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Search Results: 1 - 10 of 427092 matches for " John M Finke "
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ELISA measurement of specific non-antigen-bound antibodies to Aβ1-42 monomer and soluble oligomers in sera from Alzheimer's disease, mild cognitively impaired, and noncognitively impaired subjects
Andrea C Klaver, Mary P Coffey, Lynnae M Smith, David A Bennett, John M Finke, Loan Dang, David A Loeffler
Journal of Neuroinflammation , 2011, DOI: 10.1186/1742-2094-8-93
Abstract: Serum antibodies to Aβ1-42 monomer and soluble oligomers in AD, MCI, and NCI subjects (10/group) were measured by ELISA, subtracting polyvalent antibody binding and dissociating antibody-antigen complexes. Differences in mean antibody levels were assessed for significance with repeated measures ANOVA using restricted maximum likelihood estimation, using Tukey-Kramer tests and confidence intervals for multiple comparisons. Spearman's rank correlation was used to determine associations between anti-monomer and anti-oligomer antibody concentrations. Estimated sample sizes required to detect effects of various sizes were calculated.There were no significant differences between groups for mean anti-Aβ antibody levels, although these tended to be higher in AD than NCI specimens. Estimated group sizes of 328 and 150 for anti-Aβ monomer and oligomer antibodies, respectively, would have been required for 80% power for significance at 0.05 for a 25% increase in the AD mean relative to the NCI mean. Serum antibody concentrations to Aβ monomer and oligomers were strongly associated (correlations: 0.798 for undissociated sera, 0.564 for dissociated sera). Antibody-antigen dissociation significantly increased anti-Aβ monomer but not anti-Aβ oligomer antibody levels.The findings in this pilot study are consistent with relatively similar concentrations of specific, non-antigen-bound antibodies to Aβ1-42 monomer and soluble oligomers in AD, MCI, and NCI sera. The differences between groups for these antibodies would have required approximate group sizes of 328 and 150, respectively, for a high probability for statistical significance. These findings do not support the hypothesis that reduced levels of anti-Aβ antibodies might contribute to AD's pathogenesis.Amyloid-beta (Aβ), the major plaque-associated protein in the Alzheimer's disease (AD) brain, has become the main target for AD therapy since the formulation of the "amyloid hypothesis" [1]. The significance of serum antibodies t
German Technical Cooperation (GTZ) Supra-regional project: Promotion of Initiatives to End Female Genital Mutilation (FGM)
E Finke
African Journal of Reproductive Health , 2006,
Abstract: No s. African Journal of Reproductive Health Vol. 10 (2) 2006: pp. 18-23
Genital mutilation as an expression of power structures: Ending FGM through education, empowerment of women and removal of Taboos
E Finke
African Journal of Reproductive Health , 2006,
Abstract: No s. African Journal of Reproductive Health Vol. 10 (2) 2006: pp. 13-17
Comment on "Present and Future of the British Schools, Institutes and Societies Abroad"
Sarah Finke
Papers from the Institute of Archaeology , 2005, DOI: 10.5334/pia.256
Civil society participation in EU Governance
Barbara Finke
Living Reviews in European Governance , 2007,
Abstract: The debate on the European Union’s legitimacy crisis led to the discovery of civil society in EU governance. With the waning of the permissive consensus, politicians, bureaucrats, and academics shifted their attention towards the input-oriented dimension of democratic legitimacy which results from authentic participation and governance ‘by the people’. Participatory democracy via civil society involvement came to be considered as a promising supplement to representative democracy and entered EU documents such as the White Paper on European Governance and the draft Constitutional Treaty around the turn of the millennium. However, the origins of the current debate on civil society in EU governance can also be traced back to interest group research which has flourished since the early 1980s and the debate on ‘participatory governance’ that unfolded in the 1990s. These approaches are more concerned with effective political problem-solving and the output-dimension of democratic legitimacy which can, from this point of view, be improved by stakeholder participation and civil society engagement. In fact, two scholars who refer to ‘civil society’ do not necessarily mean the same thing and this is even less obvious if journalists, politicians or public officials allude to civil society. In order to enhance the basis of the discussion, we should seek to identify the conceptions they rely on. This will help us to understand where different arguments come from. Hence, this essay seeks to identify the different layers of the current debate on civil society participation in EU governance by unfolding the traditions of thought academic and political advocates of civil society in EU affairs currently draw on. This essay will basically distinguish between output-oriented approaches which explore the contribution of civil society groups to effective governance and problem-solving on the one hand and research that is interested in input-oriented legitimacy and participatory democracy on the other.
Compton Dominance and the Blazar Sequence
Justin Finke
Physics , 2012, DOI: 10.1088/0004-637X/763/2/134
Abstract: Does the "blazar sequence" exist, or is it a result of a selection effect, due to the difficulty in measuring the redshifts of blazars with both high synchrotron peak frequencies (\gtrsim 10^{15} Hz) and luminosities (\gtrsim 10^{46} erg s^{-1})? We explore this question with a sample of blazars from the Second Catalog of Active Galactic Nuclei (AGN) from the Fermi Large Area Telescope (LAT). The Compton dominance, the ratio of the peak of the Compton to the synchrotron peak luminosities, is essentially a redshift-independent quantity, and thus crucial to answering this question. We find that a correlation exists between Compton dominance and the peak frequency of the synchrotron component for all blazars in the sample, including ones with unknown redshift. We then construct a simple model to explain the blazar properties in our sample, where the difference between sources is due to only the magnetic field of the blazar jet emitting region, the external radiation field energy density, and the jet angle to the line of sight, with the magnetic field strength and external energy density being correlated. This model can reproduce the trends of the blazars in the sample, and predicts blazars may be discovered in the future with high synchrotron peak frequencies and luminosities. At the same time the simple model reproduces the lack of high-synchrotron peaked blazars with high Compton dominances (\gtrsim 1).
Blazars in Context in the Fermi Era
Justin Finke
Physics , 2013,
Abstract: Blazars are the most plentiful gamma-ray source at GeV energies, and despite detailed study, there is much that is not known about these sources. In this review I explore some recent results on blazars, including the controversy of the "blazar sequence", the curvature in the LAT spectra, and the location along the jet of the gamma-ray emitting region. I conclude with a discussion of alternative modeling possibilities.
Flaring gamma-ray emission from high redshift blazars
M. Orienti,F. D'Ammando,M. Giroletti,D. Dallacasa,T. Venturi,J. Finke,M. Ajello
Physics , 2015,
Abstract: High redshift blazars are among the most powerful objects in the Universe. Although they represent a significant fraction of the extragalactic hard X-ray sky, they are not commonly detected in gamma-rays. High redshift (z>2) objects represent <10 per cent of the AGN population observed by Fermi so far, and gamma-ray flaring activity from these sources is even more uncommon. The characterization of the radio-to-gamma-ray properties of high redshift blazars represent a powerful tool for the study of both the energetics of such extreme objects and the Extragalactic Background Light. We present results of a multi-band campaign on TXS 0536+145, which is the highest redshift flaring gamma-ray blazar detected so far. At the peak of the flare the source reached an apparent isotropic gamma-ray luminosity of 6.6x10^49 erg/s, which is comparable with the luminosity observed from the most powerful blazars. The physical properties derived from the multi-wavelength observations are then compared with those shown by the high redshift population. In addition preliminary results from the high redshift flaring blazar PKS 2149-306 will be discussed.
Exploring the multiband emission of TXS 0536+145: the most distant gamma-ray flaring blazar
M. Orienti,F. D'Ammando,M. Giroletti,J. Finke,M. Ajello,D. Dallacasa,T. Venturi
Physics , 2014, DOI: 10.1093/mnras/stu1644
Abstract: We report results of a multiband monitoring campaign of the flat spectrum radio quasar TXS 0536+145 at redshift 2.69. This source was detected during a very high gamma-ray activity state in 2012 March by the Large Area Telescope on board Fermi, becoming the gamma-ray flaring blazar at the highest redshift detected so far. At the peak of the flare the source reached an apparent isotropic gamma-ray luminosity of 6.6 x 10^49 erg/s which is comparable to the values achieved by the most luminous blazars. This activity triggered radio-to-X-rays monitoring observations by Swift, Very Long Baseline Array, European VLBI Network, and Medicina single-dish telescope. Significant variability was observed from radio to X-rays supporting the identification of the gamma-ray source with TXS 0536+145. Both the radio and gamma-ray light curves show a similar behaviour, with the gamma-rays leading the radio variability with a time lag of about 4-6 months. The luminosity increase is associated with a flattening of the radio spectrum. No new superluminal component associated with the flare was detected in high resolution parsec-scale radio images. During the flare the gamma-ray spectrum seems to deviate from a power law, showing a curvature that was not present during the average activity state. The gamma-ray properties of TXS 0536+145 are consistent with those shown by the high-redshift gamma-ray blazar population.
Endoscopic Detection and Surgical Repair of Congenital Tracheo-Esophageal-Fistula (TEF) ± Esophageal Atresia (EA)  [PDF]
Ralf-Bodo Tr?bs, Werner Finke
Open Journal of Pediatrics (OJPed) , 2014, DOI: 10.4236/ojped.2014.44039
Abstract: Purpose: This study was performed to evaluate the management of tracheoesophageal fistula (TEF) ± esophageal atresia (EA) under the guidance of preoperative tracheo-bronchoscopy (TrSc). Methods: Between 2007 and July 2014, a total of 26 consecutive newborns who underwent rigid TrSc for suspected TEF were identified. All associated charts and operation reports were retrospectively analyzed. Results: Distal TEF with EA (Gross C) predominated (n = 18). Furthermore, we managed 2 infants with proximal and distal TEF (Gross D) and 4 infants with isolated TEF (Gross E). In our hands, TrSc was feasible in infants with a birth weight above 1300 g. Twenty-five fistulas were identified by endoscopy in 23 patients. In one infant with a birth weight below 1000 g, an attempt to perform TrSc was interrupted, and urgent TEF closure was required. Fistula site at the carina was associated with a high rate of esophageal anastomosis under tension. During surgery, proximal TEF and isolated TEF were safely approached via right cervicotomy (n =5). Conclusion: This study supports the routine use of rigid TrSc at the time of surgery. Rigid TrSc allowed the surgical team to identify the number and location of TEFs, and the incidence of side effects was low.
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