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Search Results: 1 - 10 of 35965 matches for " Jing Su "
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Clinical data management: Current status, challenges, and future directions from industry perspectives
Zhengwu Lu, Jing Su
Open Access Journal of Clinical Trials , 2010, DOI: http://dx.doi.org/10.2147/OAJCT.S8172
Abstract: ical data management: Current status, challenges, and future directions from industry perspectives Other (18549) Total Article Views Authors: Zhengwu Lu, Jing Su Published Date June 2010 Volume 2010:2 Pages 93 - 105 DOI: http://dx.doi.org/10.2147/OAJCT.S8172 Zhengwu Lu1, Jing Su2 1Smith Hanley Consulting, Houston, Texas; 2Department of Chemical Engineering, University of Massachusetts, Amherst, MA, USA Abstract: To maintain a competitive position, the biopharmaceutical industry has been facing the challenge of increasing productivity both internally and externally. As the product of the clinical development process, clinical data are recognized to be the key corporate asset and provide critical evidence of a medicine’s efficacy and safety and of its potential economic value to the market. It is also well recognized that using effective technology-enabled methods to manage clinical data can enhance the speed with which the drug is developed and commercialized, hence enhancing the competitive advantage. The effective use of data-capture tools may ensure that high-quality data are available for early review and rapid decision-making. A well-designed, protocol-driven, standardized, site workflow-oriented and documented database, populated via efficient data feed mechanisms, will ensure regulatory and commercial questions receive rapid responses. When information from a sponsor’s clinical database or data warehouse develops into corporate knowledge, the value of the medicine can be realized. Moreover, regulators, payer groups, patients, activist groups, patient advocacy groups, and employers are becoming more educated consumers of medicine, requiring monetary value and quality, and seeking out up-todate medical information supplied by biopharmaceutical companies. All these developments in the current biopharmaceutical arena demand that clinical data management (CDM) is at the forefront, leading change, influencing direction, and providing objective evidence. Sustaining an integrated database or data repository for initial product registration and subsequent postmarketing uses is a long-term process to maximize return on investment for organizations. CDM should be the owner of driving clinical data-cleaning process in consultation with other stakeholders, such as clinical operations, safety, quality assurance, and sites, and responsible for building a knowledge base to add potential value in assisting further study designs or clinical programs. CDM needs to draw on a broad range of skills such as technical, scientific, project management, information technology (IT), systems engineering, and interpersonal skills to tackle, drive, and provide valued service in managing data within the anticipated e-clinical age. Commitment to regulatory compliance is required in this regulated industry; however, a can-do attitude with strong willingness to change and to seek ways to improve CDM functions and processes proactively are essential to continued success and t
Clinical data management: Current status, challenges, and future directions from industry perspectives
Zhengwu Lu,Jing Su
Open Access Journal of Clinical Trials , 2010,
Abstract: Zhengwu Lu1, Jing Su21Smith Hanley Consulting, Houston, Texas; 2Department of Chemical Engineering, University of Massachusetts, Amherst, MA, USAAbstract: To maintain a competitive position, the biopharmaceutical industry has been facing the challenge of increasing productivity both internally and externally. As the product of the clinical development process, clinical data are recognized to be the key corporate asset and provide critical evidence of a medicine’s efficacy and safety and of its potential economic value to the market. It is also well recognized that using effective technology-enabled methods to manage clinical data can enhance the speed with which the drug is developed and commercialized, hence enhancing the competitive advantage. The effective use of data-capture tools may ensure that high-quality data are available for early review and rapid decision-making. A well-designed, protocol-driven, standardized, site workflow-oriented and documented database, populated via efficient data feed mechanisms, will ensure regulatory and commercial questions receive rapid responses. When information from a sponsor’s clinical database or data warehouse develops into corporate knowledge, the value of the medicine can be realized. Moreover, regulators, payer groups, patients, activist groups, patient advocacy groups, and employers are becoming more educated consumers of medicine, requiring monetary value and quality, and seeking out up-todate medical information supplied by biopharmaceutical companies. All these developments in the current biopharmaceutical arena demand that clinical data management (CDM) is at the forefront, leading change, influencing direction, and providing objective evidence. Sustaining an integrated database or data repository for initial product registration and subsequent postmarketing uses is a long-term process to maximize return on investment for organizations. CDM should be the owner of driving clinical data-cleaning process in consultation with other stakeholders, such as clinical operations, safety, quality assurance, and sites, and responsible for building a knowledge base to add potential value in assisting further study designs or clinical programs. CDM needs to draw on a broad range of skills such as technical, scientific, project management, information technology (IT), systems engineering, and interpersonal skills to tackle, drive, and provide valued service in managing data within the anticipated e-clinical age. Commitment to regulatory compliance is required in this regulated industry; however, a can-do attitude wi
Robustness enhancement of cloud computing network based on coupled networks model
Zibin Su,Jing Yuan
Computer Science , 2015,
Abstract: As a novel technology, cloud computing attracts more and more people including technology enthusiasts and malicious users. Different from the classical network architecture, cloud environment has many its own features which make the traditional defense mechanism invalid. To make the network more robust against a malicious attack, we introduce a new method to mitigate this risk efficiently and systematically. In this paper, we first propose a coupled networks model which adequately considers the interactions between physical layer and virtual layer in a practical cloud computing environment. Based on this new model and our systematical method, we show that with the addition of protection of some specific nodes in the network structure, the robustness of cloud computing's network can be significantly improved whereas their functionality remains unchanged. Our results demonstrate that our new method can effectively settle the hard problems which cloud computing now is facing without much cost.
THE SECOND-ORDER APPROXIMATION OF THRESHOLD VALUE OF CHAOS

SU JING-HUI,

中国物理 B , 1993,
Abstract: For the Melnikov theory of chaos, the second-order approximation is given. Applying the result to the dynamics system with quadratic nonlinear term, it is shown that the threshold of chaos depends on initial condition and can be greater than that of the Melnikov method. The first order variational equations of some nonlinear dynamical systems are all the second-order ordinary differential equations with hyperbolic cosine function, its solution is given.
An ion-based chromogenic method of detecting for inorganic phosphate in serum and milk  [PDF]
Cai-Xia Yin, Jing Su, Fang-Jun Huo, Pin Yang
Health (Health) , 2009, DOI: 10.4236/health.2009.12013
Abstract: A rapid method for the determination of inor-ganic phosphate in serum and milk by an ion-based chromogenic is described. Serum samples were detected directly by our system, and milk was also detected after degreased through centrifugation. By this procedure the samples are not diluted. Mean serum inorganic phosphate concentration found in healthy indi-vidual is 1.14mmol/L. Values found in serum is in good agreement with those previously re-ported. Mean inorganic phosphate concentra-tion from foremilk and commercial milk are 2.5mmol/L and 12.5mmol/L respectively.
Sensitive Colorimetric and Fluorescent Detection of Mercury Using Fluorescein Derivations  [PDF]
Zhihui Xie, Fangjun Huo, Jing Su, Yutao Yang, Caixia Yin, Xuxiu Yan, Shuo Jin
Open Journal of Applied Biosensor (OJAB) , 2012, DOI: 10.4236/ojab.2012.13006
Abstract: A colorimetric and fluorometric dual-model probe for mercury (II) ion was developed employing fluorescein hydrazide (FH) in ethanol-HEPES solution (1:1, v/v, pH 8.0). The probe exhibited high selectivity and sensitivity for Hg2+ detection using UV/Vis and fluorescence spectroscopy. Addition of Hg2+ caused a visual color change from colorless to coloured and a fluorescence change from colorless to bright green. Other metal ions did not interfere with the detection of Hg2+.
Formation of drug-loaded electrospun twin fibers
Jing Zeng,YanHong Kang,GuiTian Su
Chinese Science Bulletin , 2012, DOI: 10.1007/s11434-012-4977-6
Abstract: Electrospinning is a well-known process for producing submicrometer fibers, which have wide applications in many fields, especially in tissue engineering scaffolds and drug-delivery systems. This paper presents the formation of drug-loaded electrospun twin fibers. The correlations between the twin fiber formation and the polymer materials or the loaded drugs were studied by using poly(l-lactide) and poly(l-lactide-co-glycolide) as electrospinning materials, and rifampin and paclitaxel as loaded drugs. Scanning electron microscopy showed that the formation of twin fibers is significantly affected by the loaded drug but not the polymer material. A possible reason for twin fiber formation was analyzed.
Study on Chemical Composition of Nauclea Officinalis Leaves
Kui Su,Min Gong,Jing Zhou
International Journal of Chemistry , 2009, DOI: 10.5539/ijc.v1n2p77
Abstract: Objective: The chemical composition of Nauclea officinalis leaves is analyzed to offer a theoretical base for its application. Method: Separate Nauclea officinalis leaves by solvent extraction and silica gel column, and characterize the product structure through analysis on physical properties and spectrum. Results and conclusions: 7 compounds have been separated from liposoluble part of Nauclea officinalis leaves, 5 compounds among them have been characterized, which in turn are ????-sitosterol palmitate (1), stigmast-4-en-3-one (2), ????-sitosterol (3), 24-en-cycloartenone (4) and bis (2-ethylhexyl) phthalate (5), wherein (1) and (4) are separated from Nauclea officinalis leaves for the first time.
Detection of Double-Compression in JPEG2000 Images for Application in Image Forensics
Jing Zhang,Haiying Wang,Yuting Su
Journal of Multimedia , 2009, DOI: 10.4304/jmm.4.6.379-388
Abstract: In the age of digital multimedia, the emergence of high resolution digital cameras and sophisticated photo-editing software packages makes it relatively easy to create digital image forgeries. It is increasingly important to verify the authenticity and integrity of digital images. In this paper, a new approach to detect tampered images based on double JPEG 2000 compression is proposed. The paper first analyzes the statistics of double JPEG 2000 compression, the artifacts in the Fourier transforms of DWT (Discrete Wavelet Transform) coefficient histogram, i.e., the stronger singularity in the mid and high frequencies compared with single JPEG 2000 compression; then extracts the singularity using the characteristics of DWT and detects double JPEG 2000 compression by thresholding the singularity
Weak and Strong Convergence Theorems for Nonexpansive Mappings in Banach Spaces
Zhao Jing,He Songnian,Su Yongfu
Fixed Point Theory and Applications , 2008,
Abstract: The purpose of this paper is to introduce two implicit iteration schemes for approximating fixed points of nonexpansive mapping and a finite family of nonexpansive mappings , respectively, in Banach spaces and to prove weak and strong convergence theorems. The results presented in this paper improve and extend the corresponding ones of H.-K. Xu and R. Ori, 2001, Z. Opial, 1967, and others.
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