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Search Results: 1 - 10 of 25484 matches for " Jo LK Cheung "
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A simple and rapid approach for screening of SARS-coronavirus genotypes: an evaluation study
Grace TY Chung, Rossa WK Chiu, Jo LK Cheung, Yongjie Jin, Stephen SC Chim, Paul KS Chan, YM Dennis Lo
BMC Infectious Diseases , 2005, DOI: 10.1186/1471-2334-5-87
Abstract: Thirty SARS patients were recruited. Allelic discrimination assays were developed based on the use of fluorogenic oligonucleotide probes (TaqMan). Genotyping of the SARS-coronavirus isolates obtained from these patients were carried out by the allelic discrimination assays and confirmed by direct sequencing.Genotyping based on the allelic discrimination assays were fully concordant with direct sequencing. All of the 30 SARS-coronavirus genotypes studied were characteristic of genotypes previously documented to be associated with the latter part of the epidemic. Seven of the isolates contained a previously reported major deletion but in patients not epidemiologically related to the previously studied cohort.We have developed a simple and accurate method for the characterization and screening of SARS-coronavirus genotypes. It is a promising tool for the study of epidemiological relationships between documented cases during an outbreak.The Severe Acute Respiratory Syndrome (SARS) is a recently emerged infectious disease which led to a global epidemic between 2002 and 2003. A novel coronavirus (SARS-CoV) was identified as the causative agent [1]. The genomic sequence of the SARS-CoV was promptly characterized [2,3]. Thereafter, studies had focused on the early detection of SARS-CoV and the development of diagnostic tools [4-6]. Systematic analysis of the SARS-CoV sequence information have demonstrated that characteristic viral genotypes predominated at certain periods during the course of the outbreak [7-10]. Furthermore, characterization of the viral sequences have been shown to be a useful tool for confirming epidemiological associations between infected individuals as suspected from conventional epidemiological investigations [9-11]. In-depth analysis of the available sequence data on SARS-CoV also revealed that the viral isolates could be readily subclassified into several major genotypes based on nucleotide variations at specific genomic positions [8,12]. In a larg
Antagonist-mediated down-regulation of toll-like receptors increases the prevalence of human papillomavirus infection in systemic lupus erythematosus
Shui-Lian Yu, Paul KS Chan, Chun-Kwok Wong, Cheuk-Chun Szeto, Suzanne C Ho, Karine So, May MY Yu, So-Fan Yim, Tak-Hong Cheung, Martin CS Wong, Jo LK Cheung, Apple CM Yeung, Edmund K Li, Lai-Shan Tam
Arthritis Research & Therapy , 2012, DOI: 10.1186/ar3803
Abstract: Protein levels of TLRs 3, 7, 8 and 9 in cervical epithelial cells of lupus patients and controls with or without HPV infection were assessed using flow cytometry. Characteristics associated with the differential expression of TLRs in systemic lupus erythematosus (SLE) were elucidated. The effect and interferon-stimulated genes (ISGs) (ISG15 and Mx-1) gene expressions were then measured in oncogenic HeLa (HPV18), CaSki (HPV) and C33A (HPV negative) cell lines using flow cytometry and quantitative real-time PCR. Ex vivo productions of cytokines and interferon-gamma (IFN-γ) upon TLR ligands stimulations were subsequently measured using cytometric bead array and ELISA.For subjects with HPV infection, levels of TLR3 and TLR7 were significantly lower in lupus patients compared with controls. Significantly decreased TLRs 7, 8 and 9 levels were observed in HPV-negative SLE compared to healthy controls. For SLE with and without HPV infection, TLR7 and 9 levels were significantly lower in infected SLE than those in HPV-negative patients. Independent explanatory variables associated with down-regulation of TLR7 level included HPV infection and a higher cumulative dose of prednisolone; while a higher cumulative dose of hydroxychloroquine and HPV infection were associated with down-regulation of TLR9 level. In cervical cell lines, TLRs 3, 7, 8, 9 protein levels and antiviral ISG15 and Mx-1 gene expressions were inhibited in two oncogenic HPV types. Functional data showed that the induction of pro-inflammatory cytokines by TLR ligands (R837, ssRNA and ODN2395) was greatly impaired in CaSki and HeLa than C33A cells.In conclusion, prednisolone and TLR antagonist (hydroxychloroquine) may down-regulate protein levels of TLR7 and TLR9 in lupus patients, thereby decreasing the innate immune response against HPV infection. Upon infection, HPV further down-regulate TLR7 and 9 levels for viral persistence. Furthermore, reduction of nucleic acid-sensing TLRs 7, 8 and 9 in carcinogenic HPVs
Global Existence, Uniqueness of Weak Solutions and Determining Functionals for Nonlinear Wave Equations  [PDF]
ülkü Dinlemez
Advances in Pure Mathematics (APM) , 2013, DOI: 10.4236/apm.2013.35064

We consider the initial-boundary value problem for a nonlinear wave equation with strong structural damping and nonlinear source terms in IR. We prove the global existence and uniqueness of weak solutions of the problem and then we will study the determining modes on the phase space \"\" by using energy methods and the concept of the completeness defect.

Book Review— Looking Like the Enemy: My Story of Imprisonment in Japanese American Internment Camps. By Mary Matsuda Gruenewald. NewSage Press, 2005. xi-227 pp.  [PDF]
Floyd Cheung
Advances in Literary Study (ALS) , 2014, DOI: 10.4236/als.2014.23015

A review of Looking Like the Enemy: My Story of Imprisonment in Japanese American Internment Camps by Mary Matsuda Gruenewald. The review briefly places the book in historical and intertextual context, and makes the case that Gruenewald’s special contribution is in its depiction of the psychological experience of the internment in an effective way.

Notes and observations on courtship and mating in Tityus (Atreus) magnimanus Pocock, 1897 (Scorpiones: Buthidae)
Ross, LK;
Journal of Venomous Animals and Toxins including Tropical Diseases , 2009, DOI: 10.1590/S1678-91992009000100005
Abstract: courtship and mating behaviors of the scorpion tityus (atreus) magnimanus are herein described, consisting of various components that pertain to four distinct behavioral stages. the courtship and mating rituals of tityus (atreus) magnimanus are similar to those of other scorpions. behavioral components are presented in an ethogram to demonstrate their occurrence during mating sequences. the current report is presented as observational data that were acquired during life history studies of this species.
Frequency of spermatophore production and regeneration in the males of Tityus (Atreus) magnimanus Pocock, 1897 (Scorpiones, Buthidae)
Ross, LK;
Journal of Venomous Animals and Toxins including Tropical Diseases , 2009, DOI: 10.1590/S1678-91992009000100014
Abstract: the frequency of spermatophore production and the amount of time between matings for laboratory-reared males of tityus (atreus) magnimanus to regenerate spermatophores were examined. males attain sexual maturity at the fifth or sixth instar (after a period of 137 to 155 days) and can produce initial spermatophores shortly after maturation. after mating, males can regenerate spermatophores within a single 24-hour period and remate. the present contribution represents the first report on an aspect of reproductive biology in this species and is part of a continuing study of the life history and post-embryonic development of tityus (atreus) magnimanus.
Notes on gestation periods and litter size in the arenicolous buthid scorpion Leiurus quinquestriatus (Ehrenberg, 1828) (Scorpiones: Buthidae)
Ross, LK;
Journal of Venomous Animals and Toxins including Tropical Diseases , 2009, DOI: 10.1590/S1678-91992009000200015
Abstract: the following notes on gestation periods and litter size in seven specimens of leiurus quinquestriatus are presented as observational data. specimens of leiurus quinquestriatus from southern egypt and southern israel were mated in the laboratory during 2007; afterwards, gestation periods and litter sizes of all females were recorded. previous studies on this species reported that the gestation period ranged from 150 to 155 days and that litter size was between 12 and 99 offspring. in the present study, gestation periods in specimens from both geographic regions varied from 155 to 227 days and litter sizes were between 35 and 87 offspring. the current contribution expands on previously published data on gestation periods and supports previously reported litter size in leiurus quinquestriatus.
Spirituality as “good Christian citizenship” in the pastoral epistles?
LK Pietersen
Acta Theologica , 2011,
Abstract: Dibelius, in his commentary on the Pastoral Epistles, suggested that they represented a way-of-being in the world resulting from the delay of the parousia. As such they advocate a form of spirituality which can best be described as “good Christian citizenship”. This paper, drawing on both Taylor’s understanding of the “social imaginary” and Waaijman’s understanding of spirituality, examines Dibelius’ contention by revisiting the concept of eusebeia (godliness/piety), which is prevalent in the Pastorals, in the light of the lived experience of pagans, Jews and Christians in first-century Ephesus.
The practice of scientific medicine in private practice: Fetal biometric parameters in obstetric screening ultrasonography
LK Obembe
Annals of Ibadan Postgraduate Medicine , 2004,
Abstract: No Abstract.
Radiation injury is a potentially serious complication to fluoroscopically-guided complex interventions
LK Wagner
Biomedical Imaging and Intervention Journal , 2007, DOI: 10.2349/biij.3.2.e22
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