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Search Results: 1 - 10 of 182668 matches for " Jo?o Daniel Santos Fernandes "
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The Evaluation of Bioremediation Potential of a Yeast Collection Isolated from Composting  [PDF]
Bianca Trama, Joo Daniel Santos Fernandes, Geórgia Labuto, Júlio Cézar Franco de Oliveira, Cristina Viana-Niero, Renata C. Pascon, Marcelo A. Vallim
Advances in Microbiology (AiM) , 2014, DOI: 10.4236/aim.2014.412088
Abstract: The influence of xenobiotic compounds on environment and on living organisms has been reported as an imminent public health problem. Among them we can list the contamination by Alkanes present in petroleum, hydrocarbons and organic contaminant substances from industrial effluents. Also, heavy metals are of particular interest because of their persistence in the environment contaminating the food webs. Among the innovative solutions for treatment of contaminated water and soil is the use of biological materials like living or dead microorganisms. Yeasts exhibit the ability to adapt to extreme condition such as temperature, pH and levels of organic and inorganic contaminants that make them a potential material to be used to remediate contaminated environment application. The goal of this work was to search for yeast isolates capable to use n-hexadecane (alkane hydrocarbon) as a primary carbon source and for those able to tolerate high concentration of lead (Pb) within a collection of 90 isolates obtained from the Sao Paulo Zoo composting system. The isolated yeast strains were identified by mass spectrometry (MALDI-TOF-MS) and by sequencing of the ribosomal DNA (18S and D1/D2) conserved regions. We found that the collection bares 23 isolates capable of utilizing n-hexadecane and one which is able to tolerate high concentration of lead (Pb) with a high biosorption index compared to the reference yeast strains (BY4742, PE-2, CAT-1 and BG-1). These results confirm the initial hypothesis that the Sao Paulo Zoo composting is the source for diverse yeasts species with biotechnological application potential.
Dissection technique for the study of the cerebral sulci, gyri and ventricles
Mattos, Joo Paulo;Santos, Marcos Juliano dos;Zullo, Joo Flavio Daniel;Joaquim, Andrei Fernandes;Chaddad-Neto, Feres;Oliveira, Evandro de;
Arquivos de Neuro-Psiquiatria , 2008, DOI: 10.1590/S0004-282X2008000200034
Abstract: neuroanatomy in addition to neurophysiology, are the basic areas for the proper formation from health students to specialized professionals in neuroscience. a step by step guide for practical studies of neuroanatomy is required for this kind of knowledge to become more acceptable among medical students, neurosurgeons, neurologists, neuropediatricians and psychiatric physicians. based on the well known courses of sulci, gyri and ventricles offered by beneficência portuguesa hospital in s?o paulo, brazil, two times a year, since 1994, totalizing more than 20 complete courses, and answering the request of many neuroscience students and professionals whose asked for a practical guide to the neuroanatomy study, the authors suggest a protocol for the study of superficial and deep brain structures showing how to approach the more structures as possible with minimum damage to the anatomic piece and with the smaller number of brains.
Ulcerated Lesion in Buccal Mucosa in a Patient with Paracoccidioidomycosis—Case Report  [PDF]
Giovanna Lima Vaz, Lívia Cristina de Melo Pino, Aline Gabriela Santos Costa, Ibrahim Yahia El Somailli, Joo Roberto Resende Fernandes, Elayne Christina Meireles Martins, Daniel Cohen Goldemberg, Aline Hellen da Silva Camacho, Rhanna Neves Cirqueira, Daniel Almeida da Costa
Journal of Biosciences and Medicines (JBM) , 2017, DOI: 10.4236/jbm.2017.510005
Abstract: Paracoccidioidomycosis is the most prevalent systemic mycosis in Latin America. It is a fungal infection caused by the dimorphic fungus Paracoccidioides brasiliensis. This microorganism can penetrate the human body through direct contact and can cause intense lymphadenopathy, ulcerated lesions in the oral cavity and in the skin among other alterations. In this study, we report a case of paracoccidioidomycosis with unusual clinical presentation, as it manifested in the female sex and although it did not present any relevant complaints of respiratory focus, it presented a single ulcerated lesion in the buccal mucosa. A biopsy of the lesion and a mycological examination revealed Paracoccidioidesbrasiliensis infection.
Como s?o tratadas as fraturas diafisárias fechadas do fêmur no Brasil? Estudo transversal
Pires, Robinson Esteves Santos;Fernandes, Hélio Jorge Alvachian;Belloti, Joo Carlos;Balbachevsky, Daniel;Faloppa, Flávio;Reis, Fernando Baldy dos;
Acta Ortopédica Brasileira , 2006, DOI: 10.1590/S1413-78522006000300010
Abstract: a cross-sectional study was performed during the 36th brazilian congress of orthopaedics and traumatology, where the opinions of brazilian orthopaedic surgeons addressing the treatment of femoral diaphyseal fractures in adults were surveyed. five hundred and seven questionnaires were fully completed and the results show agreement in the following topics: fracture trace configuration and injuries of soft parts or neurovascular structures as key parameters for determining treatment; fractures classification, in which ao was most frequently adopted; milled blocked anterograde intramedullary nail for treating cross-sectioned and short oblique factures at the isthmus; bridge plate for treating complex trace fractures; pre-operative skeletal traction; infection as the most frequent complication, and; postoperative low molecular weight heparin. there were opinion conflicts for the following topics: use of traction table for performing intramedullary osteosynthesis, time interval between trauma and surgery; time of antibiotics use, and; mean hospitalization time. regarding literature, there was agreement concerning key parameters for determining treatment; fixation method for simple-traces fractures at the isthmus; adopted classification; antithrombotic prophylaxis. issues such as fixation method for complex-traced fractures; time of antibiotics use; average interval between trauma and osteosynthesis, and; hospitalization time were different from literature.
Componentes externos do corpo e gordura de descarte em vacas mesti?as Charolês x Nelore abatidas com diferentes pesos
Kuss, Fernando;Restle, Joo;Brondani, Ivan Luiz;Pascoal, Leonir Luiz;Menezes, Luís Fernando Glasenapp de;Leite, Daniel Terra;Santos, Maurício Fernandes dos;
Revista Brasileira de Zootecnia , 2007, DOI: 10.1590/S1516-35982007000400016
Abstract: the objective of this experiment was to study the development of external body components and that of discarded fat in feedlot finished crossbred cows from the second (g2 - 3/4charolais (c) 1/4nellore (n) and 3/4nc) and third (g3 - 5/8cn and 5/8nc) generations of a charolais ′ nellore rotational crossbreeding program slaughtered with 465 (t465), 507 (t507) and 566 kg (t566) of body weight. at the beginning of the trial, age, body weight and body condition score averaged, respectively, 8.5 years, 388.6 kg and 2.35 points. animals were fed a diet with a forage to concentrate ratio of 48:52, which contained 12.5% of cp and 2.99 mcal of digestible energy per kg of dm. the increment in empty body weight (ebw) (376.34, 412.53 e 463.64 kg, respectively, for t465, t507 and t566) followed that of slaughter weight (sw) but ebw yield did not change and averaged 81.51% across the different sw groups. increased sw and ebw reduced the proportion of digesta content. animals with heavier body weight showed greater development of head and udder. however, skin growth was not affected leading to lower relative proportion with the increase of sw and ebw. increasing sw also resulted in lower relative participation in the ebw of the external components (16.47, 15.65 and 14.30%). deposition of internal fat increased until t507 while that of subcutaneous fat was greatest on t566, resulting in larger removal of trim fat from carcasses of t566 (4.02, 4.26 and 7.31 kg, respectively) cows. greater participation of charolais in the genotype resulted in higher head development. cows of the third generation of the rotational crossbreeding charolês ′ nellore had greater head size than those from the second generation (16.22 against 15.77 kg).
Adenoid Cystic Carcinoma of the Head and Neck: Epidemiology and Predictors of Prognosis  [PDF]
Daniel Monteiro, Joo Lino, Teresa Bernardo, Joo Fernandes, Eurico Monteiro
International Journal of Otolaryngology and Head & Neck Surgery (IJOHNS) , 2013, DOI: 10.4236/ijohns.2013.25036
Abstract: Objectives: The biologic behavior of the adenoid cystic carcinoma (ACC) and the factors predicting outcome for these tumors are still poorly understood. Our objective is to analyze the predicting factors and the value of different treatment possibilities, since none sole treatment has been standardized. Methods: A retrospective analysis of the epidemiologic, clinical and histologic aspects of ACC, as well as treatment options and other prognostic factors of all the cases of ACC of the head and neck treated at this Institution were analyzed. From 1974 until 2011, 152 patients were diagnosed with ACC and treated at the Portuguese Institute of Oncology (Porto Centre). Main outcome measures: overall survival, local recurrence and distant metastasis were calculated by the Kaplan-Meier method. Factors predictive of outcome were identified by univariate and multivariate analysis. Results: The mean age at diagnosis was 55.8 years (range, 19-83 years). Incidence was higher in the female population, with a female to male ratio of 1.7:1 respectively. The primary tumor location was hard palate and submandibular region in 56 cases, 28 in each location (24.6%), parotid gland (17 cases, 14.9%) and oral cavity excluding palate (16 cases, 14%).Distributions according to T stage were: T1 (29.8%); T2 (30.7%); T3 (17.5%); T4 (22%). The overall 1-year, 5-year and 10-year survival for all patients were 94.6%, 60.5%, 41.6%, respectively. Conclusions: Univariate survival analysis revealed that age older than 60 years (p = 0.002), solid histologic subtype (p = 0.042), advanced clinical stage (p < 0.001) and the presence of perineural invasion (p = 0.036) were correlated with a poor survival. Multivariate analysis confirmed that age and advanced clinical
Evaluation of the influence of base and alkyl bromide on synthesis of pyrazinoic acid esters through fatorial design
Fernandes, Joo Paulo dos Santos;Felli, Veni Maria Andres;
Química Nova , 2009, DOI: 10.1590/S0100-40422009000900040
Abstract: pyrazinoic acid esters have been synthesized as prodrugs of pyrazinoic acid. in the literature, its preparation is reported through the reaction of pyrazinoyl chloride with alcohols and the reaction with dcc/dmap. in this work, it is reported a 22 factorial design to evaluate the preparation of these esters through the substitution of alkyl bromides with carboxylate anion. the controlled factors were alkyl chain length of bromides (ethyl and hexyl) and the used base (triethylamine and dbu). results revealed that the used base used has significant effect on yield, and alkyl bromide used has neither significant influence, nor its interaction effect with base.
Ra a, cor e etnia em estudos epidemiológicos sobre popula es brasileiras: revis o sistemática na base PubMed Race, color and ethnicity in epidemiologic studies carried out with Brazilian populations: systematic review on the PubMed database
Juliana Fernandes Kabad,Joo Luiz Bastos,Ricardo Ventura Santos
Physis: Revista de Saúde Coletiva , 2012, DOI: 10.1590/s0103-73312012000300004
Abstract: O objetivo foi analisar o uso das variáveis ra a, cor e etnia em estudos epidemiológicos sobre popula es brasileiras. Trata-se de revis o sistemática, conduzida na base PubMed,entre janeiro de 2000 e julho de 2010. Para o conjunto dos trabalhos revisados, aplicou-se ficha com quest es sobre seus objetivos e a relevancia da classifica o étnico-racial em suas análises, características sócio-demográficas e aspectos da identifica o étnico-racial das popula es investigadas, bem como o seguimento de recomenda es quanto ao uso das classifica es de ra a, cor e etnia. Dos 1.174 artigos identificados, 151 foram elegíveis para a revis o. Maiores propor es de cada um dos seguintes aspectos foram observadas nos artigos em que a identifica o étnico-racial ocupou papel central em suas análises - destes, 18% justificaram o emprego das categorias; 16% consideraram a classifica o étnico-racial como fluida e relativa ao contexto da produ o dos dados; 65% descreveram o método da classifica o étnico-racial; 17% entenderam esta classifica o como medida de variabilidade genética; 26% interpretaram a variável como fator de risco para o desfecho em quest o; 47% consideraram fatores socioecon micos na interpreta o das desigualdades étnico-raciais; e 27% incluíram tais fatores no ajuste de modelos estatísticos. Apenas dois estudos explicitaram o conceito, que embasou o uso da variável étnico-racial. Uma propor o expressiva dos estudos epidemiológicos analisados n o segue os critérios mínimos que vêm sendo sugeridos quanto ao uso de variáveis relacionadas à classifica o étnico-racial, de modo que este aspecto deve ser aperfei oado nas pesquisas em Saúde Coletiva. This paper aims to analyze the use of the variables race, color and ethnicity in epidemiologic studies, carried out with Brazilian populations. This is a systematic review, conducted in the PubMed bibliographic database, on papers published between January 2000 and July 2010. A data extraction form was used to obtain data from all individual studies, such as their objectives, the relevance of the racial/ethnic classification in their analyses, participants' socio-demographic characteristics, including aspects related to the methods of racial classification, as well as the adherence to a set of recommendations on the use of race, color and ethnicity in biomedical publications. After initially identifying 1,174 references, 151 were included in the review. Higher proportions of each of the following results were observed among papers in which the racial/ethnic classification was central to their analyses - of
Predominance of constitutional chromosomal rearrangements in human chromosomal fragile sites  [PDF]
Inês J. Sequeira, Joo T. Mexia, Joo Santiago, Rita Mamede, Elisa Silva, Jorge Santos, Daniel Faria, José Rueff, Aldina Brás
Open Journal of Genetics (OJGen) , 2013, DOI: 10.4236/ojgen.2013.32A3002

Chromosomal fragile sites (CFSs) are loci or regions susceptible to spontaneous or induced occurrence of gaps, breaks and rearrangements. In this work, we studied the data of 4535 patients stored at DECIPHER (Database of Chromosomal Imbalance and Phenotype in Humans Using Ensembl Resources). We mapped fragile sites to chromosomal bands and divided the 23 chromosomes into fragile and non-fragile sites. The frequency of rearrangements at the chromosomal location of clones found to be deleted or duplicated in the array/CGH analysis, provided by DECIPHER, was compared in Chromosomal Fragile Sites vs. non-Fragile Sites of the human genome. The POSSUM Web was used to complement this study. The results indicated 1) a predominance of rearrangements in CFSs, 2) the absence of statistically significant difference between the frequency of rearrangements in common CFSs vs. rare CFSs, 3) a predominance of deletions over duplications in CFSs. These results on constitutional chromosomal rearrangements are evocative of the findings previously reported by others relatively to cancer supporting the current line of evidence and suggesting that a common mechanism can underlie the generation of constitutional and somatic rearrangements. The combination of insights obtained from our results and their interrelationships can indicate strategies by which the mechanisms can be targeted with preventive medical interventions.

Trimetazidine and Cellular Response in Cardiopulmonary Bypass*  [PDF]
Gerez Fernandes Martins, Aristarco G. de Siqueira Filho, Joo Bosco de F. Santos, Claudio Roberto Cavalcanti Assun??o, Alberto Valência, Gerez Martins
World Journal of Cardiovascular Surgery (WJCS) , 2013, DOI: 10.4236/wjcs.2013.35035
Abstract: Background: Organic cellular inflammatory response constitutes a pathophysiological mechanism present in all Coronary Artery Bypass Graftings (CABGs). In this aspect, the organism brings forth its defenses through answers that involve cellular components. Objectives: To evaluate, in a randomized double-blind prospective study, controlled with placebo, the effects of trimetazidine (Tmz) on cellular response, analyzed through the variation of leukocytes, neutrophils and monocytes. Patients and Method: 30 patients were randomly selected to be studied, with no more than a mild ventricular dysfunction, and divided into two groups (Tmz and placebo) stratified by echocardiography and receiving medication/placebo in a 60 mg/day dose. The samples of leukocytes, neutrophils and monocytes were obtained in the pre-operatory day without medication, at surgery day with 12 to 15 days of medication/placebo, with 5 minutes after the aortic declamping, and within 12, 24 and 48 hours after surgery. Results: The leukocytes and neutrophils levels have decreased significantly in the treated group when compared to the control group, in all analyzed moments (p = 0.012; p = 0.005). Conclusions and Clinical Implications: Trimetazidine has proved to reduce significantly the levels of total leukocytes and neutrophils in patients submitted to CABG.
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