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Search Results: 1 - 10 of 494081 matches for " Jo?o M;Fonseca "
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Role of Selective Cyclo-Oxygenase-2 Inhibitor Celecoxib in Canine Osteosarcoma Cell Culture  [PDF]
Paulo R. O. Bersano, Maria T. S. Alves, Maria F. M. R. Gartner, Adriana Camargo Ferrasi, Joo F. Lima-Neto, Fernanda C. Landim, Stephane C. Vexenat, Carlos Eduardo Fonseca Alves, Glenda Nicioli da Silva, Noeme S. Rocha
Open Journal of Pathology (OJPathology) , 2013, DOI: 10.4236/ojpathology.2013.34027
Abstract:

Background: Experimental studies have shown that cyclo-oxygenase-2 (Cox2) is related to the development and progression of tumors, since this enzyme is induced and expressed by cells such as macrophages, osteoblasts, activated endothelial cells, and tumor cells. The activity in tumors includes proliferation, cell transformation, tumor growth, invasion and metastasis and may play an important role in carcinogenesis of the canine osteosarcoma, since it has high expression in tissue fragments. The combination of selective Cox2 inhibitors and other treatment modalities is the basis for a new anti-cancer therapy strategy. This in vitro study exposed primary cells of five different canine osteosarcoma cultures to selective Cox2 inhibitor at increasing concentrations and times. Results: For Cox2 negative cultures, despite the absence of differences, greater sensitivity of cells to treatment was observed. For Cox2 positive cultures, a higher number of necrotic cells were observed (P ≤ 0.05), when compared with negative cultures. For exposure times with Celecoxib doses, no difference (P > 0.05) was found between the three times analyzed for living, apoptotic and apoptotic/necrotic cells. There are similarities in the values of 24 h and 48 h, with slight reduction of living cells, increasing those undergoing apoptosis and apoptosis/necrosis. There was significance for necrosis (P ≤ 0.05). In 72 hours, a significant difference was observed between the other two previous values (P ≤ 0.05). It was found for the group of 100 μML-1, that there was a numerically greater signaling for apoptosis and lower (P = 0.08) for necrosis, and this point was the onset of the pharmacodynamic phenomenon, with drop in the values for living cells and increased number of necrotic cells, with a tendency (P = 0.08) for reducing the percentage of necrotic cells for the group of 100 μML-1 when compared to that of

Effects of atopy and rhinitis on exhaled nitric oxide values - a systematic review
Daniela Linhares, Tiago Jacinto, Ana M Pereira, Joo A Fonseca
Clinical and Translational Allergy , 2011, DOI: 10.1186/2045-7022-1-8
Abstract: A systematic review was performed in Pubmed, Scopus and ISI Web of Knowledge. A two-step selection process was completed, and from 2357 references 19 were included. The inclusion criteria were: participants without known diseases other than rhinitis; atopy assessement by SPT or Specific IgE; and FeNO measurements according to ATS/ERS recommendations.The 8 articles measuring FeNO in children showed higher values in both allergic rhinitis and atopic children when compared with healthy children. The 11 articles performed in adults observed higher FeNO in AR patients comparatively with either healthy or atopic individuals. However, adult healthy and atopic individuals had similar FeNO values.FeNO values are higher in individuals with rhinitis and/or atopy without other health problems. These effects are small, seem to be independent and should be further studied using multivariate models. The effect of atopy was observed only in children. The combined effect of atopy and rhinitis produced higher FeNO values in adults. These results support that both atopy and rhinitis should be considered when interpreting or when defining FeNO reference values.Exhaled nitric oxide (FeNO) is associated with asthma [1], and with airway eosinophilia [2]. Recently, it was suggested that FeNO production in the airways is under the influence of Th2 cytokines, IL-4 and IL-13, responsible for induction of Inducible Nitric Oxide Synthase (iNOS) expression in the airway epithelium, and thus for the increase of FeNO in inflammatory disorders [3].Many individual factors influence FeNO values. In fact, the considerable inter-subject variability hampers the clinical interpretation of FeNO measurements [4,5]. Two important FeNO modifiers are atopy and rhinitis [6]. Some studies reported higher FeNO values in patients with atopy or allergic rhinitis alone [7-9], while others observed a relationship between elevated FeNO values and the exacerbation of rhinitis and the number of positive wheals on skin
Determinantes do aborto provocado entre mulheres admitidas em hospitais em localidade da regi?o Nordeste do Brasil
Fonseca,Walter; Misago,Chizuru; Correia,Luciano L.; Parente,Joo A. M.; Oliveira,Francisco Chagas;
Revista de Saúde Pública , 1996, DOI: 10.1590/S0034-89101996000100003
Abstract: in brazil, abortion is legally allowed only when it is necessary to save a woman's life or when pregnancy has occurred following rape. despite this law, iduced abortion is widely carried out. this study presents the findings as to the determinants of 2,084 abortions admitted to two major obstetric hospitals in fortaleza, brazil, between october 1992 and september 1993. most of these women (2,074) have admitted an attempt to terminate pregnancy and 10 women were classified as induced abortion cases based on the findings of signs of intervention such as cervical laceration, perforation or foreign bodies in the vagina or uterus. the study findings indicate that self-administration of medicines plays an important role in terminating pregnancy. among the 2,074 women who admitted to terminating the pregnancy 66% reported using misoprostol to induce abortion. misoprostol, a prostaglandin e1 analogue indicated for ulcer treatment, has been widely used as an abortifacient by women in brazil. misoprostol has some uterine effects but it is not effec-tive in inducing abortion. among women who were hospitalized for complications resulting from abortion about 59.7% were 20 to 29 years old and 22.6% were aged less than 20. the majority of the women (91.6%) were catholic and only 4.3% were illiterate. about 62% of the abortion cases lived alone or did not have a stable partner. most of the women (59.2%) reported less than 2 live births and 11.8% had experienced a previous abortion; 61.1% of the women were not using a contraceptive method at the time of conception. the main reasons for this were "fear of side effects", "did not expect to have sexual intercourse" and "did not expect to get pregnant". the authors sug-gest that the situation of a high rate of self-inflicted abortion may be changed by the application of an appropriate contraceptive and reproductive health programme.
Determinantes do aborto provocado entre mulheres admitidas em hospitais em localidade da regi o Nordeste do Brasil
Fonseca Walter,Misago Chizuru,Correia Luciano L.,Parente Joo A. M.
Revista de Saúde Pública , 1996,
Abstract: Com o objetivo de identificar os determinantes do aborto provocado entre mulheres admitidas por complica es decorrentes dos abortos, nos hospitais-maternidades públicos em Fortaleza, CE (Brasil) foram entrevistadas 4.359 pacientes entre 1o de outubro de 1992 e 30 de setembro de 1993. Os dados foram coletados através de questionário estruturado. S o apresentados os determinantes dos abortos provocados em 2.084 (48%) mulheres classificadas como tendo induzido aborto. Dois ter os (66%) das mulheres relataram a indu o do aborto com o uso isolado do Cytotec(R) (misoprostol) ou associado a outro meio abortivo. Os resultados indicam que, na popula o estudada, a indu o do aborto é prática comum entre jovens, solteiras (ou que vivem sem um parceiro estável), de baixa paridade, com escolaridade incipiente e n o-usuárias de métodos contraceptivos. Recomenda-se a realiza o de estudos que investiguem os conhecimentos relacionados a percep es, conceitos culturais do aborto, e às raz es por que mulheres pobres fracassam na ado o de métodos de planejamento familiar.
Elabora o de um programa computacional para avalia o e controle de servi os de radiologia médica de médio porte, de acordo com as diretrizes de prote o radiológica do Ministério da Saúde
Fonseca Mauro M. da,Schelin Hugo R.,Barbosa Otília D.,Tilly Joo
Radiologia Brasileira , 2001,
Abstract: Este trabalho apresenta o resultado do estudo para elabora o de um programa computacional para avalia o e controle de servi os de radiologia médica de médio porte, de acordo com as recentes diretrizes de prote o radiológica do Ministério da Saúde. A rotina do Departamento de Radiologia do Hospital S o Vicente de Paulo, Passo Fundo, RS, foi analisada, e a partir desta análise foi desenvolvido um programa computacional utilizando-se ferramentas de computa o padr o Windows. O programa, chamado de "Sistema Radiológico", foi implementado e testado com dados e medi es, ficando comprovado que a metodologia permite o acompanhamento dos requisitos da Portaria no 453 do Ministério da Saúde e possibilita ganho de eficiência em diversas atividades.
O goodwill n?o é um activo
Fonseca,Joo Carlos;
Economia Global e Gest?o , 2009,
Abstract: in the actual context of international financial crisis it was questioned by the society in general the role of accounting. on this subject, comes with special relevance the accounting treatment of goodwill on business combinations. this article analysis the goodwill concept, its economic rational and the accounting framework in the light of international financial reporting standards. from the analysis of its economic rational, insufficiencies and incoherencies were detected in the accounting treatment of goodwill translating a lack of faithful representation of the company?s financial position and performance and the true and fair view of its financial statements. all this originated an effect of increased volatility and pro-cyclicality in the performance of companies, which influenced its financial structure and the financial system and the business world. finally, given the materiality in question, it is proposed an amendment to international financial reporting standards with a grace period and retrospectively with two options.
Novos indicadores para o comércio internacional
Fonseca,Joo Carlos;
Economia Global e Gest?o , 2011,
Abstract: at the international level, to ascertain the export capacity of a country and its openness to the outside is generally used the value of exports and the sum of these with imports relative to gross domestic product. however, when relating the values of imports measured at basic prices and exports measured at purchasers? prices with the added value of an economy, the indicators are suffering from an internal inconsistency and therefore do not accurately reflect the export capacity and the degree of openness of an economy to the outside. analysing a set of 28 countries, this paper puts forward new indicators that reflect a true and fair view of the position of each country in international trade.
O goodwill n o é um activo Goodwill is not an asset
Joo Carlos Fonseca
Economia Global e Gest?o , 2009,
Abstract: No contexto da actual crise financeira internacional, a sociedade em geral questionou o papel da contabilidade. Nesta temática, surge com especial relevancia o tratamento contabilístico do goodwill no ambito de concentra es empresariais. O presente artigo analisa o conceito de goodwill e o respectivo racional económico subjacente, posteriormente enquadra-o em termos contabilísticos, à luz das International Financial Reporting Standards (IFRS). Da análise efectuada face ao racional económico subjacente, detectaram-se insuficiências e incoerências no tratamento contabilístico do goodwill, traduzindo uma falta de representa o fidedigna da posi o e do desempenho financeiro das empresas e da imagem verdadeira e apropriada das respectivas demonstra es financeiras. Tudo isto originou um efeito de maior volatilidade e pró-ciclicidade nos resultados das empresas, com influência na estrutura financeira das mesmas e no sistema financeiro e empresarial a nível mundial. Finalmente, dada a materialidade em causa, prop e-se uma altera o prospectiva às IFRS com um período de carência e retrospectivamente com duas op es. In the actual context of international financial crisis it was questioned by the society in general the role of accounting. On this subject, comes with special relevance the accounting treatment of goodwill on business combinations. This article analysis the goodwill concept, its economic rational and the accounting framework in the light of International Financial Reporting Standards. From the analysis of its economic rational, insufficiencies and incoherencies were detected in the accounting treatment of goodwill translating a lack of faithful representation of the company’s financial position and performance and the true and fair view of its financial statements. All this originated an effect of increased volatility and pro-cyclicality in the performance of companies, which influenced its financial structure and the financial system and the business world. Finally, given the materiality in question, it is proposed an amendment to International Financial Reporting Standards with a grace period and retrospectively with two options.
Novos indicadores para o comércio internacional New indicators for international trade
Joo Carlos Fonseca
Economia Global e Gest?o , 2011,
Abstract: Para se aferir da capacidade exportadora de um país e do seu grau de abertura face ao exterior, ao nível internacional, utiliza-se normalmente o valor das exporta es e o somatório destas com as importa es em rela o ao Produto Interno Bruto. No entanto, ao relacionarem os valores das importa es mensurados a pre os base e das exporta es mensurados a pre os de aquisi o com o valor acrescentado de uma economia, os indicadores padecem de uma incoerência interna e, por isso, n o traduzem adequadamente a capacidade exportadora e o grau de abertura de uma economia face ao exterior. Analisando um conjunto de 28 países, incluindo Portugal, o presente artigo avan a com novos indicadores que traduzem uma melhor imagem da posi o de cada um no comércio internacional. At the international level, to ascertain the export capacity of a country and its openness to the outside is generally used the value of exports and the sum of these with imports relative to Gross Domestic Product. However, when relating the values of imports measured at basic prices and exports measured at purchasers’ prices with the added value of an economy, the indicators are suffering from an internal inconsistency and therefore do not accurately reflect the export capacity and the degree of openness of an economy to the outside. Analysing a set of 28 countries, this paper puts forward new indicators that reflect a true and fair view of the position of each country in international trade.
Elabora??o de um programa computacional para avalia??o e controle de servi?os de radiologia médica de médio porte, de acordo com as diretrizes de prote??o radiológica do Ministério da Saúde
Fonseca, Mauro M. da;Schelin, Hugo R.;Barbosa, Otília D.;Tilly, Joo;Jakubiak, Rosangela R.;
Radiologia Brasileira , 2001, DOI: 10.1590/S0100-39842001000600008
Abstract: we present the results of a study for the development of a computational program for the evaluation and control of medium size medical radiological facilities in agreement with the recent guidelines of radiological protection of the brazilian ministry of health. the routine procedures of the radiology department of hospital s?o vicente de paulo, passo fundo, rs, brazil, were analyzed and a computer program was developed using windows tools. the program named "sistema radiológico" (radiological system) was implemented and tested with data and measurements. the results proved that the methodology employed allows fulfillment of the requirements of the directive no 453 of the brazilian ministry of health, and moreover, increases the efficiency of several other activities in the radiology department.
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