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Search Results: 1 - 10 of 104225 matches for " Jingru Zhang "
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Computing the Rectilinear Center of Uncertain Points in the Plane
Haitao Wang,Jingru Zhang
Computer Science , 2015,
Abstract: In this paper, we consider the rectilinear one-center problem on uncertain points in the plane. In this problem, we are given a set $P$ of $n$ (weighted) uncertain points in the plane and each uncertain point has $m$ possible locations each associated with a probability for the point appearing at that location. The goal is to find a point $q^*$ in the plane which minimizes the maximum expected rectilinear distance from $q^*$ to all uncertain points of $P$, and $q^*$ is called a rectilinear center. We present an algorithm that solves the problem in $O(mn)$ time. Since the input size of the problem is $\Theta(mn)$, our algorithm is optimal.
Can “Zombie Enterprises” Find Self-Help Road through Technological Innovation?  [PDF]
Jingru Liang
Chinese Studies (ChnStd) , 2017, DOI: 10.4236/chnstd.2017.63017
Abstract: “Cutting overcapacity” is the primary task of supply-side structural reform in China, which focuses on “disposing and eliminating zombie enterprises firmly”. “Zombie enterprises” usually refer to those who fall into a financial crisis but rely on the support of the government or the bank to survive. At present, the research of “zombie enterprise” by scholars at home and abroad is mainly concentrated in the macro level. But this paper argues that the enterprise is a specific market player, therefore, if you want to crack the “zombie enterprise” problem fundamentally, you should ultimately start from the enterprise, promoting the efficient use of resources through technological innovation, which helps enterprises to establish core competitiveness and drives the sustainable development of enterprises.
Does the Pay Gap in the Top Management Team Incent Enterprise Innovation?—Based on Property Rights and Financing Constraints  [PDF]
Jingru Hou
American Journal of Industrial and Business Management (AJIBM) , 2018, DOI: 10.4236/ajibm.2018.85088
Abstract: Using the patent applications data of listed firms in China from 2005 to 2014, this paper examines how the pay gap in the top management team influences enterprise innovation. The result shows that the number of patent applications especially the number of patents for invention increases significantly when the pay gap enlarges. It means the enlargement of the pay gap in the top management team could incent executives to make innovation decisions, to promote outputs of high-quality patents for invention. Finally the quality of enterprise innovation has been improved. Especially, the incentive effect of the pay gap in the top management team is more significant in private enterprises and enterprises with strong financing constraints. Therefore, enterprises in these two groups have better innovation behaviors.
Suggestions Regarding Veterinary Education Based on the National Standard Veterinaran Qualification Examination in China  [PDF]
Jianfa Wang, Xu Zhang, Donghua Guo, Jingru Guo, Rui Wu, Dongbo Sun
Creative Education (CE) , 2015, DOI: 10.4236/ce.2015.612126
Abstract: The national standard veterinarian qualification examination, which starts running in 2010 in China, is a major reform about management system of veterinary practitioners. The veterinary education is subjected to a new requirement due to the performance of the national standard veterinarian qualification examination. In the current review, the overview of veterinary education in Heilongjiang Bayi Agricultural University (HBAU) was described, and some positive suggestions were provided about the veterinary clinical diagnostics course, which is an important compulsory course undertaken by undergraduate, based on the national standard veterinarian qualification examination in China.
The Recovery Process of Murine Tracheal Epithelium Injured by 5-FU and Its Microarray Analysis
Jingru ZHANG,Nan SONG,Xinshan JIA,Shanliang SUN
Chinese Journal of Lung Cancer , 2009,
Abstract: Background and objective Although there are increasing reports on localization of tracheal stem cells, the mechanism of proliferation and differentiation of tracheal stem cells remains unclear. Methods In this study, we developed an ex vivo model of murine tracheal epithelial injury and regeneration induced by 5-FU. The regenerationprocess of murine tracheal epithelium was observed and analyzed by morphological, immunofluorescence and microarray methods. Results After treatment with 5-FU, the differentiated mature cells were dead and desquamated. Only a few cells remained in G0 phase and located on the basement membrane. After being put back in normal culture media, the cells became flat, cubic and restored as pseudostratified epithelium at last. These G0 phase cells were ABCG2 positive. We detected the differences of stem cell genes between normal tracheal epithelial cells and regenerated epithelial cells at 24 h and 48 h after injured by 5-FU using stem cell differentiation gene microarray. At 24 h, 8 genes were up-regulated and 31 genes were down-regulated. At 48 h, 5 genes were up-regulated and 42 genes were down-regulated. Conclusion The differently expressed genes were mainly associated with cell cycle regulation, intercellular junction, FGF, BMP, Notch and Wnt signaling pathways, which suggested these alterations might be closely associated with the proliferation and differentiation of tracheal stem cells.
Modulation of Anopheles stephensi Gene Expression by Nitroquine, an Antimalarial Drug against Plasmodium yoelii Infection in the Mosquito
Jian Zhang, Shuguang Zhang, Yanyan Wang, Wenyue Xu, Jingru Zhang, Haobo Jiang, Fusheng Huang
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0089473
Abstract: Background Antimalarial drugs may impact mosquito’s defense against Plasmodium parasites. Our previous study showed nitroquine significantly reduced infection of Anopheles stephensi by Plasmodium yoelii, but the underlying mechanism remains unclear. In order to understand how transmission capacity of An. stephensi was affected by nitroquine, we explored the transcriptome of adult females after different treatments, examined changes in gene expression profiles, and identified transcripts affected by the drug and parasite. Methodology/Principal Findings We extended massively parallel sequencing and data analysis (including gene discovery, expression profiling, and function prediction) to An. stephensi before and after Plasmodium infection with or without nitroquine treatment. Using numbers of reads assembled into specific contigs to calculate relative abundances (RAs), we categorized the assembled contigs into four groups according to the differences in RA values infection induced, infection suppressed, drug induced, and drug suppressed. We found both nitroquine in the blood meal and Plasmodium infection altered transcription of mosquito genes implicated in diverse processes, including pathogen recognition, signal transduction, prophenoloxidase activation, cytoskeleton assembling, cell adhesion, and oxidative stress. The differential gene expression may have promoted certain defense responses of An. stephensi against the parasite and decreased its infectivity. Conclusions/Significance Our study indicated that nitroquine may regulate several immune mechanisms at the level of gene transcription in the mosquito against Plasmodium infection. This highlights the need for better understanding of antimalarial drug’s impact on parasite survival and transmission. In addition, our data largely enriched the existing sequence information of An. stephensi, an epidemiologically important vector species.
Expression of a Functional Recombinant Human Basic Fibroblast Growth Factor from Transgenic Rice Seeds
Na An,Jiquan Ou,Daiming Jiang,Liping Zhang,Jingru Liu,Kai Fu,Ying Dai,Daichang Yang
International Journal of Molecular Sciences , 2013, DOI: 10.3390/ijms14023556
Abstract: Basic fibroblast growth factor (FGF-2) is an important member of the FGF gene family. It is widely used in clinical applications for scald and wound healing in order to stimulate cell proliferation. Further it is applied for inhibiting stem cell differentiation in cultures. Due to a shortage of plasma and low expression levels of recombinant rbFGF in conventional gene expression systems, we explored the production of recombinant rbFGF in rice grains ( Oryza sativa bFGF, OsrbFGF). An expression level of up to 185.66 mg/kg in brown rice was obtained. A simple purification protocol was established with final recovery of 4.49% and resulting in a yield of OsrbFGF reaching up to 8.33 mg/kg OsrbFGF. The functional assay of OsrbFGF indicated that the stimulating cell proliferation activity on NIH/3T3 was the same as with commercialized rbFGF. Wound healing in vivo of OsrbFGF is equivalent to commercialized rbFGF. Our results indicate that rice endosperm is capable of expressing small molecular mass proteins, such as bFGF. This again demonstrates that rice endosperm is a promising system to express various biopharmaceutical proteins.
A Research on Service Recognition  [PDF]
Shuliang Wang, Jingru Tian, Shanshan Zou
iBusiness (IB) , 2011, DOI: 10.4236/ib.2011.31010
Abstract: Service exists in the service provider and the service receiver. They can produce the contractual relationship which is value and trust mutually. People can obtain the different intension of service with different knowledge background and technique. In this paper, service is recognized in the views of 12 levels. Through the description and analysis of these 12 levels, the method for existing services is summarized. Thereby the important impact on service science is elaborated in the modern economy.
Similar Metabolic Changes Induced by HIPVs Exposure as Herbivore in Ammopiptanthus mongolicus
Jingru Sun, Xiao Zhang, Chuanjian Cao, Xindi Mei, Ningning Wang, Suli Yan, Shixiang Zong, Youqing Luo, Haijun Yang, Yingbai Shen
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0095474
Abstract: Herbivore-induced plant volatiles (HIPVs) are important compounds to prim neighboring undamaged plants; however, the mechanism for this priming process remains unclear. To reveal metabolic changes in plants exposed to HIPVs, metabolism of leaves and roots of Ammopiptanthus mongolicus seedlings exposed to HIPVs released from conspecific plants infested with larvae of Orgyia ericae were analyzed together with control and infested seedlings using nuclear magnetic resonance (NMR)-based metabolic technology and multi variate data analysis. Results presented showed that HIPVs exposure led to similar but specific metabolic changes compared with those induced by infestation in both leaves and roots. Furthermore, both HIPVs exposure and herbivore attack resulted in metabolic changes involving a series of primary and secondary metabolites in both leaves and roots. Taken together, these results suggested that priming of yet-damaged plants may be achieved by reconfiguring metabolic pathways in leaves and roots to make similar concentrations for all metabolites as those in seedlings infested. Therefore, we propose that improved readiness of defense induction of primed plants toward subsequent herbivore attack may be based on the similar metabolic profiling induced by HIPVs exposure as those caused by herbivore.
The Distribution and Morphology Alterations of Microfilaments and Microtubules in Mesophyll Cells and Root-Tip Cells of Wheat Seedlings under Enhanced Ultraviolet-B Radiation  [PDF]
Limei Gao, Yongfeng Li, Aihua Guo, Jingru Zhai, Rong Han
American Journal of Plant Sciences (AJPS) , 2014, DOI: 10.4236/ajps.2014.522358
The distribution and morphology alterations of microfilaments and microtubules in the mesophyll cells and root-tip cells of wheat seedlings, which had been radiated by enhanced ultraviolet-B (10.08 KJ·m-2·d-1), were examined through the confocal laser scanning microscope (Model FV1000, Olympus, Japan). Microtubule was labeled with an indirect immunofluorescence staining method, and microfilament was labeled with fluorescein isothiocyanate-phalloidin (FITC-Ph) as probes. The results indicated that microtubules in mesophyll cells, compared with the controls, would be depolymerized significantly, and dispersed randomly showing some spots or short rods in the cytoplasm, under the enhanced UV-B radiation condition. The microtubule bundles tended to be diffused, and the fluorescence intensity of that significantly decreased. The distribution pattern of microfilaments, which usually arranged parallelly in control cells, was broken up by enhanced UV-B radiation. We further investigated the distribution and morphology of microtubules in root-tip cells during every stage of cell division, and found that these aberrant phenomena of microtubules were often associated with abnormal cell division. Our findings suggested that the distribution, morphology and structure of cytoskeleton in mesophyll cells and root-tip cells of wheat seedlings would be affected by enhanced UV-B radiation, which might be related to abnormal cell division caused by enhanced UV-B radiation as an extracellular signal.
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