Park, Mi Ran Jo, Dohee Won, Ho Sueb Song, Sang Bae Han, Min Jong Song, Jin Tae Hong
BMC Cancer , 2012, DOI: 10.1186/1471-2407-12-228
Abstract: We used cell viability assays, DAPI/TUNEL assays, as well as western blot for detection of apoptosis related proteins and DRs to demonstrate that snake venom toxin-induced apoptosis is DR4 and DR5 dependent. We carried out transient siRNA knockdowns of DR4 and DR5 in colon cancer cells.We showed that snake venom toxin inhibited growth of colon cancer cells through induction of apoptosis. We also showed that the expression of DR4 and DR5 was increased by treatment of snake venom toxin. Moreover, knockdown of DR4 or DR5 reversed the effect of snake venom toxin. Snake venom toxin also induced JNK phosphorylation and ROS generation, however, pretreatment of JNK inhibitor and ROS scavenger reversed the growth inhibitory effect of snake venom toxin, and reduced the snake venom toxin-induced upregulation of DR4 and DR5 expression.Our results indicated that snake venom toxin could inhibit human colon cancer cell growth, and these effects may be related to ROS and JNK mediated activation of death receptor (DR4 and DR5) signals
Infection of Avian Pox Virus in Oriental Turtle-Doves
Kyung-Yeon Eo1, Young-Hoan Kim2, Kwang-Hyun Cho3, Jong-Sik Jang4, Tae-Hwan Kim5, Dongmi Kwak5 and Oh-Deog Kwon5*
Pakistan Veterinary Journal , 2011,
Abstract: Three Oriental Turtle-doves (Streptopelia orientalis) exhibiting lethargy, dyspnea, poor physical condition, and poor flight endurance, were rescued and referred to the Animal Health Center, Seoul Zoo, Korea. The doves had wart-like lesions on the legs and head. All of them died the following day after arrival, with the exception of one that survived for 6 days. Diphtheritic membranes on the tongue and oral mucosa were apparent at necropsy. Avian pox virus infection was suspected based on the proliferative skin lesions and oral diphtheritic lesions. Infection of the avian pox virus was confirmed by PCR using primers specific to the 4b core protein gene of avian pox virus. All cases were diagnosed with avian pox virus infection. This is believed to be the first description on natural infection of avian pox in Oriental Turtle-doves in Korea.
Implication of Snail in Metabolic Stress-Induced Necrosis
Cho Hee Kim,Hyun Min Jeon,Su Yeon Lee,Min Kyung Ju,Ji Young Moon,Hye Gyeong Park,Mi-Ae Yoo,Byung Tae Choi,Jong In Yook,Sung-Chul Lim,Song Iy Han,Ho Sung Kang
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0018000
Abstract: Necrosis, a type of cell death accompanied by the rupture of the plasma membrane, promotes tumor progression and aggressiveness by releasing the pro-inflammatory and angiogenic cytokine high mobility group box 1. It is commonly found in the core region of solid tumors due to hypoxia and glucose depletion (GD) resulting from insufficient vascularization. Thus, metabolic stress-induced necrosis has important clinical implications for tumor development; however, its regulatory mechanisms have been poorly investigated.
Comparison of Microbiological Assay and High-Performance Liquid Chromatography/Mass Spectrometry for the Pharmacokinetics of Cefquinome in Pigs
Jong-Hwan Lim,Hong-Gee Lee,Tae-Won Kim,In-Bae Song,Myoung-Seok Kim,Youn-Hwan Hwang,Byung-Kwon Park,Hyo-In Yun
Agricultural Journal , 2013, DOI: 10.3923/aj.2011.374.377
Abstract: A simple and sensitive Agar well diffusion bioassay with Providencia alcalifaciens ATCC 9886 and Liquid Chromatography/Mass Spectrometric (LC/MS) method for cefquinome in pig plasma was evaluated and validated. The proposed microbiological and LC/MS methods for the determination of cefquinome in plasma showed good inter-assay and intra-assay precision, accuracy and linearity. A microbiological assay and LC/MS assay for the determination of cefquinome yielded statistically identical results (r2 = 0.83). The developed microbiological method in pig plasma has been successfully utilized for pharmacokinetic study of cefquinome in pigs. Following intramuscular injection of cefquinome at 1 mg kg-1 in pigs, it was rapidly absorbed with mean Cmax of 0.40 μg mL-1 at 2.33 h. Thereafter, the plasma concentration of cefquinome was declined with 2.36 h of elimination half-life in pigs.
Exophytic inflammatory myofibroblastic tumor of the stomach in an adult woman: A rare cause of hemoperitoneum
Seong-Heum Park, Jong-Han Kim, Byung Wook Min, Tae Jin Song, Gil Soo Son, Seung Joo Kim, Sang Woo Lee, Hwan-Hoon Chung, Ju Han Lee, Jun Won Um
World Journal of Gastroenterology , 2008,
Abstract: Inflammatory myofibroblastic tumor (IMT) of the stomach in adults is extremely rare, with unpredictable prognosis. We present a 55-year-old woman with a gastric IMT. She experienced sudden abdominal pain 4 d previously. Physical examination showed mild abdominal tenderness in the hypogastrium, but no palpable abnormal abdominal mass. Abdominal CT showed a mass of approximately 8 cm in the gastrocolic ligament. On laparoscopic exploration, unexpected hemoperitoneum of approximately 1.5 L of blood was found, and an exophytic gastric mass of approximately 10 cm, appeared from the anterior wall of the gastric body along the greater curvature. Laparoscopy further showed that non-clotting blood in the abdominal cavity seemed to be from the gastric tumor. After conversion to open surgery for more precise evaluation of the cause of hemoperitoneum and the large friable tumor, gastric wedge resection, including the tumor, was conducted. The final diagnosis was consistent with IMT that originated from the gastric wall.
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