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Search Results: 1 - 10 of 45394 matches for " Jin-Hwi Kim "
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Correlation between the Digital Cervicography and Pathological Diagnosis Performed at Private Clinics in Korea
Seog-Nyeon Bae, Jin-Hwi Kim, Chung-Won Lee, Min-Jong Song, Eun-Kyung Park, Yong-Seok Lee, Keun-Ho Lee, Soo-Young Hur, Joo-Hee Yoon, Sung-Jong Lee
International Journal of Medical Sciences , 2012,
Abstract: Objective: To evaluate the correlation tendency between abnormal findings of digital cervicography and cervical pathology at private clinics in Korea. Methods: Abnormal finding of digital cervicography performed at private clinics in Korea between January 1, 2010 and May 31, 2012 were analysed retrospectively. The patient's age, abnormal findings of digital cervicography, cervical cytology, human papillomaviru (HPV) test and cervical pathology were investigated and the rate of agreement between abnormal finding of digital cervicography and cervical pathology results was calculated. Abnormal findings of digital cervicography were divided into 4 categories: atypical, compatible with CIN1, compatible with CIN2/3 and compatible with cancer. Results: The study group was composed of 1547 women with a mean (range) age of 37.4 (14-91 years). The agreement rate between abnormal findings of digital cervicography and cervical pathology was 52.0% in “compatible with CIN1”, 78.9% in “compatible with CIN2/3”, and 90.2% in “compatible with cancer”. Conclusions: Abnormal findings of digital cervicography were highly concordant with cervical intraepithelial neoplasia (CIN) and cancer examined at outpatient clinics in Korea. Therefore, abnormal interpretations of digital cervicography can be used as an excellent auxiliary technique with cervical cytology for CIN and cancer.
Flexor Tenorrhaphy Using Absorbable Suture Materials
Hyung Joo Kang,Dong Chul Lee,Jin Soo Kim,Sae Hwi Ki
Archives of Plastic Surgery , 2012, DOI: http://dx.doi.org/10.5999/aps.2012.39.4.397
Abstract: Background Nonabsorbable sutures are favorable for repairing flexor tendons. However,absorbable sutures have performed favorably in an animal model.Methods Two-strand sutures using the interlocking modified Kessler method with polydioxanoneabsorbable sutures 4-0 were used to repair completely ruptured flexor tendons in 55 fingersfrom 41 consecutive patients. The medical records of average 42 follow up weeks were analyzedretrospectively. The data analyzed using the chi-squared test, and Fisher’s exact test was used forpostoperative complications. The results were compared with those of other studies.Results Among the index, middle, ring, and little fingers were injured in 9, 17, 16, and13 fingers, respectively. The injury levels varied from zone 1 to 5. Of the 55 digits in ourstudy, there were 26 (47%) isolated flexor digitorum profundus (FDP) injuries and 29 (53%)combined FDP and with flexor digitorum superficialis injuries. Pulley repair was also conducted.Concomitant injuries of blood vessels and nerves were found in 17 patients (23 fingers); nerveinjuries occurred in 5 patients (10 fingers). Two patients had ruptures (3.6%), and one patienthad two adhesions (3.6%). Using the original Strickland criteria, all the patients were assessedto be excellent or good. Also, fibrosis and long-term foreign body tissue reactions such as stitchgranuloma were less likely occurred in our study. Compared to the Cullen’s report that usednonabsorbable sutures, there was no significant difference in the rupture or adhesion rates.Conclusions Therefore, this study suggests that appropriate absorbable core sutures can beused safely for flexor tendon repairs.
Spontaneous Evolution in Bilirubin Levels Predicts Liver-Related Mortality in Patients with Alcoholic Hepatitis
Minjong Lee, Won Kim, Yunhee Choi, Sunhee Kim, Donghee Kim, Su Jong Yu, Jeong-Hoon Lee, Hwi Young Kim, Yong Jin Jung, Byeong Gwan Kim, Yoon Jun Kim, Jung-Hwan Yoon, Kook Lae Lee, Hyo-Suk Lee
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0100870
Abstract: The accurate prognostic stratification of alcoholic hepatitis (AH) is essential for individualized therapeutic decisions. The aim of this study was to develop a new prognostic model to predict liver-related mortality in Asian AH patients. We conducted a hospital-based, retrospective cohort study using 308 patients with AH between 1999 and 2011 (a derivation cohort) and 106 patients with AH between 2005 and 2012 (a validation cohort). The Cox proportional hazards model was constructed to select significant predictors of liver-related death from the derivation cohort. A new prognostic model was internally validated using a bootstrap sampling method. The discriminative performance of this new model was compared with those of other prognostic models using a concordance index in the validation cohort. Bilirubin, prothrombin time, creatinine, potassium at admission, and a spontaneous change in bilirubin levels from day 0 to day 7 (SCBL) were incorporated into a model for AH to grade the severity in an Asian patient cohort (MAGIC). For risk stratification, four risk groups were identified with cutoff scores of 29, 37, and 46 based on the different survival probabilities (P<0.001). In addition, MAGIC showed better discriminative performance for liver-related mortality than any other scoring system in the validation cohort. MAGIC can accurately predict liver-related mortality in Asian patients hospitalized for AH. Therefore, SCBL may help us decide whether patients with AH urgently require corticosteroid treatment.
Biodegradable stent  [PDF]
Doo Yeon Kwon, Jae Il Kim, Da Yeon Kim, Hwi Ju Kang, Bong Lee, Kang Woo Lee, Moon Suk Kim
Journal of Biomedical Science and Engineering (JBiSE) , 2012, DOI: 10.4236/jbise.2012.54028
Abstract: The bare metal stent (BMS) used in the blood vessel caused the restenosis after the operation due to formation and proliferation of neointimal. Recently, as a method to overcome the problems of BMS, drug eluting stent (DES) is developed and being applied to human body which has drug reducing restenosis applied on the metal surface. DES has the advantage of greatly reducing the restenosis after the operation; however, metal stent remains in the body after the drug is released causing issues such as late thrombosis and restenosis so that currently the attention is increasing for biodegradable materials that reduce restenosis and thrombosis by degrading as a certain amount of time passes after the drug is released by the stent material. In this review, the study trend of biodegradable stent will be explained.
Latency Prolongation of P300 Event Related Potentials in Patients with and Without Asymptomatic Cerebral Infarction
Kim Kah Hwi,Chin Kah Chuan
Journal of Medical Sciences , 2005,
Abstract: In this study, we evaluate the changes on the Events-Related Potentials (ERPs) of P300 in patients with asymptomatic cerebral infarction which was detected by Magnetic Resonance Imaging (MRI). We examined 37 patients who visited University Hospital with complaint of headache or dizziness which had no episodes of stroke nor any neurological defect including obvious dementia between March 1988 to March 2000. MRI were performed and we found 23 cases of patients showed multiplelacunar infarction and 14 patients (8 male and 6 female) (with average age of 70) showed marked leuko-araiosis or periventricular high intensity with or without lacunar infarction in T2-weight image. We compared these two group with 13 healthy age-match (7 male and 6 female with average age of 68) as control group. ERPs was recorded with a band-pass filter of 0.01-120 c s-1. ERPs were derived from the Fz, Cz and Pz referenced to linked earlobe electrode and mini-mental test were performed in all subject. P300 ERPs were recorded by standard oddball paradigm with the subject seated in a reclined easy chair. In auditory paradigms, during the subject`s eyes were closed, 2,000 Hz tone were used as target and 1,000 Hz tone as none target through headphone. The target tone were presented in a random sequence at the rate of 20%. Then the subjects were instruct to count the number of target tone. Statistical analysis was performed using one factor ANOVA to determine inter-group differences. P300 latency in patients MRI showed multiple lacunar infarction (378.8 33.6 ms) and in patients MRI showed marked leuko-araiosis infarction (388.3 3.6 ms), were significantly prolonged as compare to normal healthy person (338.6 13.5 ms). However, the amplitude of P300 was remain unchanged. The scores obtained from Mini Mental State Test (MMST) were showed no significantly different between the normal elderly and patient with multiple lacunar infarction and in leuko-araiosis infarction patients Comparison the latency and amplitude of N100, P200 and N200 were also no significantly differences. The present finding, we found the P300 latency was significantly prolong in multiple lacunar infarction patients and in leuko-araiosis infarction patients. But there were no significant changes in the amplitude of P300. Thus, we can concluded that cognitive function was impaired with asymptomatic cerebral infarction.
Alternanthera sessilis Red Ethyl Acetate Fraction Exhibits Antidiabetic Potential on Obese Type 2 Diabetic Rats
Kok Keong Tan,Kah Hwi Kim
Evidence-Based Complementary and Alternative Medicine , 2013, DOI: 10.1155/2013/845172
Cytoplasmic Polyadenylation Element Binding Protein Deficiency Stimulates PTEN and Stat3 mRNA Translation and Induces Hepatic Insulin Resistance
Ilya M. Alexandrov equal contributor,Maria Ivshina equal contributor,Dae Young Jung,Randall Friedline,Hwi Jin Ko,Mei Xu,Bryan O'Sullivan-Murphy,Rita Bortell,Yen-Tsung Huang,Fumihiko Urano,Jason K. Kim,Joel D. Richter
PLOS Genetics , 2012, DOI: 10.1371/journal.pgen.1002457
Abstract: The cytoplasmic polyadenylation element binding protein CPEB1 (CPEB) regulates germ cell development, synaptic plasticity, and cellular senescence. A microarray analysis of mRNAs regulated by CPEB unexpectedly showed that several encoded proteins are involved in insulin signaling. An investigation of Cpeb1 knockout mice revealed that the expression of two particular negative regulators of insulin action, PTEN and Stat3, were aberrantly increased. Insulin signaling to Akt was attenuated in livers of CPEB–deficient mice, suggesting that they might be defective in regulating glucose homeostasis. Indeed, when the Cpeb1 knockout mice were fed a high-fat diet, their livers became insulin-resistant. Analysis of HepG2 cells, a human liver cell line, depleted of CPEB demonstrated that this protein directly regulates the translation of PTEN and Stat3 mRNAs. Our results show that CPEB regulated translation is a key process involved in insulin signaling.
Quantitative Expression Analysis of APP Pathway and Tau Phosphorylation-Related Genes in the ICV STZ-Induced Non-Human Primate Model of Sporadic Alzheimer’s Disease
Sang-Je Park,Young-Hyun Kim,Gyu-Hwi Nam,Se-Hee Choe,Sang-Rae Lee,Sun-Uk Kim,Ji-Su Kim,Bo-Woong Sim,Bong-Seok Song,Kang-Jin Jeong,Youngjeon Lee,Young Il Park,Kyoung-Min Lee,Jae-Won Huh,Kyu-Tae Chang
International Journal of Molecular Sciences , 2015, DOI: 10.3390/ijms16022386
Abstract: The accumulation and aggregation of misfolded proteins in the brain, such as amyloid-β (Aβ) and hyperphosphorylated tau, is a neuropathological hallmark of Alzheimer’s disease (AD). Previously, we developed and validated a novel non-human primate model for sporadic AD (sAD) research using intracerebroventricular administration of streptozotocin (icv STZ). To date, no characterization of AD-related genes in different brain regions has been performed. Therefore, in the current study, the expression of seven amyloid precursor protein (APP) pathway-related and five tau phosphorylation-related genes was investigated by quantitative real-time PCR experiments, using two matched-pair brain samples from control and icv STZ-treated cynomolgus monkeys. The genes showed similar expression patterns within the control and icv STZ-treated groups; however, marked differences in gene expression patterns were observed between the control and icv STZ-treated groups. Remarkably, other than β-secretase ( BACE1) and cyclin-dependent kinase 5 ( CDK5), all the genes tested showed similar expression patterns in AD models compared to controls, with increased levels in the precuneus and occipital cortex. However, significant changes in gene expression patterns were not detected in the frontal cortex, hippocampus, or posterior cingulate. Based on these results, we conclude that APP may be cleaved via the general metabolic mechanisms of increased α- and γ-secretase levels, and that hyperphosphorylation of tau could be mediated by elevated levels of tau protein kinase, specifically in the precuneus and occipital cortex.
Temporal Variations on Soil Salinity and Cation Displacement at Saemangeum and Yeongsangang Reclaimed Tidal Lands  [PDF]
Sanghun Lee, Hui-Su Bae, Hong-Kyu Kim, Tae-Hwan Noh, Geon-Hwi Lee
Journal of Agricultural Chemistry and Environment (JACEN) , 2014, DOI: 10.4236/jacen.2014.34014
Abstract: Soil salinity at reclaimed tidal land in Korea is highly variable and depending on soil characteristics and weather conditions. The objective of this study was to evaluate the temporal changes on soil salinity and the relationships between soil salinity and salinity parameters in reclaimed tidal lands. Soil samples were periodically collected at 0 - 20 cm (surface) and 20 - 40 cm (subsurface) layer at Saemangeum (sandy loam) and Yeongsangang (silty loam) reclaimed tidal land. Electrical conductivity (EC) had a wide range from 0.0 to 34.3 dS·m-1 during the experimental period. The average soil EC was 6.4 and 3.4 dS·m-1 at Saemangeum and Yeongsangang reclaimed tidal land, respectively. Soluble sodium concentration had great variations and it was the most important single factor for temporal variations of soil EC regardless of soil textural properties. Calcium concentration was negatively correlated with soil EC and soluble sodium. Soil exchangeable sodium percentage (ESP) was estimated as a function of soil sodium adsorption ratio (SAR) and a linear regression model (ESP = 6.075 (SAR) + 0.677 for Saemangeum and ESP = 3.925 (SAR) + 0.421 for Yeongsangang reclaimed tidal soil) was suggested for predicting soil ESP from soil SAR. The characteristics of reclaimed tidal lands had different shares of saline and sodic properties during the experimental period. Saemangeum reclaimed tidal soil was highly characterized by sodium, but the effect of sodium on Yeongsangang soil was less pronounced. Our results indicate that persistent monitoring and modeling on soil salinity at reclaimed tidal soil is fundamental and the results can provide some useful information for deciding management plans for diverse utilization or to reduce salt damage for stable crop production at reclaimed tidal land.
Polyphenol-Rich Fraction of Brown Alga Ecklonia cava Collected from Gijang, Korea, Reduces Obesity and Glucose Levels in High-Fat Diet-Induced Obese Mice
Eun Young Park,Eung Hwi Kim,Mi Hwi Kim,Young Wan Seo,Jung Im Lee,Hee Sook Jun
Evidence-Based Complementary and Alternative Medicine , 2012, DOI: 10.1155/2012/418912
Abstract: Ecklonia cava (E. cava) is a brown alga that has beneficial effects in models of type 1 and type 2 diabetes. However, the effects of E. cava extracts on diet-induced obesity and type 2 diabetes have not been specifically examined. We investigated the effects of E. cava on body weight, fat content, and hyperglycemia in high-fat diet- (HFD) induced obese mice and sought the mechanisms involved. C57BL/6 male mice were fed a HFD (60% fat) diet or normal chow. After 3 weeks, the HFD diet group was given extracts (200 mg/kg) of E. cava harvested from Jeju (CA) or Gijang (G-CA), Korea or PBS by oral intubation for 8 weeks. Body weights were measured weekly. Blood glucose and glucose tolerance were measured at 7 weeks, and fat pad content and mRNA expression of adipogenic genes and inflammatory cytokines were measured after 8 weeks of treatment. G-CA was effective in reducing body weight gain, body fat, and hyperglycemia and improving glucose tolerance as compared with PBS-HFD mice. The mRNA expression of adipogenic genes was increased, and mRNA expression of inflammatory cytokines and macrophage marker gene was decreased in G-CA-treated obese mice. We suggest that G-CA reduces obesity and glucose levels by anti-inflammatory actions and improvement of lipid metabolism.
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