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Search Results: 1 - 10 of 104259 matches for " Jiye Zhang "
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Synergistic Effects of Targeting Survivin and CDK1 on Nasopharyngeal Carcinoma in Vitro and in Vivo  [PDF]
Hongtao Zhou, Xinping Chen, Shuping Chen, Junhong Cai, Jiye Zhang, Shengmiao Fu
Journal of Cancer Therapy (JCT) , 2019, DOI: 10.4236/jct.2019.104024
Abstract: Background: To explore the impact of pU6-based tandem survivin and CDK1-specific short hairpin RNA on the biological behaviors of CNE-2 nasopharyngeal carcinoma cells in vitro and in vivo. Patients and Methods: The vectors of pU6-survivinshRNA, pU6-CDK1shRNA and
pU6-survivinshRNA-CDK1shRNA were constructed and transfected into CNE-2 cells with Lipofectamine TM 2000, respectively. The mRNAs and proteins of CDK1 and survivin were determined by RT-PCR and Western blotting, accordingly. MTT assay was employed to evaluate the proliferation of CNE-2 cells, and flow cytometry was performed to determine the apoptosis of CNE-2 cells. The effects of interfering survivin and CDK1 on tumorigenesis were evaluated by tumor xenografts experiments. Results: Effective plasmids were successfully constructed knocking down survivin and/or CDK1. The proliferation inhibition of CNE-2 cells by pU6-survivinshRNA-CDK1
Research on Stochastic Behavior of Traffic flow

张继业, 郑伟范
, ZHENG Weifan

- , 2016, DOI: 10.3969/j.issn.0258-2724.2016.03.012
Abstract: 随着人口和车辆的不断增加,道路发展难以满足车辆交通的需要,交通拥塞等问题日益严重.由于交通流的动态、随机、非线性、多行为主体等特征,进一步增加了交通流问题的复杂性.交通流随机行为的研究对于理解交通流的内在演化规律、管理和控制交通流具有重要作用.目前在该领域的研究已经形成了相应理论体系,建立了系列模型,并不断在实际交通中应用.本文对交通流随机行为相关的研究进行了总结,讨论了随机相互作用无关的模型如微观跟驰模型、宏观流体力学模型、介观气体动理论模型、元胞自动机模型、随机过程模型,随机相互作用相关的模型如势强度相关模型,加权顾前势模型等.通过对目前研究现状的总结和分析,对未来交通流随机影响因素及随机动力学的建模与分析进行了展望.
: With the increase of population and vehicles, the development of roads is difficult to meet the needs of vehicle traffic, traffic congestion and other issues become serious. Due to the dynamic, stochastic, non-linear and multi-behavior subject characteristics of traffic flow, the complexity of traffic flow is increased. Therefore, research on the stochastic behavior of traffic flow is important for understanding the intrinsic evolution rules of traffic systems. At present, a series of models were established in this field, the corresponding theoretical systems were formed, and continuously be applied in traffic. In this paper, the stochastic behavior of traffic flow is reviewed, the main method and development condition of various kinds of theoretical models are discussed. These models mainly include independent interactional models, such as the microscopic following models, the macroscopic fluid dynamics models, the mesoscopic gas dynamic models, the cellular automatic models. Interactional models, such as the interactional potential models and the weighted interactional potential models et al. Based on the summary and analysis of the present research, the future research on stochastic impact factors and the analysis of stochastic dynamics of traffic flow is prospected
Nonexistence of Continuous Peaking Functions
Jiye Yu
Mathematics , 1995,
Abstract: We construct a smoothly bounded pseudoconvex domain such that every boundary point has a p.s.h. peak function but some boundary point admits no (local) holomorphic peak function.
Immune Efficacy of a Genetically Engineered Vaccine against Lymphocystis Disease Virus: Analysis of Different Immunization Strategies
Fengrong Zheng,Xiuqin Sun,Xing'an Wu,Hongzhan Liu,Jiye Li,Suqi Wu,Jinxing Zhang
Evidence-Based Complementary and Alternative Medicine , 2011, DOI: 10.1155/2011/729216
Abstract: Here, we report the construction of a vaccine against lymphocystis disease virus (LCDV) using nucleic acid vaccination technology. A fragment of the major capsid protein encoding gene from an LCDV isolated from China (LCDV-cn) was cloned into an eukaryotic expression vector pEGFP-N2, yielding a recombinant plasmid pEGFP-N2-LCDV-cn0.6?kb. This plasmid was immediately expressed after liposomal transfer into the Japanese flounder embryo cell line. The recombinant plasmid was inoculated into Japanese flounder via two routes (intramuscular injection and hypodermic injection) at three doses (0.1, 5, and 15?μg), and then T-lymphopoiesis in different tissues and antibodies raised against LCDV were evaluated. The results indicated that this recombinant plasmid induced unique humoral or cell-mediated immune responses depending on the inoculation route and conferred immune protection. Furthermore, the humoral immune responses and protective effects were significantly increased at higher vaccine doses via the two injection routes. Plasmid pEGFP-N2-LCDV0.6?kb is therefore a promising vaccine candidate against LCDV in Japanese flounder. 1. Introduction Nucleic acid immunization, based on the introduction of plasmid DNA encoding a protective antigen into animal tissue, can express the plasmid-encoded protein and induce subsequent immune responses [1]. Much effort has been invested in this technology since gene engineering vaccines possess multiple advantages over killed, attenuated, or subunit vaccines [2]. Indeed, gene engineering vaccines are known to stimulate both nonspecific and specific immune responses without the need for live organisms, replicating vectors or adjuvants [3]. Antigen synthesis induced by nucleic acid vaccination imitates natural infection by intracellular pathogens and leads to subsequent cell-mediated responses and ultimately, the generation of memory lymphocyte responses [4]. Additionally, gene engineering vaccines have already been shown to provide protection for fish to various intracellular pathogens, such as viral hemorrhagic septicemia and infectious hematopoietic necrosis virus [5, 6]. Anderson et al. (1996) reported the first application of gene engineering vaccine technology where a plasmid containing the glycoprotein (G) gene of IHNV was used to stimulate a protective immune response in rainbow trout fry [7]. Furthermore, several studies have shown that a nucleic acid vaccine against IHNV provides significant protection in rainbow trout against either waterborne or injection challenges in fish that range in size from 2 to 160?g
Epidemiology, Quality and Reporting Characteristics of Systematic Reviews of Traditional Chinese Medicine Interventions Published in Chinese Journals
Bin Ma,Jiwu Guo,Guoqing Qi,Haimin Li,Jiye Peng,Yulong Zhang,Yanqin Ding,Kehu Yang
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0020185
Abstract: Systematic reviews (SRs) of TCM have become increasingly popular in China and have been published in large numbers. This review provides the first examination of epidemiological characteristics of these SRs as well as compliance with the PRISMA and AMSTAR guidelines.
Continuous tailward flow in the near-Earth magnetotail observed by TC-1 satellite
LingQian Zhang,ZhenXing Liu,ZhiWei Ma,ZuYin Pu,JiYe Wang,Chao Shen
Chinese Science Bulletin , 2007, DOI: 10.1007/s11434-007-0228-7
Abstract: On July 11, 2004, a substorm process in the period of continuous tailward flow was observed by the joint exploration of the TC-1, IMAGE and ACE satellites. The substorm observed by the TC-1 in the near-Earth has three stages: the growth phase (from 11:43 to 12:19), the pre-expansion process (from 12:19 to 12:28) and the dipolarization process. The auroral brightening was at 12:26 recorded by the FUV instrument on IMAGE, and the dipolarization occurred two minutes later. During the 45 min period of the tailward flow, the magnetotail experienced the growth phase and the pre-expansion process. When the dipolarization process began, the TC-1 entered the plasma sheet and observed a high speed earthward flow. The field-aligned tailward flow is characterized by the low temperature and high density, which is consistent with the properties of the flow from the ionosphere detected in the near-Earth magnetotail by other satellites. The tailward flow is closely related with the southward interplanetary magnetic field (IMF), and may have an important effect on the substorm.
The distribution characteristics of the flows in the near-Earth region: TC-1 observational results
LingQian Zhang,ZhenXing Liu,JiYe Wang,ZhiWei Ma,ZhuYin Pu,Chao Shen,JiuLing Guo
Chinese Science Bulletin , 2007, DOI: 10.1007/s11434-007-0433-4
Abstract: TC-1 observational results clearly indicate that the velocity of the flows in the near-Earth region is dependent on the satellite location. The flow speed decreases while satellite moves close to the Earth. The plasma flow in the region close to the Earth tends to drift into the midnight region from the dawn and dusk region while the flow in the region away from the Earth shows an opposite drift. The observational results also show that the tailward flows are mainly located in the plasma sheet boundary while the earthward flow becomes dominant in the plasma sheet. It is found that both the strong tailward and earthward flows are distributed in the region around X= 11Re, which coincides with the trigger region of the substorm onset. Hence, it may suggest that the flows are related with the trigger of the substorm onset. In addition, the BBFs coming from the mid-tail maily distributed in the region where X< 9RE and |Z|<3RE that differs from the convection.
Study on global exponential stability of neural networks and its convergence estimate

Tan Xiaohui,Zhang Jiye,Yang Yiren,

电子与信息学报 , 2003,
Abstract: In this paper, the existence, uniqueness and global exponential stability of the equilibrium point of a class of Hopfield neural networks are investigated by using Liapunov direct method. Lipschitz continuous activations are considered and the limit on self-feedback is released. It can be nonlinear instead of linear in this paper. And under this condition, some sufficient conditions and convergence estimate for global exponential stability of neural networks are obtained.
地质学报 , 2015,
Abstract: Themorphology,REEgeochemistryandU-PbgeochronologyofzirconsfromquartzmonzodioriteintheSunzhuangarea,FanshiCounty,ShanxiProvincearepresentedinthisstudy.Thezirconcrystalscanbeclassifiedintofourmaintypesas:AB,L,SandP,and24subtypessuchasAB4,AB5,L5,andS3.Themaximumcrystallizationtemperatureofzirconwasestimatedas850°C,withtheminimumof550°C.Thepeaktemperaturesofthezirconcrystallizationrangefrom650°Cto700°C.TheabundancesofThandUinthezircongrainsshowlargevariationwiththeTh/Uvalues>0.4.TheThandUvaluesalsoshowapositivecorrelationinmostzircons.TheREEabundanceofzirconinthequartzmonzodioriterangesfrom280.4ppmto2143ppmwithanaverageof856.4ppm.ThechondritenormalizedzirconREEpatternsshowtwotypes,oneischaracterizedbyHREEenrichmentandLREEdepletionwithpositiveCe-anomalyandnegativeEu-anomalywhereastheotherisHREEenrichedandLREEdepletedwithnegativeEu-anomalybutwithoutpositiveCe-anomaly,andrelativelyflatpatterns.TheLA-ICP-MSU-Pbgeochronologyonthezirconsyieldsameanageof133±0.87Ma.Ourdataonzirconmorphology,compositionandU-PbgeochronologyrevealthattheparentmagmaofthequartzmonzodioritewhichwasemplacedduringlateYanshanianhadamixedcrust-mantlesource,withcrustalcomponentsdominating.Themagmaisinferredtohavebeenwaterrichandalkalinewithinitialhighoxygenfugacity.Post-magmatichydrothermalactivityoccurredunderrelativelyreducingconditionswhichwasconductiveforgoldprecipitationintheYixingzhaigolddeposit.
Design of Magnetic Levitation Controller and Static Stability Analysis

汪科任, 罗世辉, 张继业
WANG Keren
, LUO Shihui, ZHANG Jiye

- , 2017, DOI: 10.3969/j.issn.0258-2724.2017.01.017
Abstract: 为实现磁浮列车在低轨道梁刚度下稳定悬浮,降低轨道梁建设成本,依据牛顿第二定律建立了单铁-弹性轨道-车体耦合动力学模型.首先,设计出状态观测器将悬浮电磁铁、轨道梁及车体的振动状态引入控制系统;然后,利用线性矩阵不等式求解法求解出系统的状态反馈增益矩阵,结合二者利用MATLAB进行相关动力学仿真,得出轨道梁刚度与质量分别为200 kN/m与325 kg的最佳取值.分析结果表明,与传统的基于黎卡提方程求解的控制器相比,采用线性矩阵不等式求解法具有更优的二次性能指标;所提出的控制方法能够实现系统在较低轨道梁刚度与质量下的稳定悬浮,并能在0.5 s左右进入稳定状态;系统在一定外界扰动下具有鲁棒性.
: In order to realize the stable suspension of the maglev train in the condition of low track beam stiffness, and reduce construction cost of track beam, a electromagnet-elastic-track-carbody model was established based on Newton's second law. Firstly, the vibration information of electromagnet, track beam and carbody was introduced into the control system by the designed state observer; then the feedback gain matrix was obtained using linear matrix inequality. Next, both were utilized for the dynamic simulation by MATLAB to derive the optimal track beam stiffness and quality, which are 200 kN/m and 325 kg, respectively. The analysis results show that compared with the traditional optimal controller based on the Riccati equation, the controller using linear matrix inequality control algorithm achieves a better quadratic performance index. The control strategy is able to realize the system stable suspension at small stiffness and mass of track beam, and stabilize the system after 0.5 seconds or so. The system is robust to some external disturbances
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