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Search Results: 1 - 10 of 152228 matches for " Joan Hérisson "
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Periodic pattern detection in sparse boolean sequences
Ivan Junier, Joan Hérisson, Fran?ois Képès
Algorithms for Molecular Biology , 2010, DOI: 10.1186/1748-7188-5-31
Abstract: The algorithm is particularly robust with respect to strong signal distortions such as the addition of 1's at arbitrary positions (contaminated data), the deletion of existing 1's in the sequence (missing data) and the presence of disorder in the position of the 1's (noise). This robustness property stems from an appropriate exploitation of the remarkable alignment properties of periodic points in solenoidal coordinates.The efficiency of the algorithm is demonstrated in situations where standard Fourier-based spectral methods are poorly adapted. We also show how the proposed framework allows to identify the 1's that participate in the periodic trends, i.e. how the framework allows to allocate a positional score to genes, in the same spirit of the sequence score. The software is available for public use at http://www.issb.genopole.fr/MEGA/Softwares/iSSB_SolenoidalApplication.zip webcite.There is increasing evidence that the organization of the genome plays a crucial role in the interplay between genetic regulation and chromosome structure. At the smallest scale, several experimental studies have highlighted the importance of the positions of the transcription factor binding sites in the functioning of small transcriptional regulatory networks [1-3]. At a larger - but still local - scale, in bacteria many transcription units are known to be located along the DNA close to the gene that encodes their regulating transcription factors [4-6]. At the global scale of the chromosome, both in Escherichia coli and in Saccharomyces cerevisiae, it has been previously realized that the genes that are regulated by the same transcription factor have a tendency to be periodically spaced along the DNA [7,8]. Recently, the relative positions of phylogenetically conserved gene pairs were also shown to tend to periodically organize along the DNA in E. coli [9]. Such periodic organization has been proposed to be responsible for the spatial co-localization of co-regulated genes [10]; indee
Visual Data Mining of Genomic Databases by Immersive Graph-Based Exploration
Nicolas Férey,Pierre-Emmanuel Gros,Joan Hérisson,Rachid Gherbi
Quantitative Biology , 2007,
Abstract: Biologists are leading current research on genome characterization (sequencing, alignment, transcription), providing a huge quantity of raw data about many genome organisms. Extracting knowledge from this raw data is an important process for biologists, using usually data mining approaches. However, it is difficult to deals with these genomic information using actual bioinformatics data mining tools, because data are heterogeneous, huge in quantity and geographically distributed. In this paper, we present a new approach between data mining and virtual reality visualization, called visual data mining. Indeed Virtual Reality becomes ripe, with efficient display devices and intuitive interaction in an immersive context. Moreover, biologists use to work with 3D representation of their molecules, but in a desktop context. We present a software solution, Genome3DExplorer, which addresses the problem of genomic data visualization, of scene management and interaction. This solution is based on a well-adapted graphical and interaction paradigm, where local and global topological characteristics of data are easily visible, on the contrary to traditional genomic database browsers, always focused on the zoom and details level.
Kuldsele Kaananimaale: esimestest eesti v ljar ndajatest Brasiilias
Sander Jürisson
M?etagused. Hüperajakiri , 2012,
Abstract: This article focuses on the formation of the Estonian community in Brazil at the beginning of the 20th century. There were three waves of migration: the first decade of the 20th century, the time between the two world wars and the migration of Estonian refugees after World War II. Allegedly, the first Estonians reached Brazil at the beginning of the 19th century, although this is very unlikely. The first documented case is a sailor named Jüri Jürison, who visited Rio de Janeiro during his voyage from Kronstadt to Vladivostok in 1865. The first Estonian who resided in Brazil was a missionary named Hans Tiismann, who worked as a reverend in Santa Cruz in the years 1875-1884. The first evidence of the permanent Estonian population dates from 1902.The first larger group of Estonians arrived in Brazil in 1906 and immigration continued in subsequent years. The Brazilian states, especially Sao Paolo, were on constant promotion tours in Europe in order to attract more manpower to Brazil. It is not known how many Estonians reached Brazil at the beginning of the 20th century, but based on an estimate, the number could have been between 500 and 1000. Quite a large number of them were inhabitants of Estonian communes from other parts of the Russian Empire and many of them were Baptists. Due to the difficult conditions over there, several of those who had migrated to Brazil returned to their homeland after a few years. The article describes the causes of Estonians’ emigration to Brazil, the composition of migrants, group size, and adaptation in their new homeland. Also the article examines the promotional brochure written by Johann Gutmann, which had a strong influence on migrants.
The history of reindeer in Iceland and reindeer study 1979 - 1981
Skarphédinn Thórisson
Rangifer , 1984,
Abstract: This report deals with the history of reindeer in Iceland and reindeer study in East Iceland in the years 1979 - 1981. The study included about half of the Icelandic reindeer population, i.e. that part of it affected by the proposed Austurlandsvirkjun hydro-electric power scheme. The study was originally based on Proposal for study of reindeer and ranges in Iceland by Eldar Gaare and Eigil Reimers (1978). A summary of the investigation plan is shown in Table 1. Reinens historie p Island og reinunders kelser 1979 - 1981. Abstract in Norwegian / Sammendrag: Denne rapport omhandler historien om reinsdyr p Island samt unders kelser over reinen p st-Island i rene 1979 - 1981. Disse studier omfatter omlag halvdelen av den islandske reinpopulasjon, d.v.s. den del som blir ber rt av den foresl tte hydroelektriske utbygging i Austurlandsvirkjun. Unders kelsene ble opprinnelig planlagt etter et forslag om unders kelser av rein og reinbeiter p Island utarbeidet av Eldar Gaare og Eigil Reimers. En oversikt over denne plan er vist i Tabell 1. Porojen historiaa Islannissa ja porojen tutkimusta vuosina 1979 - 1981. Abstract in Finnish / Yhteenveto: Raportti k sittelee porojen historiaa Islannissa ja ne porotutkimukset, jotka suoritettiin It -Islannissa vuosina 1979-1981. Tutkimukset k sitt v t suunnilleen puolet Islannin porokannasta tai siit sen osan, johon Austurlandsvirkjuniin ehdotettu voimalaitossuunnitelma vaikuttaa. Alunpit en tutkimukset ovat perustuneet Eldar Gaaren ja Eigil Reimersin tyohon: Ehdotus porojen ja porolaidunten tutkimuksesta Islannissa . Katsaus projektisuunnitelmista on n ytetty taulukossa 1.
Current Testing of CMOS Combinational Circuits withSingle Floating Gate Defects
Victor H. Champac,Joan Figueras
VLSI Design , 1997, DOI: 10.1155/1997/97381
The influence of obesity duration on left ventricular mass, volume and function: A pilot study  [PDF]
Juan Ybarra, June H. Romeo, Sandra Férnandez, Joan Sanchez-Hernandez
Health (Health) , 2012, DOI: 10.4236/health.2012.412A205

Introduction: Despite the bulk of evidence between obesity and cardiovascular complications, the effect of the duration of obesity (DOO) on cardiac function has so far received limited attention. The aim of the study is to study the relationship between a new, American Heart Association (AHA) and World Health Organization (WHO)-adapted formula for reporting DOO with echocardiographic findings and comorbidities in a large cohort of individuals whose BMI ranged from normal (<25 Kg·m2) to morbid obesity (>40 Kg·m2) and had been obese for varying lengths of time. Methods: 198 (M60/F138) asymptomatic patients were recruited. Patients were classified according to their reported DOO. The normal weight group (N = 92 (40/F52) was formed by those patients who did not recall maintaining a BMI > 30 Kg·m2 from age 18 while those recalling maintenance of a BMI > 30 Kg·m2 since age 18 and thereafter formed the obese group (N = 106 (M20/F86)). A detailed clinical, echo-cardiographic and analytical study was performed. Results: DOO in our series disclosed a significant correlation with left ventricular architecture and hemodynamics, left ventricular mass, cardiac output as well as the prevalence of diabetes mellitus, hypertension and insulin resistance. Stepwise multiple regression analysis revealed that almost 54% of the interventricular septum thickness’s variance can be independently predicted by a model including DOO, gender, hypertension and logtransformed HOMA. Conclusions: Our formula for estimating the duration of obesity provides a simple, user-friendly tool

Bounded Recursive Self-Improvement
E. Nivel,K. R. Thórisson,B. R. Steunebrink,H. Dindo,G. Pezzulo,M. Rodriguez,C. Hernandez,D. Ognibene,J. Schmidhuber,R. Sanz,H. P. Helgason,A. Chella,G. K. Jonsson
Computer Science , 2013,
Abstract: We have designed a machine that becomes increasingly better at behaving in underspecified circumstances, in a goal-directed way, on the job, by modeling itself and its environment as experience accumulates. Based on principles of autocatalysis, endogeny, and reflectivity, the work provides an architectural blueprint for constructing systems with high levels of operational autonomy in underspecified circumstances, starting from a small seed. Through value-driven dynamic priority scheduling controlling the parallel execution of a vast number of reasoning threads, the system achieves recursive self-improvement after it leaves the lab, within the boundaries imposed by its designers. A prototype system has been implemented and demonstrated to learn a complex real-world task, real-time multimodal dialogue with humans, by on-line observation. Our work presents solutions to several challenges that must be solved for achieving artificial general intelligence.
Un Projecte d'arxiu informatitzat de textos catalans medievals: algunes normes
Jeremy N. H. Lawrance,Joan Torruella i Casa?as
Llengua & Literatura , 1998, DOI: 10.2436/l&l.vi.1330
The Use of Ion Chromatography for the Determination of Clean-In-Place-200 (CIP-200) Detergent Traces
Wilfredo Resto,Joan Roque,Rosamil Rey,Héctor Colón
Analytical Chemistry Insights , 2006,
Abstract: Anion chromatography with conductivity detection was chosen as the analytical technique for the development of a cleaning validation method for clean-in-place (CIP) detergents. The method was developed and validated for the determination of traces of the detergent CIP-200. It was shown to be linear with a squared correlation coefficient (r2) of 0.9999 and the accuracy experiments presented average recoveries of 88.2% (area response factor) from stainless steel surfaces. The repeatability was found to be 1.6% and an intermediate precision of 1.9% across the range. The method was also shown to be sensitive with an average Detection Limit (DL) of 0.23 ppm and a Quantitation Limit (QL) of 0.70 ppm based on the amount of phosphate in the detergent sample. The phosphate signal was well resolved from typical ions encountered in water samples or any other interference presented from swabs and surfaces. The method was applied to cleaning validation samples and proved to be suitable for rapid and reliable quality control.
A member of the peptidase M48 superfamily of Porphyromonas gingivalis is associated with virulence in vitro and in vivo
Sheila Walters,Myriam Bélanger,Paulo H. Rodrigues,Joan Whitlock
Journal of Oral Microbiology , 2009, DOI: 10.3402/jom.v1i0.2021
Abstract: Background: In vivo-induced antigen technology was previously used to identify 115 genes induced in Porphyromonas gingivalis W83 during human infection. One of these, PG2197, a conserved hypothetical protein which has homology to a Zn-dependent protease, was examined with respect to a role in disease. Design: The expression of PG2197 in human periodontitis patients was investigated, but as there is increasing evidence of a direct relationship between P. gingivalis and cardiovascular disease, a mutation was constructed in this gene to also determine its role in adherence, invasion, and persistence within human coronary artery endothelial cells (HCAEC) and neutrophil killing susceptibility. Results: Plaque samples from 20 periodontitis patients were analyzed by real-time PCR, revealing that PG2197 was expressed in 60.0% of diseased sites compared to 15.8% of healthy sites, even though P. gingivalis was detected in equal numbers from both sites. The expression of this gene was also found to be up-regulated in microarrays at 5 and 30 min of invasion of HCAEC. Interestingly, a PG2197 mutant displayed increased adherence, invasion, and persistence within HCAEC when compared to the wild-type strain. Conclusion: This gene appears to be important for the virulence of P. gingivalis, both in vivo and in vitro.
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