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Search Results: 1 - 10 of 34832 matches for " Jin-Mo Chung "
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Gravitating Self-dual Chern-Simons Solitons
Bok Keun Chung,Jin-Mo Chung,Seongtag Kim,Yoonbai Kim
Physics , 2001, DOI: 10.1006/aphy.2001.6162
Abstract: Self-dual solitons of Chern-Simons Higgs theory are examined in curved spacetime. We derive duality transformation of the Einstein Chern-Simons Higgs theory within path integral formalism and study various aspects of dual formulation including derivation of Bogomolnyi type bound. We find all possible rotationally-symmetric soliton configurations carrying magnetic flux and angular momentum when underlying spatial manifolds of these objects comprise a cone, a cylinder, and a two sphere.
Regulation of Wnt signaling by nociceptive input in animal models
Yuqiang Shi, Subo Yuan, Bei Li, Jigong Wang, Susan M. Carlton, Kyungsoon Chung, Jin-Mo Chung, Shao-Jun Tang
Molecular Pain , 2012, DOI: 10.1186/1744-8069-8-47
Abstract: Fluorescent immunostaining results indicate that β-catenin, an essential protein in the canonical Wnt signaling pathway, is expressed in the superficial layers of the mouse SCDH with enrichment at synapses in lamina II. In addition, Wnt3a, a prototypic Wnt ligand that activates the canonical pathway, is also enriched in the superficial layers. Immunoblotting analysis indicates that both Wnt3a a β-catenin are up-regulated in the SCDH of various mouse pain models created by hind-paw injection of capsaicin, intrathecal (i.t.) injection of HIV-gp120 protein or spinal nerve ligation (SNL). Furthermore, Wnt5a, a prototypic Wnt ligand for non-canonical pathways, and its receptor Ror2 are also up-regulated in the SCDH of these models.Our results suggest that Wnt signaling pathways are regulated by nociceptive input. The activation of Wnt signaling may regulate the expression of spinal central sensitization during the development of acute and chronic pain.
Ischemic colitis due to obstruction of mesenteric and splenic veins: A case report
Seong-Su Hwang, Woo-Chul Chung, Kang-Moon Lee, Hyun-Jin Kim, Chang-Nyol Paik, Jin-Mo Yang
World Journal of Gastroenterology , 2008,
Abstract: Ischemic injury to the bowel is a well known disease entity that has a wide spectrum of pathological and clinical findings. A sudden drop in the colonic blood supply is essential to its development. We encountered a 41-year-old male patient, who presented with abdominal pain and bloody diarrhea. A colonoscopy showed markedly edematous mucosa with tortuous dilatation of the veins and a deep ulceration at the rectosigmoid junction. On an abdominal computed tomography (CT) scan and CT angiography, the mesenteric and splenic veins were absent with numerous venous collaterals for drainage. The patient gradually responded to oral aminosalicylate therapy, and was in remission after nine months. In most cases, non-occlusive ischemic injury is caused by idiopathic form and occlusive ischemia is caused by abnormalities of arteries and acute venous thrombosis. However, chronic venous insufficiency due to obstruction of macrovascular mesenteric vein rarely causes ischemia of the bowel. This report describes the first case of ischemic colitis caused by obstruction of the mesenteric and splenic veins.
Changes in morbidity and medical care utilization after the recent economic crisis in the Republic of Korea
Kim,Hanjoong; Chung,Woo Jin; Song,Young Jong; Kang,Dae Ryong; Yi,Jee Jeon; Nam,Chung Mo;
Bulletin of the World Health Organization , 2003, DOI: 10.1590/S0042-96862003000800006
Abstract: objective: to examine and quantify the impact of the recent economic crisis on morbidity and medical care utilization in the republic of korea. methods: 22 675 people from 6791 households and 43 682 people from 12 283 households were questioned for two nationwide surveys that took place in 1995 and 1998, respectively. a separate sample pretest-posttest design was used and we conducted c2 test and logistic regression analysis after controlling for the maturation effect of the morbidity and medical care utilization. findings: the morbidity rates of chronic disease and acute disease increased significantly by 27.1% and 9.5%, respectively, whereas the utilization rates of outpatient and inpatient services decreased by 15.1% and 5.2%, respectively. in particular, the pace of decline in the utilization rate of outpatient services varied depending on the type of disease: morbidity rates for mental and behavioural disorders were 13.7%; for cardiovascular disease, 7.1%; and for injury, 31.6%. conclusion: after the republic of korean economic crisis, the morbidity and medical care utilization rates changed significantly but the degree of change depended on the type of disease or service. the time-dependent relationship between the national economy and the morbidity and medical care utilization rates needs to be further investigated.
Risk Factors for Recurrence of Symptomatic Common Bile Duct Stones after Cholecystectomy
Ju Hyun Oak,Chang Nyol Paik,Woo Chul Chung,Kang-Moon Lee,Jin Mo Yang
Gastroenterology Research and Practice , 2012, DOI: 10.1155/2012/417821
Abstract: Purpose. The recurrence of CBD stone is still observed in a considerable number of patients. The study was to evaluate the risk factors for recurrence of symptomatic CBD stone in patients who underwent cholecystectomy after the removal of CBD stone. Methods. The medical records of patients who underwent removal of CBD stone with subsequent cholecystectomy were reviewed. The risk factors for the recurrence of symptomatic CBD stone were compared between the recurrence and the nonrecurrence group. Results. The mean follow-up period was 40.6 months. The recurrence of symptomatic CBD stones was defined as the detection of bile duct stones no sooner than 6 months after complete clearance of CBD stones, based on symptoms or signs of biliary complication. 144 patients (68 males, 47.2%) were finally enrolled and their mean age was 59.8 (range: 26~86) years. The recurrence of CBD stone occurred in 15 patients (10.4%). The mean period until first recurrence was 25.9 months. The presence of type 1 or 2 periampullary diverticulum and multiple CBD stones were the independent risk factors. Conclusion. For the patients with type 1 or 2 periampullary diverticulum or multiple CBD stones, careful followup is needed for the risk in recurrence of symptomatic CBD stone. 1. Background After a removal of common bile duct (CBD) stone, cholecystectomy is performed to prevent biliary colic, cholecystitis, pancreatitis, or CBD stone recurrence [1–3]. CBD stones usually originate in the gallbladder and then they migrate [4]. Therefore subsequent cholecystectomy would be helpful to prevent CBD stone recurrence. However recurrence of CBD stone is still observed in a considerable number of patients following cholecystectomy. Bile duct stones that are demonstrated 6 months or more after endoscopic retrograde cholangiopancreatography (ERCP) are considered to be recurrent [3, 5, 6]. There have been several studies about the prevalence of and the risk factors for CBD stone recurrence after endoscopic sphincterectomy [7–12], but little data is available on CBD stone recurrence after cholecystectomy. The risk factors for recurrent bile duct stones were known as a dilated common bile duct, gall bladder stone, biliary stricture, angulation of the CBD, previous open cholecystectomy, and periampullary diverticulum [7, 8, 10, 12, 13]. Considering the periampullary diverticulum in detail, the recent study [8] suggested that specific status in which papilla located within or on the inner rim of the diverticulum was associated with recurrence. This study aimed to evaluate the risk factors for CBD
Association between acute pancreatitis and peptic ulcer disease
Kang-Moon Lee, Chang-Nyol Paik, Woo Chul Chung, Jin Mo Yang
World Journal of Gastroenterology , 2011,
Abstract: AIM: To evaluate the relationship between peptic ulcer disease (PUD) and acute pancreatitis.METHODS: A cohort of 78 patients with acute pancreatitis were included in this study. The presence of PUD and the Helicobacter pylori (H. pylori) status were assessed by an endoscopic method. The severity of acute pancreatitis was assessed using Ranson’s score, the Acute Physiology and Chronic Health Evaluation (APACHE) II score, computed tomography severity index and the clinical data during hospitalization, all of which were compared between the patients with and without PUD. The risk factors for PUD were also evaluated.RESULTS: Among 78 patients, 41 patients (52.6%) with acute pancreatitis suffered from PUD, but only 13 (31.7%) patients with PUD were infected by H. pylori. On univariate analysis, male gender, an etiology of alcohol-induced pancreatitis, a history of smoking or alcohol consumption, elevated triglyceride and C-reactive protein levels, and high APACHE II score were significantly associated with PUD. However, on multivariate logistic regression analysis, the APACHE II score (odds ratio: 7.69; 95% confidence interval: 1.78-33.33; P < 0.01) was found to be the only independent risk factor for PUD.CONCLUSION: Patients with acute pancreatitis are liable to suffer from PUD. PUD is associated with severe acute pancreatitis according to the APACHE II score, and treatment for PUD should be considered for patients with severe acute pancreatitis.
Ischemic colitis associated with intestinal vasculitis: Histological proof in systemic lupus erythematosus
Jeong Rok Lee, Chang Nyol Paik, Jin Dong Kim, Woo Chul Chung, Kang-Moon Lee, Jin Mo Yang
World Journal of Gastroenterology , 2008,
Abstract: Ischemic colitis is an uncommon complication in patients with systemic lupus erythematosus (SLE). In previously reported cases of colitis caused by SLE, intestinal vasculitis is implicated as the causative process, but is rarely confirmed histologically. We described a case of a 32-year-old man with increased activity of SLE, who presented with hematochezia and abdominal pain due to ischemic colitis with small vessel vasculitis which was proven by sigmoidoscopic biopsy. The clinical course of the patient was improved after steroid and conservative management.
Colonic lymphangiomatosis associated with anemia
Woo Chul Chung, Hye-Kang Kim, Jin Young Yoo, Jeong Rok Lee, Kang-Moon Lee, Chang Nyol Paik, U-Im Jang, Jin Mo Yang
World Journal of Gastroenterology , 2008,
Abstract: Lymphangioma is an uncommon malformation of lymphatic system. Multiple colonic lymphangioma named as lymphangiomatosis is considered an extremely rare disease. Although lymphangioma is a benign tumor and most colonic lymphangiomas do not cause symptoms and do not require treatment, resection of lymphangioma is necessary in the presence of symptoms such as abdominal pain, bleeding, intussusceptions. We report a case of colonic lymphangiomatosis in a man who presented with abdominal discomfort and anemia, which was diagnosed and treated with endoscopic snare polypectomy.
The Pore-Forming Toxin β hemolysin/cytolysin Triggers p38 MAPK-Dependent IL-10 Production in Macrophages and Inhibits Innate Immunity
Magali Bebien,Mary E. Hensler,Suzel Davanture,Li-Chung Hsu,Michael Karin,Jin Mo Park,Lena Alexopoulou,George Y. Liu,Victor Nizet,Toby Lawrence
PLOS Pathogens , 2012, DOI: 10.1371/journal.ppat.1002812
Abstract: Group B Streptococcus (GBS) is a leading cause of invasive bacterial infections in human newborns and immune-compromised adults. The pore-forming toxin (PFT) β hemolysin/cytolysin (βh/c) is a major virulence factor for GBS, which is generally attributed to its cytolytic functions. Here we show βh/c has immunomodulatory properties on macrophages at sub-lytic concentrations. βh/c-mediated activation of p38 MAPK drives expression of the anti-inflammatory and immunosuppressive cytokine IL-10, and inhibits both IL-12 and NOS2 expression in GBS-infected macrophages, which are critical factors in host defense. Isogenic mutant bacteria lacking βh/c fail to activate p38-mediated IL-10 production in macrophages and promote increased IL-12 and NOS2 expression. Furthermore, targeted deletion of p38 in macrophages increases resistance to invasive GBS infection in mice, associated with impaired IL-10 induction and increased IL-12 production in vivo. These data suggest p38 MAPK activation by βh/c contributes to evasion of host defense through induction of IL-10 expression and inhibition of macrophage activation, a new mechanism of action for a PFT and a novel anti-inflammatory role for p38 in the pathogenesis of invasive bacterial infection. Our studies suggest p38 MAPK may represent a new therapeutic target to blunt virulence and improve clinical outcome of invasive GBS infection.
Increased Prevalence of Chronic Lymphocytic Thyroiditis in Korean Patients with Papillary Thyroid Cancer
Chang-Mo Oh, Sohee Park, Joo Young Lee, Young-Joo Won, Aesun Shin, Hyun-Joo Kong, Kui-Sun Choi, You Jin Lee, Ki- Wook Chung, Kyu-Won Jung
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0099054
Abstract: Background In recent years, some reports have suggested that papillary thyroid cancers are more frequently associated with lymphocytic thyroiditis or Hashimoto's thyroiditis. This study investigated a potential increase in the prevalence of chronic lymphocytic thyroiditis among papillary thyroid cancer patients. Materials and Methods We used national epidemiological survey data on thyroid cancer patients diagnosed in 1999, 2005, and 2008. A retrospective medical record survey was conducted by representative sampling of a national cancer incidence database. The analysis included 5,378 papillary thyroid cancer patients aged 20–79 years. We calculated the age-standardized prevalence and age-adjusted prevalence ratios using a binomial regression model with a log link for the prevalence of chronic lymphocytic thyroiditis among papillary thyroid cancer patients by sex for each year. Results The prevalence of chronic lymphocytic thyroiditis among papillary thyroid cancer patients was 4.0% and 12.8% for men and women in 1999, 6.5% and 24.6% in 2005, and 10.7% and 27.6% in 2008, respectively. Between 1999 and 2008, the age-standardized prevalence of chronic lymphocytic thyroiditis increased 4.1-fold in male patients and 2.0-fold in female patients with papillary thyroid cancer. The prevalence of other thyroid diseases, however, did not increase in either gender. Conclusions Among Korean papillary thyroid cancer patients, the prevalence of chronic lymphocytic thyroiditis increased between 1999 and 2008, whereas the prevalence of other thyroid disorders did not change.
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