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Search Results: 1 - 10 of 252113 matches for " Jo?o B; "
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L-dopa, biperideno e excre??o sebácea na doen?a de Parkinson
Villares, Joo C. B.;
Arquivos de Neuro-Psiquiatria , 1989, DOI: 10.1590/S0004-282X1989000100005
Abstract: sebum secretion was measured on the forehead of 47 patients with idiopathic parkinson's disease before and after treatment with anticholinergic (biperiden), levodopa + aaid and bromocriptine, by the osmic acid technique. another 100 patients under biperiden, levodopa 4- aaid or association of both, for at least one year, were also evaluated. the male parkinsonian ?de novo? patients have shown greater sebum secretion than female patients. it was also concluded that biperiden failed to reduce sebum secretion rate. on the other hand, it was found that l-dopa + aaid reduces the sebum secretion (cl = casual level and ser = sebum excretion rate) on both male and female patients. bromocriptine (10mg/day) was the second dopaminergic therapy employed in the present work. similarly to l-dopa, this dopaminergic agonist was able to significantly reduce sebum secretion (both cl and ser) of male patients. there was a positive and significant correlation for the 50-59 years old male patients ?de novo? between cl and tremor, hypokinesia, gait and posture or functional incapacity, before treatment. after a period of treatment correlation was no more found. in relation to parkinsonians under chronic treatment was found a positive and significant correlation between sebum secretion and hypokinesia. the level of sebum secretion on parkinsonian ?de novo:? patients before treatment was equal to parkinsonian patients under chronic treatment regardless the treatment, except for > 60 years old parkinsonians who have shown cl and ser higher than ?de novo? parkinsonian patients with the same age but without treatment. the treatment with l-dopa + aaid significantly decreased both cl and ser of ?de novo? parkinsonian patients. no difference of sebum secretion was found between parkinsonian ?de novo? patients before treatment and patients under treatment, regardless the, drugs, but after treatment with l-dopa + aaid, ?de novo? patients have shown significant lesser sebum secretion than patients
High-resolution time series of Pseudomonas aeruginosa gene expression and rhamnolipid secretion through growth curve synchronization
Dave van Ditmarsch, Joo B Xavier
BMC Microbiology , 2011, DOI: 10.1186/1471-2180-11-140
Abstract: Here, we propose a method to integrate growth curve data with endpoint measurements of secreted metabolites that is inspired by a model of exponential cell growth. If serial diluting an inoculum gives reproducible time series shifted in time, then time series of endpoint measurements can be reconstructed using calculated time shifts between dilutions. We illustrate the method using measured rhamnolipid secretion by P. aeruginosa as endpoint measurements and we integrate these measurements with high-resolution growth curves measured by OD600 and expression of rhamnolipid synthesis genes monitored using a reporter fusion. Two-fold serial dilution allowed integrating rhamnolipid measurements at a ~0.4 h-1 frequency with high-time resolved data measured at a 6 h-1 frequency. We show how this simple method can be used in combination with mutants lacking specific genes in the rhamnolipid synthesis or quorum sensing regulation to acquire rich dynamic data on P. aeruginosa virulence regulation. Additionally, the linear relation between the ratio of inocula and the time-shift between curves produces high-precision measurements of maximum specific growth rates, which were determined with a precision of ~5.4%.Growth curve synchronization allows integration of rich time-resolved data with endpoint measurements to produce time-resolved quantitative measurements. Such data can be valuable to unveil the dynamic regulation of virulence in P. aeruginosa. More generally, growth curve synchronization can be applied to many biological systems thus helping to overcome a key obstacle in dynamic regulation: the scarceness of quantitative time-resolved data.Spectrophotometric measurements are ubiquitous for quantitative analyses of dynamic biological processes. In contrast, many other useful measurements require laborious sample treatment that may include separation or extractions, colorimetric reactions, electrophoresis as well as many other biochemical analyses. These latter measurements
A mudan?a no discurso educacional das ongs/aids no Brasil: concep??es e desdobramentos práticos (1985-1998)
Góis, Joo B?sco Hora;
Interface - Comunica??o, Saúde, Educa??o , 2003, DOI: 10.1590/S1414-32832003000200003
Abstract: this article examines the main statements and conceptions present in the educational speech produced by the brazilian aids non governmental organizations - asos and examines how these speechs influenced the production of intervention projects. the paper identifies two main interconnected phases in such speechs: the universalist and the convergent ones. without denying the importance of the work of the asos, the article asserts that their use of the conception of reason sometimes led them to use simplistic and punitive forms of intervention.
Reabrindo a 'caixa-preta': rupturas e continuidades no discurso sobre Aids nos Estados Unidos (1987-98)
Góis, Joo B?sco Hora;
História, Ciências, Saúde-Manguinhos , 2002, DOI: 10.1590/S0104-59702002000300003
Abstract: the present article has the specific goal of examining aids coalition to unleash power's ideas and actions. in a broader scope, it tries to discuss issues related to scientific theory and practice concerning aids in the united states. the sources used for the present study consist of printed and electronic documents produced by aids coalition to unleash power (act up/ny). after a period of great radicalization, act up developed a less confronting position. among other factors, this was brought about by the changes that took place in the north american political scenario in the beginning of the 1990's, as well as by internal dissent. the analyzed data allow us to say that the group has been quite successful in relation to the production and the distribution of medicines for the treatment of aids. they also indicate partial changes in the competitive game for the monopoly of 'truths' about the disease.
Natural bradykinin antagonists
Calixto, Joo B.;Yunes, Rosendo A.;
Memórias do Instituto Oswaldo Cruz , 1991, DOI: 10.1590/S0074-02761991000600045
Abstract: bradykinin (bk) a nonapeptide generated in plasma during tissue injury, is involved in many physiological and pathological states. kinin actions are mediated by specific membrane receptors and involve a complex signal transducer and also second messager mechanisms. due to its inequivocal relevance, an intensive effort has been focused in recent years to develop selective and competitive bk antagonists. thus, the development of a new series of peptide bk antagonists has made an important contribution to the understanding of the pharmacological, physiological and pathophysiological role of bk, and this is certain to provide a firm basis for developing new drugs to relieve pain and inflammation. however, bk antagonists derived from peptide origin reported to date have limited clinical use due to their poor oral absortion and short duration of effect. thus, considerable effort has also been made in developing stable nonpeptide bk antagonists. up to now, most nonpeptide compounds reported to exhibit bk antagonistic activity have been derived from plants, including many flavonoids, terpenes, and also synthetic substances with various molecular structures. amongst them, the pregnane glycoside compounds isolated from the plant mandevilla velutina are the most promising. these compounds are effective in antognizing bk responses in a variety of preparations, and they also exhibit potent and long-lasting analgesic and anti-inflammatory activities. the exact mechanism underlying their action however, is not yet completely understood.
Olhos e ouvidos públicos para atos (quase) privados: a forma??o de uma percep??o pública da homossexualidade como doen?a
Góis, Joo B?sco Hora;
Physis: Revista de Saúde Coletiva , 2000, DOI: 10.1590/S0103-73312000000200004
Abstract: this article examines the making of a perception of homosexuality as a pathological and pathogenic entity. besides, it seeks to identify the way such perception modeled the association between aids and the gay community in the us. this paper contains data provided by different sources, especially those that belong to the gay community: novels, posters, movies, plays. such sources provided the material base which built the perception referred above.
Intera??o flebotomíneos, animais domésticos e dominancia de Lutzomyia (Nyssomyia) intermedia (Lutz & Neiva, 1912) em área com alto grau de antropia, no Sul do Brasil
Teodoro,Ueslei; Kühl,Joo B.;
Revista de Saúde Pública , 1997, DOI: 10.1590/S0034-89101997000600011
Abstract: information on phlebotomine collections in an area with a high level of human interference, in s. jorge do ivaí county, paraná state, southern brazil, is reported. lutzomyia (nyssomyia) intermedia (lutz & neiva, 1912) was the dominant species. the number of sandflies in domiciles decreased sharply in the second period of collection. this occurred because a pigsty was moved to a distance of approximately 100 meters from the houses by and because the basement of one the houses was cleaned out.
Quando ra?a conta: um estudo de diferen?as entre mulheres brancas e negras no acesso e permanência no ensino superior
Góis, Joo B?sco Hora;
Revista Estudos Feministas , 2008, DOI: 10.1590/S0104-026X2008000300002
Abstract: this article examines differences between white and black women in higher education in brazil. drawing from data collected at universidade federal fluminense, we discuss the reasons why black and white women occupy different positions in academic hierarchy.
Desencontros: as rela??es entre os estudos sobre a homossexualidade e os estudos de gênero no Brasil
Góis, Joo B?sco Hora;
Revista Estudos Feministas , 2003, DOI: 10.1590/S0104-026X2003000100021
Abstract: this article aims at examining the development of the field of the gay and lesbian studies in brazil and their relations with the gender studies. the author argues that historical, political and scientific field formation related problems shaped the ways both areas have interacted.
N-Laplacian equations in N with critical growth
João Marcos B. do Ó
Abstract and Applied Analysis , 1997, DOI: 10.1155/s1085337597000419
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