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Search Results: 1 - 10 of 51586 matches for " Jin-Soo Lee "
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A Retroperitoneal Inflammatory Myofibroblastic Tumor Mimicking a Germ Cell Tumor of the Undescended Testis: A Case Report and Literature Review  [PDF]
Seul-Bi Lee, Jung-Hee Yoon, Seung-Ho Kim, Yedaun Lee, Jin-Soo Lee, Jung-Wook Seo
Advances in Computed Tomography (ACT) , 2016, DOI: 10.4236/act.2016.53004
Abstract: We report here a case of an inflammatory myofibroblastic tumor in the retroperitoneum, which mimicked a germ cell tumor of the undescended testis. A 75-year-old healthy man presented with a palpable abdominal mass. On the computed tomography image, there was large, well-defined soft tissue mass in the left side of the retroperitoneum, and there was no visible left testis or seminal vesicle. After contrast enhancement, the mass appeared to be relatively homogeneous, considering its large size. With ultrasonography, it appeared as a well-defined, hypoechoic mass with intratumoral vascularity. This solid mass was surgically diagnosed as an inflammatory myofibroblastic tumor.
A Facile Synthesis of Highly Functionalized 4-Arylcoumarins via Kostanecki Reactions Mediated by DBU
In-Taek Hwang,Sun-Ah Lee,Jin-Soo Hwang,Kee-In Lee
Molecules , 2011, DOI: 10.3390/molecules16086313
Abstract: An efficient synthesis of 4-arylcoumarins has been accomplished via Kostanecki reactions of 2-hydroxybenzophenones with acetic anhydride employing DBU at ambient temperature. Using the same strategy, several 2-acyloxybenzophenone derivatives were readily converted to 3,4-difunctionalized coumarins. This protocol offers a notable improvement in reaction conditions for coumarin synthesis and takes advantage of its synthetic capability, especially for highly functionalized 4-arylcoumarins with structural diversity.
Infective endocarditis caused by methicillin-resistant Staphylococcus aureus in a young woman after ear piercing: a case report
So-Yun Nah, Moon-Hyun Chung, Jae Park, Areum Durey, Mijeong Kim, Jin-Soo Lee
Journal of Medical Case Reports , 2011, DOI: 10.1186/1752-1947-5-336
Abstract: A 29-year-old Korean woman underwent ear piercing six days before hospitalization. On admission, she had fever, erythematous maculopapular rashes on her face, signs of generalized emboli, vegetation in her mitral valve, and methicillin-resistant S. aureus bacteremia. On the basis of the blood culture results, she was treated with vancomycin in combination with gentamicin. On day six of hospitalization, a rupture of the papillary muscle of her mitral valve developed, and emergency cardiac surgery replacing her mitral valve with a prosthetic valve was performed. After eight weeks of antibiotic therapy, she was treated successfully and discharged without significant sequelae.Numerable cases of body piercing-related infective endocarditis have been reported, and since ear piercing is commonplace nowadays, the importance of risk recognition cannot be overemphasized. In our report, a patient developed infective endocarditis that was caused by methicillin-resistant S. aureus after ear piercing and that was accompanied by an interesting feature, namely facial rash.Body piercing, especially ear piercing, is popular among teenage girls and young women in Korea. A previous investigation in Korea revealed that 96.5% of female college students underwent ear piercing at a mean age of 19.3 years. Most students underwent piercing at home or at nonmedical facilities such as jewelry stores, beauty salons, or piercing shops [1]. With the increasing number of persons with body piercings, various associated complications have been reported [2,3]. Among the related adverse events, infectious complications are the most frequent, although these are preventable to a certain extent if aseptic methods are used throughout the piercing procedure. There are no established regulations or medical guidelines regarding body piercing in Korea; thus, some of the body piercings here are probably performed under suboptimal hygienic conditions. Localized infections around the pierced sites are relatively
Magnetic Separation and Antibiotics Selection Enable Enrichment of Cells with ZFN/TALEN-Induced Mutations
Hyojin Kim, Myung-Sun Kim, Gabbine Wee, Choong-il Lee, Hyongbum Kim, Jin-Soo Kim
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0056476
Abstract: The ability to enrich cells with targeted mutations greatly facilitates the process of using engineered nucleases, including zinc-finger nucleases and transcription activator-like effector nucleases, to construct such cells. We previously used surrogate reporters to enrich cells containing nuclease-induced mutations via flow cytometry. This method is, however, limited by the availability of flow cytometers. Furthermore, sorted cells occasionally fail to form colonies after exposure to a strong laser and hydrostatic pressure. Here we describe two different types of novel reporters that enable mutant cell enrichment without the use of flow cytometers. We designed reporters that express H-2Kk, a surface antigen, and the hygromycin resistance protein (HygroR), respectively, when insertions or deletions are generated at the target sequences by the activity of engineered nucleases. After cotransfection of these reporters and the engineered nuclease-encoding plasmids, H-2Kk- and HygroR-expressing cells were isolated using magnetic separation and hygromycin treatment, respectively. We found that mutant cells were drastically enriched in the isolated cells, suggesting that these two reporters enable efficient enrichment of mutants. We propose that these two reporters will greatly facilitate the use of engineered nucleases in a wider range of biomedical research.
Antibacterial Characteristics of Lotus-Type Porous Copper
Jin-Soo Lee,Yun-Soo Lee,Mok-Soon Kim,Soong-Keun Hyun,Chang-Ho Kang,Jae-Seong So,Eui-Han Yoon
Advances in Materials Science and Engineering , 2013, DOI: 10.1155/2013/608350
Abstract: Lotus-type porous copper with long cylindrical pores aligned parallel to the solidification direction was studied for use as an antibacterial material. The antibacterial performance of lotus-type porous copper samples with different specific surface areas against Escherichia coli was investigated. The results confirmed that the antibacterial effect gradually increased with specific surface area. The correlation between the pore structure of lotus-type porous metals and their antibacterial effect was also analyzed in detail. Our research proposes a new application of these metals in the water purifying system. 1. Introduction In addition to offering convenience and many lifestyle options, industrial development has caused serious environmental contamination, especially water pollution, which increases the growth of various bacteria, viruses, and protozoa that cause water-borne diseases. Removal of disease-causing organisms from drinking water is, therefore, extremely important for human health. There are several conventional chemical disinfectants such as chlorine and its derivatives and ozone [1]. However, many of these agents are carcinogens with potential harmful side effects [2]. In this regard, several researchers have recently investigated the use of inorganic antibacterial materials such as silver and copper to inhibit microbial growth. In particular, research studies on porous antibacterial materials are well under way because the antibacterial effect is proportionate to the increase in surface area [3–5]. Shen et al. [3] evaluated the antibacterial characteristics of porous ceramic composites that were decorated with ultrafine silver (II) oxide particles and fabricated by chemical oxidation. Chen et al. [4] examined Cu-TiO2 nanocomposites that could be created by photocatalytic reduction and studied their antibacterial performance in the absence of light. Lotus-type (or Gasar) porous metals [6, 7], which have long cylindrical pores aligned parallel to the solidification direction, have many advantages over other materials for antibacterial applications. For example, the specific surface area of these metals can be easily controlled by manipulating the porosity and pore diameter [6, 8–10]. These metals also exhibit high fluid permeability because of their low pressure drop [6, 11]. In addition, they are easy to manufacture and are suited for mass production because their fabrication is based on the casting process [6, 8, 10]. However, the antibacterial performance of lotus-type porous metals has not been evaluated. Here, we show the antibacterial
Genetic polymorphism and natural selection of Duffy binding protein of Plasmodium vivax Myanmar isolates
Hye-Lim Ju, Jung-Mi Kang, Sung-Ung Moon, Jung-Yeon Kim, Hyeong-Woo Lee, Khin Lin, Woon-Mok Sohn, Jin-Soo Lee, Tong-Soo Kim, Byoung-Kuk Na
Malaria Journal , 2012, DOI: 10.1186/1475-2875-11-60
Abstract: Fifty-four P. vivax infected blood samples collected from patients in Myanmar were used. The region flanking PvDBPII was amplified by PCR, cloned into Escherichia coli, and sequenced. The polymorphic characters and natural selection of the region were analysed using the DnaSP and MEGA4 programs.Thirty-two point mutations (28 non-synonymous and four synonymous mutations) were identified in PvDBPII among the Myanmar P. vivax isolates. Sequence analyses revealed that 12 different PvDBPII haplotypes were identified in Myanmar P. vivax isolates and that the region has evolved under positive natural selection. High selective pressure preferentially acted on regions identified as B- and T-cell epitopes of PvDBPII. Recombination may also be played a role in the resulting genetic diversity of PvDBPII.PvDBPII of Myanmar P. vivax isolates displays a high level of genetic polymorphism and is under selective pressure. Myanmar P. vivax isolates share distinct types of PvDBPII alleles that are different from those of other geographical areas. These results will be useful for understanding the nature of the P. vivax population in Myanmar and for development of PvDBPII-based vaccine.Plasmodium vivax Duffy binding protein (PvDBP) is one of the erythrocyte-binding proteins, which belongs to the large erythrocyte binding protein family [1]. PvDBP is expressed on the merozoite of P. vivax and plays an essential role in erythrocyte invasion of the parasite by mediating irreversible binding with its corresponding receptor, the duffy antigen receptor for chemokines (DARC), on the surface of erythrocytes [1-4]. Similar to other plasmodial proteins known to participate in such processes, PvDBP is suggested to be an important vaccine candidate antigen, because it elicits strong immune responses in humans [5,6]. Experimental evidences that antibodies against PvDBP inhibit the interaction of this protein with DARC in vitro and block the invasion of P. vivax into human erythrocytes also support
Effect of zinc injection on the corrosion products in nuclear fuel assembly  [PDF]
Jin-Soo Choi, Seung-Chul Park, Kyoung-Rok Park, Ho-Yeon Yang, O-Bong Yang
Natural Science (NS) , 2013, DOI: 10.4236/ns.2013.52027
Abstract:

The accumulation of corrosive and radioactive wastes in the primary system, including nuclear fuel assembly, significantly increases workers’ exposure to radiation. Zinc injection from 5 to 40 ppb into the Reactor Coolant System (RCS) of Pressurized Water Reactors (PWRs) has been known as an effective method to decrease the radiation fields and Primary Water Stress Corrosion Cracking (PWSCC). Zinc injection affects both corrosion product concentrations and characteristics of the deposited crud on oxide layers, because zinc is incorporated into the oxide films by displacing nickel, cobalt, and iron in primary systems. Radiation fields and corrosion might be mitigated as radioactive products, such as Co, which are removed by zinc injection. However, the zinc injection effects on fuel assembly in Nuclear Power Plants (NPPs) have not been much reported yet, even though some lab tests were carried out in USA and France. In this paper, we studied effects of zinc injection on the fuel assemblies in the Ulchin 1 NPP. The chemical and radiation analysis of radioactive corrosion products was performed to evaluate zinc injection effects on the fuel assembly in the Ulchin 1 NPP. Gamma spectroscopy was used to analyze crud samples for radioisotope contents. The Inductively Coupled Plasma-Atomic Emission Spectrometry (ICP-AES) was used to analyze crud samples for elemental contents. The concentration of radioisotope Co-58 was decreased after zinc injection to 1/22 times that before the zinc injection. 1% - 2% wt% of zinc was incorporated through the substitution of Ni in the crud oxide layer. The Ni/Fe ratio was decreased to 0.69 from 1.12 after the injection, due to the Ni substitution by zinc. It was found that NiO and NiFe2O4 were converted to ZnO and ZnFe2O4, respectively. In conclusion, zinc injecttion was found to be an essential method to reduce the amount of radioactive Co-58 in the fuel assemblies of primary systems in NPPs.

A study on the effect of different chemical routes on functionalization of MWCNTs by various groups (-COOH, -SO3H, -PO3H2)
Kumar Pawan,Park Jin-Soo,Randhawa Prabhsharan,Sharma Sandeep
Nanoscale Research Letters , 2011,
Abstract: Pristine multiwall carbon nanotubes [MWCNTs] have been functionalized with various groups (-COOH, -SO3H, -PO3H2) using different single- and double-step chemical routes. Various chemical treatments were given to MWCNTs using hydrochloric, nitric, phosphoric, and sulphuric acids, followed by a microwave treatment. The effect of the various chemical treatments and the dispersion using a surfactant via ultrasonication on the functionalization of MWCNTs has been studied. The results obtained have been compared with pristine MWCNTs. Scanning electron microscopy, energy dispersive X-ray [EDX] spectroscopy, and transmission electron microscopy confirm the dispersion and functionalization of MWCNTs. Their extent of functionalization with -SO3H and -PO3H2 groups from the EDX spectra has been observed to be higher for the samples functionalized with a double-step chemical route and a single-step chemical route, respectively. The ID/IG ratio calculated from Raman data shows a maximum defect concentration for the sample functionalized with the single-step chemical treatment using nitric acid. The dispersion of MWCNTs with the surfactant, Triton X-100, via ultrasonication helps in their unbundling, but the extent of functionalization mainly depends on the chemical route followed for their treatment. The functionalized carbon nanotubes can be used in proton conducting membranes for fuel cells.
Technical Note: Community of bacteria attached on the PVDF MF membrane surface fouled from drinking water treatment, in Seoul, Korea
Kyongmi Chon,Kangmin Chon,Jin-Soo Chang,Heekyong Oh
Drinking Water Engineering and Science Discussions , 2009,
Abstract: Alpha, beta, and gamma proteobacteria comprise approximate 68, 16, and 7% of all identified bacteria. In this study, bacterial communities that had fouled polyvinylidene fluoride microfiltration membranes, which are used for drinking water treatment, over an 18 month period were analyzed using the 16s rRNA gene clone library method. The alpha, beta, and gamma proteobacteria were composed of mainly Bradyrhizobium and Rhodopseudomonas, Ralstonia, and Legionella, respectively. The presence of a relatively high amount of alpha proteobacteria was due to the oligotrophic condition of the drinking water source, the Han River, tested in this specific case study. The second most prominent bacteria community was the beta proteobacteria, which are typically found in a freshwater environment. This finding supports the notion that the drinking water source was relatively clean. Analyses of the organic foulants indicated that the they were most likely from extra cellular polymers and/or cell fractured chemicals from bacteria or micro-organisms, as identified using organic characterizing tools, including 3 dimensional fluorescence excitation-emission matrix and Fourier transform IR analyses.
Laboratory Surveillance of Influenza-Like Illness in Seven Teaching Hospitals, South Korea: 2011–2012 Season
Ji Yun Noh, Joon Young Song, Hee Jin Cheong, Won Suk Choi, Jacob Lee, Jin-Soo Lee, Seong-Heon Wie, Hye Won Jeong, Young Keun Kim, Sung Hyuk Choi, Seung Baik Han, Byung-Hak So, Hyun Kim, Woo Joo Kim
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0064295
Abstract: Background A well-constructed and properly operating influenza surveillance scheme is essential for public health. This study was conducted to evaluate the distribution of respiratory viruses in patients with influenza-like illness (ILI) through the first teaching hospital-based surveillance scheme for ILI in South Korea. Methods Respiratory specimens were obtained from adult patients (≥18 years) who visited the emergency department (ED) with ILI from week 40, 2011 to week 22, 2012. Multiplex PCR was performed to detect respiratory viruses: influenza virus, adenovirus, coronavirus, respiratory syncytial virus, rhinovirus, human metapneumovirus, parainfluenza virus, bocavirus, and enterovirus. Results Among 1,983 patients who visited the ED with ILI, 811 (40.9%) were male. The median age of patients was 43 years. Influenza vaccination rate was 21.7% (430/1,983) during the 2011–2012 season. At least one comorbidity was found in 18% of patients. The positive rate of respiratory viruses was 52.1% (1,033/1,983) and the total number of detected viruses was 1,100. Influenza A virus was the dominant agent (677, 61.5%) in all age groups. The prevalence of human metapneumovirus was higher in patients more than 50 years old, while adenovirus was detected only in younger adults. In 58 (5.6%) cases, two or more respiratory viruses were detected. The co-incidence case was identified more frequently in patients with hematologic malignancy or organ transplantation recipients, however it was not related to clinical outcomes. Conclusion This study is valuable as the first extensive laboratory surveillance of the epidemiology of respiratory viruses in ILI patients through a teaching hospital-based influenza surveillance system in South Korea.
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