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Search Results: 1 - 10 of 4777 matches for " Joana Neves;Cardinalli "
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A novel model of distal colon cancer in athymic mice
Priolli, Denise Gon?alves;Abrantes, Ana Margarida;Neves, Silvia;Batista, Joana Neves;Cardinalli, Izilda Aparecida;Botelho, Maria Filomena;
Acta Cirurgica Brasileira , 2012, DOI: 10.1590/S0102-86502012000600001
Abstract: purpose: the present a novel adenocarcinoma model in athymic mice. methods: seven athymic mice were used. colon diversion and distal fistula were made. adenocarcinoma cells were inoculated in the submucosa of fistula. tumor growth was monitored daily. scintigraphy with 99mtc-mibi was performed to identify the tumor. results: the model of distal colon cancer is feasible. tumor detection was possible by both, macroscopically and molecular imaging. all resections demonstrated poorly differentiated tumors. colon obstruction occurred in one case, similarly to evolution in human tumors of distal colon. conclusion: the proposed model of distal colon cancer is feasible, allows for easy monitoring of tumoral growth by both, macroscopically and molecular imaging, and is suitable for studying the evolution of tumor with implementation of cytotoxic therapy in vivo.
Participa o da comunidade, ensino de História e cultura histórica
Joana Neves
S?culum : Revista de História , 2001,
Abstract:
História local e constru o da identidade social
Joana Neves
S?culum : Revista de História , 1997,
Abstract: Neste trabalho procura-se estabelecer a rela o entre a constru o da identidade social e o conhecimento de história local, entendida tanto como objeto quanto como referência para o estudo da história. Esta rela o é analisada no contexto da própria produ o do conhecimento histórico, tendo em vista a a o de transforma o que este conhecimento pode engendrar.
Controle e cerim?nia: o inquérito policial em um sistema de justi?a criminal frouxamente ajustado
Vargas, Joana Domingues;Rodrigues, Juliana Neves Lopes;
Sociedade e Estado , 2011, DOI: 10.1590/S0102-69922011000100005
Abstract: this article draws on the hypothesis that the brazilian criminal justice system is loosely coupled and that police inquiry, as an obligatory procedure, fulfils the role of establishing some degree of coordination of police activities and between the organizations of the criminal justice system. the validity of this instrument is challenged when belief in the capacity of the state to control crime is heavily shaken and replaced by demands for efficiency and greater coordination in the administration of justice. despite the desire for change, various factors come into play to maintain this investigative model.
The Prosensory Function of Sox2 in the Chicken Inner Ear Relies on the Direct Regulation of Atoh1
Joana Neves, Masanori Uchikawa, Anna Bigas, Fernando Giraldez
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0030871
Abstract: The proneural gene Atoh1 is crucial for the development of inner ear hair cells and it requires the function of the transcription factor Sox2 through yet unknown mechanisms. In the present work, we used the chicken embryo and HEK293T cells to explore the regulation of Atoh1 by Sox2. The results show that hair cells derive from Sox2-positive otic progenitors and that Sox2 directly activates Atoh1 through a transcriptional activator function that requires the integrity of Sox2 DNA binding domain. Atoh1 activation depends on Sox transcription factor binding sites (SoxTFBS) present in the Atoh1 3′ enhancer where Sox2 directly binds, as shown by site directed mutagenesis and chromatin immunoprecipitation (ChIP). In the inner ear, Atoh1 enhancer activity is detected in the neurosensory domain and it depends on Sox2. Dominant negative competition (Sox2HMG-Engrailed) and mutation of the SoxTFBS abolish the reporter activity in vivo. Moreover, ChIP assay in isolated otic vesicles shows that Sox2 is bound to the Atoh1 enhancer in vivo. However, besides activating Atoh1, Sox2 also promotes the expression of Atoh1 negative regulators and the temporal profile of Atoh1 activation by Sox2 is transient suggesting that Sox2 triggers an incoherent feed-forward loop. These results provide a mechanism for the prosensory function of Sox2 in the inner ear. We suggest that sensory competence is established early in otic development through the activation of Atoh1 by Sox2, however, hair cell differentiation is prevented until later stages by the parallel activation of negative regulators of Atoh1 function.
Desenvolvimento profissional e motiva o dos professores
Jesus, Saul Neves de,Santos, Joana Conduto Vieira
Educa??o , 2004,
Abstract: Abordaremos, neste texto, detalhes sobre estudos realizados com professores, em especial os que destacam elementos sobre seu desenvolvimento profissional e sua motiva o, levando em conta pesquisas, que utilizaram questionários e entrevistas, com 160 professores do ensino secundário, concluindo que há diversas constantes ou itinerários-tipo que caracterizam o percurso profissional de alguns desses professores, definindo suas vivências e seu percurso de vida.
Teacher training: challenges and possibilities of teaching of reproduction and sexuality in supervised curricular stage
Mayara Lustosa de Oliveira,Joana Cristina Neves de Menezes Faria
Investiga??es em Ensino de Ciências , 2012,
Abstract: This work has its origins in a survey conducted during the supervised curricular stage of Biological Sciences course at Federal University of Goiás. The article describes critically and analytically every step of the curricular stage, especially the classes with the themes: reproduction and sexuality. The classes were taught to elementary students in State College St. Bernadete in Goiania-GO. To facilitate the process of teaching and learning the trainees divided the themes into subtopics, and several teaching resources were developed for each subtopic. The research was descriptive and exploratory, using interviews with school students, teachers, supervisors and college students to collect data that allowed assessing the success of the teaching methodologies applied by the teachers in training. The field diaries of the trainees were also used to compose the analysis. Through the statements of the participants, it is considered that the methods achieved their goal in clarifying the issues. The resources used not only brought understanding, but encouraged the participation of the students. The article has been organized according to the steps of the curricular stage and it exposes all the impressions of the supervising teachers, school students and undergraduates during the internship, highlighting, comments, concerns, planning and execution process of the activities.
Interleukin-10: A Key Cytokine in Depression?
Susana Roque,Margarida Correia-Neves,Ana Raquel Mesquita,Joana Almeida Palha,Nuno Sousa
Cardiovascular Psychiatry and Neurology , 2009, DOI: 10.1155/2009/187894
Abstract: An increasing body of evidence implicates proinflammatory cytokines in psychiatric disorders, namely, in depression. Of notice, recent studies showed that anti-inflammatory cytokines, such as IL-10, also modulate depressive-like behavior. In this article, we propose that the anti-inflammatory cytokine IL-10 is a putative link between two of the most widely reported phenomenon observed in depressed patients: the disruption of the hypothalamic-pituitary-adrenal axis and the imbalanced production of cytokines. If so, IL-10 might represent a novel target for antidepressant therapy.
An assessment of the RIFLE criteria for acute renal failure in critically ill HIV-infected patients
José Lopes, Joana Fernandes, Sofia Jorge, José Neves, Francisco Antunes, Mateus Prata
Critical Care , 2007, DOI: 10.1186/cc5121
Abstract: Overall mortality was 43.3% and increased significantly from normal to class F (normal, 23.5%; class R, 50%; class I, 66.6%; and class F, 72%; P < 0.0001). The majority of patients (95%) died in the ICU within the first month of hospitalization. Multivariate regression analysis, including age, gender, comorbidity, RIFLE class and simplified acute physiology score (SAPS) II showed that only class I (odds ratio 5.12, 95% confidence interval 1.07 to 24.28, P = 0.04) and class F (odds ratio 4.6, 95% confidence interval 1.57 to 13.5, P = 0.005), as well as SAPS II (odds ratio 1.04, 95% confidence interval 1.01 to 1.07, P = 0.005) emerged as independent predictors of mortality. As SAPS II (area under receiver operating characteristic 0.699 ± 0.055; P = 0.001), the RIFLE classification had good discriminative power (area under receiver operating characteristic 0.732 ± 0.053; P < 0.0001). In sum, acute kidney injury, defined by means of the RIFLE criteria, is common among critically ill HIV-infected patients, and RIFLE seems a helpful tool in the prognostic stratification of ICU HIV-infected patients.HAART = highly active antiretroviral therapy; ICU = intensive care unit; RIFLE = Risk, Injury, Failure, Loss, and End-stage kidney disease; SAPS = simplified acute physiology score.The authors declare that they have no competing interests.JAL, JF, SJ made substantial contributions to conception and design, acquisition of data, and analysis and interpretation of data. JAL, JN, FA, and MMP were involved in drafting the manuscript and revising it critically for important intellectual content. All authors have given final approval of the version to be published.
Acute renal failure in critically ill HIV-infected patients
José Lopes, Joana Fernandes, Sofia Jorge, José Neves, Francisco Antunes, Mateus Prata
Critical Care , 2007, DOI: 10.1186/cc5141
Abstract: We evaluated retrospectively the incidence of ARF, as well as its aetiology, risk factors, therapy and outcome, among HIV-infected patients admitted to the Infectious Diseases Intensive Care Unit of our hospital between January 2002 and June 2006. ARF was defined by means of the Risk Injury Failure Loss End-stage classification [2]. ARF was considered if there was at least a 1.5-fold increase of serum creatinine or a urinary output lower than 0.5 ml/kg/hour for 6 hours.Ninety-seven patients (mean age, 42.7 ± 12.2 years; 77 male, 69 Caucasian) were evaluated. Forty-six patients (47.4%) (mean age, 43.2 ± 11.1 years; P = not significant; 39 male, P = not significant; 38 Caucasian, P = not significant) had some degree of renal dysfunction, and did not differ in terms of age, gender, race, type of HIV, CD4+ lymphocyte count, stage of HIV infection, Highly Active Antiretroviral Therapy, comorbidity, and severity of illness. Sepsis (n = 39, 84%) was the most common aetiology. Seven patients (15.2%) received renal replacement therapy (continuous venovenous haemodiafiltration). By multivariate regression analysis, age > 60 years (odds ratio, 5.32; 95% confidence interval, 1.23–23; P = 0.025), hepatitis C (odds ratio, 3.42; 95% confidence interval, 1.08–10.85; P = 0.037), as well as severity of illness (Simplified Acute Pathophysiology Score II > 50; odds ratio, 0.26; 95% confidence interval, 0.1–0.7; P = 0.008) emerged as independent predictors of ARF.The overall mortality was 43.3%, and mortality was higher among ARF patients (30 versus 12 patients; P < 0.0001). The majority of patients (95%) died within the first month of hospitalization, in the intensive care unit. Patients who did not die, however, had complete renal function recovery. Multivariate regression analysis showed that ARF (odds ratio, 0.27; 95% confidence interval, 0.1–0.67; P = 0.007) and illness severity (Simplified Acute Pathophysiology Score II >50; odds ratio, 0.19; 95% confidence interval, 0.07–0.53; P
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