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Search Results: 1 - 10 of 46538 matches for " Jin-Hyun Kim "
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A case of successful survival from ventricular free wall micro-rupture without surgery  [PDF]
Jae-Bin Seo, Ki-Hyun Jeon, Jin-Hyun Park, Sang-Hyun Kim, Joo-Hee Zo, Myung-A Kim, Woo-Young Chung
World Journal of Cardiovascular Diseases (WJCD) , 2013, DOI: 10.4236/wjcd.2013.32029
Abstract:

We report a case of successful survival from ventricular free wall rupture without surgery, which was not overt rupture but micro-rupture. The patient was diagnosed with acute myocardial infarction (AMI) and underwent primary percutaneous coronary intervention (PCI). Myocardial blood leakage could be detected on transthoracic echocardiography with intravenous infusion of contrast dye 3 days after PCI. This examination revealed that there was not overt perforation but diffuse fissure. Because of his critical condition, he was treated conservatively without surgery. Nevertheless, he survived eventually.

Human Cytomegalovirus Clinical Strain-Specific microRNA miR-UL148D Targets the Human Chemokine RANTES during Infection
Youngkyun Kim equal contributor,Sanghyun Lee equal contributor,Sungchul Kim,Donghyun Kim,Jin-Hyun Ahn,Kwangseog Ahn
PLOS Pathogens , 2012, DOI: 10.1371/journal.ppat.1002577
Abstract: The human cytomegalovirus (HCMV) clinical strain Toledo and the attenuated strain AD169 exhibit a striking difference in pathogenic potential and cell tropism. The virulent Toledo genome contains a 15-kb segment, which is present in all virulent strains but is absent from the AD169 genome. The pathogenic differences between the 2 strains are thought to be associated with this additional genome segment. Cytokines induced during viral infection play major roles in the regulation of the cellular interactions involving cells of the immune and inflammatory systems and consequently determine the pathogenic outcome of infection. The chemokine RANTES (Regulated on activation, normal T-cell expressed and secreted) attracts immune cells during inflammation and the immune response, indicating a role for RANTES in viral pathogenesis. Here, we show that RANTES was downregulated in human foreskin fibroblast (HFF) cells at a later stage after infection with the Toledo strain but not after infection with the AD169 strain. miR-UL148D, the only miRNA predicted from the UL/b' sequences of the Toledo genome, targeted the 3′-untranslated region of RANTES and induced degradation of RANTES mRNA during infection. While wild-type Toledo inhibited expression of RANTES in HFF cells, Toledo mutant virus in which miR-UL148D is specifically abrogated did not repress RANTES expression. Furthermore, miR-UL148D-mediated downregulation of RANTES was inhibited by treatment with a miR-UL148D-specific inhibitor designed to bind to the miR-UL148D sequence via an antisense mechanism, supporting the potential value of antisense agents as therapeutic tools directed against HCMV. Our findings identify a viral microRNA as a novel negative regulator of the chemokine RANTES and provide clues for understanding the pathogenesis of the clinical strains of HCMV.
Analysis of Human Cytomegalovirus-Encoded SUMO Targets and Temporal Regulation of SUMOylation of the Immediate-Early Proteins IE1 and IE2 during Infection
Eui Tae Kim, Young-Eui Kim, Ye Ji Kim, Myoung Kyu Lee, Gary S. Hayward, Jin-Hyun Ahn
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0103308
Abstract: Post-translational modification of proteins by members of the small ubiquitin-like modifier (SUMO) is involved in diverse cellular functions. Many viral proteins are SUMO targets and also interact with the cellular SUMOylation system. During human cytomegalovirus (HCMV) infection, the immediate-early (IE) proteins IE1 and IE2 are covalently modified by SUMO. IE2 SUMOylation promotes its transactivation activity, whereas the role of IE1 SUMOylation is not clear. We performed in silico, genome-wide analysis to identify possible SUMOylation sites in HCMV-encoded proteins and evaluated their modification using the E. coli SUMOylation system and in vitro assays. We found that only IE1 and IE2 are substantially modified by SUMO in E. coli, although US34A was also identified as a possible SUMO target in vitro. We also found that SUMOylation of IE1 and IE2 is temporally regulated during viral infection. Levels of SUMO-modified form of IE1 were increased during the early phase of infection, but decreased in the late phase when IE2 and its SUMO-modified forms were expressed at high levels. IE2 expression inhibited IE1 SUMOylation in cotransfection assays. As in IE2 SUMOylation, PIAS1, a SUMO E3 ligase, interacted with IE1 and enhanced IE1 SUMOylation. In in vitro assays, an IE2 fragment that lacked covalent and non-covalent SUMO attachment sites, but was sufficient for PIAS1 binding, effectively inhibited PIAS1-mediated SUMOylation of IE1, indicating that IE2 expression negatively regulates IE1 SUMOylation. We also found that the IE2-mediated downregulation of IE1 SUMOylation correlates with the IE1 activity to repress the promoter containing the interferon stimulated response elements. Taken together, our data demonstrate that IE1 and IE2 are the main viral SUMO targets in HCMV infection and that temporal regulation of their SUMOylation may be important in the progression of this infection.
Cross-Family Translational Genomics of Abiotic Stress-Responsive Genes between Arabidopsis and Medicago truncatula
Daejin Hyung, Chaeyoung Lee, Jin-Hyun Kim, Dongwoon Yoo, Young-Su Seo, Soon-Chun Jeong, Jai-Heon Lee, Youngsoo Chung, Ki-Hong Jung, Douglas R. Cook, Hong-kyu Choi
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0091721
Abstract: Cross-species translation of genomic information may play a pivotal role in applying biological knowledge gained from relatively simple model system to other less studied, but related, genomes. The information of abiotic stress (ABS)-responsive genes in Arabidopsis was identified and translated into the legume model system, Medicago truncatula. Various data resources, such as TAIR/AtGI DB, expression profiles and literatures, were used to build a genome-wide list of ABS genes. tBlastX/BlastP similarity search tools and manual inspection of alignments were used to identify orthologous genes between the two genomes. A total of 1,377 genes were finally collected and classified into 18 functional criteria of gene ontology (GO). The data analysis according to the expression cues showed that there was substantial level of interaction among three major types (i.e., drought, salinity and cold stress) of abiotic stresses. In an attempt to translate the ABS genes between these two species, genomic locations for each gene were mapped using an in-house-developed comparative analysis platform. The comparative analysis revealed that fragmental colinearity, represented by only 37 synteny blocks, existed between Arabidopsis and M. truncatula. Based on the combination of E-value and alignment remarks, estimated translation rate was 60.2% for this cross-family translation. As a prelude of the functional comparative genomic approaches, in-silico gene network/interactome analyses were conducted to predict key components in the ABS responses, and one of the sub-networks was integrated with corresponding comparative map. The results demonstrated that core members of the sub-network were well aligned with previously reported ABS regulatory networks. Taken together, the results indicate that network-based integrative approaches of comparative and functional genomics are important to interpret and translate genomic information for complex traits such as abiotic stresses.
Detection of a Single Identical Cytomegalovirus (CMV) Strain in Recently Seroconverted Young Women
Suchetha Murthy,Gary S. Hayward,Sarah Wheelan,Michael S. Forman,Jin-Hyun Ahn,Robert F. Pass,Ravit Arav-Boger
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0015949
Abstract: Infection with multiple CMV strains is common in immunocompromised hosts, but its occurrence in normal hosts has not been well-studied.
Politics of Race in East Asia: The Case of Korea and the Chinese community in South Korea
Hyun Jin Kim
Provincial China , 2012,
Abstract: The influx of Chinese into Korea has a long history. The earlier migrants were rapidly absorbed into mainstream Korean society and quickly assimilated. However, the Chinese migrants who arrived in the late 19th and early 20th centuries, the huaqiao, chose to maintain their separate, non-Korean identity. This later led to open discrimination towards the huaqiao in post-independence Korea. The adoption of modern nationalism and racial theories in Korea also facilitated the disenfranchisement of the huaqiao, whose loyalty to the Korean national state was suspected and whose economic and social rights were appropriated. The recent revival of Chinese power has led to the mellowing of Korean attitudes towards China and the Chinese. The left-aligned political parties in Korea are especially in favour of cultivating closer ties with China. The composition of the Chinese community in Korea has also been altered by the influx of new migrants from mainland China. This has led to the renaissance of the once moribund Chinese communities in Incheon and Busan, both of which now boast sizable Chinatowns. Yet the huaqiao still face problems with integrating fully into Korean society and being openly huaqiao can still lead to unwelcome attention and prejudice from native Koreans. The integration of the Chinese community in Korea remains a challenge for Korea that still holds firmly to the old nationalist ideology of the 20th century.
Immobilization of antibodies on the self-assembled monolayer by antigen-binding site protection and immobilization kinetic control  [PDF]
Myungok Yoon, Hyun Jin Hwang, Jeong Hee Kim
Journal of Biomedical Science and Engineering (JBiSE) , 2011, DOI: 10.4236/jbise.2011.44033
Abstract: The orientation of the biological molecule immobi-lized on a solid surface has been critical in devel-opment of various applications. In this study, ori-entation of antibody was retained by protecting the antigen-binding site of the antibody prior to immo-bilization to -functionalized mixed self-assembled monolayer (SAM) of 12-mercaptododecanoic acid and 1-heptanethiol. More importantly, the number of immobilization bonds formed between each an-tigen-binding site protected antibody molecule and the solid surface was controlled by optimizing the mole fraction of the activated carboxyl group of the linker molecules in the mixed SAM. The amount of antibody used in this study was approximately equivalent to the amount for one monolayer surface coverage. The resulting activity of protected immo-bilized antibody was about 10 fold higher than that of random immobilized antibody
HSF1-mediated oxidative stress response to menadione in Saccharomyces cerevisiae KNU5377Y3 by using proteomic approach  [PDF]
Il-Sup Kim, Hyun Kim, Young-Saeng Kim, Ingnyol Jin, Ho-Sung Yoon
Advances in Bioscience and Biotechnology (ABB) , 2013, DOI: 10.4236/abb.2013.41007
Abstract: The hat shock transcription factor HSF1 inthe yeast Saccharomyces cerevisiae regulates a wide range of genes and functions in diverse cellular reactions. To investigate the physiological response of HSF1 inthe presence of menadione (MD) in S. cerevisiae KNU 5377Y3, wild-type (k3wt) and isogenic hsf1 mutant (k3h1) cells were introduced. HSF1 was induced when k3wt cells were exposed to the superoxide-generating agent MD and k3h1 cells were hypersensitive to MD. Under MD stress, k3h1 cells down-regulated the expression of metabolic enzymes (Hxk, Fba1, Pgk1, Eno2, and Adh1), antioxidant enzymes (Trx2 and porin), and molecular chaperones and their cofactors (Hsp104, Ssb1, Hsp60, Hsp42, Hsp26, Hsp12, Cpr1, and Sti1). In addition, k3h1 cells increased cellular hydroperoxide levels and protein carbonylation under MD stress as compared to k3wt cells. However, there was a moderate difference in the wild-type (b3wt) and mutant (b3h1) cells derived from S. cerevisiae S288Cunder the same conditions. Thus, these results show that HSF1 is an important component of the stress response system, acting as an activator of cell rescue genes in S. cerevisiae KNU5377Y3, and its expression protects the cells from MD-induced oxidative damage by maintaining redox homeostasis and proteostasis in the presence of MD.
Development of Advanced Radiation Resistant ODS Steel for Fast Reactor System Applications  [PDF]
Tae Kyu Kim, Sanghoon Noh, Suk Hoon Kang, Hyun Ju Jin, Ga Eon Kim
World Journal of Engineering and Technology (WJET) , 2015, DOI: 10.4236/wjet.2015.33C019
Abstract:

A sodium-cooled fast reactor (SFR) is being developed at the Korea Atomic Energy Research Institute (KAERI). As in-core structural material for a SFR, advanced radiation resistant ODS steel (ARROS) has been developed. This paper summarizes the current status of ARROS development regarding an ODS steel composition, fabrication technology of ODS steel structural components and key joining technologies of ODS steel structural components.

Cyclic Topology in Complex Networks
Hyun-Joo Kim,Jin Min Kim
Physics , 2005, DOI: 10.1103/PhysRevE.72.036109
Abstract: We propose a cyclic coefficient $R$ which represents the cyclic characteristics of complex networks. If the network forms a perfect tree-like structure then $R$ becomes zero. The larger value of $R$ represents that the network is more cyclic. We measure the cyclic coefficients and the distributions of the local cyclic coefficient for both various real networks and the representative network models and characterize the cyclic structures of them.
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