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Search Results: 1 - 10 of 36688 matches for " Jinzhou Xiao "
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Circulating Fibroblast Growth Factor 23 Is Associated with Angiographic Severity and Extent of Coronary Artery Disease
Yunjun Xiao, Chaoqiong Peng, Wei Huang, Jinzhou Zhang, Min Xia, Yuan Zhang, Wenhua Ling
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0072545
Abstract: Objective Fibroblast growth factor 23 (FGF23) is a circulating regulator of phosphate and vitamin D metabolism and is associated with coronary artery calcification, and has been implicated in the pathogenesis of cardiovascular disease. The aim of this study was to determine whether circulating FGF23 concentration is independently associated with the severity and extent of coronary artery disease in patients undergoing coronary angiography. Method A cross-sectional design was used to examine the relationship between serum FGF23 and the severity and extent of coronary artery stenosis in 2076 patients undergoing coronary angiography (1263 male and 813 female, mean aged 62.5 years). Subgroup analyses were performed to assess the associations between FGF23 and coronary arterial plaque characteristics evaluated by intravascular ultrasound and 12-month incidence of target vessel revascularization (TVR) and target lesion revascularization (TLR). Findings We found a stepwise increase of serum FGF23 concentrations in patients with mild, moderate, severe stenosis or with increased number of stenotic vessels compared with those without stenosis (P<0.001). Serum FGF23 concentration was positively correlated with stenosis scores as the global index of the severity and extent of coronary artery stenosis in both male and female (r = 0.315 and r = 0.291, P<0.001). In multiple regression analyses, serum FGF23 concentration was a significant determinant of the stenosis scores independent of other traditional risk factors (standardized β = 0.326, P<0.001). Furthermore, subgroup analyses found FGF23 was significantly associated with plaque and dense calcium volumes. Multiple logistic regression analyses showed that serum FGF23 levels were significantly independent predictors of TVR and TLR. Conclusions We report an independent association between circulating FGF23 concentration and the severity and extent of coronary artery stenosis in the coronary angiographic patients. Future studies are needed to elucidate the potential biological mechanisms and whether FGF23 is a modifiable cardiovascular risk factor.
Fine Structure of Tibetan Kefir Grains and Their Yeast Distribution, Diversity, and Shift
Man Lu, Xingxing Wang, Guowei Sun, Bing Qin, Jinzhou Xiao, Shuling Yan, Yingjie Pan, Yongjie Wang
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0101387
Abstract: Tibetan kefir grains (TKGs), a kind of natural starter for fermented milk in Tibet, China, host various microorganisms of lactic acid bacteria, yeasts, and occasionally acetic acid bacteria in a polysaccharide/protein matrix. In the present study, the fine structure of TKGs was studied to shed light on this unusual symbiosis with stereomicroscopy and thin sections. The results reveal that TKGs consist of numerous small grain units, which are characterized by a hollow globular structure with a diameter between 2.0 and 9.0 mm and a wall thickness of approximately 200 μm. A polyhedron-like net structure, formed mainly by the bacteria, was observed in the wall of the grain units, which has not been reported previously to our knowledge. Towards the inside of the grain unit, the polyhedron-like net structures became gradually larger in diameter and fewer in number. Such fine structures may play a crucial role in the stability of the grains. Subsequently, the distribution, diversity, and shift of yeasts in TKGs were investigated based on thin section, scanning electron microscopy, cloning and sequencing of D1/D2 of the 26S rRNA gene, real-time quantitative PCR, and in situ hybridization with specific fluorescence-labeled oligonucleotide probes. These show that (i) yeasts appear to localize on the outer surface of the grains and grow normally together to form colonies embedded in the bacterial community; (ii) the diversity of yeasts is relatively low on genus level with three dominant species – Saccharomyces cerevisiae, Kluyveromyces marxianus, and Yarrowia lipolytica; (iii) S. cerevisiae is the stable predominant yeast species, while the composition of Kluyveromyces and Yarrowia are subject to change over time. Our results indicate that TKGs are relatively stable in structure, and culture conditions to some extent shape the microbial community and interaction in kefir grains. These findings pave the way for further study of the specific symbiotic associations between S. cerevisiae and Lactobacillus bacteria in TKGs.
Improved Stability Analysis for Neural Networks with Time-Varying Delay
Yongming Li,Junkang Tian,Jinzhou Zhao,Liehui Zhang,Tiejun Li
Mathematical Problems in Engineering , 2012, DOI: 10.1155/2012/950269
Abstract: This paper concerned the problem of delay-dependent asymptotic stability for neural networks with time-varying delay. A new class of Lyapunov functional dividing the interval delay is constructed to derive some new delay-dependent stability criteria. The obtained criteria are less conservative because free-weighting matrices method, a convex optimization approach, and a mixed dividing delay interval approach are considered. Finally, numerical examples are given to illustrate the effectiveness of the proposed method.
Herbal therapy: a new pathway for the treatment of Alzheimer's disease
Jinzhou Tian, Jing Shi, Xuekai Zhang, Yongyan Wang
Alzheimer's Research & Therapy , 2010, DOI: 10.1186/alzrt54
Abstract: The ultimate aim of Alzheimer's disease (AD) therapy is to stop or slow down the disease progression. Cholinesterase inhibitors have a modest clinical effect on the symptoms, however, and memantine - the currently available N-methyl-D-aspartate receptor antagonist - does not prevent the deterioration of dementia [1,2]. Finding an effective method to treat AD still poses a significant clinical challenge.Herbal medicine has long been used in China as therapy for dementia. The Complete Work of Jingyue published in 1624 contains the earliest known description in the world of a herbal therapeutic strategy for dementia. In the past 10 years, however, herbal drugs have seldom been approved for use alone in treating dementia. Overall, systematic review has identified a few single herbs and herbal formulations as possible effective medicine for AD (Table 1). According to the current evidence, some of these therapies show promising results in terms of their cognitive benefits. In the present commentary we discuss whether herbal therapy could be a novel pathway to treat AD, on the basis of the results from clinical trials, and the implications for potential therapy of AD pathophysiology.Ginkgo biloba extract is among the most widely used complementary therapies. A Cochrane review included 36 trials of gingko biloba, but most trials were small and of duration <3 months [3]. Nine trials were of 6 months duration and of adequate size, and were conducted to a reasonable standard. Of the four most recent trials to report results, three studies found no difference between Ginkgo biloba, at different doses, and placebo [3], and one study found very large treatment effects in favor of Ginkgo biloba, but the trial sample size was very small [4]. Another recent trial reported negative results in reducing cognitive decline in older adults with normal cognition or with mild cognitive impairment [5]. The current overall evidence that Ginkgo has a predictable and clinically significant bene
Factors associated with reporting multiple causes of death
Melanie M Wall, Jinzhou Huang, John Oswald, Diane McCullen
BMC Medical Research Methodology , 2005, DOI: 10.1186/1471-2288-5-4
Abstract: Data from 326,332 Minnesota death certificates from 1990–1998 are examined. Underlying and non-underlying causes of death are examined (based on record axis codes) as well as demographic and death-related covariates. Associations between covariates and prevalence of multiple causes of death and conditional probability of underlying compared to non-underlying causes of death are examined. The occurrence of ischemic heart disease or diabetes as underlying causes are specifically examined.Both the probability of multiple causes of death and the proportion of underlying cause compared to non-underlying cause of death are associated with demographic characteristics of the deceased and other non-medical conditions related to filing death certificate such as place of death.Multiple cause of death data provide a potentially useful way of looking for inaccuracies in reporting of causes of death. Differences across demographics in the proportion of time a cause is selected as underlying compared to non-underlying exist and can potentially provide useful information about the overall impact of causes of death in different populations.In their 1986 paper Israel, Rosenberg, and Curtin [1] gave a sort of rallying call for researchers to consider the analytical potential for multiple cause of death data collected by the United States National Center for Health Statistics (NCHS). Beginning with the implementation of the Eighth revision of the ICD in 1968, the NCHS developed and employed several computer systems to automatically select the underlying cause for each death certificate and to produce multiple cause of death data [2]. The resulting multiple cause of death datasets by year are made publically available through the NCHS website.Acknowledgment of the potential for multiple cause of death data analysis is increasing in other countries as well [3,4]. For example, the Australian Bureau of statistics point out that using multiple cause of death data allows researchers to: more
Particle filter track-before-detect implementation on GPU
Xu Tang, Jinzhou Su, Fangbin Zhao, Jian Zhou and Ping Wei
EURASIP Journal on Wireless Communications and Networking , 2013, DOI: 10.1186/1687-1499-2013-38
Abstract: Track-before-detect (TBD) based on the particle filter (PF) algorithm is known for its outstanding performance in detecting and tracking of weak targets. However, large amount of calculation leads to difficulty in real-time applications. To solve this problem, effective implementation of the PF-based TBD on the graphics processing units (GPU) is proposed in this article. By recasting the particles propagation process and weights calculating process on the parallel structure of GPU, the running time of this algorithm can greatly be reduced. Simulation results in the infrared scenario and the radar scenario are demonstrated to compare the implementation on two types of the GPU card with the CPU-only implementation.
The utility of the Hopkins Verbal Learning Test (Chinese version) for screening dementia and mild cognitive impairment in a Chinese population
Shi Jing,Tian Jinzhou,Wei Mingqing,Miao Yingchun
BMC Neurology , 2012, DOI: 10.1186/1471-2377-12-136
Abstract: Background The Hopkins Verbal Learning Test (HVLT) has been validated for detecting dementia in English-speaking populations. However, no studies have examined the Chinese version of the HVLT scale, and appropriate cut-off scores for dementia in the Chinese population remain unclear. Methods 631 subjects aged 60 and over were recruited at a memory clinic at Dongzhimen Hospital in Beijing. Of these, 249 were classified as exhibiting normal cognition (NC), 134 were diagnosed with mild cognitive impairment (MCI), 97 were diagnosed with Alzheimer’s disease (AD), 14 met the diagnosis for vascular dementia (VaD), and 50 were diagnosed with other types of dementia, including mixed dementia. The discriminative capacity of the HVLT total learning score, recognition score and total score were calculated to determine their sensitivity and specificity for detecting MCI, AD and other dementias, and various cut-off scores. Results HVLT scores were affected by age, education and sex. The HVLT total learning score exhibited an optimal balance between sensitivity and specificity using a cut-off score of 15.5 for distinguishing AD and other types of dementia from NC using the ROC curve, with sensitivity of 94.7% for distinguishing AD and all types of dementia, and specificity of 92.5% for detecting AD and 93.4% for detecting all types of dementias. We stratified the AD and MCI groups by age, and calculated the validity in each age group. In the 50–64 years age group, when the cutoff score was 18.5, the sensitivity of 0.955 and specificity of 0.921 were obtained for discriminating the NC and AD groups, and in the 65–80 years group, and optimal sensitivity and specificity values (0.948 and 0.925, respectively) were obtained with a cutoff score of 14.5. When the cutoff score was 21.5 in HVLT total recall, an optimal balance was obtained between sensitivity and specificity (69.1% and 70.7%, respectively) in distinguishing MCI from NC. Conclusion A cut-off score of 15.5 in the HVLT total learning score led to high discriminative capacity between the dementia and NC groups. This suggests that the HVLT total learning score can provide a useful tool for discriminating dementia, but not MCI, from NC in clinical and epidemiological practice.
Huperzine A for Alzheimer’s Disease: A Systematic Review and Meta-Analysis of Randomized Clinical Trials
Guoyan Yang, Yuyi Wang, Jinzhou Tian, Jian-Ping Liu
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0074916
Abstract: Background Huperzine A is a Chinese herb extract used for Alzheimer’s disease. We conducted this review to evaluate the beneficial and harmful effect of Huperzine A for treatment of Alzheimer’s disease. Methods We searched for randomized clinical trials (RCTs) of Huperzine A for Alzheimer’s disease in PubMed, Cochrane Library, and four major Chinese electronic databases from their inception to June 2013. We performed meta-analyses using RevMan 5.1 software. (Protocol ID: CRD42012003249) Results 20 RCTs including 1823 participants were included. The methodological quality of most included trials had a high risk of bias. Compared with placebo, Huperzine A showed a significant beneficial effect on the improvement of cognitive function as measured by Mini-Mental State Examination (MMSE) at 8 weeks, 12 weeks and 16 weeks, and by Hastgawa Dementia Scale (HDS) and Wechsler Memory Scale (WMS) at 8 weeks and 12 weeks. Activities of daily living favored Huperzine A as measured by Activities of Daily Living Scale (ADL) at 6 weeks, 12 weeks and 16 weeks. One trial found Huperzine A improved global clinical assessment as measured by Clinical Dementia Rating Scale (CDR). One trial demonstrated no significant change in cognitive function as measured by Alzheimer’s disease Assessment Scale-Cognitive Subscale (ADAS-Cog) and activity of daily living as measured by Alzheimer’s disease Cooperative Study Activities of Daily Living Inventory (ADCS-ADL) in Huperzine A group. Trials comparing Huperzine A with no treatment, psychotherapy and conventional medicine demonstrated similar findings. No trial evaluated quality of life. No trial reported severe adverse events of Huperzine A. Conclusions Huperzine A appears to have beneficial effects on improvement of cognitive function, daily living activity, and global clinical assessment in participants with Alzheimer’s disease. However, the findings should be interpreted with caution due to the poor methodological quality of the included trials.
A Case of Alzheimer’s Disease Was Kept Relative Stable with Sequential Therapy for Eight Years  [PDF]
Mingqing Wei, Xuekai Zhang, Jing Shi, Jingnian Ni, Ting Li, Tao Lu, Yuanyuan Shi, Liping Zhang, Pengwen Wang, Shenghua Kang, Fuyun Ma, Yumeng Li, Chenmeng Li, Jinzhou Tian
World Journal of Neuroscience (WJNS) , 2017, DOI: 10.4236/wjns.2017.72016
Abstract: Background: Although Alzheimer’s disease (AD) has been intensively investigated for many years, the effective treatments are largely missing. Commonly used conventional therapy, such as cholinesterase inhibitors (ChEI) and N-methyl D-asparate receptor antagonist, have been generally considered as having symptom-relieving rather than disease-modifying effects. Thus, how to improve cognitive function beyond such effect & time limitations has become a serious challenge. Aim: In order to solve this challenge, a sequential therapy with the integration of conventional therapy and herbal therapy was applied to AD patients. Careful clinical observation was conducted in our outpatient setting. Case Presentation: A case of probable AD received the sequential therapy has achieved relative stable cognition and overall status in eight years. Conclusion: During the treatment of this AD case in eight years, sequential therapy showed great potential in stabilizing and improving cognition and overall status. Well designed preclinical and clinical studies are needed to investigate the efficacy of sequential therapy for AD and other type of dementia.

GE Shi ming,LI Gong yi Jinzhou Infrared-tech Application Institute,Jinzhou,China,Liaoning Kefa Hi-infrared Tech,

腐蚀科学与防护技术 , 2003,
Abstract: Far infrared radiation is a means of direct heat transmission with high heating efficiency.With help of the so called matching absorbtion theory,far infrared radiation becomes an ideal technology to economize energy sources.But in fact,it is impossible by traditional heating means to implement the really spectral matching,and to implement the uniform temperature distribution of the circumstance during heating.High infrared radiation can solve these problems successfully.It combines strong radiation and strong convection and is the most efficient heating method for drying.It has some advantages for dring and curing paints,such as,reducing the heating and curing time to 50%-90%,reducing the space needed for heating facility to 50%-90%,and thereby economizing energy to 50% in comparison to the traditional ones.
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