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Search Results: 1 - 10 of 3448 matches for " Joelma Menezes "
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Sickle cell disease: Only one road, but different pathways for inflammation  [PDF]
Wendell Vilas-Boas, Bruno Ant?nio Veloso Cerqueira, Thassila Nogueira Pitanga, Magda Oliveira Seixas, Joelma Menezes, Cyntia Cajado de Souza, Elisangela Vitória Adorno, Marilda Souza Goncalves
Advances in Bioscience and Biotechnology (ABB) , 2012, DOI: 10.4236/abb.2012.324071
Abstract: Sickle cell disease (SCD) is a genetic disorder characterized by a chronic inflammatory process, and new biomarkers have been studied as promising molecules for understanding the inflammation in its pathophysiology. The hemolysis and the release of molecules associated to the hemoglobin (Hb) catabolism, such as free Hb, iron, and heme, generating a oxidant environment with production of reactive oxygen and nitrogen species. The immune system plays a very important role in the inflammation, with cells secreting pro-inflammatory cytokines and chemokines. There is also a nitric oxide (NO) resistance state, with an impaired NO bioactivity, leading to a vascular dys-function; activation of platelet, leukocytes, erythrocytes, and endothelial cells, with expression of adhesion molecules and its ligands, and several receptors, that altogether participate at inflammatory process. During inflammation, there is an increase of dendritic cells (DCs) expresse toll like receptors (TLR), but the role of DCs and TLR in SCD pathogenesis is unclear. Also, there are molecules contributing for enhance the endothelium dysfunction, such as homocysteine that has been associated with vascular complications in the pathology of other diseases and it may contribute to the vascular complications presented by SCD patients. Circulating microparticules (MPs) levels are augmented in several diseases and have been described in SCD, where cells membrane compounds are associated to cell’s thrombotic and coagulation state, such as tissue factor and phosphatidylserine (PS), which may contribute to endothelial dysfunction. The knowledge of all these biomarkers may contribute to new therapeutic approach discover, improveing SCD patient life quality.
C677T polymorphism of the MTHFR gene and variant hemoglobins: a study in newborns from Salvador, Bahia, Brazil
Couto Fábio David,Adorno Elisangela Vitória,Menezes Joelma Figueiredo,Moura Neto José Pereira
Cadernos de Saúde Pública , 2004,
Abstract: The C677T polymorphism in the methylenetetrahydrofolate reductase gene (MTHFR) is associated with an increase in total homocysteine serum levels (tHcy), described as a risk factor for cardiovascular disease. Eight hundred forty-three neonates from two different maternity hospitals, one public and another private, in Salvador, Bahia, Brazil were screened for this polymorphism by PCR and RFLP. The T-allele frequency in the total sample was 0.23, and the prevalence rates of heterozygous and homozygous carriers were 36.2% and 5.3%, respectively. The T-allele frequency differed and the T/T genotype was more prevalent at the private maternity hospital. The hemoglobin (Hb) profile was investigated by HPLC in 763 newborns. The frequency of variant Hb was higher at the public than at the private maternity hospital. The association of the C677T polymorphism and the Hb profile was investigated in 683 newborns, showing a relatively high frequency of variant Hbs and the T allele. These data could provide an important basis for further studies focusing on potential risks of vaso-occlusive events in these individuals.
Hemoglobinopathies in newborns from Salvador, Bahia, Northeast Brazil
Adorno Elisangela Vitória,Couto Fábio David,Moura Neto José Pereira de,Menezes Joelma Figueiredo
Cadernos de Saúde Pública , 2005,
Abstract: Hemoglobinopathies are hereditary disorders of the hemoglobin molecule with a high prevalence worldwide. Brazil has a prevalence of 0.1 to 0.3% of newborns with sickle cell anemia and 20.0 to 25.0% of heterozygous alpha2 thalassemia among African Brazilians. In the present study, we investigated the presence of variant hemoglobins and alpha2(3.7 Kb) and alpha2(4.2 Kb) thalassemia in newborns from Salvador, Bahia, Brazil. Samples of umbilical cord blood from a total of 590 newborns were analyzed, of which 57 (9.8%) were FAS; 36 (6.5%) FAC; one (0.2%) SF; and five (0.9%) FSC. One hundred fourteen (22.2%) newborns had alpha2(3.7 Kb) thalassemia, of whom 101 (19.7%) were heterozygous and 13 (2.5%) homozygous, showing statistical significance for hematological data between newborns with normal alpha genes and alpha2(3.7 Kb) thalassemia carriers. The alpha2(4.2 Kb) thalassemia was not found. Frequencies found in the present study confirm that hemoglobinopathies are a public health problem in Brazil, emphasizing the need for neonatal screening and genetic counseling programs.
Hemoglobinopathies in newborns from Salvador, Bahia, Northeast Brazil
Adorno, Elisangela Vitória;Couto, Fábio David;Moura Neto, José Pereira de;Menezes, Joelma Figueiredo;Rêgo, Marco;Reis, Mitermayer Galv?o dos;Gon?alves, Marilda Souza;
Cadernos de Saúde Pública , 2005, DOI: 10.1590/S0102-311X2005000100032
Abstract: hemoglobinopathies are hereditary disorders of the hemoglobin molecule with a high prevalence worldwide. brazil has a prevalence of 0.1 to 0.3% of newborns with sickle cell anemia and 20.0 to 25.0% of heterozygous a2 thalassemia among african brazilians. in the present study, we investigated the presence of variant hemoglobins and a23.7 kb and a24.2 kb thalassemia in newborns from salvador, bahia, brazil. samples of umbilical cord blood from a total of 590 newborns were analyzed, of which 57 (9.8%) were fas; 36 (6.5%) fac; one (0.2%) sf; and five (0.9%) fsc. one hundred fourteen (22.2%) newborns had a23.7 kb thalassemia, of whom 101 (19.7%) were heterozygous and 13 (2.5%) homozygous, showing statistical significance for hematological data between newborns with normal a genes and a23.7 kb thalassemia carriers. the a24.2 kb thalassemia was not found. frequencies found in the present study confirm that hemoglobinopathies are a public health problem in brazil, emphasizing the need for neonatal screening and genetic counseling programs.
CRUZ, E.; MORI, G. (orgs.) Teologia e ciências da religi o: a caminho da maioridade acadêmica no Brasil.
Joelma Aparecida Santos Xavier
Horizonte : Revista de Estudos de Teologia e Ciências da Religi?o , 2012, DOI: 10.5752/2968
Abstract:
Second Language Acquisition: Reconciling Theories  [PDF]
Vera Menezes
Open Journal of Applied Sciences (OJAppS) , 2013, DOI: 10.4236/ojapps.2013.37050
Abstract:

This article argues that previous attempts to explain SLA should not be disregarded. Instead, when they are put together, they provide a broader and deeper view of the acquisition process. There is evidence to support the claim that second language acquisition (SLA) is a complex adaptive system due to its inherent ability to adapt to different conditions present in both internal and external environments. Based on this understanding, widely discussed second language theories, including behaviorism, will be treated as explanations of parts of a whole, since each captures a different aspect of SLA. In order to justify this assumption, excerpts from some English language learning histories are provided to exemplify how learners describe their learning processes. The final claim is that SLA should be seen as a chaotic/complex system.

Levels of high-density lipoprotein cholesterol (HDL-C) among children with steady-state sickle cell disease
Magda O Seixas, Larissa C Rocha, Mauricio B Carvalho, Joelma F Menezes, Isa M Lyra, Valma ML Nascimento, Ricardo D Couto, ájax M Atta, Mitermayer G Reis, Marilda S Goncalves
Lipids in Health and Disease , 2010, DOI: 10.1186/1476-511x-9-91
Abstract: We prospectively analyzed biochemical, inflammatory and hematological biomarkers of 152 steady-state infants with SCD and 132 healthy subjects using immunochemistry, immunoassay and electronic cell counter respectively. Clinical data were collected from patient medical records.Of the 152 infants investigated had a significant positive association of high-density lipoprotein cholesterol with hemoglobin (P < 0.001), hematocrit (P < 0.001) and total cholesterol (P < 0.001) and a negative significant association with reticulocytes (P = 0.046), leukocytes (P = 0.015), monocytes (P = 0.004) and platelets (P = 0.005), bilirubins [total bilirubin (P < 0.001), direct bilirubin (P < 0.001) and indirect bilirubin (P < 0.001], iron (P < 0.001), aminotransferases [aspartate aminotransferase (P = 0.004), alanine aminotransferase (P = 0.035)], lactate dehydrogenase (P < 0.001), urea (P = 0.030), alpha 1-antitrypsin (P < 0.001), very low-density lipoprotein cholesterol (P = 0.003), triglycerides (P = 0.005) and hemoglobin S (P = 0.002). Low high-density lipoprotein cholesterol concentration was associated with the history of cardiac abnormalities (P = 0.025), pneumonia (P = 0.033) and blood transfusion use (P = 0.025). Lipids and inflammatory markers were associated with the presence of cholelithiasis.We hypothesize that some SCD patients can have a specific dyslipidemic subphenotype characterized by low HDL-C with hypertriglyceridemia and high VLDL-C in association with other biomarkers, including those related to inflammation. This represents an important step toward a more reliable clinical prognosis. Additional studies are warranted to test this hypothesis and the probably mechanisms involved in this complex network of markers and their role in SCD pathogenesis.Sickle cell disease (SCD) clinical outcomes vary widely from mild to severe and the disease has been associated with multi-organ damage and risk of early mortality [1,2]. Acute and chronic clinical manifestations of SCD
C677T polymorphism of the MTHFR gene and variant hemoglobins: a study in newborns from Salvador, Bahia, Brazil
Couto, Fábio David;Adorno, Elisangela Vitória;Menezes, Joelma Figueiredo;Moura Neto, José Pereira;Rêgo, Marco Ant?nio Vasconcelos;Reis, Mitermayer Galv?o dos;Gon?alves, Marilda Souza;
Cadernos de Saúde Pública , 2004, DOI: 10.1590/S0102-311X2004000200021
Abstract: the c677t polymorphism in the methylenetetrahydrofolate reductase gene (mthfr) is associated with an increase in total homocysteine serum levels (thcy), described as a risk factor for cardiovascular disease. eight hundred forty-three neonates from two different maternity hospitals, one public and another private, in salvador, bahia, brazil were screened for this polymorphism by pcr and rflp. the t-allele frequency in the total sample was 0.23, and the prevalence rates of heterozygous and homozygous carriers were 36.2% and 5.3%, respectively. the t-allele frequency differed and the t/t genotype was more prevalent at the private maternity hospital. the hemoglobin (hb) profile was investigated by hplc in 763 newborns. the frequency of variant hb was higher at the public than at the private maternity hospital. the association of the c677t polymorphism and the hb profile was investigated in 683 newborns, showing a relatively high frequency of variant hbs and the t allele. these data could provide an important basis for further studies focusing on potential risks of vaso-occlusive events in these individuals.
VADICO, Luiz. Filmes de Cristo, oito aproxima es. S o Paulo: a lápis, 2009, 232p.
Joelma Aparecida dos Santos Xavier
Horizonte : Revista de Estudos de Teologia e Ciências da Religi?o , 2011, DOI: 10.5752/2099
Abstract:
Determina??o do nível de dano econ?mico de Cerotoma tingomarianus Bechyné (Coleoptera: Chrysomelidae) em Phaseolus vulgaris L. cv. Pérola
Fazolin, Murilo;Estrela, Joelma L.V.;
Neotropical Entomology , 2004, DOI: 10.1590/S1519-566X2004000500014
Abstract: the common bean cultivar perola is widely planted in brazil, and it is heavily attacked by leaf-feeding chrysomelids of the genus cerotoma. the objective of this study was to determine the economic injury level (eil) for c. tingomarianus, as a basis for the establishment of an integrated pest management (ipm) program for this pest in rio branco (acre, brazil). the trial was conducted at the experimental station of embrapa acre using the cultivar perola. the experiment was arranged as a split-plot in a randomized block design, with four replications. the main plots consisted of five plants at the developmental stages: v3 = first trifoliolate leaf, v4 = third trifoliolate leaf, r6 = initiation of flowering, r7 = pod formation and r8 = pod maturation, and the sub-plots were the four defoliation levels (0%, 33%, 66% and 100%). the response variables were: 1) grain production (g/plant); 2) average duration of each plant development phase (days) and leaf area production (cm2). the formula for determination of the eil, corrected for the number of insects sampled, was applied based on the coefficients used for the regression curves of percent defoliation versus yield reduction. new regression curves were determined as a function of these eil and of the cost of application of the control (c2) and the cost of 1 kg of beans (c1). the high r2 values obtained for the regression curves indicate reliability in their use to determine the eil of c. tingomarianus for the common bean cultivar perola.
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