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Search Results: 1 - 10 of 475834 matches for " John E. S. Lawrence "
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Towards Ecological Civilization: Ideas from Azerbaijan  [PDF]
Urkhan Alakbarov, John E. S. Lawrence
Journal of Human Resource and Sustainability Studies (JHRSS) , 2015, DOI: 10.4236/jhrss.2015.33013
Abstract: This discussion/review article traces relationships between an innovative strategic, national approach to national human resources development and enhancing national capacity for a more ecologically knowledgeable, sensitive society in a former Soviet country. With stunning speed following independence, Azerbaijan managed its extractive industries (oil and natural gas) effectively, rising to the top globally in annual GDP growth. Its determination to translate “black gold to human gold (BGHG)” and to diversify its economy led to a broad decade-long effort to modernize linkages between education, training and livelihood preparation. A complex national strategy to achieve BGHG was put in place, involving among other components, national labor force surveys, accelerated skills development, and employment service reforms. Given the pressing need for cleanup of Soviet industrial detritus, as well as emerging awareness of environmental responsibility among all sectors, unique “eco-civil” initiatives were launched both in schools and in civil service training programs. The resulting mosaic of public and private sector cooperation in meeting the twin goals of BGHG and a more “eco-civil” society can serve as a model for the region and beyond.
Getting It Right: Being Smarter about Clinical Trials
Barnett S Kramer ,Joan Wilentz,Duane Alexander,John Burklow,Lawrence M Friedman,Richard Hodes,Ruth Kirschstein,Amy Patterson,Griffin Rodgers,Stephen E Straus
PLOS Medicine , 2006, DOI: 10.1371/journal.pmed.0030144
Distribution of the Median in Samples from the Laplace Distribution  [PDF]
John Lawrence
Open Journal of Statistics (OJS) , 2013, DOI: 10.4236/ojs.2013.36050

The Laplace distribution is one of the oldest defined and studied distributions. In the one-parameter model (location parameter only), the sample median is the maximum likelihood estimator and is asymptotically efficient. Approximations for the variance of the sample median for small to moderate sample sizes have been studied, but no exact formula has been published. In this article, we provide an exact formula for the probability density function of the median and an exact formula for the variance of the median.

Epstein-Barr virus-encoded EBNA1 enhances RNA polymerase III-dependent EBER expression through induction of EBER-associated cellular transcription factors
Thomas J Owen, John D O'Neil, Christopher W Dawson, Chunfang Hu, Xiaoyi Chen, Yunhong Yao, Victoria HJ Wood, Louise E Mitchell, Robert J White, Lawrence S Young, John R Arrand
Molecular Cancer , 2010, DOI: 10.1186/1476-4598-9-241
Abstract: Our data confirm that in epithelial cells EBNA1 can enhance cellular pol III transcription. Transient expression of EBNA1 in Ad/AH cells stably expressing the EBERs led to induction of both EBER1 and EBER2 and conversely, expression of a dominant negative EBNA1 led to reduced EBER expression in EBV-infected Ad/AH cells. EBNA1 can induce transcription factors used by EBER genes, including TFIIIC, ATF-2 and c-Myc. A variant chromatin precipitation procedure showed that EBNA1 is associated with the promoters of these genes but not with the promoters of pol III-transcribed genes, including the EBERs themselves. Using shRNA knock-down, we confirm the significance of both ATF-2 and c-Myc in EBER expression. Further, functional induction of a c-Myc fusion protein led to increased EBER expression, providing c-Myc binding sites upstream of EBER1 were intact. In vivo studies confirm elevated levels of the 102 kD subunit of TFIIIC in the tumour cells of EBV-positive nasopharyngeal carcinoma biopsies.Our findings reveal that EBNA1 is able to enhance EBER expression through induction of cellular transcription factors and add to the repertoire of EBNA1's transcription-regulatory properties.In the 46 years since its discovery, the ubiquitous Epstein-Barr Virus (EBV) has been found to be closely associated with a wide range of epithelial and lymphoid malignancies [1]. During all typical forms of latent EBV infection and B-cell immortalisation, two highly expressed gene products are the non-polyadenylated RNAs, Epstein-Barr Virus encoded RNAs 1 and 2 (EBER1 and EBER2). Although no definitive role for the EBERs in cell transformation or malignant growth has been elucidated, several studies highlight the EBERs as making a significant contribution to EBV-associated malignancies [2-5] probably through direct interactions with cellular proteins with which they are known to form complexes. These include PKR [6,7], RIG-I [8], La [9] and ribosomal protein L22 [10-12]. In addition, the EBERs
Attend to the “Small p” Stuff: State Policy Issues Affecting Cervical Cancer Efforts  [PDF]
Beth E. Meyerson, Carrie A. Lawrence, Jennifer S. Smith
Open Journal of Obstetrics and Gynecology (OJOG) , 2014, DOI: 10.4236/ojog.2014.48066

Background: States in the United States have primary public health authority. This is the case with cervical cancer, and yet little is known about state policy issues affecting the comprehensive public health response. This study identifies and explores state policy issues affecting cervical cancer efforts in the United States. Methods: Key informant interviews were conducted with a purposeful sample of 15 professionals affiliated with cervical cancer prevention and treatment from national, state and local levels; across sectors: public, private and non-profit; and aspects of the work: screening, treatment and vaccine; program implementation, research, coalition work, and policy. Results: Identified policy issues were administrative and implementation oriented (“small p” policy issues). While participants recognized the importance of laws for vaccine or no cost screening access, the key policy issues preventing successful cervical cancer efforts involved 1) health system complexity; 2) general lack of state level policy, program and funding coordination; and 3) social and organizational cultural issues affecting the adoption of national recommendations and reinforcing program inertia. Conclusions: Understanding state policy issues in cervical cancer is critical for public health success. Dramatic reduction or even elimination of cervical cancer in the United States depends upon the policy work in the “little p” policy areas such as planning and health system organization to affect change. This will require greater leadership and coordination of state efforts across myriad programs. It will require health system improvements, and also the adoption of new practice and program behaviors to capitalize on available technology to reach underserved women.

The Genetics of Axonal Transport and Axonal Transport Disorders
Jason E Duncan,Lawrence S. B Goldstein
PLOS Genetics , 2006, DOI: 10.1371/journal.pgen.0020124
Abstract: Neurons are specialized cells with a complex architecture that includes elaborate dendritic branches and a long, narrow axon that extends from the cell body to the synaptic terminal. The organized transport of essential biological materials throughout the neuron is required to support its growth, function, and viability. In this review, we focus on insights that have emerged from the genetic analysis of long-distance axonal transport between the cell body and the synaptic terminal. We also discuss recent genetic evidence that supports the hypothesis that disruptions in axonal transport may cause or dramatically contribute to neurodegenerative diseases.
On the Matrix Description of Calabi-Yau Compactifications
S. Kachru,A. Lawrence,E. Silverstein
Physics , 1997, DOI: 10.1103/PhysRevLett.80.2996
Abstract: We point out that the matrix description of M-theory compactified on Calabi-Yau threefolds is in many respects simpler than the matrix description of a $T^6$ compactification. This is largely because of the differences between D6 branes wrapped on Calabi-Yau threefolds and D6 branes wrapped on six-tori. In particular, if we define the matrix theory following the prescription of Sen and Seiberg, we find that the remaining degrees of freedom are decoupled from gravity.
Lawrence Connors,Ashley J. Deans,John S. Hagelin
Physics , 1992,
Abstract: We show that supersymmetry automatically leads to density fluctuations $\Delta T/T\sim6\times10^{-6}$ in agreement with the recent COBE measurement.
A SiC TMA GLAO design for PLT?
Will Saunders,Jon S. Lawrence,John W. V. Storey,Roger Haynes
Physics , 2010,
Abstract: A 'PILOT-Like Telescope' is likely to have differences in science goals to the original PILOT. Furthermore, our understanding of the environmental conditions at Dome C has changed significantly since the start of the PILOT design study in June 2007. Therefore, it is timely to re-examine some of the basic design decisions. We present here one alternative concept: a silicon-carbide, GLAO-assisted, three-mirror anastigmat, and possibly equatorial, PILOT-Like-Telescope.
Direct Imaging of the CMB from Space
Michael A. Janssen,Douglas Scott,Martin White,Michael D. Seiffert,Charles R. Lawrence,Krzysztof M. Gorski,Mark Dragovan,Todd Gaier,Ken Ganga,Samuel Gulkis,Andrew E. Lange,Steven M. Levin,Philip M. Lubin,Peter Meinhold,Anthony C. S. Readhead,Paul L. Richards,John E. Ruhl
Physics , 1996,
Abstract: Fundamental information about the Universe is encoded in anisotropies of the Cosmic Microwave Background (CMB) radiation. To make full use of this information, an experiment must image the entire sky with the angular resolution, sensitivity, and spectral coverage necessary to reach the limits set by cosmic variance on angular scales >~10'. Recent progress in detector technology allows this to be achieved by a properly designed space mission that fits well within the scope of NASA's Medium-class Explorer program. An essential component of the mission design is an observing strategy that minimizes systematic effects due to instrumental offset drifts. The detector advances make possible a `spin chopping' approach that has significant technical and scientific advantages over the strategy used by COBE, which reconstructed an image of the sky via inversion of a large matrix of differential measurements. The advantages include increased angular resolution, increased sensitivity, and simplicity of instrumentation and spacecraft operations. For the parameters typical of experiments like the Primordial Structures Investigation (PSI) and the Far InfraRed Explorer (FIRE), we show that the spin-chopping strategy produces images of the sky and power spectra of CMB anisotropies that contain no significant systematic artifacts.
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